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Category: Cardiology | Monthly Briefing

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August 2011 Briefing - Cardiology

Last Updated: September 01, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Cardiology for August 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Predictors of Child Ventricular Assist Device Mortality ID'd

WEDNESDAY, Aug. 31 (HealthDay News) -- In children with ventricular assist device (VAD) support, congenital etiology, norepinephrine requirement, C-reactive protein (CRP) levels higher than 6.3 mg/dL, and central venous pressure (CVP) greater than 17 mm Hg are independent predictors of in-hospital mortality, according to a study published in the Sept. 6 issue of the Journal of the American College of Cardiology.

Abstract
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CPR Pre-Heart Rhythm Analysis Does Not Affect Outcomes

WEDNESDAY, Aug. 31 (HealthDay News) -- For patients with out-of-hospital cardiac arrest, the outcome of a brief period of cardiopulmonary resuscitation (CPR) with early rhythm analysis is similar to that of a longer period of CPR with delayed rhythm analysis; and the use of an impedance threshold device (ITD) during standard CPR does not significantly improve survival with satisfactory function, according to two studies published in the Sept. 1 issue of the New England Journal of Medicine.

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Undernutrition in Early Life Ups CHD Risk in Adult Women

WEDNESDAY, Aug. 31 (HealthDay News) -- Exposure to undernutrition during postnatal developmental periods of childhood, adolescence, or young adulthood is associated with an increased risk of coronary heart disease (CHD) in adult women, according to a study published online Aug. 25 in the European Heart Journal.

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Lower Early Restenosis Rate With Drug-Eluting Balloons

WEDNESDAY, Aug. 31 (HealthDay News) -- Drug-eluting balloons (DEBs) seem to be safe and effective for treating long infrapopliteal lesions, according to a study published online Aug. 29 in the Journal of the American College of Cardiology.

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Lack of Slow Wave Sleep Ups Hypertension Risk in Older Men

TUESDAY, Aug. 30 (HealthDay News) -- The percentage of slow wave sleep (SWS) is significantly associated with incident hypertension in men aged 65 years and older, even after adjusting for confounding variables, according to a study published online Aug. 29 in Hypertension.

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ESC: Addition of IABC to PCI Doesn't Reduce Infarct Size

TUESDAY, Aug. 30 (HealthDay News) -- For patients with anterior ST-segment elevation myocardial infarction (STEMI) without shock, use of intra-aortic balloon counterpulsation (IABC) plus percutaneous coronary intervention (PCI) does not reduce the size of myocardial infarct more than PCI alone, according to a study published online Aug. 29 in the Journal of the American Medical Association, to coincide with its presentation at the European Society of Cardiology Congress 2011, held Aug. 27-31, in Paris, France.

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Apixaban Superior to Warfarin for Stroke Prevention in A-Fib

MONDAY, Aug. 29 (HealthDay News) -- Apixaban is superior to warfarin in lowering the risk of stroke or systemic embolism, and reduces the rate of major bleeding and mortality in patients with atrial fibrillation, according to a study published online Aug. 28 in the New England Journal of Medicine to coincide with the European Society of Cardiology Congress 2011 held Aug. 27 to 31 in Paris, France.

Abstract
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Editorial (subscription or payment may be required)

Colchicine Safe, Effective Adjunct in Recurrent Pericarditis

MONDAY, Aug. 29 (HealthDay News) -- Colchicine appears to be safe and effective for the secondary prevention of recurrent pericarditis, according to a study published online first August 28 in the Annals of Internal Medicine.

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Drug-Eluting Stents Better for Saphenous Vein Graft Lesions

MONDAY, Aug. 29 (HealthDay News) -- Drug-eluting stents are better than bare-metal stents for reducing the risk of adverse events for patients undergoing percutaneous coronary intervention for de-novo saphenous vein graft lesions, according to a study published online Aug. 28 in The Lancet, to coincide with the European Society of Cardiology Congress held Aug. 27 to 31 in Paris, France.

Abstract
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Editorial (subscription or payment may be required)

Public Sector Funds Large Part of State Obesity-Related Costs

MONDAY, Aug. 29 (HealthDay News) -- Between 22 and 55 percent of U.S. state-level obesity-related costs are financed by the public sector via Medicare and Medicaid, according to a study published online June 16 in Obesity.

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Loss of Jobs Means Loss of Health Coverage for Many in U.S.

MONDAY, Aug. 29 (HealthDay News) -- For American adults who lose their health insurance coverage when they lose their jobs, the majority remain uninsured, delay getting needed health care or prescriptions, and report financial difficulties paying medical bills, according to a report published online Aug. 24 by The Commonwealth Fund.

Report

Being Happily Married Ups Survival 15 Years Post Bypass

FRIDAY, Aug. 26 (HealthDay News) -- Married individuals, particularly those in a highly satisfying marriage, are significantly more likely to be alive 15 years after coronary artery bypass grafting (CABG), according to a study published online Aug. 22 in Health Psychology.

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Complementary Medicine Used More by Health Care Workers

FRIDAY, Aug. 26 (HealthDay News) -- U.S. health care workers, especially health care providers, are more likely to use complementary and alternative medicine (CAM) than the general, employed U.S. population, according to a study published online Aug. 22 in Health Services Research.

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Pharmaceutical Ads Often Don't Adhere to U.S. FDA Guidelines

THURSDAY, Aug. 25 (HealthDay News) -- Physician-targeting pharmaceutical advertisements have low rates of adherence to U.S. Food and Drug Administration (FDA) guidelines and provide inadequate information for safe prescribing, according to a study published online Aug. 17 in PLoS One.

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Ambulatory BP Monitoring Cost-Effective Diagnostic Strategy

WEDNESDAY, Aug. 24 (HealthDay News) -- Ambulatory monitoring of blood pressure is the most cost-effective strategy for the diagnosis of hypertension, according to a study published online Aug. 24 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Diastolic Dysfunction Ups Heart Failure Risk in Elderly

WEDNESDAY, Aug. 24 (HealthDay News) -- Left ventricular diastolic dysfunction worsens over time and with advancing age, increasing the risk of subsequent heart failure, according to a study published in the Aug. 24/31 issue of the Journal of the American Medical Association.

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Adenosine-Induced Stress CT Provides Accurate Heart Scans

WEDNESDAY, Aug. 24 (HealthDay News) -- Adenosine-induced stress 128-slice dual source high-pitch myocardial computed tomography perfusion (CTP) has good diagnostic accuracy at low radiation for simultaneous assessment of reversible myocardial ischemia and coronary stenosis compared to CT angiography (CTA) and cardiac magnetic resonance imaging (CMR), according to a study published online Aug. 23 in Circulation: Cardiovascular Imaging.

Abstract
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Clinical Features Differ for Men and Women With Heart Failure

WEDNESDAY, Aug. 24 (HealthDay News) -- Compared to men, women hospitalized for heart failure have different clinical characteristics and length of hospital stay, but similar clinical presentations, in-hospital mortality, and quality of care for most parameters, according to a study published online Aug. 23 in Circulation: Heart Failure.

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Dietary Portfolio Significantly Lowers LDL-C in Hyperlipidemia

TUESDAY, Aug. 23 (HealthDay News) -- Patients with hyperlipidemia using a specific dietary portfolio at different levels of intensity have greater reductions in low-density lipoprotein cholesterol (LDL-C) during six months of follow-up than those receiving low-saturated fat dietary advice, according to a study published Aug. 24/31 in the Journal of the American Medical Association.

Abstract
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Hospitalization Ups Unintentional Discontinuation of Meds

TUESDAY, Aug. 23 (HealthDay News) -- Hospital or intensive care unit (ICU) admission is associated with unintentional discontinuation of medication for chronic diseases, according to a study published online Aug. 23 in the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Biologic Therapies for Psoriasis Do Not Up CV Risk

TUESDAY, Aug. 23 (HealthDay News) -- Biologic therapies anti-interleukin (IL)-12 and IL-23 [anti-IL-12/23] and anti-tumor necrosis factor α (TNF-α) in patients with chronic plaque psoriasis (CPP) do not increase the risk of major adverse cardiovascular events (MACEs), according to a meta-analysis published online Aug. 24 in the Journal of the American Medical Association.

Abstract
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U.S. Door-To-Balloon Time Shortens From 2005 to 2010

TUESDAY, Aug. 23 (HealthDay News) -- The door-to-balloon (D2B) time (from hospital arrival to mechanical reperfusion) in patients with acute myocardial infarction (MI) undergoing primary percutaneous coronary intervention in the United States improved between 2005 and 2010, according to a study published online Aug. 22 in Circulation.

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Omega-3 Cost-Effective for Hypertriglyceridemia

MONDAY, Aug. 22 (HealthDay News) -- A validated model indicates that prescription ω-3 fatty acids (P-OM3) offer cost-effective reduction of adverse cardiac events and triglyceride levels in patients with severe (≥500 mg/dL) hypertriglyceridemia (SHTG), according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

Abstract
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Similar Platelet Response With 50 or 100 mg Dose of Aspirin

MONDAY, Aug. 22 (HealthDay News) -- Patients with coronary heart disease undergoing treatment with 50 or 100 mg aspirin for five years showed no difference in platelet response or cardiovascular (CV) events, according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

Abstract
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Traditional Risk Factors Up Early RA Cardiovascular Events

FRIDAY, Aug. 19 (HealthDay News) -- Traditional cardiovascular (CV) risk factors increase the risk of new cardiovascular events (CVEs) in patients with rheumatoid arthritis (RA), with disease activity increasing the risk, and treatment with disease modifying antirheumatic drugs (DMARDs) decreasing the risk, according to a study published online Aug. 15 in Arthritis Research & Therapy.

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Omecamtiv Mecarbil Well Tolerated in Healthy Adults

FRIDAY, Aug. 19 (HealthDay News) -- Omecamtiv mecarbil is well-tolerated in healthy adults up to a dose of 0.625 mg/kg per hour, and shows dose- and concentration-dependent improvement in left ventricular systolic function in healthy adults and patients with stable systolic heart failure, according to two studies published in the Aug. 20 European Society of Cardiology special issue of The Lancet.

Abstract - Teerlink
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Abstract - Cleland
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Editorial (subscription or payment may be required)

Coronary Artery Calcium Stratifies Cardiovascular Risk

FRIDAY, Aug. 19 (HealthDay News) -- Coronary artery calcium (CAC) seems to be a better predictor of cardiovascular events than high-sensitivity C-reactive protein (hsCRP), according to a study published in the Aug. 20 European Society of Cardiology special issue of The Lancet.

Abstract
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Editorial (subscription or payment may be required)

CDC: 2010/2011 Flu Vaccination Coverage Studied

THURSDAY, Aug. 18 (HealthDay News) -- Influenza vaccination coverage among health care personnel (HCP) and pregnant women in the 2010/2011 influenza season was similar to coverage for the 2009/2010 season, according to two reports in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text - Health Care Personnel
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TV Viewing Reduces Life Expectancy in Australian Adults

THURSDAY, Aug. 18 (HealthDay News) -- Television (TV) viewing time is correlated with a substantial reduction in life expectancy among Australian adults, according to a study published online Aug. 15 in the British Journal of Sports Medicine.

Abstract
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High Cumulative Malpractice Risk for All Physicians

THURSDAY, Aug. 18 (HealthDay News) -- Physicians in all specialties have a high cumulative risk of facing a malpractice claim by age 65; although most claims do not lead to indemnity payments, according to a study published in the Aug. 18 issue of the New England Journal of Medicine.

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Fructose-Rich Corn Syrup Intake Raises CVD Risk

THURSDAY, Aug. 18 (HealthDay News) -- Consuming high-fructose corn syrup (HFCS) for two weeks at 25 percent of energy requirements (E) increases triglycerides, low-density lipoprotein (LDL), and apolipoprotein B (apoB) levels in young adults comparably to fructose but more than glucose, according to a study published online Aug. 17 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Pericardial Fat Volume Tied to Atherosclerotic Plaque Burden

WEDNESDAY, Aug. 17 (HealthDay News) -- Pericardial fat volume is more strongly associated with coronary atherosclerotic plaque burden than body mass index (BMI) or waist circumference, according to a study published online Aug. 16 in Radiology.

Abstract
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Coronary Stents and Peri-Op Antiplatelet Drug Use Reviewed

TUESDAY, Aug. 16 (HealthDay News) -- In patients on dual antiplatelet therapy (DAPT) undergoing non-cardiac surgery (NCS) within one year of coronary stenting, APT withdrawal should be decided after assessing the risk of perioperative bleeding and cardiac ischemic events, particularly stent thrombosis (ST), according to a review published online Aug. 5 in the Journal of Thrombosis & Haemostatis.

Abstract
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Selective Use of Drug-Eluting Stents Tied to Reduced Costs

TUESDAY, Aug. 16 (HealthDay News) -- The change from liberal use of drug-eluting stents (DES) in 2004 to 2006 to selective use in 2007 was associated with a small but statistically significant increase in target lesion revascularization (TLR), and a modest reduction in total cardiovascular costs, according to a study published online Aug. 15 in Circulation.

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Patient Care Improves With Anticoagulation Service

TUESDAY, Aug. 16 (HealthDay News) -- A Pharmacist-Directed Anticoagulation Service (PDAS) improves the quality of care for patients taking the anticoagulant drug warfarin in an inpatient setting by coordinating the transition of care from an inpatient to an outpatient setting, according to a study published online Aug. 10 in the Journal of Hospital Medicine.

Abstract
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Predictors of Survival After Cardiac Arrest in ICU Identified

MONDAY, Aug. 15 (HealthDay News) -- Independent predictors of survival following cardiac arrest which occurs in the intensive care unit (ICU) include the presenting rhythm, age, and duration of cardiopulmonary resuscitation (CPR), according to a study published online Aug. 15 in CMAJ, the Journal of the Canadian Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Antiretrovirals Raise Cholesterol in HIV-Infected Children

MONDAY, Aug. 15 (HealthDay News) -- Children with HIV receiving antiretroviral therapy have increased cholesterol levels; and hypercholesterolemia in children perinatally infected with HIV remains elevated over time, according to two studies published in the Aug. 15 issue of the Journal of Acquired Immune Deficiency Syndromes.

Abstract - Rhoads
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Abstract - Jacobson
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Epidermal Electronic System Monitors Heart, Brain Activity

FRIDAY, Aug. 12 (HealthDay News) -- An ultrathin epidermal electronic system (EES), comparable to skin, can effectively monitor the electrical activity of heart, brain, and skeletal muscle when laminated onto the skin like a temporary transfer tattoo, according to a study published in the Aug. 12 issue of Science.

Abstract
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Editorial (subscription or payment may be required)

Trastuzumab Ups Cardiotoxicity Risk in Some Elderly Women

FRIDAY, Aug. 12 (HealthDay News) -- In elderly women with breast cancer and a history of cardiac disease or diabetes, treatment with trastuzumab is associated with an increased risk of cardiotoxicity, according to a study published online Aug. 9 in the Annals of Oncology.

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Niacin Linked to Improved Erectile Function

FRIDAY, Aug. 12 (HealthDay News) -- Men with moderate to severe erectile dysfunction (ED) and dyslipidemia have significantly improved erectile function with treatment with niacin, according to a study published online Aug. 2 in The Journal of Sexual Medicine.

Abstract
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Severe or Bilateral Carotid Stenosis Tied to Brain Atrophy

THURSDAY, Aug. 11 (HealthDay News) -- In patients with symptomatic atherosclerotic disease, severe or bilateral carotid stenosis is associated with the progression of global, cortical, and subcortical atrophy, according to a study published in the August issue of the Annals of Neurology.

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Heart Disease Risk Higher in Female Versus Male Smokers

THURSDAY, Aug. 11 (HealthDay News) -- Compared with nonsmokers, women who smoke have a significantly higher risk of coronary heart disease than do male smokers, independent of other cardiovascular risk factors, according to a review published online Aug. 11 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Rivaroxaban Noninferior to Warfarin for Stroke Prevention

WEDNESDAY, Aug. 10 (HealthDay News) -- Rivaroxaban is noninferior to warfarin for the prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation, with no significant differences in major bleeding risk, according to a study published online Aug. 10 in the New England Journal of Medicine.

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Optogenetics by Tandem Cell Unit Feasible in Cardiac Muscle

WEDNESDAY, Aug. 10 (HealthDay News) -- Using a tandem cell unit (TCU) strategy, optogenetics is shown to be feasible for controlling excitation and contraction in cardiac muscle, according to an experimental study published online Aug. 9 in Circulation: Arrhythmia and Electrophysiology.

Abstract
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Poor Verbal Memory in Elderly With Low Ejection Fraction

WEDNESDAY, Aug. 10 (HealthDay News) -- In older patients with heart failure, there is a significant association between memory function and left ventricular ejection fraction (EF), with verbal delayed recall and recognition most affected by an EF of less than 30 percent, according to a study published in the August issue of the Archives of Neurology.

Abstract
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Higher Diagnostic Blood Loss Tied to Higher Anemia Risk

WEDNESDAY, Aug. 10 (HealthDay News) -- Increased blood loss from diagnostic phlebotomy increases the risk for moderate to severe hospital-acquired anemia (HAA) among patients with acute myocardial infarction (AMI), according to a study published online Aug. 8 in the Archives of Internal Medicine.

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Obstructive CAD Detection Rates Vary Between Hospitals

TUESDAY, Aug. 9 (HealthDay News) -- Significant interhospital variation exists in the rate of detection of obstructive coronary artery disease (CAD) in patients undergoing elective coronary angiography, according to a study published in the Aug. 16 issue of the Journal of the American College of Cardiology.

Abstract
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Familial Factors Predict VTE in Unaffected Siblings

TUESDAY, Aug. 9 (HealthDay News) -- Familial risk factors are significant predictors of venous thromboembolism (VTE) among unaffected siblings between the ages of 10 to 69 years, and although the absolute risk increases with age, the relative contribution of familial factors decreases with age, according to a study published online Aug. 8 in Circulation.

Abstract
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ILVSF in Hypertrophic Cardiomyopathy Has Poor Prognosis

MONDAY, Aug. 8 (HealthDay News) -- Impaired left ventricular systolic function (ILVSF) in hypertrophic cardiomyopathy (HC) is associated with increased risk of heart failure death or heart transplantation, and of cardiovascular dysfunctions, including cardiac dilatation, decreased development of small arterioles, and fibrosis, according to a study published in the Aug. 15 issue of The American Journal of Cardiology.

Abstract
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Coronary Calcium Predictive of Restenosis Post SES Implantation

FRIDAY, Aug. 5 (HealthDay News) -- Multidetector computed tomography assessment of coronary calcium may be a useful technique for predicting outcomes following sirolimus-eluting stent (SES) implantation, with lesions with higher calcium scores exhibiting greater lumen loss after SES implantation, according to a study published in the Aug. 15 issue of The American Journal of Cardiology.

Abstract
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Cost of Interacting With Payers Higher in U.S. Than Canada

FRIDAY, Aug. 5 (HealthDay News) -- Physician practices in the United States spend considerably more on interactions with health plans than Canadian practices, according to a study published in the August issue of Health Affairs.

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Pulse Oximetry Able to Detect Congenital Heart Defects

FRIDAY, Aug. 5 (HealthDay News) -- Pulse oximetry is a reasonably accurate screening test for detecting congenital heart defects in newborns, according to a study published online Aug. 5 in The Lancet.

Abstract
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Five MicroRNAs Highly Expressed in Symptomatic Plaques

FRIDAY, Aug. 5 (HealthDay News) -- Specific microRNAs (miRNAs) are highly expressed in symptomatic atherosclerotic plaques, and may have a role in modulation of stroke-related proteins, according to a study published online Aug. 4 in Stroke.

Abstract
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Nurse Case Managers Improve Cardiac Risk Control in Diabetes

FRIDAY, Aug. 5 (HealthDay News) -- Nurse case managers can improve the percentage of patients with diabetes who achieve control of hypertension, hyperglycemia, and hyperlipidemia, according to a study published in the August issue of Diabetes Care.

Abstract
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Lower Post MI Physical Activity in Areas With Low Income

THURSDAY, Aug. 4 (HealthDay News) -- Low neighborhood socioeconomic status (SES) is a significant predictor of lower uptake of leisure-time physical activity (LTPA) by survivors of myocardial infarction (MI), even after adjusting for individual SES and clinical profile, according to a study published online Aug. 2 in the American Journal of Preventive Medicine.

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Even Small Amount of Exercise Lowers Heart Disease Risk

TUESDAY, Aug. 2 (HealthDay News) -- A dose-response relationship is seen between leisure-time physical activity (LTPA) and the risk of coronary heart disease (CHD) risk, with significant reductions seen with less than or equivalent to 150 minutes/week of moderate-intensity LTPA and additional risk reductions for those engaging in activity equivalent to 300 minutes/week, according to a meta-analysis published online Aug. 1 in Circulation.

Abstract
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Lower Risk of Repeat Vascular Events in Young Adults on Statins

TUESDAY, Aug. 2 (HealthDay News) -- Young adults treated with a statin for an ischemic stroke of unknown etiology are at lower risk for subsequent vascular events than were those who are untreated, according to a study published in the Aug. 2 issue of Neurology.

Abstract
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Midlife Vascular Risk Factors Impact Structural Brain Aging

MONDAY, Aug. 1 (HealthDay News) -- Hypertension, diabetes, smoking, and obesity in midlife are associated with accelerated progression of structural brain aging, and decline in executive function a decade later, according to a study published in the Aug. 2 issue of Neurology.

Abstract
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Risk Factors for Sudden Cardiac Death, CHD Can Be Different

MONDAY, Aug. 1 (HealthDay News) -- Although sudden cardiac death (SCD) and coronary heart disease (CHD) have several risk factors in common, echocardiogram (ECG) findings and clinical parameters, including hypertension, race/ethnicity, body mass index (BMI), and heart rate, can help differentiate SCD and incident CHD, according to a study published online July 20 in Heart.

Abstract
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