Here are what the editors at HealthDay consider to be the most important developments in OBGYN & Women's Health for February 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Cigarette Smoking Associated With Congenital Heart Defects
MONDAY, Feb. 28 (HealthDay News) -- Women who smoke cigarettes during the first trimester of pregnancy may increase their offspring's risk for congenital heart defects (CHDs), according to research published online Feb. 28 in Pediatrics.
Adequate Breast-Feeding Tied to Less Childhood Adiposity
MONDAY, Feb. 28 (HealthDay News) -- Adequate breast-feeding of a baby exposed to diabetes in utero may protect against childhood adiposity, according to a study published in the March issue of Diabetes Care.
Distress Before Fertility Treatment Not Tied to Outcome
FRIDAY, Feb. 25 (HealthDay News) -- The emotional distress some women experience prior to undergoing fertility treatment appears to have no bearing on the likelihood that the treatment will result in a successful pregnancy, according to a literature analysis published Feb. 23 in BMJ.
Trastuzumab Tied to Disease-Free Survival at Four Years
FRIDAY, Feb. 25 (HealthDay News) -- In women with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer, treatment with trastuzumab for one year after chemotherapy is associated with significant disease-free survival at a four-year follow-up, according to a study published online Feb. 25 in The Lancet Oncology.
Eating Breakfast Tied to Lower BMI in Postpartum Teens
THURSDAY, Feb. 24 (HealthDay News) -- Postpartum teens who eat breakfast on most days consume fewer calories from snacks and sweetened drinks, and have a lower body mass index (BMI) than those who tend to skip breakfast, according to a study published in the January issue of the Journal of the American Dietetic Association.
Metastatic Breast Cancer Treatment Guidelines Updated
THURSDAY, Feb. 24 (HealthDay News) -- The American Society of Clinical Oncology has issued updated guidelines for the use of bone-modifying agents (BMAs) in treating breast cancer patients with bone metastases to include a new drug, denosumab, and provide new advice regarding a potentially serious complication of treatment, osteonecrosis of the jaw (ONJ); an overview of the guideline update was published online Feb. 22 in the Journal of Clinical Oncology.
Bupropion Improves Sexual Function in Type 2 Diabetes
WEDNESDAY, Feb. 23 (HealthDay News) -- Patients with type 2 diabetes who are treated with bupropion (BU) for major depressive disorder (MDD) show significant improvement in sexual function, according to a study published in the February issue of Diabetes Care.
Nitroglycerin Strengthens Bones in Older Women
WEDNESDAY, Feb. 23 (HealthDay News) -- Nitroglycerin ointment appears to increase bone mineral density (BMD) and decrease bone resorption in postmenopausal women when administered daily, according to research published in the Feb. 23 issue of the Journal of the American Medical Association.
Type 1 Diabetes Tied to Shorter Breast-Feeding Duration
WEDNESDAY, Feb. 23 (HealthDay News) -- Although mothers with type 1 diabetes are less likely to partially or exclusively breast-feed at two months, diabetes is not an independent risk factor for the initiation and maintenance of breast-feeding, according to a study published in the February issue of Diabetes Care.
Breast Cancer History Lowers Accuracy of Mammogram
TUESDAY, Feb. 22 (HealthDay News) -- Mammography screening for breast cancer may be less accurate among women with a personal history of breast cancer (PHBC), despite a higher underlying cancer rate, relative to women without PHBC, according to a study published in the Feb. 23 issue of the Journal of the American Medical Association.
FDA Issues Label Changes for Antipsychotic Drug Class
TUESDAY, Feb. 22 (HealthDay News) -- The U.S. Food and Drug Administration has notified health care providers that the Pregnancy section of drug labels for the entire class of antipsychotic drugs has been updated. The new drug labels include additional and consistent information regarding the potential risk for abnormal muscle movements (extrapyramidal signs [EPS]) and withdrawal symptoms among newborns whose mothers received the drugs in the third trimester of pregnancy.
False Positives Fall With Greater Volume of Mammograms
TUESDAY, Feb. 22 (HealthDay News) -- Interpreting a high volume of mammograms may not lead radiologists to find more cancers but may help them to better distinguish between malignant and non-malignant lesions, according to research published online Feb. 22 in Radiology.
Considerable Lack of Test Result Follow-Up in Hospitals
MONDAY, Feb. 21 (HealthDay News) -- Failure to follow up on test results is a considerable problem, which can negatively impact patient health, according to a review published in the February issue of BMJ Quality & Safety.
Hyperprolactinemia Diagnosis Sufficient With Single Test
MONDAY, Feb. 21 (HealthDay News) -- One serum blood test is sufficient to diagnose hyperprolactinemia, and dynamic testing of prolactin secretion should be avoided, according to new guidelines published in the February issue of the Journal of Clinical Endocrinology & Metabolism.
Low Pay for New Female Doctors Tied to Gender, Not Job
MONDAY, Feb. 21 (HealthDay News) -- In 2008, male physicians who were newly trained in New York State made an average of $16,819 more than newly trained female physicians, compared to a $3,600 difference in 1999, according to a study published in the February issue of Health Affairs.
Lower Risk of False Positive With Digital Mammography
FRIDAY, Feb. 18 (HealthDay News) -- The risk of false-positive results is lower with digital mammography compared to screen-film mammography, with no significant difference in the cancer detection rate between the two, according to a study published in the February issue of Radiology.
Noninvasive Method Accurately Identifies Trisomy 21
FRIDAY, Feb. 18 (HealthDay News) -- Plasma DNA sequencing using circulating cell-free fetal (ccff) DNA can be used as an accurate noninvasive method of detecting trisomy 21, according to a study published online Feb. 11 in the American Journal of Obstetrics & Gynecology.
Alcohol Intoxication Increases Sleep Disruption in Women
FRIDAY, Feb. 18 (HealthDay News) -- Alcohol intoxication elevates subjective sleepiness and disrupts sleep objectively in women more than in men, regardless of family history of alcoholism, according to a study published online Feb. 15 in Alcoholism: Clinical & Experimental Research.
FDA Warns Against Terbutaline for Preterm Labor
THURSDAY, Feb. 17 (HealthDay News) -- Injectable terbutaline should not be used for prevention or prolonged treatment of preterm labor in pregnant women because of the potential for serious maternal heart problems and death, according to a warning issued by the U.S. Food and Drug Administration. The agency also warned that oral terbutaline should not be used for prevention or any treatment of preterm labor because of similar safety concerns and the fact that it has not been shown to be effective.
Oral Bisphosphonates May Lower Colorectal Cancer Risk
THURSDAY, Feb. 17 (HealthDay News) -- Use of oral bisphosphonates for more than one year in postmenopausal women is associated with a 59 percent decrease in the relative risk of colorectal cancer, according to a study published online Feb. 14 in the Journal of Clinical Oncology.
New U.S. Report on the Nation's Health 2010 Released
WEDNESDAY, Feb. 16 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention's National Center for Health Statistics' 34th annual report, presenting the latest information on health status and determinants, utilization of health care, health care resources, expenditures, and a special feature on death and dying, was published Feb. 16.
Mammogram Sensitivity Varies by Week of Menstrual Cycle
WEDNESDAY, Feb. 16 (HealthDay News) -- Premenopausal women who schedule regular mammograms may benefit by undergoing screening during the first week of their menstrual cycle, according to research published in the February issue of Radiology.
MRI With Mammography Useful for High-Risk Women
TUESDAY, Feb. 15 (HealthDay News) -- When used together with mammography, magnetic resonance imaging (MRI) is a useful screening tool for high-risk women who have undergone chest irradiation, according to research published online Feb. 15 in Radiology.
Most Recalled Medical Devices Given Lenient Approval
TUESDAY, Feb. 15 (HealthDay News) -- The majority of medical devices recalled from 2005 to 2009 for risk of serious health hazard or death were approved by the less strict 510(k) process intended for devices considered low or moderate risk, according to a study published online Feb. 14 in the Archives of Internal Medicine.
Researchers Explore Nature of Difficult Clinical Encounters
MONDAY, Feb. 14 (HealthDay News) -- Both patients and physicians can bring qualities to a clinical encounter that result in its being perceived as difficult, and patients involved in these types of encounters have worse short-term outcomes, according to research published online Jan. 25 in the Journal of General Internal Medicine.
First 3-D Mammography Test Cleared
FRIDAY, Feb. 11 (HealthDay News) -- The first three-dimensional mammography system has been approved by the U.S. Food and Drug Administration.
Addison's Disease Is a Risk Factor for Hip Fracture
FRIDAY, Feb. 11 (HealthDay News) -- Clinically diagnosed and undiagnosed cases of Addison's disease (AD) are associated with hip fractures in patients aged 30 years or older, with the highest risk in women aged 50 years or younger, according to a study published online Jan. 19 in the Journal of Internal Medicine.
X-Rays in Utero, Early Infancy Could Raise Cancer Risk
FRIDAY, Feb. 11 (HealthDay News) -- In utero and early infancy exposure to diagnostic X-rays may increase the risk for childhood cancers, according to research published online Feb. 10 in BMJ.
Low-Molecular-Weight Heparin May Not Prevent Thrombosis
THURSDAY, Feb. 10 (HealthDay News) - Low-dose low-molecular-weight-heparin (LMWH) does not effectively prevent venous thromboembolism (VTE) in high-risk pregnant women, according to a study published online Jan. 13 in the Journal of Thrombosis and Haemostasis.
Piperonyl Butoxide Tied to Mental Development Delay
THURSDAY, Feb. 10 (HealthDay News) -- Prenatal exposure to piperonyl butoxide may delay mental development at 36 months of age, according to research published online Feb. 7 in Pediatrics.
Public Sector Plays Big Role in Drug Research
WEDNESDAY, Feb. 9 (HealthDay News) -- Public-sector research institutions (PSRIs) appear to play a bigger role in drug discovery than was previously thought, contributing to the discovery of about 10 to 20 percent of drugs approved for new drug applications since 1990, according to research published in the Feb. 10 issue of the New England Journal of Medicine.
Prenatal Myelomeningocele Surgery Improves Outcomes
WEDNESDAY, Feb. 9 (HealthDay News) -- Prenatal surgery for myelomeningocele decreases the need for shunting and improves motor outcomes at 30 months, though it is linked to an increased risk of preterm delivery and uterine dehiscence at delivery, according to a study published online Feb. 9 in the New England Journal of Medicine.
Axillary Lymph Node Dissection Does Not Affect Survival
TUESDAY, Feb. 8 (HealthDay News) -- Patients who have limited sentinel lymph node (SLN) metastatic breast cancer have similar survival rates when treated with sentinel lymph node dissection (SLND) or axillary lymph node dissection (ALND), according to a study published in the Feb. 9 issue of the Journal of the American Medical Association.
Antenatal HIV Exposure Tied to Lower Infant Antibodies
TUESDAY, Feb. 8 (HealthDay News) -- Infants exposed to HIV in the womb, but not infected at birth, have lower infant-specific antibody responses against some diseases, compared to infants not exposed to HIV, according to a study published in the Feb. 9 issue of the Journal of the American Medical Association.
Metabolic Syndrome Doesn't Affect Female Sexual Function
TUESDAY, Feb. 8 (HealthDay News) -- Metabolic syndrome appears to have little impact on sexual function in middle- to old-aged women, according to a study published online Jan. 14 in the Journal of Sexual Medicine.
U.S. Task Force Mammogram Recommendations Questioned
MONDAY, Feb. 7 (HealthDay News) -- Initiating mammography at a younger age and screening more frequently than the U.S. Preventive Services Task Force (USPSTF) recommends will likely result in more lives saved, according to a study published in the February issue of the American Journal of Roentgenology.
Breast-Feeding May Boost Health of Cancer Survivors
MONDAY, Feb. 7 (HealthDay News) -- Female childhood cancer survivors should be encouraged to breast-feed as a health behavior that is protective against many late effects of cancer treatment, according to a review published online Jan. 21 in the Journal of Cancer Survivorship.
Drug Approved to Help Prevent Preterm Birth
FRIDAY, Feb. 4 (HealthDay News) -- Makena (hydroxyprogesterone caproate) has been approved by the U.S. Food and Drug Administration to help prevent birth before 37 weeks of pregnancy in women who have had at least one prior early delivery.
Rare Stroke Affects Pregnant and Postpartum Women
FRIDAY, Feb. 4 (HealthDay News) -- The American Heart Association (AHA) has compiled a series of evidence-based recommendations for the diagnosis, management, and treatment of cerebral venous thrombosis (CVT), and specifically for its management during pregnancy and postpartum, detailed in a statement published online Feb. 3 in Stroke.
Timing of Hormone Therapy Influences Breast Cancer Risk
THURSDAY, Feb. 3 (HealthDay News) -- For women taking postmenopausal hormone therapy, breast cancer risk is greater among users of estrogen-progestin formulations, and those who begin treatment earlier, according to a study published online Jan. 28 in the Journal of the National Cancer Institute.
CDC: U.S. Teenage Birth Rate Declines, Reaches Low
WEDNESDAY, Feb. 2 (HealthDay News) -- The U.S. teenage birth rate has resumed its decline, reaching a historic low in 2009, according to a report published in the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS) February Data Brief.
Primer Helps Doctors Counsel About Sex in Pregnancy
TUESDAY, Feb. 1 (HealthDay News) -- Sex during pregnancy is generally safe, and abstinence should be recommended only for women at risk of preterm labor or antepartum hemorrhage due to placenta previa, according to a primer published online Jan. 31 in CMAJ, the journal of the Canadian Medical Association.
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