Maternal Age Over 45 Linked to Higher Maternal and Fetal RiskLast Updated: December 15, 2010. Pregnancy at extreme advanced maternal age is associated with increased maternal and fetal risk, according to research published in the December issue of the American Journal of Obstetrics & Gynecology.
WEDNESDAY, Dec. 15 (HealthDay News) -- Pregnancy at extreme advanced maternal age is associated with increased maternal and fetal risk, according to research published in the December issue of the American Journal of Obstetrics & Gynecology.
Yariv Yogev, M.D., of the Rabin Medical Center in Tel Aviv, Israel, and colleagues compared the condition of 177 women aged 45 years and older at the time of delivery in a 10:1 ratio to women age 20 to 29, 30 to 39, and 40 to 44 years from 2000 to 2008. They obtained data from the delivery room logbook and a perinatal database at their institution.
The researchers found that the rates of gestational diabetes mellitus, hypertensive complications, and preeclampsia toxemia were higher for the study group compared with the whole group (17 versus 5.6 percent, 19.7 versus 4.5 percent, and 10.7 versus 1.8 percent, respectively). The cesarean section delivery rate was significantly higher for the study group (78.5 versus 28.9 percent), as were the rates of breech presentation, postpartum hemorrhage, blood products transfusion, febrile complications, prolonged hospitalization, and low birth weight. A subgroup analysis of women from 45 to 49 years of age compared with those at least 50 years of age revealed that rates of hypertension, gestational diabetes mellitus, and preterm delivery were significantly higher in the latter group.
"Our findings suggest that this age group is a distinct obstetric high-risk entity; this information may be used for more accurate consultation with women who are contemplating pregnancy in this age group," the authors write.