Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for May 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
BMD and FRAX Score Tied to Fracture Risk in Diabetes
TUESDAY, May 31 (HealthDay News) -- In older adults with type 2 diabetes mellitus (DM), bone mineral density (BMD) T score and age or World Health Organization Fracture Risk Algorithm (FRAX) score are associated with increased fracture risk, according to a study published in the June 1 issue of the Journal of the American Medical Association.
Effect Estimates May Be Inflated in Biomarker Studies
TUESDAY, May 31 (HealthDay News) -- Biomarker effects are often overestimated in highly cited studies compared to the effects reported in subsequent meta-analyses of the same associations, according to a review published in the June 1 issue of the Journal of the American Medical Association.
Use of Energy Drinks Should Be Discouraged in Children
TUESDAY, May 31 (HealthDay News) -- Sports and energy drink consumption is widespread, and youth should be made aware of the potential health risks of those drinks, according to a clinical report published online May 29 in Pediatrics.
APOL1 Donor Gene Linked to Renal Graft Survival
TUESDAY, May 31 (HealthDay News) -- Significantly shorter renal allograft survival is seen in recipients of kidneys donated by African-American (AA) donors with two apolipoprotein L1 gene (APOL1) risk variants compared to patients receiving a kidney from a donor with zero or one risk variant, according to a study published in the May issue of the American Journal of Transplantation.
Lack of Sleep May Increase Body Mass Index in Children
TUESDAY, May 31 (HealthDay News) -- Young children who do not get enough sleep may have an increased risk of becoming overweight, according to a study published online May 26 in BMJ.
Phone Counseling Improves Outcomes in Diabetes Patients
FRIDAY, May 27 (HealthDay News) -- Telephone-delivered cognitive behavioral therapy (CBT) coupled with a walking program may not improve A1c levels in patients with type 2 diabetes and depression, but it appears to improve other important outcomes, according to research published online April 6 in Medical Care.
Television in Child's Bedroom Linked to Unhealthy Lifestyle
FRIDAY, May 27 (HealthDay News) -- Having a TV in the bedroom (TVIB) is associated with unhealthy behaviors in Hispanic children, according to a study published in the May/June issue of the American Journal of Health Promotion.
Work-Related Activity Boosts Number of Active Adults
THURSDAY, May 26 (HealthDay News) -- More than 70 percent of U.S. adults meet the minimum threshold for physical activity when occupational physical activity is taken into consideration, according to research published in the May 27 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
Contact With Drug Industry Linked to Positive Attitudes
WEDNESDAY, May 25 (HealthDay News) -- The extent of contact that medical students have with the pharmaceutical industry is associated with positive attitudes about marketing, according to a review published online May 24 in PLoS Medicine.
Erectile Dysfunction Linked to Diabetic Retinopathy
TUESDAY, May 24 (HealthDay News) -- Significant erectile dysfunction (ED) is associated with diabetic retinopathy (DR) severity, independent of age, diabetes duration, macrovascular comorbidities, and cardiovascular risk factors, according to a study published in the May issue of Urology.
Patient-Physician Gender Concordance Aids Obese Males
TUESDAY, May 24 (HealthDay News) -- Patient-physician gender concordance has a positive correlation with exercise and diet/nutrition counseling in obese male patients, according to a study published in the June issue of the American Journal of Preventive Medicine.
Excess Medical Costs Tied to Diabetes in Youth Substantial
MONDAY, May 23 (HealthDay News) -- The excess medical expenditures related to diabetes among youth are substantial, and this is particularly true for insulin-treated diabetes mellitus (ITDM), according to a study published in the May issue of Diabetes Care.
High Prevalence of Vitamin D Deficiency in Obese Teens
MONDAY, May 23 (HealthDay News) -- Obese adolescents have a very high prevalence of low vitamin D status, according to a study published in the May issue of the Journal of Adolescent Health.
Excessive Business Travel Tied to Poor Health, Obesity
FRIDAY, May 20 (HealthDay News) -- People who travel extensively for business are more likely to be obese and to rate their health as poor or fair than peers whose business travel demands are lighter, according to research published in the April issue of the Journal of Occupational and Environmental Medicine.
Ultrasonography Results Show Lower NAFLD Prevalence
FRIDAY, May 20 (HealthDay News) -- Use of liver ultrasonography indicates that the prevalence of hepatic steatosis and nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes may be lower than previously reported, according to a study published in the May issue of Diabetes Care.
Selenium Has Modest Benefits for Plasma Lipid Levels
FRIDAY, May 20 (HealthDay News) -- Selenium supplementation appears to modestly benefit plasma lipid levels among individuals with relatively low selenium status, according to a study published in the May 17 issue of the Annals of Internal Medicine.
Many Medical Students Lack Confidence in Medical Law
FRIDAY, May 20 (HealthDay News) -- The majority of medical students lack confidence in their knowledge and skills across many areas of medical law, according to a study published online May 16 in the Journal of Medical Ethics.
Selenium May Improve Graves' Orbitopathy Symptoms
WEDNESDAY, May 18 (HealthDay News) -- Treatment of patients with mild Graves' orbitopathy with selenium may improve quality of life, reduce ocular involvement, and slow disease progression, according to a study published in the May 19 issue of the New England Journal of Medicine.
Third Antihyperglycemic Agents Produce Similar Results
WEDNESDAY, May 18 (HealthDay News) -- There are no significant differences between the class of antihyperglycemic agents given to patients with uncontrolled type 2 diabetes who are already treated with metformin and a sulfonylurea, according to a meta-analysis published in the May 17 issue of the Annals of Internal Medicine.
Patients With Type 2 Diabetes Do Not Benefit From Leptin
TUESDAY, May 17 (HealthDay News) -- Recombinant methionyl human (r-Met hu) leptin does not have clinically important effects on insulin sensitivity independent of weight loss in obese people with newly diagnosed type 2 diabetes, according to a study published in the May issue of Diabetes.
BMI of 35kg/m² or More Associated With Mortality
TUESDAY, May 17 (HealthDay News) -- In older U.S. adults, moderately severe obesity may be related to mortality, whereas lower levels of obesity are correlated with new or worsening disability within two years, according to a study published in the May 17 issue of the Annals of Internal Medicine.
Fractalkine and Receptor Linked to Adipose Inflammation
FRIDAY, May 13 (HealthDay News) -- Fractalkine (CX3CL1) and its receptor CX3CR1 may be involved in adipose inflammation, obesity, insulin resistance, and type 2 diabetes, according to a study published in the May issue of Diabetes.
GnRH Antagonists Effective Option in IVF
FRIDAY, May 13 (HealthDay News) -- The treatment of women with in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with gonadotrophin-releasing hormone (GnRH) antagonists results in a similar live-birth rate, and is associated with a lower incidence of ovarian hyperstimulation syndrome (OHSS) compared to standard treatment with GnRH agonists, according to a meta-analysis published online May 11 in the Cochrane Database of Systematic Reviews.
Poor Sleep Quality Linked to Worse Glucose Control
THURSDAY, May 12 (HealthDay News) -- Early-middle-aged adults with type 2 diabetes show an association between poor sleep quality and higher levels of fasting glucose, fasting insulin, and estimated insulin resistance, according to a study published in the May issue of Diabetes Care.
Medical Education Participants Recognize Funding Bias
WEDNESDAY, May 11 (HealthDay News) -- Although most medical professionals believe that commercial funding of continuing medical education (CME) introduces bias, most are not willing to pay higher fees to offset or eliminate such funding sources, according to a study published in the May 9 issue of the Archives of Internal Medicine.
Limited Evidence Exists for Alzheimer's Risk Factors
WEDNESDAY, May 11 (HealthDay News) -- The existing evidence is insufficient to draw firm conclusions about the association of any modifiable factor with the risk of Alzheimer's disease (AD), according to a study published online May 9 in the Archives of Neurology.
Novel Genomic Predictor Indicates Breast CA Survival
TUESDAY, May 10 (HealthDay News) -- A genomic predictor combining estrogen receptor (ER) status with chemoresistance, chemosensitivity, and endocrine sensitivity may identify patients with newly diagnosed breast cancer with a high chance of survival following taxane and anthracycline chemotherapy, according to a study published in the May 11 issue of the Journal of the American Medical Association.
Low Vitamin D Tied to Adiposity and High HDL in Children
MONDAY, May 9 (HealthDay News) -- Low 25-hydroxyvitamin D (25[OH]D) levels are associated with high measures of adiposity and low levels of high-density lipoprotein (HDL) cholesterol in both black and white children, according to a study published in the May issue of the Journal of Clinical Endocrinology & Metabolism.
Diabetes Symptoms Improve With Aerobic Exercise
MONDAY, May 9 (HealthDay News) -- Aerobic exercise alone or combined with resistance training significantly improves cardiovascular (CV) risk factors including hemoglobin A1c, systolic blood pressure (SBP), triglycerides, and waist circumference in patients with type 2 diabetes, according to a meta-analysis published online April 27 in Diabetes Care.
Severe Vitamin D Deficiency Tied to Mortality in Diabetes
FRIDAY, May 6 (HealthDay News) -- Severe vitamin D deficiency may be predictive of increased all-cause mortality in patients with type 1 diabetes, but it is not associated with microvascular complications in the kidney or eye, according to a study published online April 27 in Diabetes Care.
Higher Metabolic Rates May Predict Early Mortality
FRIDAY, May 6 (HealthDay News) -- Higher metabolic rates, measured by 24-hour energy expenditure (24EE) or resting metabolic rate (RMR), may predict early natural mortality in Pima Indians, according to a study published online March 30 in the Journal of Clinical Endocrinology & Metabolism.
Health Literacy Limited Among Patients on Hemodialysis
FRIDAY, May 6 (HealthDay News) -- A substantial proportion of patients treated with chronic hemodialysis have limited health literacy, especially African-Americans, those with lower educational levels, and veterans, according to a study published online May 5 in the Clinical Journal of the American Society of Nephrology.
Structured Exercise Beats Advice Only for Lowering HbA1c
TUESDAY, May 3 (HealthDay News) -- Structured exercise training is associated with a reduction in hemoglobin A1c (HbA1c) in patients with type 2 diabetes, while physical activity advice is associated with lower HbA1c only when combined with dietary advice, according to a meta-analysis published in the May 4 issue of the Journal of the American Medical Association.
Central Obesity Tied to Cardiac Patient Mortality
TUESDAY, May 3 (HealthDay News) -- Central obesity is associated with increased mortality in individuals with coronary artery disease (CAD), even in those with a normal body mass index (BMI), according to a review published in the May 10 issue of the Journal of the American College of Cardiology.
Midlife Obesity Linked to Increased Risk of Dementia
TUESDAY, May 3 (HealthDay News) -- Being overweight or obese in midlife may increase the risk of dementia, Alzheimer's disease (AD), and vascular dementia (VaD), according to a study published in the May 3 issue of Neurology.
Tradjenta Approved for Type 2 Diabetes
MONDAY, May 2 (HealthDay News) -- Tradjenta (linagliptin) tablets, combined with diet and exercise, have been approved by the U.S. Food and Drug Administration to control blood sugar in people with type 2 diabetes, the agency said Monday.
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