FRIDAY, Aug. 19 (HealthDay News) -- The significant association between Staphylococcus aureus (S. aureus) biofilms and chronic rhinosinusitis (CRS) is attributed to skewing of the T-cell response toward the T-helper2 pathway, independent of superantigen activities, according to a study published online Aug. 11 in Allergy.
Andrew Foreman, B.M.B.S., Ph.D., from the University of Adelaide in Australia, and colleagues aimed to document the adaptive immune responses that characterize S. aureus biofilm-associated CRS, and the pathogenic role of staphylococcal superantigens and S. aureus biofilms in the inflammatory make-up of CRS. Sinonasal mucosa were collected from 53 diseased individuals and 15 controls for the determination of S. aureus and Haemophilus influenzae biofilms, presence of total and superantigen-specific immunoglobulin E (IgE), and measurement of cytokines that characterize the T-helper pathways.
The investigators found that S. aureus biofilms and superantigens significantly correlated with CRS. The presence of S. aureus biofilms was associated with across-the-CRS-spectrum eosinophilic inflammation, attributed to T-helper2 skewing of the host's adaptive immune response (elevated Eosinophilic Cationic Protein and interleukin-5). This response was distinguishable from the superantigenic effect resulting in IgE induction.
"This study provides novel evidence of a link between S. aureus biofilms and skewing of the T-cell response toward the T-helper2 pathway that is independent of superantigen activities," the authors write.
Abstract
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