Here are what the editors at HealthDay consider to be the most important developments in Rheumatology for April 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Wegener's Granulomatosis Tied to Higher Solid Tumor Risk
THURSDAY, April 28 (HealthDay News) -- The increased risk of solid malignancies seen in patients with Wegener's granulomatosis treated with etanercept during the Wegener's Granulomatosis Etanercept Trial (WGET) remained increased during long-term post-trial follow-up, according to a study published online April 11 in Arthritis & Rheumatism.
Cervical Instabilities Progress in Rheumatoid Arthritis
TUESDAY, April 26 (HealthDay News) -- In patients with rheumatoid arthritis (RA), vertical subluxation (VS) and subaxial subluxation (SAS) increase over time, especially in patients with pre-existing VS, SAS, and/or mutilating changes, according to a study published in the April 15 issue of Spine.
Ultrasound Shows Pathology in Joints Despite Remission
WEDNESDAY, April 20 (HealthDay News) -- Children with juvenile idiopathic arthritis (JIA) in clinical remission may continue to show signs of pathology on joint ultrasounds, which may be indicative of ongoing inflammation, according to a study published online April 11 in Arthritis Care & Research.
Physical Activity Guidelines May Improve Survival
WEDNESDAY, April 20 (HealthDay News) -- Meeting the recommendations set out in the federal 2008 Physical Activity Guidelines for Americans is associated with reduced all-cause mortality in U.S. adults, according to a study published online April 5 in the American Journal of Preventive Medicine.
Adalimumab Maintains Remission of Childhood Uveitis
MONDAY, April 18 (HealthDay News) -- Children with noninfectious childhood uveitis are more likely to remain in remission when treated with adalimumab compared to infliximab, according to a study published in the April issue of Arthritis Care & Research.
Self-Rated Health Predicts Outcomes of Joint Replacement
THURSDAY, April 14 (HealthDay News) -- Mental well-being and self-rated health (SRH) predict outcomes of total joint replacements, more than patients' prior physical health, according to a study published online March 18 in Arthritis Care & Research.
Adalimumab Antibodies Linked to Treatment Failure
WEDNESDAY, April 13 (HealthDay News) -- Development of antibodies against adalimumab may have an effect on treatment discontinuation, disease activity, and remission in patients with rheumatoid arthritis (RA), according to a study published April 13 in an infectious disease and immunology themed issue of the Journal of the American Medical Association.
Diabetes and Disease Activity Predict Depression in Lupus
TUESDAY, April 12 (HealthDay News) -- Diabetes mellitus and systemic lupus erythematosus (SLE)-related disease activity appear to increase the likelihood of developing depression in SLE, according to a study published in the April issue of Arthritis Care & Research.
Rheumatoid Arthritis Treatment May Reduce Diabetes Risk
MONDAY, April 11 (HealthDay News) -- Extended use of tumor necrosis factor α (TNFα) antagonists in patients with rheumatoid arthritis (RA) may reduce the risk of developing insulin resistance (IR), according to a review published in the April issue of Arthritis Care & Research.
First U.S. Test to Diagnose Dengue Fever Approved
MONDAY, April 11 (HealthDay News) -- The first test to help diagnose people with symptoms of the mosquito-borne virus dengue fever has been approved by the U.S. Food and Drug Administration.
Imatinib Reduces Cutaneous Systemic Sclerosis Symptoms
MONDAY, April 11 (HealthDay News) -- Imatinib mesylate is well tolerated by patients with diffuse cutaneous systemic sclerosis (dcSSc) with improvement in skin thickening and forced vital capacity (FVC), according to a study published online March 11 in the Annals of the Rheumatic Diseases.
'Global Trigger Tool' Identifies 10 Times More Errors
THURSDAY, April 7 (HealthDay News) -- Use of the new Global Trigger Tool, developed by the Institute for Healthcare Improvement, detects at least 10 times more adverse events than other methods currently in use, according to a study published in the April issue of Health Affairs.
Guidelines for Juvenile Arthritis Treatment Published
THURSDAY, April 7 (HealthDay News) -- New guidelines for the treatment of children with juvenile idiopathic arthritis (JIA) have been developed by the American College of Rheumatology; the guidelines are based on the best available scientific evidence and expert opinion and have been published in the April issue of Arthritis Care & Research.
Rituximab Does Not Improve Safety Profile of RA Treatment
MONDAY, April 4 (HealthDay News) -- Combining rituximab with a tumor necrosis factor (TNF) inhibitor and methotrexate (MTX) in patients with rheumatoid arthritis (RA) does not offer any safety improvement, according to a study published in the March issue of Arthritis & Rheumatism.
Patients, Doctors Agree OA Care Needs Improvement
MONDAY, April 4 (HealthDay News) -- Patients with osteoarthritis (OA) and health professionals involved in treatment agree about health care provision for OA, stressing the need for an OA specialist in primary care and better information at or soon after diagnosis, according to a study published online March 8 in Arthritis Care & Research.
Autoimmune Diseases Number Two Cause of Chronic Illness
FRIDAY, April 1 (HealthDay News) -- Autoimmune diseases are the second leading cause of chronic illness in the United States and constitute a major direct and indirect economic burden to the U.S. health care system, according to a report released by the American Autoimmune Related Diseases Association (AARDA) on March 22 at a congressional briefing.
Cell Phone Proximity to Hip Tied to Bone Mineralization
FRIDAY, April 1 (HealthDay News) -- Men who carry their cell phone next to their hip may have reduced bone mineral content (BMC) and bone mineral density (BMD) in same side hip, according to a study published in the March issue of the Journal of Craniofacial Surgery.
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