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Category: Endocrinology | Monthly Briefing

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November 2010 Briefing - Diabetes & Endocrinology

Last Updated: December 01, 2010.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for November 2010. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Diabetes Linked to Poor Breast Cancer Outcomes

TUESDAY, Nov. 30 (HealthDay News) -- Women with diabetes mellitus and breast cancer appear to be at a higher risk of mortality and other negative breast cancer-related events, according to two studies published online Nov. 29 in the Journal of Clinical Oncology. Several other studies published online also highlight the links between obesity, diabetes, and poor breast cancer prognosis.

Abstract - Peairs
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Abstract - Erickson
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IOM Sets New Vitamin D, Calcium Intake Levels

TUESDAY, Nov. 30 (HealthDay News) -- In a new report, the Institute of Medicine (IOM) has set new dietary intake levels for vitamin D and calcium, and the agency notes that most North Americans already get enough calcium and vitamin D to be healthy.

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Diabetes Mortality High Despite Better Management

TUESDAY, Nov. 30 (HealthDay News) -- Since management of type 1 diabetes improved markedly in the 1980s, survival rates in those with the disease have improved as well, but mortality is still much higher than that in the general population, according to research published in the December issue of Diabetes Care.

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Diabetes Family History May Not Worsen Effects of Inactivity

TUESDAY, Nov. 30 (HealthDay News) -- First-degree relatives (FDRs) of individuals with type 2 diabetes do not appear to sustain greater deleterious effects of physical inactivity in regards to adipose tissue metabolism compared to control subjects, according to a study published in the November issue of Diabetes.

Abstract
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High-Protein, Low-Glycemic-Index Diet Stops Weight Regain

WEDNESDAY, Nov. 24 (HealthDay News) -- After weight loss, a maintenance diet higher in protein and with a modest reduction in the glycemic index prevents significant weight regain better than other diets, according to a study in the Nov. 25 issue of the New England Journal of Medicine.

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Axiron Approved as First Underarm Testosterone Drug

WEDNESDAY, Nov. 24 (HealthDay News) -- Axiron has been approved by the U.S. Food and Drug Administration as the first topical testosterone solution to be applied to the underarm, makers Eli Lilly and Acrux said in a news release.

National Institute on Aging

Diabetes-Depression Link Appears Bidirectional

WEDNESDAY, Nov. 24 (HealthDay News) -- The relationship between depression and diabetes appears to be bidirectional: those with diabetes may be at higher risk for depression, and vice versa, according to research published in the Nov. 22 issue of the Archives of Internal Medicine.

Abstract
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Reallocation of Care Would Increase PCPs' Work Weeks

WEDNESDAY, Nov. 24 (HealthDay News) -- Specialists spend a substantial amount of time providing routine chronic disease follow-up care, and reallocating half of this care to primary care physicians (PCPs) would add a few work weeks for each PCP, according to research published online Oct. 18 in Medical Care.

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Combination Exercise Linked to Benefits in Type 2 Diabetes

TUESDAY, Nov. 23 (HealthDay News) -- In individuals with type 2 diabetes, a combination of aerobic and resistance training -- but not either one alone -- is associated with improved HbA1c levels compared to not exercising, according to research published in the Nov. 24 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Testosterone Effects Do Not Last in Frail Elderly Men

FRIDAY, Nov. 19 (HealthDay News) -- Improvements in muscle strength, lean mass, and quality of life (QoL) among frail elderly men during six months of testosterone treatment are not maintained six months after discontinuation of treatment, according to a study published online Nov. 17 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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U.S. Health Insurance Compared to 10 Other Nations

FRIDAY, Nov. 19 (HealthDay News) -- Adults in the United States spend more time and money on health insurance than those in many other developed nations, and ultimately deal with more coverage-related disputes and denials, according to research published online Nov. 18 in Health Affairs.

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Fraud in Scientific Literature Appears Intentional

THURSDAY, Nov. 18 (HealthDay News) -- Scientific papers retracted after publication due to fraudulent data represent a calculated, deliberate effort to deceive, according to research published online Nov. 15 in the Journal of Medical Ethics.

Abstract
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DHT Treatment Not Linked to Effect on Prostate Growth

WEDNESDAY, Nov. 17 (HealthDay News) -- The use of dihydrotestosterone (DHT) in older men doesn't appear to have an effect on prostate growth, though it does decrease spinal bone mineral density, according to research published in the Nov. 16 issue of the Annals of Internal Medicine.

Abstract
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Editorial (subscription or payment may be required)

OTC Analgesics Up Risk of Congenital Cryptorchidism

WEDNESDAY, Nov. 17 (HealthDay News) -- Use of over-the-counter pain medication during pregnancy -- particularly in the second trimester -- may increase the risk of congenital cryptorchidism, a finding which may explain recent marked increases in the incidence of this condition, according to research published online Nov. 8 in Human Reproduction.

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Childhood, Teenage Abuse Linked to Diabetes in Adulthood

FRIDAY, Nov. 12 (HealthDay News) -- Moderate to severe physical and sexual abuse in childhood and adolescence appears to increase the risk for type 2 diabetes in adult women, partly because of the higher body mass index in women who were abused as children, according to a study published online Nov. 9 in the American Journal of Preventive Medicine.

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Vitamin D Tied to Cardiovascular Risk Factors, Disease

FRIDAY, Nov. 12 (HealthDay News) -- Researchers combing a large database have found evidence to suggest that vitamin D levels play a highly significant role in cardiovascular health, according to an article published in the Oct. 1 issue of the American Journal of Cardiology.

Abstract
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Physician-Industry Financial Ties Decreased Since 2004

FRIDAY, Nov. 12 (HealthDay News) -- Fewer physicians received drug samples, food and beverages, reimbursement, or payment for professional services in 2009 than in 2004, but a large majority of physicians still report financial relationships with industry, according to research published in the Nov. 8 issue of the Archives of Internal Medicine.

Abstract
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Pramlintide Effective Adjunctive Therapy for Diabetes

THURSDAY, Nov. 11 (HealthDay News) -- The synthetic amylin analogue pramlintide appears to be somewhat more effective than placebo as adjunctive treatment for diabetes in several clinical scenarios, according to research published in the November/December issue of the Annals of Family Medicine.

Abstract
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Low Vitamin D Levels Not Tied to Postpartum MS Relapses

THURSDAY, Nov. 11 (HealthDay News) -- Although pregnancy and exclusive breast-feeding are strongly related to low vitamin D levels in multiple sclerosis (MS) patients, these low levels are not related to an increased risk of postpartum MS relapses, according to research published online Nov. 8 in the Archives of Neurology.

Abstract
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Infant Diet May Affect Beta-Cell Autoimmunity Markers

WEDNESDAY, Nov. 10 (HealthDay News) -- In infants at increased risk for type 1 diabetes due to human leukocyte antigen (HLA) genotype, supplementing breast milk with a highly hydrolyzed milk formula is associated with fewer signs of beta-cell autoimmunity into childhood, according to research published in the Nov. 11 issue of the New England Journal of Medicine.

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Obese Teens at Risk of Being Severely Obese As Adults

TUESDAY, Nov. 9 (HealthDay News) -- Obese adolescents face a higher risk of developing severe obesity in young adulthood, according to research published in the Nov. 10 issue of the Journal of the American Medical Association.

Abstract
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Task Force Provides Guidelines for Post-Bariatric Surgery

MONDAY, Nov. 8 (HealthDay News) -- A new clinical practice guideline focuses on the nutritional and endocrine management of adults after bariatric surgery in an effort to prevent complications, weight regain, and progression of obesity-associated comorbidities, including diabetes. The guideline has been published in the November issue of the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Fitness Tied to Lower Mortality Despite Adiposity Category

MONDAY, Nov. 8 (HealthDay News) -- Women with high cardiorespiratory fitness (CRF) have lower all-cause mortality than less fit women in all categories of adiposity, according to a study in the November issue of Medicine & Science in Sports & Exercise.

Abstract
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Kombiglyze XR Approved for Adult Type 2 Diabetes

FRIDAY, Nov. 5 (HealthDay News) -- The combination drug Kombiglyze (saxagliptin, metformin XR) has been approved by the U.S. Food and Drug Administration to help control blood sugar in adults with type 2 diabetes, makers AstraZeneca and Bristol-Myers Squibb said Friday.

American Diabetes Association

Obesity Epidemic Influenced by Social Transmission

FRIDAY, Nov. 5 (HealthDay News) -- America's obesity epidemic is expected to continue to worsen until at least 42 percent of all adults are obese, and "social contagion" of obesity is in important factor, according to research published online Nov. 4 in PLoS Computational Biology.

Abstract
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Low Vitamin D Ups Mortality Risk in Patients With Diabetes

FRIDAY, Nov. 5 (HealthDay News) -- Low vitamin D levels increase the risk of all-cause mortality in patients with diabetes but do not appear to specifically increase the risk of progression to micro- or macroalbuminuria, according to research published in the October issue of Diabetes Care.

Abstract
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Placental Growth Factor May Be Marker for Pregnancy Location

FRIDAY, Nov. 5 (HealthDay News) -- Placental growth factor (PIGF) may serve as an effective diagnostic biomarker for early pregnancy location and pregnancy outcome, according to a study published online Nov. 3 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Men With Diabetes Have Higher Colorectal Cancer Risk

THURSDAY, Nov. 4 (HealthDay News) -- Men -- but not women -- with type 2 diabetes mellitus (DM) have a modestly increased risk of colorectal cancer (CRC), though insulin use is not related to a substantially increased CRC risk, according to a study in the October issue of Gastroenterology.

Abstract
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Gene Variants Affect Diabetes Treatment Response

THURSDAY, Nov. 4 (HealthDay News) -- Researchers have identified variants in 40 genes linked to the incidence of type 2 diabetes, response to treatment with metformin, or response to lifestyle intervention, according to a report published in the October issue of Diabetes.

Abstract
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In Metabolic Syndrome, Microalbuminuria a Risk Marker

THURSDAY, Nov. 4 (HealthDay News) -- The presence of microalbuminuria is an additional marker that can identify a high-risk subset of patients without diabetes who have the metabolic syndrome, according to research published in the Oct. 1 issue of the American Journal of Cardiology.

Abstract
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Androgen-Deprivation Therapy Linked to Physical Decline

THURSDAY, Nov. 4 (HealthDay News) -- Men with prostate cancer on androgen-deprivation therapy (ADT) do not appear to suffer accelerated cognitive decline but may have diminished physical function and quality of life (QoL), according to a pair of studies published online Nov. 1 in the Journal of Clinical Oncology.

Abstract - Cognitive Function Study
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Abstract - Physical Function Study
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Paricalcitol Found to Reduce Albuminuria in Type 2 Diabetes

THURSDAY, Nov. 4 (HealthDay News) -- The selective vitamin D receptor activator paricalcitol can reduce albuminuria in patients with type 2 diabetes already being treated with renin-angiotensin-aldosterone system inhibitors, according to research published online Nov. 4 in The Lancet.

Abstract
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Metformin May Lower Mortality in Heart Failure Patients

WEDNESDAY, Nov. 3 (HealthDay News) -- Metformin, either alone or in combination with sulfonylurea, appears to increase one-year and long-term survival in patients with type 2 diabetes mellitus (DM) and chronic heart failure (CHF), according to research published in the Oct. 1 issue of the American Journal of Cardiology.

Abstract
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Preventing Obesity in Young Black Girls Proves Challenging

WEDNESDAY, Nov. 3 (HealthDay News) -- A variety of interventions, including hip-hop dancing, group counseling, home/family interventions, and health education, failed to prevent obesity or body mass index (BMI) gain in young African-American girls in a pair of research studies published in the November issue of the Archives of Pediatrics & Adolescent Medicine.

Abstract - Robinson
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Abstract - Klesges
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Editorial (subscription or payment may be required)

Change to Healthier Beverages in Schools Is Slow

WEDNESDAY, Nov. 3 (HealthDay News) -- Despite Institute of Medicine guidelines recommending only the sale of water, 100 percent juice, and 1 percent or nonfat milk from vending machines in elementary schools, the percentage of students attending public schools that adhere to these guidelines has increased only to 16 percent, according to research published online Nov. 1 in the Archives of Pediatrics & Adolescent Medicine.

Abstract
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Incidence of End-Stage Renal Disease Due to Diabetes Down

MONDAY, Nov. 1 (HealthDay News) -- The incidence of end-stage renal disease attributed to diabetes (ESRD-D) among individuals with diagnosed diabetes has declined since 1996 in all U.S. regions and most states, according to a report published in the Oct. 29 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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