FRIDAY, Aug. 1 (HealthDay News) -- Nifedipine, a calcium antagonist with relaxant effects on the myometrium, didn't significantly improve the success of external cephalic version in women with a fetus in breech presentation, according to research published in the August issue of Obstetrics & Gynecology.
Marjolein Kok, M.D., of the Academic Medical Centre in Amsterdam, the Netherlands, and colleagues analyzed data from 310 women with a breech presentation singleton fetus at a gestational age of 36 weeks or later. The women were randomized to receive nifedipine or placebo before the attempted external cephalic version. Women in the treatment group received 10 milligrams of the drug 30 and 15 minutes before the procedure.
The researchers found no significant difference in success rates for the procedure between the groups and no significant difference in the rates of Caesarean delivery in the women.
"Cephalic presentation after external cephalic version in our study was not different from the success rates of the placebo groups described in other studies ranging from 28 to 68 percent. Therefore, we feel confident that the external cephalic version was carried out properly. In addition, the Caesarean delivery rate for breech presentation in this trial was 68 percent. After external cephalic version in 310 women, 120 delivered vaginally in cephalic position. Thus, our study confirms the benefits of external cephalic version in the reduction of maternal and neonatal complications," the authors write.
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