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Category: Gastroenterology | Monthly Briefing

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September 2010 Briefing - Gastroenterology

Last Updated: October 01, 2010.

 

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Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for September 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

FDG-PET Predicts Need for Resection in Esophageal Cancer

THURSDAY, Sept. 30 (HealthDay News) -- A complete response (CR) to chemoradiotherapy (CRT) treatment of esophageal cancer seen on [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) scanning predicts a good outcome, and, if confirmed in larger studies, may be used to identify patients who do not need esophagectomy, according to research published online Sept. 27 in the Journal of Clinical Oncology.

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Vaccines Provide Hep B Immunity in Children for at Least 5 Years

WEDNESDAY, Sept. 29 (HealthDay News) -- Infants vaccinated with hexavalent vaccines, including hexavac, appear to maintain immunity to hepatitis B for at least five years after primary vaccination, suggesting that booster doses are not necessary to maintain immunity, according to a study published online Sept. 29 in The Lancet Infectious Diseases.

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Taribavirin Shows Benefit in Hepatitis C Versus Ribavirin

TUESDAY, Sept. 28 (HealthDay News) -- Taribavirin (TBV) appears to be a safe and effective alternative to ribavirin (RBV) for treating chronic hepatitis C, with lower associated rates of anemia, according to research published in the October issue of Hepatology.

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Terlipressin Linked to Sodium Reduction in Bleeding Patients

TUESDAY, Sept. 28 (HealthDay News) -- Patients with severe portal-hypertensive bleeding who are treated with terlipressin commonly have an acute reduction in serum sodium concentration that is associated with neurological complications and is usually reversible after the treatment is ended, according to research published in the October issue of Hepatology.

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Factors Tied to Higher Risk of Liver Cancer in Hep C Patients

FRIDAY, Sept. 24 (HealthDay News) -- People with elevated hepatitis C virus (HCV) RNA and ALT levels and HCV genotype 1 appear to be at increased risk for developing hepatocellular carcinoma, according to research published online Sept. 20 in the Journal of Clinical Oncology.

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Incidental Adnexal Masses Not Uncommon at Colonography

THURSDAY, Sept. 23 (HealthDay News) -- Among older women undergoing colonography, incidental indeterminate adnexal masses identified at unenhanced computed tomography (CT) are relatively common, though additional work-up isn't likely to find ovarian cancers; however, women with normal findings at CT aren't protected from developing ovarian cancer in the next few years, according to research published in the October issue of Radiology.

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Halting Imatinib After 3 Years May Lead to Tumor Progression

THURSDAY, Sept. 23 (HealthDay News) -- Interruption of imatinib after three years of treatment among patients with advanced gastrointestinal stromal tumors (GIST) who had been responding to treatment is likely to result in rapid disease progression, according to a study published online Sept. 22 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

In Unresectable Gall Bladder Cancer, Chemotherapy Benefits

THURSDAY, Sept. 23 (HealthDay News) -- Chemotherapy, particularly modified gemcitabine and oxaliplatin (mGEMOX), appears to be superior to best supportive care (BSC) in the treatment of patients with unresectable gall bladder cancer, according to research published online Sept. 20 in the Journal of Clinical Oncology.

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Disc Batteries Can Cause Severe Esophageal Damage

TUESDAY, Sept. 21 (HealthDay News) -- Ingestion of disc batteries can cause severe injury among pediatric patients and require emergency endoscopic retrieval, according to research published in the September issue of the Archives of Otolaryngology -- Head & Neck Surgery.

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Stool DNA Tests Not Cost-Effective for Cancer Screening

TUESDAY, Sept. 21 (HealthDay News) -- Screening Medicare beneficiaries for colorectal cancer (CRC) using stool DNA testing is not currently cost-effective, but could be if the cost per test dropped dramatically or if adherence to the testing were substantially better than for other screening tests, according to an analysis published in the Sept. 21 issue of the Annals of Internal Medicine.

Abstract
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Lowest Dose of Aspirin Reduces Colorectal Cancer Risk

THURSDAY, Sept. 16 (HealthDay News) -- Regular use of low-dose aspirin appears to reduce the risk of colorectal cancer (CRC) in the general population, which is evident after just five years of use, according to a study published online Sept. 15 in Gut.

Abstract
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Adherence Low for Colorectal Cancer Screening Program

WEDNESDAY, Sept. 15 (HealthDay News) -- Adherence to biennial fecal occult blood testing (FOBT) to detect signs of colorectal cancer (CRC) was low among members of a Washington State health plan, which potentially compromised its effectiveness in reducing CRC mortality, according to a study in the September/October issue of the Annals of Family Medicine.

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Depression, Burnout Have Dire Impact on Medical Training

TUESDAY, Sept. 14 (HealthDay News) -- Depressed medical students are more likely to endorse depression stigma attitudes than nondepressed students, and those with burnout are more likely to engage in unprofessional conduct and less likely to hold altruistic views of physicians' social responsibilities than those without burnout, according to two articles published in the Sept. 15 issue of the Journal of the American Medical Association.

Abstract - Schwenk
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Abstract - Dyrbye
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Sacrifice Makes Industry Gifts Seem More Acceptable

TUESDAY, Sept. 14 (HealthDay News) -- Residents who are reminded of the sacrifices they made to attain their medical education tend to rate the acceptability of industry-sponsored gifts higher than those who are not reminded, according to research published in the Sept. 15 issue of the Journal of the American Medical Association.

Abstract
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Re-Consent Important Before Secondary Use of Genetic Data

MONDAY, Sept. 13 (HealthDay News) -- Most research participants want to be asked for secondary consent -- referred to as re-consent -- before their existing personal genetic data are added to the federal database of Genotypes and Phenotypes (dbGaP), according to research published in the September issue of the Journal of Empirical Research on Human Research Ethics.

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Women's Weight Before Colon Cancer Linked to Mortality Risk

THURSDAY, Sept. 9 (HealthDay News) -- Among postmenopausal women with colon cancer, those who are underweight or obese or have increased abdominal obesity before the diagnosis appear to be at increased risk of mortality, according to research published in the September issue of Cancer Epidemiology, Biomarkers & Prevention.

Abstract
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Crohn's-Related Surgery Risk in Children Rarer Than Thought

THURSDAY, Sept. 9 (HealthDay News) -- The risk of bowel surgery in pediatric Crohn's disease (CD) patients appears to be lower than previously reported, and early initiation of immunomodulators does not appear to influence the risk of bowel surgery, according to research published in the September issue of Clinical Gastroenterology and Hepatology.

Abstract
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Annual Medical Liability Costs Surpass $50 Billion

THURSDAY, Sept. 9 (HealthDay News) -- The annual costs of the medical liability system in the United States total more than $50 billion, which accounts for a relatively small but non-trivial portion of total health care spending, according to an article in the September issue of Health Affairs.

Abstract
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More Stomach, Fewer Chest Complaints Seen in ERs

WEDNESDAY, Sept. 8 (HealthDay News) -- The percentage of non-injury visits to the emergency department for stomach pain has increased, while the percentage of chest pain-related visits has decreased, and use of advanced imaging for both has increased substantially, according to a September data brief released by the National Center for Health Statistics (NCHS).

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Gemcitabine Not Superior for Resected Pancreatic Cancer

TUESDAY, Sept. 7 (HealthDay News) -- For patients who undergo complete resection of pancreatic cancer, treatment with gemcitabine does not result in improved overall survival compared to treatment with fluorouracil plus folinic acid, though it may lead to fewer adverse events, according to a study in the Sept. 8 issue of the Journal of the American Medical Association.

Abstract
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Bowel Disease Is Risk Factor for Recurrent VTE

FRIDAY, Sept. 3 (HealthDay News) -- Individuals with inflammatory bowel disease (IBD) who have had a venous thromboembolism (VTE) have a higher risk of having a recurrence than those with a prior VTE but no IBD, according to a study in the September issue of Gastroenterology.

Abstract
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Bisphosphonates May Raise Esophageal Cancer Risk

FRIDAY, Sept. 3 (HealthDay News) -- Oral bisphosphonate use over five years may double one's risk of developing esophageal cancer, according to a study published online Sept. 2 in BMJ.

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Editorial

No Increased Mortality With Undiagnosed Celiac Disease

FRIDAY, Sept. 3 (HealthDay News) -- Older individuals with undiagnosed celiac disease (CD) are at increased risk for osteoporosis and hypothyroidism compared to those without CD, but they do not have an increased mortality risk, according to a study in the September issue of Gastroenterology.

Abstract
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Plant Fibers May Play Role in Crohn's Pathogenesis

THURSDAY, Sept. 2 (HealthDay News) -- Plantain and broccoli soluble plant fibers inhibit the translocation of Escherichia coli (E. coli) across microfold epithelial cells (M-cells) and Peyer's patches, but an emulsifier in many processed foods increases it, according to research published online Sept. 2 in Gut.

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Metformin Shows Promise As Cancer Chemopreventive Drug

WEDNESDAY, Sept. 1 (HealthDay News) -- A trio of studies published online Sept. 1 in Cancer Prevention Research highlight the possibility that metformin and possibly other biguanide drugs may eventually prove useful in chemoprevention of various cancers, including lung and colon cancer.

Abstract - Memmott
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Abstract - Hosono
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Abstract - Pollak
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