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Category: Neurology | Monthly Briefing

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April 2011 Briefing - Neurology

Last Updated: May 02, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Neurology for April 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Increasing Cancer Burden Projected for Ethnic Minorities

THURSDAY, April 28 (HealthDay News) -- Consideration of genetic, ethnic, biologic, and sociological factors is necessary to appropriately diagnose and treat cancer in all U.S. subpopulations, according to the President's Cancer Panel 2009 to 2010 report published April 28.

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Autism Treatment Program May Help Toddler Subset

THURSDAY, April 28 (HealthDay News) -- An autism treatment approach, Hanen's "More Than Words" (HMTW), appears to improve communication skills in a subset of children younger than 2 years showing early signs of an autism spectrum disorder, according to a study published online March 22 in the Journal of Child Psychology and Psychiatry.

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Acute Neurological Toxicity Tied to Overall Survival

THURSDAY, April 28 (HealthDay News) -- Acute neurological toxicities (NTs) are significantly associated with late NT and overall survival in patients with high-grade gliomas treated with surgery and chemoradiation, according to a study published online April 12 in the British Journal of Cancer.

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Group Care Feasible in Patients With Parkinson's Disease

THURSDAY, April 28 (HealthDay News) -- Group patient visits, in which medical appointments are shared by patients with a common condition, may provide a feasible means of caring for patients with Parkinson's disease, according to research published online April 27 in Neurology.

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Leprosy in Southern U.S. May Be a Zoonosis

WEDNESDAY, April 27 (HealthDay News) -- In the Southern United States, wild armadillos and many humans with leprosy are infected with the same strain, and leprosy may be a zoonosis in the region, according to a study published in the April 28 issue of the New England Journal of Medicine.

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Preoperative MRI Doesn't Affect Scoliosis Surgery Outcomes

WEDNESDAY, April 27 (HealthDay News) -- Preoperative magnetic resonance imaging (MRI) for adolescent idiopathic scoliosis may not affect the surgical outcome even if a neural abnormality is detected, according to a study published in the April 15 issue of Spine.

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Epilepsy Drug Nonadherence Tied to Socioeconomic Status

TUESDAY, April 26 (HealthDay News) -- Adherence to antiepileptic drug therapy in children with newly diagnosed epilepsy varies greatly between children, and is significantly correlated with socioeconomic status, according to a study published in the April 27 issue of the Journal of the American Medical Association.

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ACC/AHA Issue Blood Pressure Control Guidelines for Elderly

TUESDAY, April 26 (HealthDay News) -- The American College of Cardiology (ACC) and the American Heart Association (AHA) have released a consensus document to help clinicians control and reduce the risks for high blood pressure in elderly adults; the document has been published online April 25 in the Journal of the American College of Cardiology.

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AAP: Chemical Management Policy Needs Revision

MONDAY, April 25 (HealthDay News) -- Stating that the Toxic Substances Control Act (TSCA) of 1976 has failed to protect children, pregnant women, and others from marketplace exposure to harmful chemicals, the American Academy of Pediatrics (AAP) recommends current U.S. chemical management policy be revised, according to a policy report published online April 25 in Pediatrics.

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Persistent Poverty Undermines Cognitive Function at Age 5

MONDAY, April 25 (HealthDay News) -- Persistent poverty at a very early age is an independent risk factor that can undermine a child's cognitive development at age 5, according to a study published online April 20 in the Journal of Epidemiology & Community Health.

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Approval for Meningitis Vaccine Expanded to Include Toddlers

MONDAY, April 25 (HealthDay News) -- Use of the Menactra vaccine has been expanded by the U.S. Food and Drug Administration to prevent meningitis and other forms of meningococcal disease in children as young as 9 months, the agency said in a news release.

Centers for Disease Control and Prevention

Tooth Loss Not Independently Linked to Cognitive Function

FRIDAY, April 22 (HealthDay News) -- Tooth loss due to periodontitis is not independently associated with reduced cognitive function, but may be a marker for poor cognitive function when combined with low socioeconomic status (SES) and advanced age, according to a study published in the April 1 issue of the Journal of the American Dental Association.

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Cognitive Therapy Found to Reduce Cortical Activation

FRIDAY, April 22 (HealthDay News) -- Cognitive behavioral therapy (CBT) may improve Gilles de la Tourette Syndrome (GTS) symptoms by modifying motor cortical activation, according to a study published in the April issue of the International Journal of Cognitive Therapy.

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Treatment-Resistant Epilepsy Common in Idiopathic Autism

THURSDAY, April 21 (HealthDay News) -- Treatment-resistant epilepsy (TRE) is relatively common in patients with autism, but surgical resection and vagus nerve stimulator (VNS) implantation offer limited benefit, according to a study published online April 19 in Epilepsia.

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CDC: Half of States Have Smoke-Free Policies

THURSDAY, April 21 (HealthDay News) -- Comprehensive smoke-free policies among U.S. states increased dramatically between 2000 and 2010, making the Healthy People 2020 target of all states having comprehensive smoke-free policies achievable with continued efforts and accelerated efforts in the Southern states, according a report in the April 22 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Pesticide Exposure Tied to Lower IQ in Children

THURSDAY, April 21 (HealthDay News) -- Pesticide exposure appears to be associated with poorer IQ scores in children and may impair cognitive development, according to three studies published online April 21 in Environmental Health Perspectives.

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Multilevel Surgery Improves Outcomes in Cerebral Palsy

THURSDAY, April 21 (HealthDay News) -- Functional and dynamic positional outcomes improve in children with hemiplegic cerebral palsy who undergo single-event multilevel surgery, according to a study published in the April 6 issue of The Journal of Bone & Joint Surgery.

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Depression After Traumatic Brain Injury Common

THURSDAY, April 21 (HealthDay News) -- About 30 percent of people who suffer traumatic brain injury (TBI) will experience depression, but there is a dearth of evidence to guide the care of the 1.2 million people in the United States who experience TBI each year, according to research published by the Agency for Healthcare Research and Quality.

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Restricted Life Space Tied to Increased Alzheimer's Risk

THURSDAY, April 21 (HealthDay News) -- Older adults whose life space is restricted to the home environment have a substantially increased risk of Alzheimer's disease (AD), according to a study published online March 22 in the American Journal of Geriatric Psychiatry.

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Calcium Supplements Modestly Increase Risk of Heart Attack

WEDNESDAY, April 20 (HealthDay News) -- Use of personal calcium supplements -- with or without vitamin D -- modestly increases the risk of cardiovascular events, especially myocardial infarction (MI), a finding obscured in the Women's Health Initiative Calcium/Vitamin D Supplementation Study (WHI CaD Study), according to an article published online April 19 in BMJ.

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More Than Five Million Youth Treated for Football Injuries

WEDNESDAY, April 20 (HealthDay News) -- An estimated 5.25 million children and adolescents in the age group 6 to 17 years were treated for football-related injury in U.S. emergency departments from 1990 to 2007, according to a study published in the March issue of Clinical Pediatrics.

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Physical Activity Guidelines May Improve Survival

WEDNESDAY, April 20 (HealthDay News) -- Meeting the recommendations set out in the federal 2008 Physical Activity Guidelines for Americans is associated with reduced all-cause mortality in U.S. adults, according to a study published online April 5 in the American Journal of Preventive Medicine.

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Arterial Obstruction Status Impacts IV Thrombolysis Benefit

WEDNESDAY, April 20 (HealthDay News) -- The infarct growth attenuating treatment effect of tissue plasminogen activator (tPA) is greater in ischemic stroke patients with arterial obstruction, according to a study published online April 7 in the Annals of Neurology.

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Off-Label Use of Recombinant Factor VIIa High

WEDNESDAY, April 20 (HealthDay News) -- Off-label use of recombinant factor VIIa (rFVIIa) in the hospital setting greatly exceeds use for approved indications; off-label use does not appear to reduce mortality and may increase the risk for thromboembolism, according to research published in the April 19 issue of the Annals of Internal Medicine.

Abstract - Logan
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Abstract - Yank
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Alcohol, Energy Drink Mix Impairs Behavioral Inhibition

TUESDAY, April 19 (HealthDay News) -- Alcohol mixed with energy drinks (AmED) increases self-reported stimulation and impairs behavioral response inhibition compared to alcohol alone, according to a study published online April 19 in Alcoholism: Clinical and Experimental Research.

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Diagnostic Guidelines for Alzheimer's Disease Updated

TUESDAY, April 19 (HealthDay News) -- The National Institute on Aging and the Alzheimer's Association have updated their diagnostic guidelines for Alzheimer's disease for the first time in 27 years; the guidelines have been published online April 19 in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

More Information

Multiple Sclerosis Variance Linked to UVB Rays, Epstein-Barr

TUESDAY, April 19 (HealthDay News) -- Much of the variance of multiple sclerosis (MS) in England can be explained by exposure to infectious mononucleosis (IM), caused by the Epstein-Barr virus (EBV), and ultraviolet B radiation (UVB), according to a study published in the April 19 issue of Neurology.

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Preterm Birth May Raise Attention Deficit Disorder Risk

TUESDAY, April 19 (HealthDay News) -- Children who are born moderately or extremely preterm may have an increased risk of developing attention-deficit/hyperactivity disorder (ADHD), according to a study published online April 18 in Pediatrics.

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Maternal Obesity Linked to Neurodevelopmental Disorders

MONDAY, April 18 (HealthDay News) -- Maternal obesity and overweight may be linked to neurodevelopmental problems in offspring in childhood, adolescence, or adulthood, according to a review published online March 17 in Obesity Reviews.

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Room for Improvement in Polio Surveillance Observed

FRIDAY, April 15 (HealthDay News) -- Surveillance and reporting standards for polio are below par in many world regions and vary at subnational levels, according to a report published in the April 15 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Stroke Outcomes Similar in Children and Young Adults

FRIDAY, April 15 (HealthDay News) -- Children and young adults who experience acute ischemic stroke tend to have similar stroke severity and clinical outcomes, even though they have different etiology and risk factors, according to a study published online March 21 in the Annals of Neurology.

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New Method May Quantify Response to Spinal Cord Injury

FRIDAY, April 15 (HealthDay News) -- Inflammation after a spinal cord injury (SCI) is nonresolving, and can be characterized by quantification of lymphocytes using resolution indexes (Ri) and resolution plateaus (Rp), according to an experimental study published online March 22 in Brain Pathology.

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Neighborhood Social Cohesion May Reduce Stroke Mortality

FRIDAY, April 15 (HealthDay News) -- Social cohesion at the neighborhood level is associated with a protective effect against stroke mortality, especially for whites, according to a study published online April 14 in Stroke.

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Psychiatric Symptoms More Common in Youth With Epilepsy

THURSDAY, April 14 (HealthDay News) -- Children with epilepsy (CWE) have a higher prevalence of psychiatric symptoms compared to their peers without epilepsy, according to a study published online March 29 in Epilepsia.

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FDA: Penumbra Coil 400 System Recalled

THURSDAY, April 14 (HealthDay News) -- The U.S. Food and Drug Administration has notified health care providers of a class 1 recall of Penumbra Inc.'s Penumbra Coil 400 system, as a defect may cause premature detachment of the coil, which can lead to serious injury, including blood clots and stroke, due to the coil unintentionally migrating.

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Ecstasy May Reduce Hippocampal Volume

THURSDAY, April 14 (HealthDay News) -- Ecstasy (3, 4-methylenedioxymethamphetamine) users have a reduced hippocampal volume, which may explain their memory deficits, according to a study published online March 28 in the Journal of Neurology, Neurosurgery & Psychiatry.

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Atrophy in AD-Related Areas Tied to Disease Development

THURSDAY, April 14 (HealthDay News) -- Researchers have found a correlation between atrophy in Alzheimer's disease (AD)-related brain areas and subsequent AD, which also appears to be influenced by vascular risk factors (VRF), according to two articles published online April 13 in Neurology.

Abstract - Dickerson
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New RX for Large Brain Aneurysm

WEDNESDAY, April 13 (HealthDay News) -- A new option to repair a large aneurysm in the brain has been approved by the U.S. Food and Drug Administration.

this approval

More Than Half of U.S. Adults Take Dietary Supplements

WEDNESDAY, April 13 (HealthDay News) -- Adult U.S. dietary supplement intake has increased since 1988-1994, according to a National Center for Health Statistics (NCHS) data brief published April 13 by the U.S. Centers for Disease Control and Prevention.

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Epilepsy May Increase the Risk of Cerebral Tumors

WEDNESDAY, April 13 (HealthDay News) -- Individuals who have new-onset epilepsy have an increased risk for developing cerebral tumors, according to a study published online March 28 in the Journal of Neurology, Neurosurgery & Psychiatry.

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Bone Marrow Recipients Develop PML Symptoms Earlier

TUESDAY, April 12 (HealthDay News) -- Bone marrow recipients have a shorter average time to development of the first symptoms of progressive multifocal leukoencephalopathy (PML), but they may survive longer than solid organ recipients post symptom onset, according to a study published online March 7 in the Annals of Neurology.

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Memantine Not Indicated in Mild Alzheimer's Disease

TUESDAY, April 12 (HealthDay News) -- Memantine provides no treatment benefit in mild Alzheimer's disease (AD) and has only limited efficacy in moderate AD, according to a meta-analysis published online April 11 in the Archives of Neurology.

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Neurocognitive Impairment Up in Childhood Cancer Survivors

MONDAY, April 11 (HealthDay News) -- Survivors of childhood cancer may be at risk of neurocognitive impairment associated with fatigue and sleep disorders, according to a study published online April 11 in Cancer.

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Teens Born Preterm Have Less White Matter, Lower IQ

FRIDAY, April 8 (HealthDay News) -- Reduced brain white matter (WM) among adolescents who were born preterm is linked with negative effects on their cognition, behavior, and academic success, according to a study published online March 9 in the Annals of Neurology.

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Meditation Affects Brain Activation to Reduce Pain

FRIDAY, April 8 (HealthDay News) -- Meditation significantly reduces both pain intensity and unpleasantness, and the pain relief is associated with alterations in brain regions related to cognitive modulation of pain, according to a study published in the April 6 issue of The Journal of Neuroscience.

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Virtual Reality Improves Stroke Patients' Motor Skills

FRIDAY, April 8 (HealthDay News) -- Virtual reality (VR) technology can assist in arm motor recovery after stroke, according to a meta-analysis published online April 7 in Stroke.

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'Global Trigger Tool' Identifies 10 Times More Errors

THURSDAY, April 7 (HealthDay News) -- Use of the new Global Trigger Tool, developed by the Institute for Healthcare Improvement, detects at least 10 times more adverse events than other methods currently in use, according to a study published in the April issue of Health Affairs.

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Horizant Approved to Treat Restless Legs Syndrome

THURSDAY, April 7 (HealthDay News) -- Horizant extended release tablets (gabapentin enacarbil) have been approved as a once-daily treatment for restless legs syndrome (RLS).

restless legs syndrome

Welders Show Early Damage to Dopaminergic Neurons

THURSDAY, April 7 (HealthDay News) -- Exposure to manganese (Mn) fumes during welding may lead to dysfunction in the nigrostriatal dopamine system, according to a study published online April 6 in Neurology.

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Brain Atrophy Measures Predict Risk of Alzheimer's

THURSDAY, April 7 (HealthDay News) -- Single-time-point or longitudinal magnetic resonance (MR) imaging measures can be used to predict which adults with mild cognitive impairment (MCI) are more likely to progress to Alzheimer's disease (AD), according to a study published online April 6 in Radiology.

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Device Approved to Treat Brain Aneurysm

WEDNESDAY, April 6 (HealthDay News) -- A new device to treat brain aneurysm has been approved by the U.S. Food and Drug Administration.

aneurysms affecting the brain

Clusterin Lacks Biomarker Potential for Alzheimer's

WEDNESDAY, April 6 (HealthDay News) -- Plasma clusterin levels are significantly associated with prevalence and severity of Alzheimer's disease (AD), but not with incidence, according to a study published in the April 6 issue of the Journal of the American Medical Association.

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Non-Communicable Diseases Present a Global Health Crisis

WEDNESDAY, April 6 (HealthDay News) -- The global burden of non-communicable diseases (NCDs) is increasing, and a global movement is needed to tackle them, according to a report published online April 6 in The Lancet.

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Alteration in Health Outcomes Post Estrogen Therapy

TUESDAY, April 5 (HealthDay News) -- Among postmenopausal women with prior hysterectomy, cessation of conjugated equine estrogen (CEE) therapy reduces the risk of stroke, and the risk of breast cancer remains reduced, according to a study to be published on April 6 in the Journal of the American Medical Association.

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Neural Correlates Found for Addictive Eating Behavior

TUESDAY, April 5 (HealthDay News) -- Addictive-like eating behavior appears to be linked with neural activation patterns similar to those seen in substance dependence, according to research published online April 4 in the Archives of General Psychiatry.

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Little Support Found for Medication of Autism Symptoms

MONDAY, April 4 (HealthDay News) -- Early behavioral and developmental interventions may benefit children with autism spectrum disorders (ASDs), but there is little evidence to support medical interventions, according to three studies published online April 4 in Pediatrics.

Abstract - Warren
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Abstract - Krishnaswami
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Four New Alzheimer's Disease Genes Identified

MONDAY, April 4 (HealthDay News) -- Researchers have identified four new genes linked to Alzheimer's disease that individually appear to add to the risk of developing the disease; their findings have been published online April 3 in Nature Genetics.

Abstract
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Cancer Rates, Cancer Mortality Rates Falling in U.S.

FRIDAY, April 1 (HealthDay News) -- Newly diagnosed cancer rates and cancer-related mortality rates in the United States are steadily declining, according to the "Annual Report to the Nation on the Status of Cancer," published online March 31 in the Journal of the National Cancer Institute.

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Autoimmune Diseases Number Two Cause of Chronic Illness

FRIDAY, April 1 (HealthDay News) -- Autoimmune diseases are the second leading cause of chronic illness in the United States and constitute a major direct and indirect economic burden to the U.S. health care system, according to a report released by the American Autoimmune Related Diseases Association (AARDA) on March 22 at a congressional briefing.

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Lower Exercise Tolerance in Patients With Turner Syndrome

FRIDAY, April 1 (HealthDay News) -- Women with Turner syndrome (TS) have lower maximal aerobic capacity and lower exercise tolerance than controls, according to a study published in the April 1 issue of The American Journal of Cardiology.

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