Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for August 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Cord Colitis Syndrome Distinct From Other Post-HSCT Diarrhea
WEDNESDAY, Aug. 31 (HealthDay News) -- For patients undergoing hematopoietic stem-cell transplantation (HSCT), cord colitis syndrome is clinically and histopathologically distinct from acute graft-versus-host disease (GVHD) and other causes of diarrhea, and responds to empirical therapy of antibiotics, according to a study published in the Sept. 1 issue of the New England Journal of Medicine.
Cost-Effective Perinatal HBV Transmission Prevention ID'ed
WEDNESDAY, Aug. 31 (HealthDay News) -- In hepatitis B surface-antigen-positive pregnant women, administration of lamivudine or hepatitis B immune globulin (HBIG) in the third trimester is a cost-effective method for prevention of perinatal transmission of hepatitis B, according to a study published in the September issue of Obstetrics and Gynecology.
Variable Survival Benefit of Radioembolization in HCC
WEDNESDAY, Aug. 31 (HealthDay News) -- The survival benefit for patients with hepatocellular carcinoma (HCC) treated with radioembolization with yttrium-90-labeled resin microspheres is affected by numerous factors with the most significant, independent prognostic factors including Eastern Cooperative Oncology Group (ECOG) performance status, international normalized ratio >1.2, tumor burden and extrahepatic disease, according to a study published online June 30 in Hepatology.
Loss of Jobs Means Loss of Health Coverage for Many in U.S.
MONDAY, Aug. 29 (HealthDay News) -- For American adults who lose their health insurance coverage when they lose their jobs, the majority remain uninsured, delay getting needed health care or prescriptions, and report financial difficulties paying medical bills, according to a report published online Aug. 24 by The Commonwealth Fund.
Addition of Oxaliplatin Ups Survival in Stage II/III Colon CA
MONDAY, Aug. 29 (HealthDay News) -- In patients with stage II/III colon cancer, the addition of oxaliplatin to fluorouracil plus leucovorin (FULV) therapy (FULV plus oxaliplatin [FLOX]) is superior to FULV in improving disease-free survival (DFS), but not overall survival (OS), but in patients younger than 70 years, oxaliplatin improves OS, according to a study published online Aug. 22 in the Journal of Clinical Oncology.
Complementary Medicine Used More by Health Care Workers
FRIDAY, Aug. 26 (HealthDay News) -- U.S. health care workers, especially health care providers, are more likely to use complementary and alternative medicine (CAM) than the general, employed U.S. population, according to a study published online Aug. 22 in Health Services Research.
Pharmaceutical Ads Often Don't Adhere to U.S. FDA Guidelines
THURSDAY, Aug. 25 (HealthDay News) -- Physician-targeting pharmaceutical advertisements have low rates of adherence to U.S. Food and Drug Administration (FDA) guidelines and provide inadequate information for safe prescribing, according to a study published online Aug. 17 in PLoS One.
CDC: Reporting Delays Occurred in German E. coli Outbreak
THURSDAY, Aug. 25 (HealthDay News) -- During the outbreak of hemolytic uremic syndrome (HUS) and bloody diarrhea related to shiga toxin-producing Escherichia coli O104:H4 (STEC) in Germany during May and June 2011, there was a median delay of 20 days between symptom onset and reporting the cases, according to a study published in the U.S. Centers for Disease Control and Prevention's October Emerging Infectious Diseases.
Stereotactic Radiotherapy Treats Colorectal Liver Mets
THURSDAY, Aug. 25 (HealthDay News) -- Stereotactic body radiotherapy is a safe and effective treatment for colorectal liver metastases, with a strong association between local control and overall survival even for heavily pretreated patients, according to a study published in the September 1 Cancer.
CT Enterography More Sensitive Than Capsule Endoscopy
WEDNESDAY, Aug. 24 (HealthDay News) -- In patients with obscure gastrointestinal bleeding (OGIB), multiphase computed tomographic (CT) enterography is significantly more sensitive than capsule endoscopy for detecting small bowel bleeding sources and masses, according to a study published online June 3 in Radiology.
Dual Hepatitis B, C Infection Ups Lifetime HCC Risk
TUESDAY, Aug. 23 (HealthDay News) -- The individual and combined effects of HBV and HCV on hepatocellular carcinoma (HCC) vary according to age and gender, according to a study published online Aug. 22 in the Journal of Clinical Oncology.
Five Strategies Suggested to Reduce HCC Recurrence
MONDAY, Aug. 22 (HealthDay News) -- Hepatocellular carcinoma (HCC) recurrence in patients who have undergone liver transplantation may be reduced by following potential strategies in five steps before and after transplant surgery, according to a study published online Aug. 10 in the American Journal of Transplantation.
Celiac Disease May Be Risk Factor for Infertility
MONDAY, Aug. 22 (HealthDay News) -- Women with unexplained infertility may be at a higher risk of undiagnosed celiac disease, according to a study published in the May-June issue of the Journal of Reproductive Medicine.
CDC: Legionellosis Incidence Up During 2000 to 2009
FRIDAY, Aug. 19 (HealthDay News) -- The incidence of reported legionellosis in the United States almost tripled between 2000 and 2009; however, the reason for the increase remains unclear, according to a report in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
CDC: 2010/2011 Flu Vaccination Coverage Studied
THURSDAY, Aug. 18 (HealthDay News) -- Influenza vaccination coverage among health care personnel (HCP) and pregnant women in the 2010/2011 influenza season was similar to coverage for the 2009/2010 season, according to two reports in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
High Cumulative Malpractice Risk for All Physicians
THURSDAY, Aug. 18 (HealthDay News) -- Physicians in all specialties have a high cumulative risk of facing a malpractice claim by age 65; although most claims do not lead to indemnity payments, according to a study published in the Aug. 18 issue of the New England Journal of Medicine.
Peanut Butter Products Linked to Salmonellosis Outbreak
WEDNESDAY, Aug. 17 (HealthDay News) -- A nationwide outbreak of human Salmonella Typhimurium infections in the United States in 2008 has been attributed to eating a specific brand of contaminated peanut butter and peanut products, according to a study published in the Aug 18 issue of the New England Journal of Medicine.
Large Variation in Reoperation Rate After Colorectal Surgery
WEDNESDAY, Aug. 17 (HealthDay News) -- Reoperation rates after colorectal surgery vary significantly between hospitals and among surgeons in England, according to a study published online Aug. 16 in BMJ.
Coronary Stents and Peri-Op Antiplatelet Drug Use Reviewed
TUESDAY, Aug. 16 (HealthDay News) -- In patients on dual antiplatelet therapy (DAPT) undergoing non-cardiac surgery (NCS) within one year of coronary stenting, APT withdrawal should be decided after assessing the risk of perioperative bleeding and cardiac ischemic events, particularly stent thrombosis (ST), according to a review published online Aug. 5 in the Journal of Thrombosis & Haemostatis.
Early Neurolysis Reduces Pain in Inoperable Pancreatic CA
TUESDAY, Aug. 16 (HealthDay News) -- Early endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) is associated with reduced pain and may decrease morphine consumption in patients with painful, inoperable pancreatic adenocarcinoma, according to a study published online Aug. 15 in the Journal of Clinical Oncology.
Bevacizumab, Chemo Beneficial in Advanced Gastric Cancer
TUESDAY, Aug. 16 (HealthDay News) -- The addition of bevacizumab to chemotherapy is linked to improved progression-free survival and overall response rate in the treatment of advanced gastric cancer, according to a study published online Aug. 15 in the Journal of Clinical Oncology.
Genetic Association Identified for RAC1, Ulcerative Colitis
FRIDAY, Aug. 12 (HealthDay News) -- A genetic association has been identified between RAC1 and ulcerative colitis, with increased expression linked to susceptibility to colitis in humans and disruption of Rac1 in mice protecting against dextran sulphate sodium (DSS)-induced colitis, according to an experimental study published in the August issue of Gastroenterology.
Linaclotide Safe, Effective for Treating Chronic Constipation
WEDNESDAY, Aug. 10 (HealthDay News) -- Linaclotide significantly improves bowel and abdominal symptoms, and reduces the severity of constipation in patients suffering from chronic constipation, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.
Most Colostomies After Anal Cancer Therapy Tumor Related
WEDNESDAY, Aug. 10 (HealthDay News) -- Most colostomies performed following radiotherapy or chemoradiotherapy for anal cancer are tumor related, with one-third therapy related, according to a study published online Aug. 8 in the Journal of Clinical Oncology.
Cost of Interacting With Payers Higher in U.S. Than Canada
FRIDAY, Aug. 5 (HealthDay News) -- Physician practices in the United States spend considerably more on interactions with health plans than Canadian practices, according to a study published in the August issue of Health Affairs.
Gastric Bypass Tied to Reduced Fat Intake in Humans, Rats
THURSDAY, Aug. 4 (HealthDay News) -- Gastric bypass is associated with reduced intake of and preference for fat in rats, and reduced intake of dietary fat for humans, according to an experimental study published online in July 6 in the American Journal of Physiology.
Intrinsic Subtypes of Gastric Cancer Linked to Survival
THURSDAY, Aug. 4 (HealthDay News) -- Intrinsic subtypes of gastric cancer (GC) with distinct gene expression patterns are correlated with patient survival and response to chemotherapy, according to a study published in the August issue of Gastroenterology.
One-Shot Flu Vaccine Partially Effective After Teen Transplant
MONDAY, Aug. 1 (HealthDay News) -- A single dose of pandemic influenza A (pH1N1/09) vaccine offers a modest rate of seroconversion in pediatric liver transplant patients above the age of 10 years, according to a study published in the August issue of Liver Transplantation.
CA 19-9, Ultrasound Feasible for Pancreatic Cancer Detection
MONDAY, Aug. 1 (HealthDay News) -- Screening for tumor marker CA 19-9 followed by targeted endoscopic ultrasound (EUS) when the level is elevated represents a feasible approach for identifying early pancreatic adenocarcinoma in a high-risk population, according to a study published in the July issue of Gastrointestinal Endoscopy.
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