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Category: Endocrinology | Monthly Briefing

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September 2010 Briefing - Diabetes & Endocrinology

Last Updated: October 01, 2010.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for September 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

In Breast Cancer, Early Fertility Preservation Referral Better

THURSDAY, Sept. 30 (HealthDay News) -- Referring young, newly diagnosed breast cancer patients to a reproductive specialist before surgery may speed up fertility preservation (FP) procedures and allow time for two cycles of ovarian stimulation (OS) between surgery and initiation of chemotherapy, according to research published online Sept. 27 in the Journal of Clinical Oncology.

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Look AHEAD Results Favor Intensive Lifestyle Intervention

TUESDAY, Sept. 28 (HealthDay News) -- Intensive lifestyle intervention (ILI) for patients with type 2 diabetes can result in sustained improvements in cardiovascular risk factors and in fitness, according to a report published in the Sept. 27 issue of the Archives of Internal Medicine.

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Exercise Preserves Functioning in Women With Osteopenia

TUESDAY, Sept. 28 (HealthDay News) -- An exercise program in elderly women with osteopenia appears to preserve physical functioning and decrease the risk of fractures and mortality, according to a study in the Sept. 27 issue of the Archives of Internal Medicine.

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FDA to Greatly Restrict Use of Rosiglitazone

THURSDAY, Sept. 23 (HealthDay News) -- The U.S. Food and Drug Administration has announced plans to substantially restrict the use of rosiglitazone (Avandia) in type 2 diabetes patients unable to control their disease with other medications.

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Metabolic Syndrome Tied to Doubled Risk of CV Outcomes

TUESDAY, Sept. 21 (HealthDay News) -- Individuals with metabolic syndrome have a doubled risk of cardiovascular outcomes and a 58 percent higher risk of all-cause mortality, according to a meta-analysis published in the Sept. 28 issue of the Journal of the American College of Cardiology.

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Type of RNA Molecule Less Abundant in Diabetes

MONDAY, Sept. 20 (HealthDay News) -- People with diabetes mellitus appear to have lower blood levels of microRNAs (miRNAs) compared with healthy individuals, and these lower levels are detectable before manifestation of the disease, according to research published in the Sept. 17 issue of Circulation Research.

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Pazopanib Promising for Differentiated Thyroid Cancers

MONDAY, Sept. 20 (HealthDay News) -- Pazopanib results in a partial response in nearly half of patients with metastatic, rapidly progressive, and radioiodine-refractory differentiated thyroid cancers, according to research published online Sept. 20 in The Lancet Oncology.

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FDA Initiates Safety Review of Pioglitazone (Actos)

MONDAY, Sept. 20 (HealthDay News) -- The U.S. Food and Drug Administration has announced the start of a safety review of the type 2 diabetes drug pioglitazone (Actos), as preliminary results of a long-term observational study indicate an increased risk of bladder cancer in patients with the longest exposure to pioglitazone and the highest cumulative dose of the drug.

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Youths With Type 2 Diabetes Show Autoimmunity Evidence

MONDAY, Sept. 20 (HealthDay News) -- There may be evidence of islet autoimmunity contributing to insulin deficiency in obese youths with type 2 diabetes, and clinical characteristics may be significantly different between those with and without diabetes autoantibody (DAA) positivity, according to a study published in the September issue of Diabetes Care.

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Diabetes, Elevated A1C Increase Heart Failure Risk

MONDAY, Sept. 20 (HealthDay News) -- For patients with stable coronary artery disease (CAD), having an elevated A1C level increases the risk of heart failure, as does diabetes, independent of other risk factors, according to research published in the September issue of Diabetes Care.

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Metabolic Imbalance Linked With Asthma in Children

MONDAY, Sept. 20 (HealthDay News) -- Children with an imbalanced metabolism, which could be due to diet and/or exercise deficiencies, may be at an increased risk for developing asthma regardless of their body mass index (BMI), according to research published online Sept. 17 in the American Journal of Respiratory and Critical Care Medicine.

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Type 1 Diabetes Incidence Up in Children in Italy

MONDAY, Sept. 20 (HealthDay News) -- The incidence of type 1 diabetes rose in Italian children from 1990 to 2003, with large geographical variation observed, according to an age-period-cohort analysis published in the September issue of Diabetes.

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Insulin Resistance Linked to Reduced Mitochondrial Function

FRIDAY, Sept. 17 (HealthDay News) -- Insulin resistance appears to have a negative effect on mitochondrial function that isn't due to hyperglycemia, as seen in research on fasting individuals published in the September issue of Diabetes.

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Brain Fatty Acid Uptake Greater in Metabolic Syndrome

FRIDAY, Sept. 17 (HealthDay News) -- Metabolic syndrome appears to enhance brain fatty acid uptake, an effect that may be attenuated by weight loss, according to research published in the September issue of Diabetes.

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Lung Function Tied to Diabetes and Heart Disease Risk

THURSDAY, Sept. 16 (HealthDay News) -- Restrictive impaired lung function among men without a history of cardiovascular disease or diabetes appears to be associated with fatal coronary heart disease (CHD) and incident type 2 diabetes, according to a study published in the September issue of Diabetes Care.

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Most in Asian Malay Group With Diabetes Have Poor BP Control

THURSDAY, Sept. 16 (HealthDay News) -- More than 75 percent of an Asian Malay population with diabetes has poor glycemic and blood pressure (BP) control, according to a study published in the September issue of the Archives of Ophthalmology.

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High Cortisol Levels Associated With Cardiovascular Death

THURSDAY, Sept. 16 (HealthDay News) -- High levels of cortisol strongly predict cardiovascular death, even in people without pre-existing cardiovascular disease (CVD), according to research published online Aug. 25 in the Journal of Clinical Endocrinology & Metabolism.

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Leptin, Ghrelin May Play a Part in Weight Regain

THURSDAY, Sept. 16 (HealthDay News) -- Leptin and ghrelin appear to play important, and gender-specific, roles in the risk for weight regain in people who lose weight by dieting, according to research published online Aug. 18 in the Journal of Clinical Endocrinology & Metabolism.

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Insufficient Sleep May Lower Insulin Sensitivity

THURSDAY, Sept. 16 (HealthDay News) -- One week's sleep restriction decreases insulin sensitivity significantly in healthy subjects, raising questions about the effect chronic short sleep duration could have on insulin resistance-related disease processes, according to research published in the September issue of Diabetes.

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Anemia Therapy in Diabetes Patients With CKD Carries Risk

THURSDAY, Sept. 16 (HealthDay News) -- Patients with chronic kidney disease (CKD), type 2 diabetes, and anemia treated with an erythropoiesis-stimulating agent (ESA) who have a poor initial response are at higher risk for cardiovascular events and death than better-responding patients, according to a study in the Sept. 16 issue of the New England Journal of Medicine.

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Hyperglycemia Linked to Poor Outcomes in Ischemic Stroke

WEDNESDAY, Sept. 15 (HealthDay News) -- Among patients who suffer ischemic stroke, hyperglycemia at admission may increase the risks for poor outcomes after thrombolysis, according to a study in the September issue of the Archives of Neurology.

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Participatory Decision Making May Help Diabetes Patients

WEDNESDAY, Sept. 15 (HealthDay News) -- Participatory decision making (PDM), in which patients actively participate in their medical encounter, appears to increase medication adherence and improve hemoglobin A1c and low-density lipoprotein (LDL) cholesterol levels in patients with type 2 diabetes, according to research published in the September/October issue of the Annals of Family Medicine.

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Depression, Burnout Have Dire Impact on Medical Training

TUESDAY, Sept. 14 (HealthDay News) -- Depressed medical students are more likely to endorse depression stigma attitudes than nondepressed students, and those with burnout are more likely to engage in unprofessional conduct and less likely to hold altruistic views of physicians' social responsibilities than those without burnout, according to two articles published in the Sept. 15 issue of the Journal of the American Medical Association.

Abstract - Schwenk
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Abstract - Dyrbye
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Sacrifice Makes Industry Gifts Seem More Acceptable

TUESDAY, Sept. 14 (HealthDay News) -- Residents who are reminded of the sacrifices they made to attain their medical education tend to rate the acceptability of industry-sponsored gifts higher than those who are not reminded, according to research published in the Sept. 15 issue of the Journal of the American Medical Association.

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Re-Consent Important Before Secondary Use of Genetic Data

MONDAY, Sept. 13 (HealthDay News) -- Most research participants want to be asked for secondary consent -- referred to as re-consent -- before their existing personal genetic data are added to the federal database of Genotypes and Phenotypes (dbGaP), according to research published in the September issue of the Journal of Empirical Research on Human Research Ethics.

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Exposure to Lead May Delay Onset of Puberty in Girls

FRIDAY, Sept. 10 (HealthDay News) -- Exposure to lead (Pb) in childhood is associated with an increased risk of delayed puberty in girls, particularly in girls who also have high levels of cadmium (Cd), according to a study published online July 30 in Environmental Health Perspectives.

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Pituitary Sensitivity May Lead to Infertility in Obese Women

FRIDAY, Sept. 10 (HealthDay News) -- Infertility in obese women may be due to the ovarian-disrupting response of the pituitary gland to high insulin levels, according to a mouse study published in the Sept. 8 issue of Cell Metabolism.

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Annual Medical Liability Costs Surpass $50 Billion

THURSDAY, Sept. 9 (HealthDay News) -- The annual costs of the medical liability system in the United States total more than $50 billion, which accounts for a relatively small but non-trivial portion of total health care spending, according to an article in the September issue of Health Affairs.

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Guidelines Developed for Congenital Adrenal Hyperplasia

THURSDAY, Sept. 9 (HealthDay News) -- Clinical practice guidelines for congenital adrenal hyperplasia (CAH) have been developed by a task force of The Endocrine Society and published in the September issue of the Journal of Clinical Endocrinology & Metabolism.

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A1C Usefulness in Detecting New Diabetes Limited

FRIDAY, Sept. 3 (HealthDay News) -- Testing serum A1C levels is less sensitive for detecting individuals at risk for diabetes than other tests, but can be used for ongoing screening and diagnosis in those whose baseline A1C is already elevated, according to research published in the September issue of Diabetes Care.

Abstract - Lorenzo
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Abstract - Takahashi
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Mouse Study Clarifies Fish Oil Anti-Inflammatory Effect

FRIDAY, Sept. 3 (HealthDay News) -- The ω-3 fatty acids found in fish oil are able to reduce obesity-related inflammation and insulin resistance by stimulating the anti-inflammatory effects of the G protein-coupled receptor 120 (GPR120), which is found only on pro-inflammatory macrophages in mature fat cells, according to a study in mice published in the Sept. 3 issue of Cell.

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Early Severe Hypoglycemia Tied to Poorer Cognition

FRIDAY, Sept. 3 (HealthDay News) -- Exposure to severe hypoglycemia (SH) at an early age may negatively impact long-term cognitive function in individuals with type 1 diabetes, according to a study published in the September issue of Diabetes Care.

Abstract
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Ezetimibe/Simvastatin Combo Lowers LDL in Type 2 Diabetes

FRIDAY, Sept. 3 (HealthDay News) -- For patients with type 2 diabetes who are not meeting recommended low-density lipoprotein (LDL) cholesterol goals, adding ezetimibe to simvastatin treatment significantly increases the likelihood of reaching an LDL cholesterol level below 70 mg/dL, according to a study published in the September issue of Diabetes Care.

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Low Vitamin D Level May Raise Risk of Type 2 Diabetes

FRIDAY, Sept. 3 (HealthDay News) -- Having a higher plasma 25-hydroxyvitamin D (25-OHD) concentration appears to decrease the risk of type 2 diabetes in women, independent of other risk factors, according to a study published in the September issue of Diabetes Care.

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Bariatric Surgery Cost-Effective in Very Obese With Diabetes

THURSDAY, Sept. 2 (HealthDay News) -- Both gastric bypass and gastric banding are cost-effective ways to reduce diabetes-associated complications and mortality among severely obese individuals with diabetes, according to research published in the September issue of Diabetes Care.

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Sibutramine May Raise Risks in Those With CVD, Diabetes

WEDNESDAY, Sept. 1 (HealthDay News) -- In overweight or obese subjects with cardiovascular disease (CVD) and diabetes, long-term use of sibutramine is associated with an increased risk of nonfatal myocardial infarction (MI) and nonfatal stroke but not cardiovascular death or any-cause death, according to a study in the Sept. 2 issue of the New England Journal of Medicine.

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Metformin Shows Promise As Cancer Chemopreventive Drug

WEDNESDAY, Sept. 1 (HealthDay News) -- A trio of studies published online Sept. 1 in Cancer Prevention Research highlight the possibility that metformin and possibly other biguanide drugs may eventually prove useful in chemoprevention of various cancers, including lung and colon cancer.

Abstract - Memmott
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Abstract - Hosono
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Abstract - Pollak
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Fatty Liver Linked to Insulin Resistance in Obese Teens

WEDNESDAY, Sept. 1 (HealthDay News) -- In obese adolescents, fatty liver -- independent of visceral fat and intramyocellular lipid content (IMCL) -- is associated with impaired insulin activity in the muscles and liver; along with other findings, this suggests the liver plays a key role in insulin resistance in these individuals, according to research published in the August issue of Diabetes Care.

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Growth Factor Inhibition May Help Diabetes Patients

WEDNESDAY, Sept. 1 (HealthDay News) -- Inhibiting transforming growth factor-β1 (TGF-β1) expression in CD34+ cells may prove therapeutic for patients with type 2 diabetes by increasing the cells' vascular repair ability, according to research published in the August issue of Diabetes.

Abstract
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