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Category: Rheumatology | Monthly Briefing

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February 2011 Briefing - Rheumatology

Last Updated: March 01, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Rheumatology for February 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Cochrane Review Examines Safety of Biologic Agents

MONDAY, Feb. 28 (HealthDay News) -- Patients taking biologic agents for rheumatoid arthritis and other inflammatory conditions may experience a higher rate of adverse events, withdrawals from studies due to adverse events, and tuberculosis reactivation, compared to placebo, according to a literature review published online Feb. 16 in the Cochrane Database of Systematic Reviews.

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Definitions of Rheumatoid Arthritis Remission Proposed

FRIDAY, Feb. 25 (HealthDay News) -- The American College of Rheumatology and the European League Against Rheumatism have developed two provisional definitions of remission in rheumatoid arthritis that can be applied uniformly and used as outcome measures in clinical trials, according to an article published in the March issue of Arthritis & Rheumatism.

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Equations Predict Quadriceps Strength in Knee Osteoarthritis

THURSDAY, Feb. 24 (HealthDay News) -- Predictive equations can be used to assess maximal quadriceps strength in individuals who have osteoarthritis in a knee joint, according to a study published in the February issue of Arthritis Care & Research.

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Ultrasound Detects Silent Enthesitis in Arthritis

WEDNESDAY, Feb. 23 (HealthDay News) -- Ultrasonography with power Doppler (US-PD) may detect clinically silent enthesitis in patients with juvenile idiopathic arthritis (JIA) and other enthesitis-related arthritis, according to research published online Feb. 10 in Arthritis Care & Research.

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Nitroglycerin Strengthens Bones in Older Women

WEDNESDAY, Feb. 23 (HealthDay News) -- Nitroglycerin ointment appears to increase bone mineral density (BMD) and decrease bone resorption in postmenopausal women when administered daily, according to research published in the Feb. 23 issue of the Journal of the American Medical Association.

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Fostamatinib Safe, Not Effective in Rheumatoid Arthritis

MONDAY, Feb. 21 (HealthDay News) -- Fostamatinib disodium (R788), an oral spleen tyrosine kinase inhibitor, is safe but ineffective for treatment of patients with rheumatoid arthritis (RA) who failed biologic therapies, according to a study published in the February issue of Arthritis & Rheumatism.

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Low Pay for New Female Doctors Tied to Gender, Not Job

MONDAY, Feb. 21 (HealthDay News) -- In 2008, male physicians who were newly trained in New York State made an average of $16,819 more than newly trained female physicians, compared to a $3,600 difference in 1999, according to a study published in the February issue of Health Affairs.

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Different Therapies Improve Chronic Fatigue Outcomes

FRIDAY, Feb. 18 (HealthDay News) -- For chronic fatigue patients, cognitive behavior therapy (CBT) and graded exercise therapy (GET) may moderately improve outcomes when added to specialist medical care (SMC), according to research published online Feb. 18 in The Lancet.

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Insomnia in Arthritis Tied to Pain, Depression Ups Risk

FRIDAY, Feb. 18 (HealthDay News) -- Sleep disturbances are more prevalent among adults with arthritis compared to those without the disease, with the greatest risk affecting those with anxiety and depression, according to a study published in the February issue of Arthritis Care & Research.

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New U.S. Report on the Nation's Health 2010 Released

WEDNESDAY, Feb. 16 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention's National Center for Health Statistics' 34th annual report, presenting the latest information on health status and determinants, utilization of health care, health care resources, expenditures, and a special feature on death and dying, was published Feb. 16.

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Steroids Up Risk of Bowel Perforation in Arthritis Patients

WEDNESDAY, Feb. 16 (HealthDay News) -- Rheumatoid arthritis (RA) patients treated with glucocorticoids or with a history of diverticulitis have increased risk of gastrointestinal (GI) perforation, according to a study in the February issue of Arthritis & Rheumatism.

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Most Recalled Medical Devices Given Lenient Approval

TUESDAY, Feb. 15 (HealthDay News) -- The majority of medical devices recalled from 2005 to 2009 for risk of serious health hazard or death were approved by the less strict 510(k) process intended for devices considered low or moderate risk, according to a study published online Feb. 14 in the Archives of Internal Medicine.

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Obesity, Arthritis Shorten Quality-Adjusted Life-Years

TUESDAY, Feb. 15 (HealthDay News) -- A substantial number of quality-adjusted life-years are lost due to knee osteoarthritis and obesity, with a disproportionate number of black and Hispanic women affected, according to a study published in the Feb. 15 issue of the Annals of Internal Medicine.

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High Body Mass Index Linked to Poor Infliximab Response

TUESDAY, Feb. 15 (HealthDay News) -- Patients suffering from rheumatoid arthritis (RA) who have a high body mass index (BMI) respond less well to infliximab, even when adjusting for disease activity and anti-citrullinated protein antibody status, according to a study published in the February issue of Arthritis & Rheumatism.

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Researchers Explore Nature of Difficult Clinical Encounters

MONDAY, Feb. 14 (HealthDay News) -- Both patients and physicians can bring qualities to a clinical encounter that result in its being perceived as difficult, and patients involved in these types of encounters have worse short-term outcomes, according to research published online Jan. 25 in the Journal of General Internal Medicine.

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Joint Effusions Signal Possible Lyme Arthritis

MONDAY, Feb. 14 (HealthDay News) -- Children with joint effusions in a Lyme-endemic area of the Northeastern United States may have Lyme arthritis, especially if there is knee involvement, according to a study published in the Feb. 2 issue of The Journal of Bone & Joint Surgery.

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Traditional Measures Miss Obesity in Women With Lupus

MONDAY, Feb. 14 (HealthDay News) -- Obese women with systemic lupus erythematosus (SLE) may be misclassified by anthropometric measures. Dual X-ray absorptiometry (DXA) can be used to adjust the traditional guidelines to improve diagnostic accuracy, according to a study published in the February issue of Arthritis Care & Research.

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Addison's Disease Is a Risk Factor for Hip Fracture

FRIDAY, Feb. 11 (HealthDay News) -- Clinically diagnosed and undiagnosed cases of Addison's disease (AD) are associated with hip fractures in patients aged 30 years or older, with the highest risk in women aged 50 years or younger, according to a study published online Jan. 19 in the Journal of Internal Medicine.

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Systemic Vasculitis Cardiac Risk Factors Identified

THURSDAY, Feb. 10 (HealthDay News) -- Patients diagnosed with Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) are at greater cardiovascular (CV) risk, according to a study published online Jan. 14 in Arthritis Care & Research.

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Few Rheumatoid Arthritis Patients Get Lipids Screen

THURSDAY, Feb. 10 (HealthDay News) -- Primary lipid screening was carried out in less than half of eligible rheumatoid arthritis (RA) patients, many of whom see their rheumatologist as often or more than their primary care provider (PCP), according to a study published online Jan. 18 in Arthritis & Rheumatism.

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Public Sector Plays Big Role in Drug Research

WEDNESDAY, Feb. 9 (HealthDay News) -- Public-sector research institutions (PSRIs) appear to play a bigger role in drug discovery than was previously thought, contributing to the discovery of about 10 to 20 percent of drugs approved for new drug applications since 1990, according to research published in the Feb. 10 issue of the New England Journal of Medicine.

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Rheumatic Diseases Afflict 1 in 12 Women, 1 in 20 Men

WEDNESDAY, Feb. 9 (HealthDay News) -- About 8 percent of women and 5 percent of men will develop an inflammatory autoimmune rheumatic disease such as rheumatoid arthritis (RA) during their lifetime, according to research published online Dec. 28 in Arthritis & Rheumatism.

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Data Collection Shows Fibromyalgia Symptoms Pattern

TUESDAY, Feb. 8 (HealthDay News) -- Longitudinal data collection by hand-held Ecological Momentary Assessment (EMA) devices, which record daily symptoms of fibromyalgia syndrome (FMS), reveals small but significant temporal relationships between pain, fatigue, and emotional distress, according to a study published in the January issue of the Journal of Pain.

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Cancer Prognosis Similar After Biologics Therapy

MONDAY, Feb. 7 (HealthDay News) -- Cancers that develop after anti-tumor necrosis factor (TNF) therapy for rheumatoid arthritis (RA) are similar with respect to stage at presentation and survival rates, according to a study published online Jan. 18 in Arthritis & Rheumatism.

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Poorer Arthritis Patients More Likely to Be Depressed

MONDAY, Feb. 7 (HealthDay News) -- Patients with rheumatoid arthritis (RA) who are of lower socioeconomic status may be at greater risk of depression, according to a study published in the February issue of Arthritis Care & Research.

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Early Prophylaxis Effective for Children With Hemophilia

THURSDAY, Feb. 3 (HealthDay News) -- Prophylactic treatment of bleeding and arthropathy in children with hemophilia A is effective, particularly when initiated early in life, according to a study published online Jan. 21 in the Journal of Thrombosis and Haemostasis.

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Givinostat a Promising Treatment for Juvenile Arthritis

THURSDAY, Feb. 3 (HealthDay News) -- Treatment of systemic onset juvenile idiopathic arthritis (SOJIA) with Givinostat, an orally active histone deacetylase inhibitor, for 12 weeks appears to be safe, well-tolerated, and effective, according to a study published online Jan. 18 in Arthritis & Rheumatism.

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Age, Race, and Wealth Affect Arthritis Drug Receipt

TUESDAY, Feb. 1 (HealthDay News) -- Among Medicare-managed rheumatoid arthritis (RA) patients, receipt of disease-modifying antirheumatic drugs (DMARDs) varies based on demographic and other factors, according to a study published in the Feb. 2 issue of the Journal of the American Medical Association.

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