THURSDAY, Aug. 25 (HealthDay News) -- Stereotactic body radiotherapy is a safe and effective treatment for colorectal liver metastases, with a strong association between local control and overall survival even for heavily pretreated patients, according to a study published in the September 1 Cancer.
Daniel T. Chang, M.D., from Stanford University in California, and colleagues investigated the outcomes of stereotactic body radiotherapy in patients with colorectal liver metastases. A total of 65 patients with 102 lesions treated from August 2002 to May 2009 were included (median follow-up 1.2 years). Patients with one to four lesions were given one to six fractions of stereotactic body radiotherapy (median dose 42 gray [Gy]) and radiologic imaging for three or more months posttreatment. The three-fraction dose required for more than 90 percent local control was estimated using a tumor control probability (TCP) model after converting the schedule into a biologically equivalent dose (BED), single-fraction equivalent dose, or linear quadratic model-based single-fraction dose.
The investigators found that before stereotactic body radiotherapy, 47 (72 percent) and 27 (42 percent) patients had one or more, and two or more chemotherapy regimens, respectively. A significant association was observed between total dose, dose/fraction and BED with local control by lesion on separate evaluation by multivariate analysis. Nonactive extra hepatic disease was correlated with overall survival on multivariate analysis and sustained local control was closely associated. The estimated dose range needed for more than 90 percent local control for one year was 46 to 52 Gy in three fractions.
"Liver stereotactic body radiotherapy is well tolerated and effective for colorectal liver metastases," the authors write.
One of the study authors disclosed a financial relationship with Bayer.
Abstract
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