FRIDAY, May 27 (HealthDay News) -- OnabotulinumtoxinA (BoNT-A) intradetrusor injection may be clinically beneficial and is well tolerated by adults with neurogenic detrusor overactivity (NDO) and antimuscarinic-refractory incontinence, according to a study published in the June issue of The Journal of Urology.
Sender Herschorn, M.D., from the University of Toronto, and colleagues investigated the efficacy of BoNT-A for NDO secondary to spinal cord injury or multiple sclerosis in 57 patients aged 18 to 75 years. Participants had antimuscarinic-refractory urinary incontinence and were randomly allocated to receive cystoscopic injection of BoNT-A 300 U (28 patients) or placebo (29 patients). At week 36, open-label BoNT-A 300 U was offered to all patients, and 24 in each of the treatment and follow-up groups who received open-label therapy were followed up for a further six months. Daily urinary incontinence frequency was recorded in a three-day voiding diary at week six. Changes in the International Consultation on Incontinence Questionnaire and the urinary incontinence quality-of-life scale at week six were also assessed. These evaluations were repeated after the open-label treatment.
The investigators found that, compared to placebo, the mean daily frequency of urinary incontinence episodes was significantly lower with BoNT-A treatment at week six (1.31 versus 4.76). BoNT-A treatment was also associated with improvements in urodynamic and quality-of-life parameters compared with placebo, which were evident at six weeks and persisted at weeks 24 and 36. Urinary tract infection was the most common adverse event in all the groups.
"OnabotulinumtoxinA is well tolerated and provides clinically beneficial improvement for up to nine months," the authors write.
Several authors disclosed financial relationships with the pharmaceutical industry, including Allergan, which supported the study.
Copyright © 2011 HealthDay. All rights reserved.
|Previous: Television in Child's Bedroom Linked to Unhealthy Lifestyle||Next: Acetaminophen Prescriptions for Children Often Incorrect|
Reader comments on this article are listed below. Review our comments policy.
Submit your opinion:
Are you a Doctor, Pharmacist, PA or a Nurse?
Join the Doctors Lounge online medical community