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Category: Internal Medicine | Monthly Briefing

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August 2011 Briefing - Internal Medicine

Last Updated: September 01, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for August 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Predictors of Child Ventricular Assist Device Mortality ID'd

WEDNESDAY, Aug. 31 (HealthDay News) -- In children with ventricular assist device (VAD) support, congenital etiology, norepinephrine requirement, C-reactive protein (CRP) levels higher than 6.3 mg/dL, and central venous pressure (CVP) greater than 17 mm Hg are independent predictors of in-hospital mortality, according to a study published in the Sept. 6 issue of the Journal of the American College of Cardiology.

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Cord Colitis Syndrome Distinct From Other Post-HSCT Diarrhea

WEDNESDAY, Aug. 31 (HealthDay News) -- For patients undergoing hematopoietic stem-cell transplantation (HSCT), cord colitis syndrome is clinically and histopathologically distinct from acute graft-versus-host disease (GVHD) and other causes of diarrhea, and responds to empirical therapy of antibiotics, according to a study published in the Sept. 1 issue of the New England Journal of Medicine.

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Electronic Records Tied to Better Diabetes Care, Outcomes

WEDNESDAY, Aug. 31 (HealthDay News) -- Medical practices using electronic health records (EHRs) achieve significantly higher composite standards for diabetes care and outcomes than those using paper records, according to a study published in the Sept. 1 issue of the New England Journal of Medicine.

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CPR Pre-Heart Rhythm Analysis Does Not Affect Outcomes

WEDNESDAY, Aug. 31 (HealthDay News) -- For patients with out-of-hospital cardiac arrest, the outcome of a brief period of cardiopulmonary resuscitation (CPR) with early rhythm analysis is similar to that of a longer period of CPR with delayed rhythm analysis; and the use of an impedance threshold device (ITD) during standard CPR does not significantly improve survival with satisfactory function, according to two studies published in the Sept. 1 issue of the New England Journal of Medicine.

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Japan's Universal Health System Evaluated

WEDNESDAY, Aug. 31 (HealthDay News) -- The disproportionate aging population in Japan and societal influences may negatively impact the country's universal health care system, according to six articles published in a Japan series online Aug. 30 in The Lancet.

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Undernutrition in Early Life Ups CHD Risk in Adult Women

WEDNESDAY, Aug. 31 (HealthDay News) -- Exposure to undernutrition during postnatal developmental periods of childhood, adolescence, or young adulthood is associated with an increased risk of coronary heart disease (CHD) in adult women, according to a study published online Aug. 25 in the European Heart Journal.

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Composition of ICU Team Affects Professional Burnout

WEDNESDAY, Aug. 31 (HealthDay News) -- The composition of caregiver teams in intensive care units (ICUs) affects the risk of professional burnout, with an increased proportion of female nurses associated with a decreased risk, according to a study published online Aug. 18 in the American Journal of Respiratory and Critical Care Medicine.

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Cost-Effective Perinatal HBV Transmission Prevention ID'ed

WEDNESDAY, Aug. 31 (HealthDay News) -- In hepatitis B surface-antigen-positive pregnant women, administration of lamivudine or hepatitis B immune globulin (HBIG) in the third trimester is a cost-effective method for prevention of perinatal transmission of hepatitis B, according to a study published in the September issue of Obstetrics and Gynecology.

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Variable Survival Benefit of Radioembolization in HCC

WEDNESDAY, Aug. 31 (HealthDay News) -- The survival benefit for patients with hepatocellular carcinoma (HCC) treated with radioembolization with yttrium-90-labeled resin microspheres is affected by numerous factors with the most significant, independent prognostic factors including Eastern Cooperative Oncology Group (ECOG) performance status, international normalized ratio >1.2, tumor burden and extrahepatic disease, according to a study published online June 30 in Hepatology.

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Saffron ID'ed as Potential Therapy for Liver CA

TUESDAY, Aug. 30 (HealthDay News) -- Saffron reduces the number and incidence of hepatic dyschromatic nodules and the number and area of placental glutathione S-transferase-positive foci in livers of diethylnitrosamine (DEN)-treated rats, according to an experimental study published online July 19 in Hepatology.

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Metabolic Syndrome Linked to Chronic Kidney Disease Risk

TUESDAY, Aug. 30 (HealthDay News) -- Metabolic syndrome (MetS) and its components are significantly associated with the development of estimated glomerular filtration rates (eGFR) less than 60 ml/min/1.73 m², according to a meta-analysis published online Aug. 18 in the Clinical Journal of the American Society of Nephrology.

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Four Categories of Eligibility for Contraceptive Use Endorsed

TUESDAY, Aug. 30 (HealthDay News) -- Clinicians should assess the appropriateness of contraceptives for women with specific medical conditions or characteristics based on the four categories of medical eligibility defined by the 2010 U.S. Medical Eligibility Criteria for Contraceptive Use (U.S. MEC), according to a Committee Opinion published in the September issue of Obstetrics & Gynecology.

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BCL2L1 Linked to Colorectal Cancer-Related Processes

TUESDAY, Aug. 30 (HealthDay News) -- BCL2L1 is involved in several colorectal cancer-related processes and its protein expression is associated with chromosome 20q gain, according to a study published online Aug. 18 in The Journal of Pathology.

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Counseling Helps Smokers With Comorbid Disorders Quit

TUESDAY, Aug. 30 (HealthDay News) -- Counseling by primary care providers (PCPs) is effective for encouraging smoking cessation for individuals with and without alcohol, drug, or mental (ADM) disorders, according to a study published online Aug. 22 in Nicotine & Tobacco Research.

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Aerobic Training Better Than Resistance Training for Obese

TUESDAY, Aug. 30 (HealthDay News) -- For sedentary, overweight and obese adults, aerobic training (AT) is more effective than resistance training (RT) at reducing visceral fat, total abdominal fat, liver fat, alanine aminotransferase (ALT) levels, and fasting insulin resistance (HOMA), and there is no additional benefit of adding RT to AT, according to a study published online Aug. 16 in the American Journal of Physiology - Endocrinology and Metabolism.

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Lack of Slow Wave Sleep Ups Hypertension Risk in Older Men

TUESDAY, Aug. 30 (HealthDay News) -- The percentage of slow wave sleep (SWS) is significantly associated with incident hypertension in men aged 65 years and older, even after adjusting for confounding variables, according to a study published online Aug. 29 in Hypertension.

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ESC: Mortality Up With High Serum Cathepsin S in Elderly

TUESDAY, Aug. 30 (HealthDay News) -- High circulating serum cathepsin S levels are associated with an increased risk of mortality in the elderly, according to a study published online Aug. 29 in the Journal of the American Medical Association, to coincide with its presentation at the European Society of Cardiology Congress 2011, held Aug. 27 to 31, in Paris, France.

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ESC: Addition of IABC to PCI Doesn't Reduce Infarct Size

TUESDAY, Aug. 30 (HealthDay News) -- For patients with anterior ST-segment elevation myocardial infarction (STEMI) without shock, use of intra-aortic balloon counterpulsation (IABC) plus percutaneous coronary intervention (PCI) does not reduce the size of myocardial infarct more than PCI alone, according to a study published online Aug. 29 in the Journal of the American Medical Association, to coincide with its presentation at the European Society of Cardiology Congress 2011, held Aug. 27-31, in Paris, France.

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Public Sector Funds Large Part of State Obesity-Related Costs

MONDAY, Aug. 29 (HealthDay News) -- Between 22 and 55 percent of U.S. state-level obesity-related costs are financed by the public sector via Medicare and Medicaid, according to a study published online June 16 in Obesity.

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Drug-Eluting Stents Better for Saphenous Vein Graft Lesions

MONDAY, Aug. 29 (HealthDay News) -- Drug-eluting stents are better than bare-metal stents for reducing the risk of adverse events for patients undergoing percutaneous coronary intervention for de-novo saphenous vein graft lesions, according to a study published online Aug. 28 in The Lancet, to coincide with the European Society of Cardiology Congress held Aug. 27 to 31 in Paris, France.

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Colchicine Safe, Effective Adjunct in Recurrent Pericarditis

MONDAY, Aug. 29 (HealthDay News) -- Colchicine appears to be safe and effective for the secondary prevention of recurrent pericarditis, according to a study published online first August 28 in the Annals of Internal Medicine.

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Apixaban Superior to Warfarin for Stroke Prevention in A-Fib

MONDAY, Aug. 29 (HealthDay News) -- Apixaban is superior to warfarin in lowering the risk of stroke or systemic embolism, and reduces the rate of major bleeding and mortality in patients with atrial fibrillation, according to a study published online Aug. 28 in the New England Journal of Medicine to coincide with the European Society of Cardiology Congress 2011 held Aug. 27 to 31 in Paris, France.

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Loss of Jobs Means Loss of Health Coverage for Many in U.S.

MONDAY, Aug. 29 (HealthDay News) -- For American adults who lose their health insurance coverage when they lose their jobs, the majority remain uninsured, delay getting needed health care or prescriptions, and report financial difficulties paying medical bills, according to a report published online Aug. 24 by The Commonwealth Fund.

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Self-Efficacy Tied to Achieving Physical Activity Goals in RA

MONDAY, Aug. 29 (HealthDay News) -- For patients with rheumatoid arthritis (RA) having self-efficacy at baseline is tied to achieving physical activity goals, which has a direct effect on uality of life, according to a study published online Aug. 25 in Arthritis Care & Research.

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Wide Gaps in Immune Responses Post Flu Infection

MONDAY, Aug. 29 (HealthDay News) -- The wide gap in the antiviral and inflammatory response seen in symptomatic and asymptomatic individuals exposed to influenza A infection is mediated by genomic signatures, according to a study published online Aug. 25 in PLoS Genetics.

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Higher 90-Day Mortality in New Jersey Weekend Stroke Admits

FRIDAY, Aug. 26 (HealthDay News) -- Patients with stroke admitted to New Jersey hospitals on weekends have a significantly increased 90-day mortality compared to those admitted on weekdays, but stroke admissions to comprehensive stroke centers (CSCs) have similar 90-day mortality for weekend versus weekday admissions, according to a study published online Aug. 25 in Stroke.

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Extended-Release Opioid Pain Medication Approved

FRIDAY, Aug. 26 (HealthDay News) -- Nucynta ER (tapentadol extended release) has been approved by the U.S. Food and Drug Administration to treat moderate-to-severe chronic pain in adults, maker Janssen Pharmaceuticals said.

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Expedited Partner Therapy Use Benefits Gonorrhea, Chlamydia

FRIDAY, Aug. 26 (HealthDay News) -- Expedited partner therapy should be used in accordance with the Centers for Disease Control and Prevention's (CDC) guidelines to prevent reinfection by treating partners of patients with gonorrhea and chlamydia who are unable or unwilling to seek medical care, according to a committee opinion published in the September issue of Obstetrics & Gynecology.

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Obesity Epidemic Increasing Worldwide

FRIDAY, Aug. 26 (HealthDay News) -- Obesity appears to be increasing worldwide, affecting countries in varying degrees and negatively impacting quality of life and increasing associated societal costs, however, a new weight loss model and national government intervention may help slow and reverse the epidemic, according to four studies published in an obesity series online August 25 in The Lancet.

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Substantial Chemo Exposure Rates Among Oncology Nurses

FRIDAY, Aug. 26 (HealthDay News) -- Oncology nurses practicing outside of hospital inpatient units report considerable rates of chemotherapy exposure to skin and eyes, which are lowered with adequate staffing and resources, and adherence to recognized practice standards, according to a study published online Aug. 16 in BMJ Quality & Safety.

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Clinical, Lab Variables Predict Survival in Advanced CA

FRIDAY, Aug. 26 (HealthDay News) -- A combination of clinical and laboratory variables can effectively predict two-week and two-month survival in patients with advanced cancer who are no longer being treated, according to a study published online Aug. 25 in the BMJ.

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Early Plasma Exchange Tied to Improved Course of HUS

FRIDAY, Aug. 26 (HealthDay News) -- Early plasma exchange therapy is associated with increased median platelet count and glomerular filtration rate, decreased median lactate dehydrogenase concentration, and improved neurological status in adults with diarrhea-associated hemolytic uremic syndrome (HUS), according to a study published online Aug. 25 in The Lancet.

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Being Happily Married Ups Survival 15 Years Post Bypass

FRIDAY, Aug. 26 (HealthDay News) -- Married individuals, particularly those in a highly satisfying marriage, are significantly more likely to be alive 15 years after coronary artery bypass grafting (CABG), according to a study published online Aug. 22 in Health Psychology.

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Complementary Medicine Used More by Health Care Workers

FRIDAY, Aug. 26 (HealthDay News) -- U.S. health care workers, especially health care providers, are more likely to use complementary and alternative medicine (CAM) than the general, employed U.S. population, according to a study published online Aug. 22 in Health Services Research.

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Pharmaceutical Ads Often Don't Adhere to U.S. FDA Guidelines

THURSDAY, Aug. 25 (HealthDay News) -- Physician-targeting pharmaceutical advertisements have low rates of adherence to U.S. Food and Drug Administration (FDA) guidelines and provide inadequate information for safe prescribing, according to a study published online Aug. 17 in PLoS One.

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Firazyr Approved for Acute Hereditary Angioedema

THURSDAY, Aug. 25 (HealthDay News) -- Firazyr (icatibant) has been approved by the U.S. Food and Drug Administration to treat acute attacks of hereditary angioedema (HAE) in adults.

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S-Nitrosylation of Toxins Prevents Clostridium Infection

THURSDAY, Aug. 25 (HealthDay News) -- S-nitrosylation of Clostridium difficile (C. difficile) toxins in the intestines of infected hosts is suggested to attenuate virulence and prevent Clostridium difficile infection (CDI), according to an experimental study published online Aug. 21 in Nature Medicine.

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CDC: Reporting Delays Occurred in German E. coli Outbreak

THURSDAY, Aug. 25 (HealthDay News) -- During the outbreak of hemolytic uremic syndrome (HUS) and bloody diarrhea related to shiga toxin-producing Escherichia coli O104:H4 (STEC) in Germany during May and June 2011, there was a median delay of 20 days between symptom onset and reporting the cases, according to a study published in the U.S. Centers for Disease Control and Prevention's October Emerging Infectious Diseases.

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Socioeconomic Status, Gender Affect Cystic Fibrosis Survival

THURSDAY, Aug. 25 (HealthDay News) -- For patients with cystic fibrosis, socioeconomic status and gender remained constant, strong predictors of survival above the annual median age at death from 1959 to 2008, according to a study published online Aug. 24 in the BMJ.

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Helium Lung Morphometry Sensitive to Emphysema Changes

THURSDAY, Aug. 25 (HealthDay News) -- In patients with chronic obstructive pulmonary disease (COPD), non-invasive helium 3 (3He) lung morphometry is more sensitive in identifying in vivo early emphysematous changes in alveolar geometry than low-dose computed tomography (CT) or traditional pulmonary function testing (PFT), according to a study published online July 6 in Radiology.

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Elevated 1H MRS Metabolites Tied to Cognitive Function

THURSDAY, Aug. 25 (HealthDay News) -- For cognitively normal older adults, elevated proton magnetic resonance spectroscopy (1H MRS) metabolite choline (Cho)/creatine (Cr) ratios are associated with lower scores on cognitive tests, according to a study published online Aug. 24 in Neurology.

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Airway Infections Correlate With Narcolepsy Onset in China

WEDNESDAY, Aug. 24 (HealthDay News) -- In China, narcolepsy onset is significantly associated with seasonal and annual patterns of upper airway infections, including H1N1 influenza, and increased three-fold following the 2009 H1N1 winter influenza pandemic, independent of H1N1 vaccination in the majority of cases, according to a study published online Aug. 22 in the Annals of Neurology.

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Ambulatory BP Monitoring Cost-Effective Diagnostic Strategy

WEDNESDAY, Aug. 24 (HealthDay News) -- Ambulatory monitoring of blood pressure is the most cost-effective strategy for the diagnosis of hypertension, according to a study published online Aug. 24 in The Lancet.

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Botox Approved to Treat Urinary Incontinence

WEDNESDAY, Aug. 24 (HealthDay News) -- Botox (onabotulinumtoxinA) has been approved by the U.S. Food and Drug Administration to treat urinary incontinence in people with neurological conditions such as spinal cord injury and multiple sclerosis.

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CDC: Two Salmonella Outbreaks Investigated

WEDNESDAY, Aug. 24 (HealthDay News) -- Two outbreaks of Salmonella infections, Salmonella Altona and Salmonella Johannesburg, have been linked to chicks and ducklings from a single mail-order hatchery, according to an update from the Centers for Disease Control and Prevention (CDC).

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Azithromycin Decreases COPD Exacerbation Frequency

WEDNESDAY, Aug. 24 (HealthDay News) -- In selected patients with chronic obstructive pulmonary disorder (COPD), daily azithromycin for one year together with usual treatment decreases the frequency of exacerbations but increases the frequency of hearing decrements, according to a study published Aug. 25 in the New England Journal of Medicine.

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CT Enterography More Sensitive Than Capsule Endoscopy

WEDNESDAY, Aug. 24 (HealthDay News) -- In patients with obscure gastrointestinal bleeding (OGIB), multiphase computed tomographic (CT) enterography is significantly more sensitive than capsule endoscopy for detecting small bowel bleeding sources and masses, according to a study published online June 3 in Radiology.

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Six Factors Impact Survival in Elderly Asians With Cancer

WEDNESDAY, Aug. 24 (HealthDay News) -- Six domains of comprehensive geriatric assessment (CGA) including age, albumin level, Eastern Cooperative Oncology Group (ECOG) performance status, geriatric depression scale (GDS) status, malnutrition risk, and disease stage are important predictors of overall survival (OS) in elderly Asian patients with cancer, according to a study published online Aug. 22 in the Journal of Clinical Oncology.

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Prevalence of Mental Disorders Linked to Gender Differences

WEDNESDAY, Aug. 24 (HealthDay News) -- The prevalence rates of mental illness are associated with gender differences, with women having higher rates of anxiety or depression and men having higher rates of substance abuse or antisocial disorders, according to a study published online Aug. 15 in the Journal of Abnormal Psychology.

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High Serum Phosphate Tied To Renal Disease Progression

WEDNESDAY, Aug. 24 (HealthDay News) -- Serum phosphate is an independent risk factor for progression of renal disease in patients with proteinuric chronic kidney disease (CKD) and may reduce the renoprotective effect of ACE inhibitors, according to a study published online Aug. 18 in the Journal of the American Society of Nephrology.

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Diastolic Dysfunction Ups Heart Failure Risk in Elderly

WEDNESDAY, Aug. 24 (HealthDay News) -- Left ventricular diastolic dysfunction worsens over time and with advancing age, increasing the risk of subsequent heart failure, according to a study published in the Aug. 24/31 issue of the Journal of the American Medical Association.

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Clinical Features Differ for Men and Women With Heart Failure

WEDNESDAY, Aug. 24 (HealthDay News) -- Compared to men, women hospitalized for heart failure have different clinical characteristics and length of hospital stay, but similar clinical presentations, in-hospital mortality, and quality of care for most parameters, according to a study published online Aug. 23 in Circulation: Heart Failure.

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Hospitalization Ups Unintentional Discontinuation of Meds

TUESDAY, Aug. 23 (HealthDay News) -- Hospital or intensive care unit (ICU) admission is associated with unintentional discontinuation of medication for chronic diseases, according to a study published online Aug. 23 in the Journal of the American Medical Association.

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Dietary Portfolio Significantly Lowers LDL-C in Hyperlipidemia

TUESDAY, Aug. 23 (HealthDay News) -- Patients with hyperlipidemia using a specific dietary portfolio at different levels of intensity have greater reductions in low-density lipoprotein cholesterol (LDL-C) during six months of follow-up than those receiving low-saturated fat dietary advice, according to a study published Aug. 24/31 in the Journal of the American Medical Association.

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Drinkers, Smokers Less Likely to Adhere to Chemoprevention

TUESDAY, Aug. 23 (HealthDay News) -- Women at high risk of breast cancer who drink alcohol each day are less likely to adhere fully to chemoprevention at one month, and cigarette smokers are less likely to adhere adequately at 36 months, according to a study published online Aug. 23 in Cancer Prevention Research.

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Biologic Therapies for Psoriasis Do Not Up CV Risk

TUESDAY, Aug. 23 (HealthDay News) -- Biologic therapies anti-interleukin (IL)-12 and IL-23 [anti-IL-12/23] and anti-tumor necrosis factor α (TNF-α) in patients with chronic plaque psoriasis (CPP) do not increase the risk of major adverse cardiovascular events (MACEs), according to a meta-analysis published online Aug. 24 in the Journal of the American Medical Association.

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Incidental Screening Has No Impact on Adrenocortical CA

TUESDAY, Aug. 23 (HealthDay News) -- Detection rates and clinical outcomes in adrenocortical carcinoma (ACC) show no improvement due to incidental screening resulting from scans done for other purposes, according to a study published in the September issue of The Journal of Urology.

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Dual Hepatitis B, C Infection Ups Lifetime HCC Risk

TUESDAY, Aug. 23 (HealthDay News) -- The individual and combined effects of HBV and HCV on hepatocellular carcinoma (HCC) vary according to age and gender, according to a study published online Aug. 22 in the Journal of Clinical Oncology.

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U.S. Door-To-Balloon Time Shortens From 2005 to 2010

TUESDAY, Aug. 23 (HealthDay News) -- The door-to-balloon (D2B) time (from hospital arrival to mechanical reperfusion) in patients with acute myocardial infarction (MI) undergoing primary percutaneous coronary intervention in the United States improved between 2005 and 2010, according to a study published online Aug. 22 in Circulation.

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Mobile Phone-Based System Tied to Lower Glycated Hemoglobin

MONDAY, Aug. 8 (HealthDay News) -- A mobile phone-based treatment/behavioral coaching program significantly improves glycated hemoglobin levels over 12 months in patients with type 2 diabetes, according to a study published online July 25 in Diabetes Care.

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NSAID Intolerance Indicative of Intolerance to Etoricoxib

MONDAY, Aug. 22 (HealthDay News) -- Patients with urticaria and/or angioedema with hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) may also be intolerant to etoricoxib, according to a study published online Aug. 11 in Allergy.

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Dalteparin Sodium Effective, Safe in Upper-Extremity DVT

MONDAY, Aug. 22 (HealthDay News) -- Patients with upper-extremity deep-vein thrombosis (DVT) may be treated safely with either dalteparin sodium followed by warfarin or dalteparin sodium monotherapy for three months with a successful outcome, according to a study published online Aug. 12 in the Journal of Thrombosis and Haemostasis.

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Follow-Up Time Affects Age-Related CA Survival Difference

MONDAY, Aug. 22 (HealthDay News) -- The relative survival of children and adults with medulloblastomas and primitive neuroectodermal tumors (PNETs) is affected by the length of follow-up, with adults having a worse prognosis four years after diagnosis, according to a study published online Aug. 11 in Cancer.

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Omega-3 Cost-Effective for Hypertriglyceridemia

MONDAY, Aug. 22 (HealthDay News) -- A validated model indicates that prescription ω-3 fatty acids (P-OM3) offer cost-effective reduction of adverse cardiac events and triglyceride levels in patients with severe (≥500 mg/dL) hypertriglyceridemia (SHTG), according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

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Diabetes, Hypertension Up Risk for Open-Angle Glaucoma

MONDAY, Aug. 22 (HealthDay News) -- Components of metabolic syndrome, including diabetes mellitus (DM) and systemic arterial hypertension (HTN) either alone or in combination, are associated with higher risk of open-angle glaucoma (OAG); whereas, the presence of hyperlipidemia lowers the risk, according to a study published in the July issue of Ophthalmology.

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Polymorphisms Tied to Smoking Behavior Up Lung Cancer Risk

MONDAY, Aug. 22 (HealthDay News) -- Genetic variations in the CYP2A6 and CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4) genes are together associated with an increase in cigarette consumption and nicotine dependence, and can independently and additively increase lung cancer risk, according to a study published online July 11 in the Journal of the National Cancer Institute.

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Methotrexate Lowers Response to Pneumococcal Vaccine

MONDAY, Aug. 22 (HealthDay News) -- In patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA), treatment with methotrexate (MTX), but not with tumor necrosis factor (TNF) blockers, reduces antibody response after vaccination with pneumococcal conjugate vaccine, according to a study published online Aug. 10 in Arthritis & Rheumatism.

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Similar Platelet Response With 50 or 100 mg Dose of Aspirin

MONDAY, Aug. 22 (HealthDay News) -- Patients with coronary heart disease undergoing treatment with 50 or 100 mg aspirin for five years showed no difference in platelet response or cardiovascular (CV) events, according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

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Traditional Risk Factors Up Early RA Cardiovascular Events

FRIDAY, Aug. 19 (HealthDay News) -- Traditional cardiovascular (CV) risk factors increase the risk of new cardiovascular events (CVEs) in patients with rheumatoid arthritis (RA), with disease activity increasing the risk, and treatment with disease modifying antirheumatic drugs (DMARDs) decreasing the risk, according to a study published online Aug. 15 in Arthritis Research & Therapy.

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Peak Brown Adipose Tissue Activity Seen in Adolescence

FRIDAY, Aug. 19 (HealthDay News) -- Peak brown adipose tissue (BAT) activity occurs in adolescence among both boys and girls and is inversely associated with body mass index (BMI)-percentile, according to a study published online Aug. 12 in The Journal of Pediatrics.

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Excess Body Fat in Elderly Tied to Decreased Life Expectancy

FRIDAY, Aug. 19 (HealthDay News) -- Excess body fat, as measured by body mass index (BMI), in elderly adults older than 75 years is associated with decreased life expectancy, according to a study published in the June issue of the Journal of the American Geriatrics Society.

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Testosterone Gel Ups Sexual Function in Hypogonadism

FRIDAY, Aug. 19 (HealthDay News) -- Testosterone replacement therapy (TRT) with Testim (testosterone 1 percent) topical gel for 12 months significantly increases total testosterone (TT), free testosterone (FT), and total brief male sexual function inventory (BMSFI) score in men with hypogonadism, according to a study published online Aug. 11 in The Journal of Sexual Medicine.

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Omecamtiv Mecarbil Well Tolerated in Healthy Adults

FRIDAY, Aug. 19 (HealthDay News) -- Omecamtiv mecarbil is well-tolerated in healthy adults up to a dose of 0.625 mg/kg per hour, and shows dose- and concentration-dependent improvement in left ventricular systolic function in healthy adults and patients with stable systolic heart failure, according to two studies published in the Aug. 20 European Society of Cardiology special issue of The Lancet.

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Staphylococcal Biofilms Linked to Chronic Rhinosinusitis

FRIDAY, Aug. 19 (HealthDay News) -- The significant association between Staphylococcus aureus (S. aureus) biofilms and chronic rhinosinusitis (CRS) is attributed to skewing of the T-cell response toward the T-helper2 pathway, independent of superantigen activities, according to a study published online Aug. 11 in Allergy.

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Budesonide Ups Expression of GILZ and FKBP51 in Asthma

FRIDAY, Aug. 19 (HealthDay News) -- Treatment with inhaled budesonide increases the expression of GILZ and FKBP51 in patients with atopic asthma, according to a study published online Aug. 9 in the British Journal of Pharmacology.

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Coronary Artery Calcium Stratifies Cardiovascular Risk

FRIDAY, Aug. 19 (HealthDay News) -- Coronary artery calcium (CAC) seems to be a better predictor of cardiovascular events than high-sensitivity C-reactive protein (hsCRP), according to a study published in the Aug. 20 European Society of Cardiology special issue of The Lancet.

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CDC: Legionellosis Incidence Up During 2000 to 2009

FRIDAY, Aug. 19 (HealthDay News) -- The incidence of reported legionellosis in the United States almost tripled between 2000 and 2009; however, the reason for the increase remains unclear, according to a report in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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CDC: Flu Vaccine Recommendations Unchanged

THURSDAY, Aug. 18 (HealthDay News) -- Influenza vaccination of all persons aged ≥6 months in the United States continues to be recommended for the 2011/2012 influenza season, as in previous influenza seasons, according to an Aug. 18 early-release report in the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Moderate Drinking Tied to Lower Dementia Risk in Seniors

THURSDAY, Aug. 18 (HealthDay News) -- Light to moderate drinking is associated with a decreased risk of dementia and cognitive impairment in older individuals and does not appear to be linked to impaired cognition in younger individuals, according to a review published online Aug. 11 in Neuropsychiatric Disease and Treatment.

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CDC: 2010/2011 Flu Vaccination Coverage Studied

THURSDAY, Aug. 18 (HealthDay News) -- Influenza vaccination coverage among health care personnel (HCP) and pregnant women in the 2010/2011 influenza season was similar to coverage for the 2009/2010 season, according to two reports in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Factors Identified for Spinal Stenosis Surgery Outcome

THURSDAY, Aug. 18 (HealthDay News) -- A history of psychiatric disease and a higher preoperative body mass index (BMI) are associated with poorer clinical outcomes following surgery for lumbar spinal stenosis, while more severe preoperative disability results in a better outcome, according to a study published in the July issue of The Spine Journal.

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Increase in Malaria Despite Initial Preventive Success

THURSDAY, Aug. 18 (HealthDay News) -- A rebound in malaria attacks has been seen in Africa, especially among older children and adults, following the initial decrease after distribution of long-lasting insecticide (deltamethrin)-treated nets (LLINs) and artemisinin-based combination therapies, according to a study published online Aug. 18 in The Lancet Infectious Diseases.

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TV Viewing Reduces Life Expectancy in Australian Adults

THURSDAY, Aug. 18 (HealthDay News) -- Television (TV) viewing time is correlated with a substantial reduction in life expectancy among Australian adults, according to a study published online Aug. 15 in the British Journal of Sports Medicine.

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Majority of DVT Cases After Surgery Linked to Catheter Use

THURSDAY, Aug. 18 (HealthDay News) -- Following general surgical operations, the incidence of deep venous thrombosis (DVT) is low, but more than 60 percent of cases are catheter-induced, according to a study published online Aug. 15 in the Archives of Surgery.

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High Cumulative Malpractice Risk for All Physicians

THURSDAY, Aug. 18 (HealthDay News) -- Physicians in all specialties have a high cumulative risk of facing a malpractice claim by age 65; although most claims do not lead to indemnity payments, according to a study published in the Aug. 18 issue of the New England Journal of Medicine.

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Echolucency, Microemboli Combo Predicts Ipsilateral Stroke Risk

THURSDAY, Aug. 18 (HealthDay News) -- A combination of embolic signals (ES) detection and plaque morphology can be used to predict the risk of ipsilateral stroke in patients with asymptomatic carotid stenosis (ACS), according to a study published online Aug. 17 in Neurology.

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Rituximab Suppresses Autoantibodies to Insulin

THURSDAY, Aug. 18 (HealthDay News) -- Treatment with rituximab differentially suppresses autoantibodies to insulin (IAAs) in all patients with new-onset type 1A diabetes for a year, a

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