Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for March 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Pediatric Endocrinologists Vary Widely in Diabetes Practices
WEDNESDAY, March 31 (HealthDay News) -- Pediatric endocrinologists vary widely in their management of pediatric type 2 diabetes, with younger providers likely managing the disease more aggressively, according to research published in the March issue of Diabetes Care.
Exercise Improves Insulin Sensitivity in Type 2 Diabetes
WEDNESDAY, March 31 (HealthDay News) -- Patients with type 2 diabetes who undergo exercise training can restore their mitochondrial function and increase insulin sensitivity, according to a study published in the March issue of Diabetes.
Telemonitoring Program Beneficial in Type 2 Diabetes
TUESDAY, March 30 (HealthDay News) -- Among individuals with type 2 diabetes and inadequate glycemic control, management with a home telemonitoring program leads to larger reductions in A1C compared to a monthly care coordination phone call, though both improve glycemic control, according to research published in the March issue of Diabetes Care.
Parathyroid Procedure Linked to Scar-Related Benefits
TUESDAY, March 30 (HealthDay News) -- The use of video-assisted parathyroidectomy (VAP) may lead to better scar outcomes compared to bilateral cervical exploration (BCE), according to research published in the March issue of the Archives of Otolaryngology -- Head & Neck Surgery.
Regular Diabetes Screenings Should Start Early
TUESDAY, March 30 (HealthDay News) -- In the United States, initiation of screening for type 2 diabetes between ages 30 and 45, with repeat screenings every three to five years, is cost effective, according to a study published online March 30 in The Lancet.
Diabetes Ups Post-Op Mortality Risk in Cancer Patients
MONDAY, March 29 (HealthDay News) -- Cancer patients with preexisting diabetes have a greater risk of dying after surgery compared to patients without diabetes, according to research published in the April issue of Diabetes Care.
Common Signals May Underlie Obesity and Drug Addiction
MONDAY, March 29 (HealthDay News) -- Over-consumption of calorie-rich food may trigger a reaction similar to cocaine and heroin addiction-like responses, according to a study in rats published online March 28 in Nature Neuroscience.
Four Risk Factors Linked to Life Expectancy Disparities
THURSDAY, March 25 (HealthDay News) -- Four preventable risk factors -- smoking, high blood pressure, elevated blood glucose, and overweight and obesity -- account for a significant proportion of the nation's disparities in life expectancy, according to a study published March 23 in PLoS Medicine.
Outcomes of Depression Drug Treatment Affected by Diabetes
THURSDAY, March 25 (HealthDay News) -- The effectiveness of medical treatment for depression in type 2 diabetes patients is adversely affected by diabetes-related complications, pain and other factors, according to research published in the March issue of Diabetes Care.
Reaching Out for Support Tied to Lower Diabetes Mortality Risk
THURSDAY, March 25 (HealthDay News) -- Patients with type 1 and type 2 diabetes who have a propensity to reach out for social support have lower odds of dying compared to their more independent counterparts, according to a study in the March issue of Diabetes Care.
Diabetes Now a Major Public Health Problem in China
WEDNESDAY, March 24 (HealthDay News) -- Diabetes has become a serious public health burden in China, suggesting a need for prevention and treatment approaches, according to research published in the March 25 issue of the New England Journal of Medicine.
Use of Pain Relievers Linked to Lower Estrogen Levels
WEDNESDAY, March 24 (HealthDay News) -- More frequent use of analgesics is associated with lower estrogen levels in postmenopausal women, which may reduce the risk of breast or ovarian cancer, according to a study published online March 23 in Cancer Epidemiology, Biomarkers & Prevention.
Continuous Glucose Monitoring Shows Benefit in Critically Ill
TUESDAY, March 23 (HealthDay News) -- Real-time continuous glucose monitoring (CGM) in critically ill patients reduces severe hypoglycemic events, but doesn't lead to better glycemic control compared to intensive insulin therapy based on an algorithm, according to research published in the March issue of Diabetes Care.
Growth Hormone Beneficial Beyond Increasing Height
MONDAY, March 22 (HealthDay News) -- Growth hormone has additional benefits besides increasing height in children, including improvements in lipid profile and increases in bone mineral density, according to a review published online March 22 in Pediatrics.
Atorvastatin Linked to Insulin Resistance, Ambient Glycemia
MONDAY, March 22 (HealthDay News) -- In individuals with hypercholesterolemia, the use of atorvastatin is associated with higher fasting insulin and glycated hemoglobin, suggesting insulin resistance and higher ambient glycemia, according to research published in the March 23 issue of the Journal of the American College of Cardiology.
Hypoglycemia Risk Reduced With Pre-Pregnancy Insulin Therapy
MONDAY, March 22 (HealthDay News) -- Treating women with type 1 diabetes with the insulin analog prandial insulin aspart (IAsp) prior to their becoming pregnant reduces the risk of severe hypoglycemia at every stage of pregnancy, according to a study in the March issue of Diabetes Care.
Losartan Conjugate Reduces Advanced Liver Fibrosis in Rats
FRIDAY, March 19 (HealthDay News) -- The use of a conjugate containing losartan to target hepatic stellate cells reduces advanced liver fibrosis in rats, and ghrelin shows antifibrotic effects in injured rodent livers, according to two studies published in the March issue of Hepatology.
Low-Fat Diet May Not Reduce Cardio Risks After Menopause
FRIDAY, March 19 (HealthDay News) -- In postmenopausal women, a low-fat diet has little effect on cardiovascular risk factors and no overall effect on coronary heart disease and stroke, according to a study published online Feb. 17 in the American Journal of Clinical Nutrition.
Increased Risk of Death Persists After Hip Fracture
THURSDAY, March 18 (HealthDay News) -- In older adults, hip fracture is associated with both a short- and long-term increased risk of death, according to a meta-analysis published in the March 16 issue of the Annals of Internal Medicine.
Salsalate May Improve Glycemic Control in Type 2 Diabetes
THURSDAY, March 18 (HealthDay News) -- Salsalate improves markers of glycemic control in patients with type 2 diabetes and may provide a new avenue for the treatment of the disease, subject to further research on the drug's renal and cardiac impact, according to a study in the March 16 issue of the Annals of Internal Medicine.
Diabetes Education Linked to Comprehensive Clinical Care
WEDNESDAY, March 17 (HealthDay News) -- People with diabetes who receive diabetes self-management education (DSME) have a higher likelihood of receiving more comprehensive diabetes clinical care, according to research published in the winter issue of Diabetes Spectrum.
Effects of Hemoglobin-Based Oxygen Carriers Studied
MONDAY, March 15 (HealthDay News) -- Vasoconstrictor side effects of a hemoglobin-based oxygen carrier (HBOC) are not improved with reduction of low molecular weight hemoglobin concentrations to less than 1 percent, and are worse in animals with reduced nitric oxide levels associated with endothelial dysfunction due to diabetes or a high-fat diet, according to a study in the March issue of Anesthesiology. The findings give new insights into how to better understand and utilize these HBOCs, otherwise known as artificial blood.
FDA Adds Boxed Warning to Clopidogrel Label
FRIDAY, March 12 (HealthDay News) -- The U.S. Food and Drug Administration has added a boxed warning to the anti-blood-clotting drug clopidogrel (Plavix) to alert consumers and health care professionals that the drug may be less effective in patients who are unable to metabolize it in order to convert it into its active form.
Leptin Shows Advantages Over Insulin in Type 1 Diabetes
FRIDAY, March 12 (HealthDay News) -- The ability of leptin to restore hemoglobin A1c to normal in mice with diabetes (along with its additional benefits relating to body fat and cholesterol) suggests that the hormone may have a role in treating type 1 diabetes mellitus (T1DM) in humans, and may have both short- and long-term advantages over insulin monotherapy, according to research published online March 1 in the Proceedings of the National Academy of Sciences.
Diabetic Nephropathy Classification Developed
FRIDAY, March 12 (HealthDay News) -- A new consensus on the classification of type 1 and type 2 diabetes-related nephropathy, dividing diabetic nephropathy into four hierarchical glomerular lesions with varying degrees of severity, may aid international clinical practice, according to an article published online Feb. 18 in the Journal of the American Society of Nephrology.
Weight-Loss Camp Linked to Blood Pressure, BMI Benefit
THURSDAY, March 11 (HealthDay News) -- A residential weight-loss camp for preteens and teens is associated with lower blood pressure as well as weight reduction, according to research published online March 1 in Pediatrics.
Eating During Day May Prevent Obesity With Night Shift
THURSDAY, March 11 (HealthDay News) -- Eating during the day prevents the weight gain and disrupted circadian rhythms associated with eating at night in a rat model of shift work, according to a study in the March issue of Endocrinology.
Thiazolidinediones Not Linked to Diabetic Macular Edema
THURSDAY, March 11 (HealthDay News) -- In patients with type 2 diabetes, thiazolidinedione exposure is not associated with an increased risk of diabetic macular edema. In addition, an intravitreous dexamethasone drug delivery system shows promise in the treatment of persistent diabetic macular edema, according to research published in the March issue of the Archives of Ophthalmology.
Female Moderate Drinkers May Be Less Likely to Gain Weight
THURSDAY, March 11 (HealthDay News) -- Women who are light to moderate drinkers and enter middle age at normal weight may be less likely to become overweight or obese than those who do not drink, according to a study in the March 8 issue of the Archives of Internal Medicine.
Passive Response to Social Stress Linked to Depression
THURSDAY, March 11 (HealthDay News) -- Rats that are more passive in response to social stress exhibit signs of depression that may be associated with the regulation of corticotropin-releasing factor (CRF), a hormone that initiates the endocrine branch of the stress response, according to a study published online Feb. 16 in Endocrinology.
Thyroid Hormone Analogue Improves Cholesterol Lowering
WEDNESDAY, March 10 (HealthDay News) -- The addition of the thyroid hormone analogue eprotirome to conventional statin therapy further reduces low-density lipoprotein (LDL) cholesterol substantially, without significant adverse events, according to a study in the March 11 issue of the New England Journal of Medicine.
Pizza, Soda Consumption Falls When Prices Go Up
WEDNESDAY, March 10 (HealthDay News) -- Consumption of takeaway pizza and soda falls when prices increase, and altering the price of these two items could help Americans eat a more healthful diet, according to a study in the March 8 issue of the Archives of Internal Medicine.
Obesity Linked to Higher Mortality Rate in Colon Cancer
TUESDAY, March 9 (HealthDay News) -- In patients with colon cancer, obesity was associated with higher rates of cancer recurrence and mortality, according to research published online March 9 in Clinical Cancer Research.
Vitamin D Deficiency Common Among Dialysis Patients
FRIDAY, March 5 (HealthDay News) -- Kidney disease patients who have low blood levels of the protein albumin and who begin hemodialysis during the winter season are almost certain to develop vitamin D deficiency, according to a study in the March 1 issue of the Clinical Journal of the American Society of Nephrology.
Insulin Defects Linked to Impaired Female Reproduction
FRIDAY, March 5 (HealthDay News) -- Alterations in insulin signaling in lean, normoglycemic mice are associated with female reproductive defects and less successful pregnancies, according to a study published online Feb. 22 in Endocrinology.
Study Explores Links Between Obesity and Depression
FRIDAY, March 5 (HealthDay News) -- People who are obese are at increased risk of developing depression and, conversely, depressed people are at increased risk of developing obesity, according to a meta-analysis published in the March issue of the Archives of General Psychiatry.
Glycated Hemoglobin Beats Glucose in Prognostic Value
WEDNESDAY, March 3 (HealthDay News) -- Glycated hemoglobin has a similar association with diabetes risk as fasting glucose, and it has a stronger association with cardiovascular disease and mortality risk, according to research published in the March 4 issue of the New England Journal of Medicine.
Vitamin D May Cut Cardiovascular Disease Risk
WEDNESDAY, March 3 (HealthDay News) -- Vitamin D supplementation at moderate to high doses may decrease cardiovascular disease (CVD) risk, but calcium supplements appear to have little impact on cardiovascular health, according to a review published in the March 2 issue of the Annals of Internal Medicine.
Weight Loss Found to Reduce Carotid Artery Wall Thickness
WEDNESDAY, March 3 (HealthDay News) -- Weight loss can reduce carotid vessel wall volume and thickness (VWV) and blood pressure, regardless of type of diet followed; and, three years later, most subjects on low-fat and low-carbohydrate diets preserve moderate weight loss despite some regain, according to one study published online March 1 in Circulation, and another study in the March 2 Annals of Internal Medicine.
Vitamin D Receptor Agonists Block Prostate Cancer Growth
THURSDAY, Feb. 25 (HealthDay News) -- Vitamin D receptor (VDR) agonists can reduce the growth of prostate cancer cells containing a common, androgen-regulated, growth-promoting gene fusion, according to a study published online Feb. 10 in Endocrinology.
Insulin Found to Regulate Itself in Healthy People
MONDAY, March 1 (HealthDay News) -- Insulin stimulates its own secretion from pancreatic β-cells in response to glucose in healthy people, according to a study published online Feb. 15 in the Proceedings of the National Academy of Sciences.
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