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Category: Pathology | Monthly Briefing

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March 2011 Briefing - Pathology

Last Updated: April 01, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pathology for March 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Skeletal Immaturity Does Not Affect Broken Bones' Healing

THURSDAY, March 31 (HealthDay News) -- People who break both the radius and ulna before reaching skeletal maturity heal just as well as those who are skeletally mature, and subjective measures of illness may be more predictive of degree of disability than objective measures of impairment, according to research published in the March 16 issue of The Journal of Bone & Joint Surgery.

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Tetanus Cases Rare but Some Populations More Vulnerable

THURSDAY, March 31 (HealthDay News) -- Tetanus cases and fatalities in the United States have decreased by more than 95 percent and more than 99 percent, respectively, since the disease became reportable in 1947, but sporadic cases do still occur, and some populations are more at risk for contracting the potentially life-threatening disease, according to research published in the April 1 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Heart Defect in Children Related to Migraine With Aura

THURSDAY, March 31 (HealthDay News) -- The prevalence of patent foramen ovale (PFO), a common defect in the wall between the two upper chambers of the heart, is significantly greater in children who have migraines with aura, according to a study published online March 31 in The Journal of Pediatrics.

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Growth Hormone Increases Adult Height in Turner's

THURSDAY, March 31 (HealthDay News) -- Treatment with growth hormone may result in greater adult height for girls with Turner's syndrome, and the addition of low-dose estrogen to the treatment regimen may further improve results, according to research published in the March 31 issue of the New England Journal of Medicine.

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Small Number of Second Cancers Linked to Radiotherapy

WEDNESDAY, March 30 (HealthDay News) -- Only a small proportion of second cancers are attributable to radiotherapy for primary tumors in adults, according to a study published online March 30 in The Lancet Oncology.

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Changes Seen in Incidence of ESRD From Lupus Nephritis

WEDNESDAY, March 30 (HealthDay News) -- For children with lupus nephritis (LN)-associated end-stage renal disease (ESRD), disparities in treatment and mortality exist by several demographic characteristics; also, incidence rates have increased in younger patients and in African-Americans since 1995, according to two articles published online March 28 in Arthritis & Rheumatism.

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Abstract - Costenbader
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Accurate Cerebral Aneurysm Diagnosis by CT Angiography

WEDNESDAY, March 30 (HealthDay News) -- Computed tomographic (CT) angiography, especially by modern multidetector CT, is a highly accurate tool for diagnosing cerebral aneurysms, according to a meta-analysis published online March 9 in the Annals of Neurology.

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Online Health Records Less Used by Minorities, Poor

WEDNESDAY, March 30 (HealthDay News) -- Online personal health records (PHRs) are less frequently used by racial or ethnic minorities and patients with low annual income, according to a study published in the March 28 issue of the Archives of Internal Medicine.

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Basophil Infiltration Into Skin Lesions Common

WEDNESDAY, March 30 (HealthDay News) -- Immunohistochemical analysis reveals that basophils infiltrate into skin lesions in numerous skin diseases, according to a study published online March 4 in Allergy.

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Discharge to Skilled Nursing Facilities Linked to Death

WEDNESDAY, March 30 (HealthDay News) -- Patients with heart failure discharged to skilled nursing facilities (SNFs) have an increased risk for rehospitalization and death, according to a study published online March 29 in Circulation: Heart Failure.

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High Number of 'Medalists' Free From Diabetes Complications

WEDNESDAY, March 30 (HealthDay News) -- The relatively high proportion of patients with type 1 diabetes for 50 years or more without complications indicates the presence of protective factors, according to a study published in the April issue of Diabetes Care.

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Air Pollution May Compromise Lung Transplant Patients

TUESDAY, March 29 (HealthDay News) -- Lung transplant patients who have high exposure to traffic-related air pollution may be at increased risk for bronchiolitis obliterans syndrome (BOS) and death, according to research published online March 23 in Thorax.

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PSA Screening Predicted by Age, Life Expectancy

TUESDAY, March 29 (HealthDay News) -- Age and life expectancy are strong predictors of prostate-specific antigen (PSA) screening, which appears to be administered excessively to older men with limited life expectancy, according to research published online March 28 in the Journal of Clinical Oncology.

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Radiation Risk From Airport Full-Body Scanners Limited

TUESDAY, March 29 (HealthDay News) -- Full-body scanners being deployed by the Transportation Security Administration in airports throughout the United States do not appear to increase risks related to radiation exposure, according to a special article published online March 28 in the Archives of Internal Medicine.

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Elevated Risk Factors Linked to Atrial Fibrillation

TUESDAY, March 29 (HealthDay News) -- More than half the burden of atrial fibrillation (AF) results from having one or more elevated cardiovascular risk factors and is theoretically preventable, according to a study published online March 28 in Circulation.

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Bariatric Surgery Weight Loss Tied to Migraine Improvement

TUESDAY, March 29 (HealthDay News) -- Severely obese people who suffer from migraines experience improvement in their headaches after losing a significant amount of weight following bariatric surgery, according to a study published in the March 29 issue of Neurology.

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Decline Seen in Global Youth Mortality Over Last 50 Years

TUESDAY, March 29 (HealthDay News) -- Overall mortality declined substantially between 1955 and 2004 in children aged 14 years or younger and in females aged 15 to 24, but a smaller decline was evident for males aged 15 to 24 years, according to a study published online March 29 in The Lancet.

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Room Cleaning Linked to Lower Drug-Resistant Infections

TUESDAY, March 29 (HealthDay News) -- Enhanced intensive care unit (ICU) cleaning may reduce methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) transmission, according to a study published in the March 28 issue of the Archives of Internal Medicine.

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Guidelines Provided for Deep Vein Thrombosis Management

MONDAY, March 28 (HealthDay News) -- Blood thinners should not be the only therapy considered for patients with deep vein thrombosis (DVT), according to a scientific statement published online March 21 in Circulation.

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Cardiac Risk Management Improves After Calcium Scan

MONDAY, March 28 (HealthDay News) -- Coronary artery calcium (CAC) scanning provides better risk factor control in coronary artery disease (CAD) without increasing downstream medical costs, according to a study published online March 23 in the Journal of the American College of Cardiology.

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Hormone Therapy Improves Prostate Cancer Survival

FRIDAY, March 25 (HealthDay News) -- In men with locally advanced prostate cancer, six months of hormone therapy combined with radiation significantly reduces prostate-cancer-specific and all-cause mortality compared with radiotherapy alone, according to a study published online March 25 in The Lancet Oncology.

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Imatinib Improves Survival in Chronic Myeloid Leukemia

FRIDAY, March 25 (HealthDay News) -- Patients with chronic myeloid leukemia (CML) in complete cytogenetic remission (CCyR) for two years after starting imatinib have similar survival to that of the general population, according to a study published online March 21 in the Journal of the National Cancer Institute.

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Novel Immune Therapy Attacks Pancreatic Tumor Stroma

FRIDAY, March 25 (HealthDay News) -- A novel immune therapy using CD40 agonist antibodies to attack the stroma surrounding pancreatic tumors appears to show efficacy in mice and humans, according to a study published online March 25 in Science.

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Tuberculosis Rates in United States at All-Time Low

THURSDAY, March 24 (HealthDay News) -- The rate of tuberculosis (TB) infection in the United States continues to decline, but the goal of elimination has not been met, and the infection disproportionately affects foreign-born individuals and ethnic minorities, according to a report published in the March 25 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Thromboembolism May Recur With Residual Vein Obstruction

THURSDAY, March 24 (HealthDay News) -- In patients with provoked or unprovoked deep vein thrombosis (DVT), residual vein obstruction (RVO) is associated with a slight increase in the risk of recurrent venous thromboembolism (VTE) but does not seem to predict recurrent VTE in patients with unprovoked DVT following discontinuation of anticoagulation therapy, according to a meta-analysis published online March 7 in the Journal of Thrombosis and Haemostasis.

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Window Period Infection Risk Low in High-Risk HIV Donors

THURSDAY, March 24 (HealthDay News) -- Among HIV high-risk donors (HRDs), the predicted risk of window period (WP) infection is low and varies significantly according to donor behavior, according to a meta-analysis published online March 2 in the American Journal of Transplantation.

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Reduced Hours for Trainees Has Had Little Effect in U.S.

THURSDAY, March 24 (HealthDay News) -- Reducing work hours for doctors in training to less than 80 per week has had little impact on patient outcomes or postgraduate training in the United States, according to a literature review published online March 22 in BMJ.

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Mercury Exposure and CVD Not Associated

WEDNESDAY, March 23 (HealthDay News) -- Exposure to mercury does not appear to increase the risk of stroke, coronary heart disease, or total cardiovascular disease, according to research published in the March 24 issue of the New England Journal of Medicine.

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Shorter Closure Time for in Vitro Adult Platelet Transfusion

WEDNESDAY, March 23 (HealthDay News) -- Transfusion of adult platelets into neonatal blood results in shorter platelet function analyzer closure time compared with neonatal platelets, according to a study published online Feb. 14 in the Journal of Thrombosis and Haemostasis.

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Rapid Assessment Identifies Low-Risk Chest Pain Patients

WEDNESDAY, March 23 (HealthDay News) -- A novel two-hour accelerated diagnosis protocol (ADP) appears quite accurate in identifying patients with chest pains who are at low risk for a major adverse cardiac event and could probably be discharged early, according to research published online March 23 in The Lancet.

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Lower Troponin Assay Threshold Aids MI Diagnosis

WEDNESDAY, March 23 (HealthDay News) -- Lowering the diagnostic threshold of plasma troponin in patients with suspected acute coronary syndrome (ACS) is associated with lower risk of death and recurrent myocardial infarction (MI), according to a study published in the March 23/30 issue of the Journal of the American Medical Association.

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Chronic Otitis Media Associated With Changes in Taste

WEDNESDAY, March 23 (HealthDay News) -- Children with chronic otitis media with effusion (COME) have different taste thresholds, which may be associated with their increased body mass index (BMI), according to a study published in the March issue of the Archives of Otolaryngology -- Head & Neck Surgery.

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Pelvic Asymmetry Identified in Cerebral Palsy Patients

TUESDAY, March 22 (HealthDay News) -- Patients with cerebral palsy (CP) often exhibit transverse pelvic asymmetry, which is most prominent above the acetabulum and more frequent in patients with windswept hips, according to a study published online March 10 in the Journal of Pediatric Orthopaedics.

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HIV Tropism Testing Guidelines Established

TUESDAY, March 22 (HealthDay News) -- The European Consensus Group on the clinical management of tropism testing has established guidelines for tropism testing prior to the initiation of maraviroc therapy for HIV; the guidelines have been published online March 22 in The Lancet Infectious Diseases.

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Multiple Sclerosis Slows After Stem Cell Transplant

TUESDAY, March 22 (HealthDay News) -- Patients with multiple sclerosis (MS) with active lesions who undergo hematopoietic stem cell transplantation (HSCT) have improved progression-free survival compared to patients without active lesions, according to a study published in the March 22 issue of Neurology.

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Antibiotics Reduce Risk of ICU-Acquired Infection

MONDAY, March 21 (HealthDay News) -- Critically ill patients given prophylactic antibiotics may be significantly less likely to be infected by intensive care unit (ICU)-acquired, highly resistant microorganisms, according to research published online March 21 in The Lancet Infectious Diseases.

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Taiwanese With Diabetes at Higher Risk of Prostate Cancer

MONDAY, March 21 (HealthDay News) -- The incidence of prostate cancer among men in Taiwan is increasing, and men with diabetes are at an increased risk of prostate cancer, according to research published in the March issue of Diabetes Care.

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Group B Strep Still Main Cause of Neonatal Meningitis

MONDAY, March 21 (HealthDay News) -- Group B streptococci (GBS) is still the dominant cause of neonatal bacterial meningitis, whereas Escherichia coli (E. coli) is the most common cause among preterm infants, according to a study published in the March issue of The Pediatric Infectious Disease Journal.

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Majority of Parents Approve of Smoke Exposure Testing

MONDAY, March 21 (HealthDay News) -- The majority of parents, both smokers and nonsmokers, want their children tested for tobacco-smoke exposure as part of their children's health care settings, according to a study published online March 21 in Pediatrics.

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Uterine Risk Factors Impact Endometrial Cancer Survival

FRIDAY, March 18 (HealthDay News) -- Uterine risk factors (RF) strongly influence survival of women with endometrial cancer, independent of nodal metastasis, according to research published in the March issue of the American Journal of Obstetrics & Gynecology.

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Inflammatory Marker Tied to Colorectal Cancer Risk

FRIDAY, March 18 (HealthDay News) -- Higher plasma levels of the soluble tumor necrosis factor receptor 2 (sTNFR-2) appear to be associated with an increased risk of colorectal cancer (CRC) among women, with anti-inflammatory drugs reducing the risk of CRC among women with high baseline sTNFR-2 levels, according to a study published in the March issue of Gastroenterology.

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Stem Cells Linked to Functional Recovery of Heart Post MI

FRIDAY, March 18 (HealthDay News) -- In patients with left ventricular (LV) dysfunction due to remote myocardial infarction, injections of autologous bone marrow progenitor cells reduce heart size and scar tissue size, and improve regional contractility, according to a study published online March 17 in Circulation Research.

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CDC: HIV Transmitted Through Living Kidney Donation

THURSDAY, March 17 (HealthDay News) -- Despite HIV screening of the donor, using serologic testing, HIV was transmitted from a living kidney donor to the transplant recipient recently in New York City, according to a report in the March 18 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Professional Values of U.S. and U.K. Doctors Examined

THURSDAY, March 17 (HealthDay News) -- A core of professional values exists among doctors in the United States and the United Kingdom, though significant differences exist in how these values are expressed and prioritized, according to a study published online March 7 in BMJ Quality & Safety.

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Novel Virus May Be Cause of Severe Febrile Illness in China

THURSDAY, March 17 (HealthDay News) -- Chinese researchers have identified a novel bunyavirus that may be the cause of severe fever with thrombocytopenia syndrome (SFTS); their research has been published online March 16 in the New England Journal of Medicine.

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Hepatitis A Virus Antigenic Variants Identified

THURSDAY, March 17 (HealthDay News) -- An outbreak of hepatitis A in men who have sex with men (MSM) revealed several antigenic variants of the hepatitis A virus, which may have escaped the protective effect of vaccination, reinforcing the importance of completing vaccination schedules, especially among the immunocompromised, according to a study published online March 16 in Emerging Infectious Diseases.

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Fever Not Tied to Influenza Virus Shedding Duration

WEDNESDAY, March 16 (HealthDay News) -- Health care personnel (HCP) infected with influenza (H1N1) 2009 virus who return to work 24 hours after defervescence may still be shedding virus, according to a study published online March 16 in Emerging Infectious Diseases.

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U.S. Death Rate Reaches All-Time Low

WEDNESDAY, March 16 (HealthDay News) -- The age-adjusted death rate for the United States has fallen for 10 straight years and has reached an all-time low of 741 per 100,000, or 2,436,682 deaths, in 2009, down 2.3 percent from 2008, according to a new report issued by the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics.

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Outcomes Differ Among Hepatitis C-Related Vasculitides

WEDNESDAY, March 16 (HealthDay News) -- Among patients with hepatitis C virus (HCV)-related vasculitis, those with polyarteritis nodosa (PAN) have a more severe and acute clinical presentation and a higher rate of clinical remission, according to a study published online Feb. 25 in Arthritis Care & Research.

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Raised Triglyceride Levels Do Not Cause Type 2 Diabetes

WEDNESDAY, March 16 (HealthDay News) -- Genetically raised circulating triglyceride levels do not increase the risk of type 2 diabetes, or raise fasting glucose or insulin levels, according to a study published in the March issue of Diabetes.

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More Cholera Cases and Deaths Expected in Haiti

WEDNESDAY, March 16 (HealthDay News) -- Mathematical modeling estimates that more cases of cholera than expected will occur in the coming months in Haiti, but many could be averted by the provision of clean water, vaccinations, and increased antibiotic distribution, according to a study published online March 16 in The Lancet.

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Heavy Smoking Prevalence Decline Greatest in California

TUESDAY, March 15 (HealthDay News) -- Between 1965 and 2007, the prevalence of high-intensity smoking declined in California and in the remaining states, according to a study published in the March 16 issue of the Journal of the American Medical Association.

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High Phosphorus Level Tied to Kidney Disease Mortality

TUESDAY, March 15 (HealthDay News) -- In patients with chronic kidney disease, evidence suggests that there is an association between higher serum levels of phosphorus and mortality, but there is a lack of strong and consistent evidence associating serum calcium and parathyroid hormone levels with risk of death or cardiovascular events, according to a meta-analysis published in the March 16 issue of the Journal of the American Medical Association.

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Vitamin D Insufficiency Does Not Increase in Parkinson's

TUESDAY, March 15 (HealthDay News) -- The prevalence of vitamin D insufficiency does not increase during the progression of early Parkinson's disease (PD), according to a study published in the March issue of the Archives of Neurology.

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Local Immune Response Predictive of Cancer Prognosis

MONDAY, March 14 (HealthDay News) -- Immunological CD8 and FOXP3 cell infiltrate after neoadjuvant chemotherapy may be a predictive factor of survival for patients with breast cancer, according to a study published online Feb. 3 in The Journal of Pathology.

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Presence of Biomarker May Indicate Early Emphysema

MONDAY, March 14 (HealthDay News) -- Otherwise healthy smokers with low DLCO have elevated levels of endothelial microparticles (EMPs) in their blood, which may help clinicians diagnose early stage emphysema, according to research published online March 11 in the American Journal of Respiratory and Critical Care Medicine.

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VAP-1 Predicts Mortality in Patients With Type 2 Diabetes

MONDAY, March 14 (HealthDay News) -- The level of serum vascular adhesion protein-1 (VAP-1), a protein involved in inflammation, can predict the 10-year mortality risk among patients with type 2 diabetes, according to a study published in the March issue of Diabetes.

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Potassium Level Tied to African-American Diabetes Risk

MONDAY, March 14 (HealthDay News) -- Low serum potassium concentrations found in African-Americans may be a contributing factor to their increased risk of type 2 diabetes, according to a study published online March 2 in The American Journal of Clinical Nutrition.

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Risk of Infection, Malignancy With Anti-TNF Therapy Unclear

FRIDAY, March 11 (HealthDay News) -- Patients with early rheumatoid arthritis taking anti-tumor necrosis factor (TNF) therapy without prior use of disease-modifying anti-rheumatic drugs (DMARD)/methotrexate do not have an increased risk of serious infections or malignancies, according to a meta-analysis published online Feb. 25 in Arthritis & Rheumatism.

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Depression Linked to Adverse Renal Disease Outcomes

FRIDAY, March 11 (HealthDay News) -- Symptoms of depression are associated with subsequent adverse outcomes in patients with renal disease, according to a study published online March 10 in the Clinical Journal of the American Society of Nephrology.

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Impact of Adiposity Measures on Heart Disease Risk Alike

FRIDAY, March 11 (HealthDay News) -- Body mass index (BMI), waist circumference, and waist-to-hip ratio all have a similar strength of association with cardiovascular disease, but do not significantly improve risk prediction when information on blood pressure, diabetes, and lipid levels is available, according to a study published online March 11 in The Lancet.

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Statins May Lower Markers of Immune Activation in HIV

THURSDAY, March 10 (HealthDay News) -- Atorvastatin use decreases cellular markers of immune activation and inflammation in patients infected with HIV type 1 (HIV-1), though it does not affect plasma HIV-1 RNA levels, according to a study published online Feb. 15 in The Journal of Infectious Diseases.

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MicroRNA Expression Tied to Prostate Cancer Recurrence

THURSDAY, March 10 (HealthDay News) -- Biochemical recurrence of localized prostate cancer in patients treated with radical prostatectomy is linked to high levels of microRNAs (miRNAs), according to a study published in the March issue of The Journal of Urology.

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High Polychlorinated Biphenyl Concentrations May Affect IVF

THURSDAY, March 10 (HealthDay News) -- Higher serum polychlorinated biphenyl (PCB) concentration levels that are within the normal range for women in the general U.S. population are associated with failed implantation in women undergoing in vitro fertilization (IVF), according to a study published online Feb. 24 in Environmental Health Perspectives.

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Depression Care in Hospital May Improve Cardiac Outcomes

THURSDAY, March 10 (HealthDay News) -- Among patients with depression and cardiac illness, managing depression during hospitalization improves mental health outcomes and may also improve medical outcomes after intervention, according to a study published online March 8 in Circulation: Cardiovascular Quality and Outcomes.

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Drug Delays Microalbuminuria in Type 2 Diabetes

WEDNESDAY, March 9 (HealthDay News) -- Olmesartan, an angiotensin-receptor blocker, delays the onset of microalbuminuria in people with type 2 diabetes, but it also appears to be associated with an increased risk of fatal cardiovascular events, according to research published in the March 10 issue of the New England Journal of Medicine.

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Interstitial Lung Abnormalities Tied to Reduced Lung Capacity

WEDNESDAY, March 9 (HealthDay News) -- Interstitial lung abnormalities on high-resolution computed tomographic (HRCT) scans appear to be associated with reduced total lung capacity and a lesser amount of emphysema among smokers, according to a study published in the March 10 issue of the New England Journal of Medicine.

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Ethnic Differences Seen in Academic Measures for U.K. Docs

WEDNESDAY, March 9 (HealthDay News) -- United Kingdom-trained physicians and medical students with ethnic minority backgrounds tend to underperform academically compared to their white peers, according to a meta-analysis published online March 8 in BMJ.

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Cyclophosphamide Treatment Tied to Urinary Tract Cancer

WEDNESDAY, March 9 (HealthDay News) -- Patients with systemic necrotizing vasculitides (SNV) treated with cyclophosphamide (CYC) have a five-fold higher risk of developing urinary tract cancer (UTC), according to a study published online Feb. 17 in Arthritis & Rheumatism.

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High HDL Cholesterol Tied to Decreased Colon Cancer Risk

WEDNESDAY, March 9 (HealthDay News) -- Higher concentrations of serum high-density lipoprotein (HDL) cholesterol are associated with a reduced risk of colon cancer, according to a study published online March 7 in Gut.

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Pharmacological Meta-Analyses Rarely Report Disclosures

TUESDAY, March 8 (HealthDay News) -- Meta-analyses of pharmacological treatments rarely include information addressing primary study funding and conflicts of interest (COIs) of the authors for the included randomized control trials (RCTs), according to a study published in the March 9 issue of the Journal of the American Medical Association.

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Fatty Liver Independently Linked to Type 2 Diabetes

TUESDAY, March 8 (HealthDay News) -- Ultrasound-diagnosed fatty liver is independently associated with an increased risk of type 2 diabetes mellitus (T2DM), according to a study published online Jan. 20 in the Journal of Clinical Endocrinology & Metabolism.

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Mediterranean Diet Tied to Lower Metabolic Syndrome Risk

TUESDAY, March 8 (HealthDay News) -- Adherence to a Mediterranean diet is associated with a reduced risk of metabolic syndrome (MetS) and has beneficial effects on its individual components, according to a meta-analysis published in the March 15 issue of the Journal of the American College of Cardiology.

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Link Found Between Cognitive Function, Neighborhood

TUESDAY, March 8 (HealthDay News) -- Growing old in a psychosocially hazardous neighborhood may have a diminishing effect on cognitive functioning in people with the ε4 variant of the apolipoprotein E (APOE) gene, according to research published in the March issue of the Archives of General Psychiatry.

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Atrial Fibrillation Tied to Higher Incidence of Dementia

TUESDAY, March 8 (HealthDay News) -- Atrial fibrillation (AF) is associated with an increased incidence of dementia, and this association is strongest in patients with stroke, according to a meta-analysis published in the March 8 issue of Neurology.

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Low-Level Lead Exposure May Spike Blood Pressure in Labor

TUESDAY, March 8 (HealthDay News) -- Low-level lead exposure, measured by umbilical blood lead levels, suggests a significant association with elevations in maternal blood pressure during labor and delivery, according to a study published online Feb. 3 in Environmental Health Perspectives.

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Cerebral Palsy Incidence Down in Preterm Survivors

MONDAY, March 7 (HealthDay News) -- The incidence and severity of cerebral palsy (CP) among preterm survivors decreased significantly from 1990 to 1993 onward, possibly because of a reduction in severe cystic periventricular leukomalacia (c-PVL), according to a study published online March 3 in The Journal of Pediatrics.

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Cancer Patients Willing to Undergo Pre-Trial Testing

MONDAY, March 7 (HealthDay News) -- Patients with advanced malignancies appear to be quite willing to undergo pharmacodynamic (PD) and pharmacokinetic (PK) tests in order to be enrolled in clinical trials, according to research published online Jan. 18 in Cancer.

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New Noninvasive Method for Diagnosis of Trisomy 21

MONDAY, March 7 (HealthDay News) -- A combined approach using methylated DNA immunoprecipitation (MeDiP) and real-time quantitative PCR (qPCR) of maternal peripheral blood allows noninvasive prenatal diagnosis (NIPD) of trisomy 21 (Down's syndrome), according to research published online March 6 in Nature Medicine.

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FDA: Topiramate (Topamax) Tied to Risk of Oral Clefts

FRIDAY, March 4 (HealthDay News) -- The U.S. Food and Drug Administration has notified health care providers and consumers that new data indicate that women who take topiramate (Topamax) during pregnancy increase the risk for cleft lip and cleft palate in their offspring.

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Physical Activity Tied to Mortality in Kidney Recipients

FRIDAY, March 4 (HealthDay News) -- Low physical activity (PA) in renal transplant recipients (RTRs) is independently associated with increased risk for cardiovascular and all-cause mortality, according to a study published online March 3 in the Clinical Journal of the American Society of Nephrology.

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Inflammatory Bowel Disease Tied to Thromboembolism Risk

FRIDAY, March 4 (HealthDay News) -- Patients suffering from inflammatory bowel disease (IBD) have twice the risk of developing venous thromboembolism (VTE) compared to the general population, according to a study published online Feb. 21 in Gut.

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Molecular Tumor Burden Predicts Colon Cancer Outcome

THURSDAY, March 3 (HealthDay News) -- In patients with node-negative colorectal cancer, the occult molecular tumor burden in the lymph nodes is an independent predictor of the time to recurrence and disease-free survival, according to a study published online Feb. 9 in Clinical Cancer Research.

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Eribulin Improves Survival in Metastatic Breast Cancer

THURSDAY, March 3 (HealthDay News) -- Among women with heavily pretreated metastatic breast cancer, eribulin mesilate may significantly improve survival compared to currently available treatments, according to a study published online March 3 in The Lancet.

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High Hepatitis B Immunity in U.S. Children, Adolescents

THURSDAY, March 3 (HealthDay News) -- Children and adolescents in the United States have high rates of immunity against hepatitis B virus (HBV), although adults have much lower rates, according to a study published in the March 1 issue of the Annals of Internal Medicine.

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Exposure to Insecticides May Up Autoimmune Disease Risk

THURSDAY, March 3 (HealthDay News) -- Women who are exposed to insecticides at home or in the workplace have an increased risk of rheumatoid arthritis (RA), or systemic lupus erythematosus (SLE), according to a study published in the February issue of Arthritis Care & Research.

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Cannabis Use in Youth Ups Incident Psychosis Risk

THURSDAY, March 3 (HealthDay News) -- Cannabis use among youth is associated with an increased risk of later incident psychotic symptoms, with continued cannabis use increasing the risk for persistent psychotic symptoms, according to a study published online March 1 in BMJ.

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Role of Diabetes in Premature Death Is Substantial

WEDNESDAY, March 2 (HealthDay News) -- Diabetes is substantially associated with premature mortality from cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, according to research published in the March 3 issue of the New England Journal of Medicine.

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Intensive Glucose Therapy May Not Be Best in Type 2 Diabetes

WEDNESDAY, March 2 (HealthDay News) -- Therapy designed to intensively lower glucose in people with type 2 diabetes and cardiovascular risk factors appears to lower the risk of nonfatal heart attack but is associated with an increased risk for all-cause mortality, according to research published in the March 3 issue of the New England Journal of Medicine.

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Maternal Opioid Use Tied to Higher Birth Defect Risk

WEDNESDAY, March 2 (HealthDay News) -- Maternal use of opioid analgesics just prior to or during early pregnancy is associated with a modestly higher risk of certain birth defects, according to a study published online Feb. 24 in the American Journal of Obstetrics & Gynecology.

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Current and Former Smokers at Higher Breast Cancer Risk

WEDNESDAY, March 2 (HealthDay News) -- Postmenopausal women who used to smoke or who currently smoke appear to be at a higher risk of invasive breast cancer than postmenopausal women who never smoked, according to a study published online March 1 in BMJ.

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Increased Dietary Potassium Tied to Lower Stroke Risk

WEDNESDAY, March 2 (HealthDay News) -- Higher dietary potassium intake is correlated with reduced rates of stroke and may also lower the risk of coronary heart disease (CHD) and total cardiovascular disease (CVD), according to a meta-analysis published in the March 8 issue of the Journal of the American College of Cardiology.

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Obesity Associated With Risk of Dissimilar Breast Cancers

WEDNESDAY, March 2 (HealthDay News) -- High body mass index (BMI) and low levels of physical activity are associated with increased risk of triple-negative and estrogen receptor-positive (ER+) breast cancers in postmenopausal women, according to a study published online March 1 in Cancer Epidemiology, Biomarkers & Prevention.

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Rare Variants in HMGA1 Gene Linked to Type 2 Diabetes

WEDNESDAY, March 2 (HealthDay News) -- The presence of functional gene variants of high-mobility group A1 (HMGA1) protein (a crucial regulator of insulin receptor [INSR] gene expression) is associated with type 2 diabetes mellitus (DM) in individuals of white European ancestry, according to a study published in the March 2 issue of the Journal of the American Medical Association.

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Risk of Death From Heart Attacks Not Linked to Gender

TUESDAY, March 1 (HealthDay News) -- The association between female gender and increased mortality among patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) does not persist after adjusting for age and comorbidities, according to a study published in the January issue of the American Heart Journal.

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U.S. Breast Cancer Incidence Rates Stabilized After 2003

TUESDAY, March 1 (HealthDay News) -- Breast cancer incidence rates among non-Hispanic (NH) white women in the United States stabilized between 2003 and 2007 after a sharp decline between 2002 and 2003 that followed a drop in the use of postmenopausal hormone therapy, according to a study published online Feb. 28 in Cancer Epidemiology, Biomarkers & Prevention.

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