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Category: Oncology | Monthly Briefing

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January 2010 Briefing - Oncology

Last Updated: February 01, 2010.

 

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Here are what the editors at HealthDay consider to be the most important developments in Oncology for January 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Colorectal Cancer Screening Approach Studied in Seniors

FRIDAY, Jan. 29 (HealthDay News) -- The use of computed tomographic (CT) colonography appears safe and effective for colorectal cancer screening in older individuals, according to research published in the February issue of Radiology.

Abstract
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Adding Trastuzumab May Help in Advanced Breast Cancer

FRIDAY, Jan. 29 (HealthDay News) -- In women with HER2-positive locally advanced or inflammatory breast cancer, adding neoadjuvant and adjuvant trastuzumab to neoadjuvant chemotherapy may improve event-free survival, according to a study in the Jan. 30 issue of The Lancet.

Abstract
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Comment (subscription or payment may be required)

T Cells Linked to Skin Cancer After Kidney Transplant

FRIDAY, Jan. 29 (HealthDay News) -- Components of the immune system, particularly high numbers of regulatory T cells, predict whether a kidney transplant recipient is likely to develop a type of skin cancer, according to a study published online Jan. 28 in the Journal of the American Society of Nephrology.

Abstract
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Immunotherapy for Metastatic Prostate Cancer Explored

FRIDAY, Jan. 29 (HealthDay News) -- Treatment with a prostate-specific antigen (PSA)-targeted poxviral vaccine substantially improves overall survival among metastatic prostate cancer patients, according to the results of a phase II study published online Jan. 25 in the Journal of Clinical Oncology.

Abstract
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Editorial

Photodynamic Therapy Linked to Oral Cancer Benefit

THURSDAY, Jan. 28 (HealthDay News) -- Photodynamic therapy (PDT) appears useful in treating early-stage cancer of the mouth or oropharynx, either as a primary treatment or as an addition to unsuccessful surgery or radiation, according to research published in the January issue of Lasers in Surgery and Medicine.

Abstract
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Lifestyle Affects Incontinence Risk After Prostatectomy

THURSDAY, Jan. 28 (HealthDay News) -- In men who undergo radical prostatectomy, obesity and physical inactivity are associated with an increased prevalence of urinary incontinence, according to a study in the February issue of The Journal of Urology.

Abstract
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Prostate Cancer Treatment May Differ by Provider Type

WEDNESDAY, Jan. 27 (HealthDay News) -- Prostate cancer treatment for low-income men differs significantly between private providers and county hospitals, according to a study published online Jan. 25 in Cancer.

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Neoadjuvant Therapy Found Beneficial in Rectal Cancer

WEDNESDAY, Jan. 27 (HealthDay News) -- In patients with poor-risk, potentially operable rectal cancer, intensification of systemic therapy with neoadjuvant combination chemotherapy before standard treatment may result in good long-term outcomes, according to a study published online Jan. 26 in The Lancet Oncology.

Abstract
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Velcade Prescribing Information Changed

WEDNESDAY, Jan. 27 (HealthDay News) -- Takeda Oncology and the U.S. Food and Drug Administration have announced important revisions to the prescribing information for the drug Velcade (bortezomib) related to dosing in patients with hepatic impairment.

Safety Alert
Velcade Prescribing Information
Takeda Letter to the Health Care Professional

Race, Ethnicity Linked to Liver Cancer Survival

TUESDAY, Jan. 26 (HealthDay News) -- African-American patients with liver cancer have the worst survival among racial and ethnic groups even when they receive appropriate and equivalent treatment, according to a study published online Jan. 25 in Cancer.

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Researchers Explain Link Between Obesity, Liver Cancer

MONDAY, Jan. 25 (HealthDay News) -- Obesity promotes hepatocellular carcinoma by stimulating production of two inflammatory cytokines, according to an animal study in the Jan. 22 issue of Cell.

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Study Compares Digital and Screen-Film Mammography

MONDAY, Jan. 25 (HealthDay News) -- Breast screening with full-field digital mammography (FFDM) exposes women to a lesser glandular radiation dose per view compared to screen-film mammography, according to a study in the February American Journal of Roentgenology.

Abstract
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Quitting Smoking Can Increase Lung Cancer Survival Odds

FRIDAY, Jan. 22 (HealthDay News) -- Early-stage lung cancer patients who are smokers when they are diagnosed may significantly increase their chances of survival if they quit smoking, according to a study published online Jan. 21 in BMJ.

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Editorial (subscription or payment may be required)

Vitamin D Levels May Affect Risk of Colon Cancer

FRIDAY Jan. 22 (HealthDay News) -- There is an inverse association between pre-diagnostic circulating levels of vitamin D and the risk of colorectal cancer, although more research is needed to see whether increasing vitamin D concentration could lower the risk of the cancer, according to a study published online Jan. 21 in BMJ.

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Ovarian Cancer Early Diagnosis Prospects Evaluated

FRIDAY, Jan. 22 (HealthDay News) -- Proteomic-based biomarker discovery and contrast-enhanced ultrasound may be the best combination for accurately identifying early-stage epithelial ovarian cancer in women, according to a perspective in the February issue of the American Journal of Roentgenology.

Abstract
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Virus Testing Most Effective in Detecting Cervical Cancers

THURSDAY, Jan. 21 (HealthDay News) -- Screening women 35 and older for human papillomavirus (HPV) is more effective than conventional cytology in detecting invasive cervical cancers, while HPV screening in younger women leads to over-diagnosis of precancerous lesions that often regress, according to a study published online Jan. 19 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Nurses Often Deeply Affected by Workplace Errors

THURSDAY, Jan. 21 (HealthDay News) -- Nurses are deeply affected by errors they make in the intraoperative environment and need more guidance on what constitutes an error in order to encourage more open reporting, according to a study in the Jan. 10 issue of the AORN Journal.

Abstract
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Tylenol Recall in Effect Includes Several Other Drugs

WEDNESDAY, Jan. 20 (HealthDay News) -- McNeil Consumer Healthcare has recently expanded its voluntary recall of some over-the-counter drugs to include about 500 lots of products, according to officials from the Office of Compliance in the Center for Drug Evaluation and Research at the U.S. Food and Drug Administration.

More Information

Skin Cancer Checks Needed for Patients on Voriconazole

WEDNESDAY, Jan. 20 (HealthDay News) -- Patients receiving long-term treatment for fungal infections who show signs of photosensitivity or chronic photodamage should be monitored for skin cancer formation, according to an article published online Jan. 18 in the Archives of Dermatology.

Abstract
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Palliative Surgery Benefits Weighed in Spinal Metastasis

TUESDAY, Jan. 19 (HealthDay News) -- Palliative surgery for spinal metastasis can deliver satisfaction to patients and their family members in terms of improved quality of life, including neurological improvement, reduced pain and longer patient survival, according to a study in the January issue of The Spine Journal.

Abstract
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Disparities Seen in United Kingdom Cancer Care

FRIDAY, Jan. 15 (HealthDay News) -- In the United Kingdom, social factors such as age, gender, and socioeconomic status continue to affect access to hospital care for common cancers, according to a study published online Jan. 14 in BMJ.

Abstract
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Heart Failure Therapy Useful in Drug-Induced Cardiomyopathy

FRIDAY, Jan. 15 (HealthDay News) -- In cancer patients with anthracycline-induced cardiomyopathy, early treatment with modern heart failure therapies can restore left ventricular ejection fraction (LVEF), according to research published in the Jan. 19 issue of the Journal of the American College of Cardiology.

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NSAIDs May Help Slow Basal Cell Carcinoma Development

FRIDAY, Jan. 15 (HealthDay News) -- The nonsteroidal anti-inflammatory drug (NSAID) celecoxib (Celebrex) effectively inhibits the development of skin basal cell carcinoma (BCC) in highly susceptible patients compared to placebo, according to a study in the January issue of Cancer Prevention Research.

Abstract
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Perspective 1 (subscription or payment may be required)
Perspective 2 (subscription or payment may be required)

Financial Ties to Industry More Common for Key Authors

FRIDAY, Jan. 15 (HealthDay News) -- Authors who perform key scientific roles in clinical trials are more likely to have financial ties to industry, particularly if the trial is industry sponsored, according to a study published online Jan. 11 in the Journal of Clinical Oncology.

Abstract
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Editorial

Long-Term Risk of Cancer High for Endometrial Hyperplasia

THURSDAY, Jan. 14 (HealthDay News) -- Women with endometrial hyperplasia are at much higher long-term risk of developing endometrial cancer if their hyperplasia is atypical, according to a study published online Jan. 11 in the Journal of Clinical Oncology.

Abstract
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Novel Breast Cancer Therapy Targets Cancer Stem Cells

THURSDAY, Jan. 14 (HealthDay News) -- Blockading interleukin 8 (IL-8) receptors to kill off cancer stem cells (CSCs) may be a novel approach to treating breast cancer, according to a study published Jan. 4 in the Journal of Clinical Investigation.

Abstract
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Scan Can Find Small Cancers Undetected in Usual Evaluation

THURSDAY, Jan. 14 (HealthDay News) -- Whole-body positron emission tomography-computed tomography (PET-CT) can detect certain small cancers early in some patients in whom standard evaluation has failed to detect disease, making earlier treatment possible, according to a study published online Jan. 11 in the Archives of Neurology.

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Stenting for Biliary Drainage in Pancreatic Cancer Studied

WEDNESDAY, Jan. 13 (HealthDay News) -- Placing a stent to facilitate biliary drainage prior to surgery in patients with cancer of the pancreatic head and obstructive jaundice increases complication rates and does not improve the outcome of the surgery, according to a study in the Jan. 14 New England Journal of Medicine.

Abstract
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Editorial (subscription or payment may be required)

Physical Therapy Can Cut Risk of Post-Surgical Lymphedema

WEDNESDAY, Jan. 13 (HealthDay News) -- The risk of secondary lymphedema in breast cancer surgery patients can be significantly reduced by the early introduction of post-surgical physical therapy, according to a study published online Jan. 12 in BMJ.

Abstract
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Editorial (subscription or payment may be required)

Superficial Thrombophlebitis May Not Be Linked to Cancer

WEDNESDAY, Jan. 13 (HealthDay News) -- Contrary to numerous medical textbooks, patients who present with a single episode of unprovoked superficial venous thrombophlebitis do not have an increased short-term risk of developing cancer, according to a study in the January/February issue of the Annals of Family Medicine.

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Biomedical Research Funding Shows Decline in 2008

TUESDAY, Jan. 12 (HealthDay News) -- After increasing since 1994, annual funding for biomedical research topped out at $90.2 billion in 2007 and began to decline in 2008, according to a study in the Jan. 13 issue of the Journal of the American Medical Association.

Abstract
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Editorial

Test Results Can Affect Breast Cancer Treatment Decisions

TUESDAY, Jan. 12 (HealthDay News) -- The results of an assay to predict the risk of recurrence and the benefit of chemotherapy in breast cancer patients has a significant impact on treatment decisions for both physicians and patients, according to a study published online Jan. 11 in the Journal of Clinical Oncology.

Abstract
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Editorial

Little Discussion by Cancer Physicians of End-of-Life Care

TUESDAY, Jan. 12 (HealthDay News) -- Many physicians are not willing to discuss prognosis and end-of-life issues with terminally ill cancer patients, preferring to wait until they show symptoms or have exhausted all treatments, according to a study published online Jan. 11 in Cancer.

Abstract
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Clinical Benefits of Circumcision Remain Unclear

TUESDAY, Jan. 12 (HealthDay News) -- Although strong evidence shows that circumcision can prevent HIV infection in sub-Saharan African men, it's unclear if the procedure is associated with an overall reduced risk of sexually transmitted infections, urinary tract infections or penile cancer, according to a study in the January/February issue of the Annals of Family Medicine.

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Childhood Cancer Survivor Cardiovascular Risk Studied

MONDAY, Jan. 11 (HealthDay News) -- Survivors of childhood cancer are at increased cardiovascular risk as they age if they were treated with full-body or torso irradiation or are physically inactive, according to a study in the January Cancer Epidemiology, Biomarkers & Prevention.

Abstract
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Survey Looks at Breast Cancer Surgeon Practice, Patient Care

MONDAY, Jan. 11 (HealthDay News) -- Many breast cancer surgeons do not conform to optimal patient and practice management processes related to clinical information, patient decision support and quality of care, according to a study in the January issue of Medical Care.

Abstract
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Imetelstat Shows Potential for Prostate, Brain Cancer

FRIDAY, Jan. 8 (HealthDay News) -- The telomerase inhibitor imetelstat may be useful in treating glioblastoma and prostate cancer, according to research published online Jan. 4 in Clinical Cancer Research and online Nov. 11 in the International Journal of Cancer.

Abstract - Study 1
Full Text - Study 1 (subscription or payment may be required)
Abstract - Study 2
Full Text - Study 2 (subscription or payment may be required)

Vitamin and Drug Combination May Benefit Breast Cancer

THURSDAY, Jan. 7 (HealthDay News) -- The active form of vitamin D selectively reduces the production of aromatase, which catalyzes the production of estrogen, in breast cancers, and, when combined with aromatase inhibitors, further reduces tumor growth, according to a study in the January issue of Endocrinology.

Abstract
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Colonoscopy May Be Overused in Low-Risk Individuals

THURSDAY, Jan. 7 (HealthDay News) -- Surveillance colonoscopy is often overused in low-risk individuals without adenomas and underused in high-risk individuals with advanced adenomas, according to a study in the January issue of Gastroenterology.

Abstract
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Pomegranates May Offer Benefits Against Breast Cancer

WEDNESDAY, Jan. 6 (HealthDay News) -- Compounds derived from pomegranates could help prevent estrogen-responsive breast cancers, according to research published in the January issue of Cancer Prevention Research.

Abstract
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Extended Interferon Not Found Beneficial in Melanoma

WEDNESDAY, Jan. 6 (HealthDay News) -- In patients with intermediate and high-risk primary melanoma, continuation of low-dose interferon therapy beyond 18 months is not beneficial, according to a study published online Jan. 4 in the Journal of Clinical Oncology.

Abstract
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Lifestyle Reduces Depression in Breast Cancer Survivors

WEDNESDAY, Jan. 6 (HealthDay News) -- In breast cancer survivors, regular physical activity and tea consumption may help prevent depression, according to a study published online Jan. 4 in the Journal of Clinical Oncology.

Abstract
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Updated Method May Predict Breast Cancer Recurrence

WEDNESDAY, Jan. 6 (HealthDay News) -- IBTR! version 2.0 -- a Web-based nomogram to predict ipsilateral breast tumor recurrence after breast-conserving therapy -- may be accurate in most patients with a low-to-moderate risk but overestimates risk in some higher-risk patients, according to a study published online Jan. 4 in the Journal of Clinical Oncology.

Abstract
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Editorial

Survival Studied in Myeloma and Myelodysplastic Syndrome

TUESDAY, Jan. 5 (HealthDay News) -- Overall survival for multiple myeloma (MM) patients has increased substantially in recent decades for patients aged 65 years or younger, while prognosis for survival in patients with myelodysplastic syndromes (MDS) can be determined by methylation in key genes, according to a pair of studies published online Dec. 28 in the Journal of Clinical Oncology.

Abstract - Turesson
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Abstract - Shen
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Parents, Doctors of Childhood Cancer Survivors Studied

MONDAY, Jan. 4 (HealthDay News) -- Many pediatric oncologists are not comfortable with their older patients who survived childhood cancer, nor well informed on guidelines for long-term follow-up care, according to a study published online Dec. 28 in the Journal of Clinical Oncology. According to another study in the same issue, the stress of a child having cancer does not increase the risk of the parents divorcing.

Abstract - Henderson
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Abstract - Syse
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Probe Shows Potential for Identifying Breast Cancers

MONDAY, Jan. 4 (HealthDay News) -- The radiolabeled peptide analog 64Cu-TP3805, which has a high affinity for the receptor for the oncogene product VPAC1, appears useful in identifying breast cancers with PET imaging, according to the results of an animal study published online Dec. 15 in the Journal of Nuclear Medicine.

Abstract
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Radiofrequency Ablation Found Therapeutic for Lung Cancer

MONDAY, Jan. 4 (HealthDay News) -- Radiofrequency (RF) ablation appears to be a viable option for patients with primary non-small cell lung cancer (NSCLC) who aren't candidates for surgical treatment, according to research published in the January issue of Radiology.

Abstract
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Genotype Can Figure in Cancer Prognosis and Treatment

MONDAY, Jan. 4 (HealthDay News) -- A patient's genotype can affect their prognosis in certain cancers, as well as their medication tolerance, and should be taken into account in evaluation and treatment, according to a pair of studies published online Dec. 28 in the Journal of Clinical Oncology.

Abstract - Damm
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Abstract - Toffoli
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Acupuncture Can Relieve Anti-Estrogen Side Effects

MONDAY, Jan. 4 (HealthDay News) -- Acupuncture is as effective as the drug venlafaxine in relieving vasomotor symptoms caused by anti-estrogen hormone treatment for breast cancer, and it does not cause adverse events, according to a study published Dec. 28 in the Journal of Clinical Oncology.

Abstract
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Self-Efficacy May Affect Patients' Levels of Fatigue

FRIDAY, Jan. 1 (HealthDay News) -- Breast cancer survivors (BCS) and multiple sclerosis (MS) patients are likely to report less fatigue as a result of physical activity if they have a strong sense of self-efficacy and are not depressed, according to a study published online Nov. 30 in Psychosomatic Medicine.

Abstract
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Tea Drinking May Lower Endometrial Cancer Risk

FRIDAY, Jan. 1 (HealthDay News) -- Tea drinking, in particular drinking green tea, can reduce the risk of endometrial cancer, according to a meta-analysis reported in the December issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Seniors Getting Chemo May Have More Adverse Events

FRIDAY, Jan. 1 (HealthDay News) -- Older patients with non-small-cell lung cancer (NSCLC) who get chemotherapy have higher risk of adverse events, necessitating a balance between symptom management and treatment risks, according to a study published online Dec. 28 in the Journal of Clinical Oncology.

Abstract
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Editorial

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