WEDNESDAY, Aug. 17 (HealthDay News) -- The pretibial surfaces of the legs of patients with diabetic dermopathy have significantly lower skin blood flow on normal-appearing skin than in control patients, whereas dermopathy lesions have higher blood flow, according to a study published in the September issue of the Journal of the American Academy of Dermatology.
Alexandra Brugler, from the Creighton University School of Medicine in Omaha, Neb., and colleagues investigated the local skin blood flow in patients with diabetic dermopathy. Using laser Doppler technology, cutaneous blood flow was measured in 25 patients with type 1 diabetes and evident diabetic dermopathy (average age, 51 ± 2 years) and was compared with blood flow in 58 patients with type 1 diabetics without dermopathy (average age, 41 ± 2 years) and 67 individuals without diabetes (average age, 47 ± 3 years). Flow values were measured at three sites on the pretibial area on the legs of each individual, at lesion sites, and at standard sites on the upper and lower extremities.
The investigators found that the skin blood flow at 35 degrees Celsius on the normal-appearing skin areas decreased markedly to 1.1 ± 0.1 mL/min/100g in the diabetic dermopathy group, compared with both the nondiabetic group (2.1 ± 0.3 mL/min/100g) and the type 1 diabetic control group (1.7 ± 0.1 mL/min/100g). Noticeably higher blood flow of 2.5 ± 0.3 mL/min/100g was observed in the dermopathy lesions.
"These results suggest that patients susceptible to diabetic dermopathy have a functional abnormality in blood flow leading to this scarring process," the authors write.
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