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Pregnancy From Donor Egg Raises Hypertension Risk

Last Updated: November 23, 2010.

Pregnancies resulting from in vitro fertilization using donated eggs are more likely to result in gestational hypertension and preeclampsia than vitro fertilization pregnancies in which autologous eggs are implanted, and pregnancies from cryopreserved embryos are also tied to a higher risk for hypertensive disorders, according to a study in the December issue of Obstetrics & Gynecology.

TUESDAY, Nov. 23 (HealthDay News) -- Pregnancies resulting from in vitro fertilization (IVF) using donated eggs are more likely to result in gestational hypertension and preeclampsia than IVF pregnancies in which autologous eggs are implanted, and pregnancies from cryopreserved embryos are also tied to a higher risk for hypertensive disorders, according to a study in the December issue of Obstetrics & Gynecology.

Peter C. Klatsky, M.D., of the Women & Infants Hospital of Rhode Island in Providence, and colleagues compared the incidence of preeclampsia or gestational hypertension in the third trimester among 158 pregnant women who underwent IVF using autologous oocytes or donated oocytes. The authors also compared data on preterm delivery, low birth weight, and embryo cryopreservation.

The researchers found the rates for both gestational hypertension and preeclampsia were significantly higher for recipients of donated eggs (24.7 and 16.9 percent, respectively) than for women using their own eggs (7.4 and 4.9 percent, respectively). Also, women receiving donated eggs were more likely to deliver prematurely (34 versus 19 percent). Hypertensive disorders were five times more likely among women whose pregnancies were initiated using cryopreserved embryos.

"Pregnancies derived from donor oocytes and cryopreserved-thawed embryos may be at a higher risk for hypertensive disorders of pregnancy. These findings inform future research and help counsel women using assisted reproductive technology," the authors write.

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