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Category: Pharmacy | Monthly Briefing

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August 2011 Briefing - Pharmacy

Last Updated: September 01, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for August 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Saffron ID'ed as Potential Therapy for Liver CA

TUESDAY, Aug. 30 (HealthDay News) -- Saffron reduces the number and incidence of hepatic dyschromatic nodules and the number and area of placental glutathione S-transferase-positive foci in livers of diethylnitrosamine (DEN)-treated rats, according to an experimental study published online July 19 in Hepatology.

Abstract
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Four Categories of Eligibility for Contraceptive Use Endorsed

TUESDAY, Aug. 30 (HealthDay News) -- Clinicians should assess the appropriateness of contraceptives for women with specific medical conditions or characteristics based on the four categories of medical eligibility defined by the 2010 U.S. Medical Eligibility Criteria for Contraceptive Use (U.S. MEC), according to a Committee Opinion published in the September issue of Obstetrics & Gynecology.

Report (subscription or payment may be required)

AAP Recommends Quadrivalent MMRV for Most Children

TUESDAY, Aug. 30 (HealthDay News) -- Use of measles-mumps-rubella-varicella vaccine (MMRV) is generally preferred over separate injections of measles-mumps-rubella (MMR) and varicella vaccines, unless there is a personal or family history of seizures, or difficulty communicating the risks involved to parents or caregivers, according to a policy statement by the American Academy of Pediatrics (AAP), published online Aug. 28 in Pediatrics.

Report

Colchicine Safe, Effective Adjunct in Recurrent Pericarditis

MONDAY, Aug. 29 (HealthDay News) -- Colchicine appears to be safe and effective for the secondary prevention of recurrent pericarditis, according to a study published online first August 28 in the Annals of Internal Medicine.

Abstract
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Apixaban Superior to Warfarin for Stroke Prevention in A-Fib

MONDAY, Aug. 29 (HealthDay News) -- Apixaban is superior to warfarin in lowering the risk of stroke or systemic embolism, and reduces the rate of major bleeding and mortality in patients with atrial fibrillation, according to a study published online Aug. 28 in the New England Journal of Medicine to coincide with the European Society of Cardiology Congress 2011 held Aug. 27 to 31 in Paris, France.

Abstract
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Drug-Eluting Stents Better for Saphenous Vein Graft Lesions

MONDAY, Aug. 29 (HealthDay News) -- Drug-eluting stents are better than bare-metal stents for reducing the risk of adverse events for patients undergoing percutaneous coronary intervention for de-novo saphenous vein graft lesions, according to a study published online Aug. 28 in The Lancet, to coincide with the European Society of Cardiology Congress held Aug. 27 to 31 in Paris, France.

Abstract
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Xalkori Approved for Advanced Lung Cancer

MONDAY, Aug. 29 (HealthDay News) -- Xalkori (crizotinib) and a companion diagnostic test have been approved by the U.S. Food and Drug Administration to treat advanced non-small cell lung cancer (NSCLC) that express an abnormal anaplastic lymphoma kinase (ALK) gene, the agency said in a news release.

this approval

Erythropoietin Alfa Therapy Safe Addition in Cervical Cancer

MONDAY, Aug. 29 (HealthDay News) -- Erythropoietin alfa (EPO) can be safely used in addition to adjuvant chemotherapy and pelvic radiotherapy (CRT) for patients with cervical cancer, but it does not provide a significant benefit in recurrence-free survival (RFS) or overall survival (OS), according to a study published online Aug. 22 in the Journal of Clinical Oncology.

Abstract
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Addition of Oxaliplatin Ups Survival in Stage II/III Colon CA

MONDAY, Aug. 29 (HealthDay News) -- In patients with stage II/III colon cancer, the addition of oxaliplatin to fluorouracil plus leucovorin (FULV) therapy (FULV plus oxaliplatin [FLOX]) is superior to FULV in improving disease-free survival (DFS), but not overall survival (OS), but in patients younger than 70 years, oxaliplatin improves OS, according to a study published online Aug. 22 in the Journal of Clinical Oncology.

Abstract
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Loss of Jobs Means Loss of Health Coverage for Many in U.S.

MONDAY, Aug. 29 (HealthDay News) -- For American adults who lose their health insurance coverage when they lose their jobs, the majority remain uninsured, delay getting needed health care or prescriptions, and report financial difficulties paying medical bills, according to a report published online Aug. 24 by The Commonwealth Fund.

Report

Extended-Release Opioid Pain Medication Approved

FRIDAY, Aug. 26 (HealthDay News) -- Nucynta ER (tapentadol extended release) has been approved by the U.S. Food and Drug Administration to treat moderate-to-severe chronic pain in adults, maker Janssen Pharmaceuticals said.

this drug

IOM: Few Health Issues Caused By Vaccines

FRIDAY, Aug. 26 (HealthDay News) -- Few health issues or illnesses appear to be associated with or caused by vaccines, according to a new report published online August 25 from the Institute of Medicine(IOM).

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Expedited Partner Therapy Use Benefits Gonorrhea, Chlamydia

FRIDAY, Aug. 26 (HealthDay News) -- Expedited partner therapy should be used in accordance with the Centers for Disease Control and Prevention's (CDC) guidelines to prevent reinfection by treating partners of patients with gonorrhea and chlamydia who are unable or unwilling to seek medical care, according to a committee opinion published in the September issue of Obstetrics & Gynecology.

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Complementary Medicine Used More by Health Care Workers

FRIDAY, Aug. 26 (HealthDay News) -- U.S. health care workers, especially health care providers, are more likely to use complementary and alternative medicine (CAM) than the general, employed U.S. population, according to a study published online Aug. 22 in Health Services Research.

Abstract
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Pharmaceutical Ads Often Don't Adhere to U.S. FDA Guidelines

THURSDAY, Aug. 25 (HealthDay News) -- Physician-targeting pharmaceutical advertisements have low rates of adherence to U.S. Food and Drug Administration (FDA) guidelines and provide inadequate information for safe prescribing, according to a study published online Aug. 17 in PLoS One.

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Firazyr Approved for Acute Hereditary Angioedema

THURSDAY, Aug. 25 (HealthDay News) -- Firazyr (icatibant) has been approved by the U.S. Food and Drug Administration to treat acute attacks of hereditary angioedema (HAE) in adults.

U.S. Hereditary Angioedema Association

CDC: HPV Vaccine Rates Lag Behind Other Teen Vaccines

THURSDAY, Aug. 25 (HealthDay News) -- Vaccination coverage in adolescents appears to be increasing, however, the increase in human papillomavirus (HPV) coverage among adolescent females has been lagging, according to a report in the August 26 issue of the Centers for Disease Control and Prevention (CDC)'s Morbidity and Mortality Weekly Report.

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Botox Approved to Treat Urinary Incontinence

WEDNESDAY, Aug. 24 (HealthDay News) -- Botox (onabotulinumtoxinA) has been approved by the U.S. Food and Drug Administration to treat urinary incontinence in people with neurological conditions such as spinal cord injury and multiple sclerosis.

National Library of Medicine

Azithromycin Decreases COPD Exacerbation Frequency

WEDNESDAY, Aug. 24 (HealthDay News) -- In selected patients with chronic obstructive pulmonary disorder (COPD), daily azithromycin for one year together with usual treatment decreases the frequency of exacerbations but increases the frequency of hearing decrements, according to a study published Aug. 25 in the New England Journal of Medicine.

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Olaparib Promising Option for Ovarian Cancer Treatment

WEDNESDAY, Aug. 24 (HealthDay News) -- Treatment with olaparib offers a promising therapeutic option for patients with ovarian cancer, according to a study published online Aug. 22 in The Lancet Oncology.

Abstract
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Hospitalization Ups Unintentional Discontinuation of Meds

TUESDAY, Aug. 23 (HealthDay News) -- Hospital or intensive care unit (ICU) admission is associated with unintentional discontinuation of medication for chronic diseases, according to a study published online Aug. 23 in the Journal of the American Medical Association.

Abstract
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NSAID Intolerance Indicative of Intolerance to Etoricoxib

MONDAY, Aug. 22 (HealthDay News) -- Patients with urticaria and/or angioedema with hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) may also be intolerant to etoricoxib, according to a study published online Aug. 11 in Allergy.

Abstract
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Dalteparin Sodium Effective, Safe in Upper-Extremity DVT

MONDAY, Aug. 22 (HealthDay News) -- Patients with upper-extremity deep-vein thrombosis (DVT) may be treated safely with either dalteparin sodium followed by warfarin or dalteparin sodium monotherapy for three months with a successful outcome, according to a study published online Aug. 12 in the Journal of Thrombosis and Haemostasis.

Abstract
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Omega-3 Cost-Effective for Hypertriglyceridemia

MONDAY, Aug. 22 (HealthDay News) -- A validated model indicates that prescription ω-3 fatty acids (P-OM3) offer cost-effective reduction of adverse cardiac events and triglyceride levels in patients with severe (≥500 mg/dL) hypertriglyceridemia (SHTG), according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

Abstract
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Similar Platelet Response With 50 or 100 mg Dose of Aspirin

MONDAY, Aug. 22 (HealthDay News) -- Patients with coronary heart disease undergoing treatment with 50 or 100 mg aspirin for five years showed no difference in platelet response or cardiovascular (CV) events, according to a study published in the Sept. 1 issue of The American Journal of Cardiology.

Abstract
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Methotrexate Lowers Response to Pneumococcal Vaccine

MONDAY, Aug. 22 (HealthDay News) -- In patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA), treatment with methotrexate (MTX), but not with tumor necrosis factor (TNF) blockers, reduces antibody response after vaccination with pneumococcal conjugate vaccine, according to a study published online Aug. 10 in Arthritis & Rheumatism.

Abstract
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Traditional Risk Factors Up Early RA Cardiovascular Events

FRIDAY, Aug. 19 (HealthDay News) -- Traditional cardiovascular (CV) risk factors increase the risk of new cardiovascular events (CVEs) in patients with rheumatoid arthritis (RA), with disease activity increasing the risk, and treatment with disease modifying antirheumatic drugs (DMARDs) decreasing the risk, according to a study published online Aug. 15 in Arthritis Research & Therapy.

Abstract
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Testosterone Gel Ups Sexual Function in Hypogonadism

FRIDAY, Aug. 19 (HealthDay News) -- Testosterone replacement therapy (TRT) with Testim (testosterone 1 percent) topical gel for 12 months significantly increases total testosterone (TT), free testosterone (FT), and total brief male sexual function inventory (BMSFI) score in men with hypogonadism, according to a study published online Aug. 11 in The Journal of Sexual Medicine.

Abstract
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Omecamtiv Mecarbil Well Tolerated in Healthy Adults

FRIDAY, Aug. 19 (HealthDay News) -- Omecamtiv mecarbil is well-tolerated in healthy adults up to a dose of 0.625 mg/kg per hour, and shows dose- and concentration-dependent improvement in left ventricular systolic function in healthy adults and patients with stable systolic heart failure, according to two studies published in the Aug. 20 European Society of Cardiology special issue of The Lancet.

Abstract - Teerlink
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Abstract - Cleland
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Budesonide Ups Expression of GILZ and FKBP51 in Asthma

FRIDAY, Aug. 19 (HealthDay News) -- Treatment with inhaled budesonide increases the expression of GILZ and FKBP51 in patients with atopic asthma, according to a study published online Aug. 9 in the British Journal of Pharmacology.

Abstract
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Pre-Surgery Factor VIII in Hemophilia A Ups Inhibitor Risk

FRIDAY, Aug. 19 (HealthDay News) -- Patients with hemophilia A treated with intensive factor VIII (FVIII) treatment for surgery at first exposure are at an increased risk of developing inhibiting antibodies toward FVIII (inhibitors), as compared to those treated for bleeding and given prophylactic FVIII, according to a review published online Aug. 12 in the Journal of Thrombosis and Haemostasis.

Abstract
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CDC: Flu Vaccine Recommendations Unchanged

THURSDAY, Aug. 18 (HealthDay News) -- Influenza vaccination of all persons aged ≥6 months in the United States continues to be recommended for the 2011/2012 influenza season, as in previous influenza seasons, according to an Aug. 18 early-release report in the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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CDC: 2010/2011 Flu Vaccination Coverage Studied

THURSDAY, Aug. 18 (HealthDay News) -- Influenza vaccination coverage among health care personnel (HCP) and pregnant women in the 2010/2011 influenza season was similar to coverage for the 2009/2010 season, according to two reports in the Aug. 19 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

Full Text - Health Care Personnel
Full Text - Pregnant Women

Increase in Malaria Despite Initial Preventive Success

THURSDAY, Aug. 18 (HealthDay News) -- A rebound in malaria attacks has been seen in Africa, especially among older children and adults, following the initial decrease after distribution of long-lasting insecticide (deltamethrin)-treated nets (LLINs) and artemisinin-based combination therapies, according to a study published online Aug. 18 in The Lancet Infectious Diseases.

Abstract
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Rituximab Suppresses Autoantibodies to Insulin

THURSDAY, Aug. 18 (HealthDay News) -- Treatment with rituximab differentially suppresses autoantibodies to insulin (IAAs) in all patients with new-onset type 1A diabetes for a year, according to a study published online Aug. 10 in Diabetes.

Abstract
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High Vitamin D Levels Up Nonmelanoma Skin Cancer Risk

WEDNESDAY, Aug. 17 (HealthDay News) -- Higher baseline serum 25-hydroxyvitamin D (25-OHD) levels are significantly and positively associated with an increased risk of nonmelanoma skin cancer (NMSC), according to a study published online Aug. 15 in the Archives of Dermatology.

Abstract
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Significant Differences ID'd Between Antimanic Drugs

WEDNESDAY, Aug. 17 (HealthDay News) -- The various treatments for acute mania show statistically and clinically significant differences with haloperidol, risperidone, and olanzapine having better efficacy than other drugs, and olanzapine, risperidone, and quetiapine having lower dropout rates than haloperidol, which has the highest efficacy, according to a meta-analysis published online Aug. 17 in The Lancet.

Abstract
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Prolonged Tetracycline for Acne Lowers S. aureus Colonization

WEDNESDAY, Aug. 17 (HealthDay News) -- In patients with acne, the prolonged use of tetracycline antibiotics lowers the prevalence of colonization by Staphylococcus aureus (S. aureus) and does not increase resistance to tetracycline antibiotics, according to a study published in the August issue of the Archives of Dermatology.

Abstract
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Pegloticase Tied to Lower Uric Acid Levels in Chronic Gout

TUESDAY, Aug. 16 (HealthDay News) -- Pegloticase lowers uric acid levels in patients with refractory chronic gout, according to a study published in the Aug. 17 issue of the Journal of the American Medical Association.

Abstract
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Radioactive Iodine for Thyroid Cancer Rises From 1999 to 2008

TUESDAY, Aug. 16 (HealthDay News) -- The proportion of patients with well-differentiated thyroid cancer receiving radioactive iodine following a total thyroidectomy increased significantly from 1999 to 2008, with much of the variation in use associated with hospital characteristics, according to a study published in the Aug. 17 issue of the Journal of the American Medical Association.

Abstract
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Coronary Stents and Peri-Op Antiplatelet Drug Use Reviewed

TUESDAY, Aug. 16 (HealthDay News) -- In patients on dual antiplatelet therapy (DAPT) undergoing non-cardiac surgery (NCS) within one year of coronary stenting, APT withdrawal should be decided after assessing the risk of perioperative bleeding and cardiac ischemic events, particularly stent thrombosis (ST), according to a review published online Aug. 5 in the Journal of Thrombosis & Haemostatis.

Abstract
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Patient Care Improves With Anticoagulation Service

TUESDAY, Aug. 16 (HealthDay News) -- A Pharmacist-Directed Anticoagulation Service (PDAS) improves the quality of care for patients taking the anticoagulant drug warfarin in an inpatient setting by coordinating the transition of care from an inpatient to an outpatient setting, according to a study published online Aug. 10 in the Journal of Hospital Medicine.

Abstract
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Bevacizumab, Chemo Beneficial in Advanced Gastric Cancer

TUESDAY, Aug. 16 (HealthDay News) -- The addition of bevacizumab to chemotherapy is linked to improved progression-free survival and overall response rate in the treatment of advanced gastric cancer, according to a study published online Aug. 15 in the Journal of Clinical Oncology.

Abstract
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Antidepressants Don't Impact Stimulants' Efficacy in ADHD

TUESDAY, Aug. 16 (HealthDay News) -- In adults with attention deficit hyperactivity disorder (ADHD), concomitant use of antidepressants does not affect the safety or efficacy of osmotic release oral system methylphenidate (OROS-MPH), according to a study published online Aug. 5 in CNS Neuroscience & Therapeutics.

Abstract
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Chinese Herbal Decoction Cuts Time to H1N1 Fever Resolution

TUESDAY, Aug. 16 (HealthDay News) -- Chinese herbal decoction maxingshigan-yinqiaosan, alone or in combination with oseltamivir, is associated with a reduced time to fever resolution in patients with H1N1 influenza virus infection, according to a study published in the Aug. 16 issue of the Annals of Internal Medicine.

Abstract
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Early Sulfonylureas Benefit Mice With Neonatal Diabetes

MONDAY, Aug. 15 (HealthDay News) -- For mice with neonatal diabetes mellitus (NDM) with adenosine triphosphate (ATP)-sensitive K channel mutations (KATP), early treatment with sulphonylurea therapy leads to permanent remission in approximately 30 percent of cases, according to an experimental study published online Aug. 3 in Diabetes.

Abstract
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Antiretrovirals Raise Cholesterol in HIV-Infected Children

MONDAY, Aug. 15 (HealthDay News) -- Children with HIV receiving antiretroviral therapy have increased cholesterol levels; and hypercholesterolemia in children perinatally infected with HIV remains elevated over time, according to two studies published in the Aug. 15 issue of the Journal of Acquired Immune Deficiency Syndromes.

Abstract - Rhoads
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Abstract - Jacobson
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Clindamycin More Effective in Treating Soft Tissue Infections

MONDAY, Aug. 15 (HealthDay News) -- Use of trimethoprim-sulfamethoxazole and β-lactams for treatment of pediatric skin and soft tissue infections (SSTIs) is associated with increased risks of treatment failure and recurrence compared to treatment with clindamycin, according to a study published online Aug. 15 in Pediatrics.

Abstract
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Niacin Linked to Improved Erectile Function

FRIDAY, Aug. 12 (HealthDay News) -- Men with moderate to severe erectile dysfunction (ED) and dyslipidemia have significantly improved erectile function with treatment with niacin, according to a study published online Aug. 2 in The Journal of Sexual Medicine.

Abstract
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Trastuzumab Ups Cardiotoxicity Risk in Some Elderly Women

FRIDAY, Aug. 12 (HealthDay News) -- In elderly women with breast cancer and a history of cardiac disease or diabetes, treatment with trastuzumab is associated with an increased risk of cardiotoxicity, according to a study published online Aug. 9 in the Annals of Oncology.

Abstract
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Evidence Lacking That Aspirin Use in IVF Improves Birth Rate

THURSDAY, Aug. 11 (HealthDay News) -- Aspirin use for women undergoing in vitro fertilization (IVF) cannot be recommended due to lack of evidence indicating effectiveness in improving outcomes, according to a review published online Aug. 10 in the Cochrane Database of Systematic Reviews.

Abstract
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tPA, DNase Improves Fluid Drainage in Pleural Infection

THURSDAY, Aug. 11 (HealthDay News) -- Combined intrapleural tissue plasminogen activator (t-PA) and DNase therapy improves fluid drainage in patients with pleural infection and reduces hospital stay duration and the frequency of surgical referral, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.

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Rivaroxaban Noninferior to Warfarin for Stroke Prevention

WEDNESDAY, Aug. 10 (HealthDay News) -- Rivaroxaban is noninferior to warfarin for the prevention of stroke or systemic embolism in patients with nonvalvular atrial fibrillation, with no significant differences in major bleeding risk, according to a study published online Aug. 10 in the New England Journal of Medicine.

Abstract
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Editorial

Chimeric Receptor-Modified T-Cells Show Potential in CLL

WEDNESDAY, Aug. 10 (HealthDay News) -- Autologous T-cells expressing an anti-CD19 chimeric antigen receptor (CART19) have the potential for in vivo proliferation, and long-term persistence in patients with chronic lymphoid leukemia (CLL), according to a study published online Aug. 10 in the New England Journal of Medicine.

Abstract
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Editorial

Linaclotide Safe, Effective for Treating Chronic Constipation

WEDNESDAY, Aug. 10 (HealthDay News) -- Linaclotide significantly improves bowel and abdominal symptoms, and reduces the severity of constipation in patients suffering from chronic constipation, according to a study published in the Aug. 11 issue of the New England Journal of Medicine.

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Tofacitinib With Methotrexate Efficacious in Active RA

TUESDAY, Aug. 9 (HealthDay News) -- Tofacitinib with methotrexate (MTX) is effective, tolerable, and safe for patients with active rheumatoid arthritis (RA) and inadequate response to MTX alone, according to a study published in the August issue of Arthritis Care & Research.

Abstract
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Doublet Chemo Improves Survival in Elderly With NSCLC

TUESDAY, Aug. 9 (HealthDay News) -- Despite more toxic effects, doublet chemotherapy with carboplatin and weekly paclitaxel is associated with significantly higher survival benefits than monotheraphy with either vinorelbine or gemcitabine in elderly patients with advanced non-small-cell lung cancer (NSCLC), according to a study published online Aug. 9 in The Lancet.

Abstract
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Soy Isoflavones Don't Prevent Menopausal Bone Loss

TUESDAY, Aug. 9 (HealthDay News) -- Soy isoflavone tablets, administered once daily, do not prevent bone loss or menopausal symptoms in women during the first five years of menopause, according to a study published in the Aug. 8/22 issue of the Archives of Internal Medicine.

Abstract
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More Neurology Residents Comfortable Using tPA for Stroke

MONDAY, Aug. 8 (HealthDay News) -- The number of graduating U.S. neurology residents with experience, and who report feeling comfortable, treating acute ischemic stroke patients with tissue-type plasminogen activator (tPA) increased from 2000 to 2010, with more residents having exposure to stroke teams and formal training in the National Institutes of Health Stroke Scale, according to a study published online Aug. 4 in Stroke.

Abstract
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Oral Contraceptives Beneficial in Inflammatory Polyarthritis

MONDAY, Aug. 8 (HealthDay News) -- In women with inflammatory polyarthritis (IP), use of oral contraceptives (OCs) before or during symptom onset is associated with beneficial functional outcome, according to a study published in the August issue of Arthritis & Rheumatism.

Abstract
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Cost of Interacting With Payers Higher in U.S. Than Canada

FRIDAY, Aug. 5 (HealthDay News) -- Physician practices in the United States spend considerably more on interactions with health plans than Canadian practices, according to a study published in the August issue of Health Affairs.

Abstract
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Antidepressant Prescriptions for Non-Psych Disorders Up

FRIDAY, Aug. 5 (HealthDay News) --The number of antidepressants prescribed by non-psychiatrist physicians to patients without a psychiatric disorder continues to rise, according to a study published in the August issue of Health Affairs.

Abstract
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CDC: Age Range Expanded for Meningococcal Vaccine

THURSDAY, Aug. 4 (HealthDay News) -- MenACWY-CRM (Menveo, Novartis Vaccines and Diagnostics), a quadrivalent meningococcal conjugate vaccine, appears to be safe and effective for use with the recently extended age indication, and is interchangeable with the other licensed meningococcal conjugate vaccine, MenACWY-D (Menactra, Sanofi Pasteur), according to a report in the Aug. 5 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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First Treatment Solely for Scorpion Stings Approved

THURSDAY, Aug. 4 (HealthDay News) -- Anascorp, the first injection devised solely to treat scorpion stings, has been approved by the U.S. Food and Drug Administration.

Medline Plus

Teens Who Misuse Controlled Meds More Likely to Abuse Drugs

THURSDAY, Aug. 4 (HealthDay News) -- Among adolescents who take at least one prescribed controlled medication, 22 percent report misuse, and misusers are significantly more likely to have a positive screening result for drug abuse, according to a study published in the August issue of the Archives of Pediatrics & Adolescent Medicine.

Abstract
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Intrinsic Subtypes of Gastric Cancer Linked to Survival

THURSDAY, Aug. 4 (HealthDay News) -- Intrinsic subtypes of gastric cancer (GC) with distinct gene expression patterns are correlated with patient survival and response to chemotherapy, according to a study published in the August issue of Gastroenterology.

Abstract
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Lebrikizumab Ups Lung Function in Adults With Asthma

THURSDAY, Aug. 4 (HealthDay News) -- Treatment with lebrikizumab increases lung function in adults with asthma, especially for those with high levels of serum periostin, according to a study published online Aug. 3 in the New England Journal of Medicine.

Abstract
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FDA: High-Dose Fluconazole Tied to Birth Defects

WEDNESDAY, Aug. 3 (HealthDay News) -- The U.S. Food and Drug Administration has notified health care professionals and patients that treatment with chronic, high doses (400 to 800 mg/day) of fluconazole (Diflucan) during the first trimester of pregnancy may be associated with a rare and distinct set of birth defects in infants.

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High Risk of Adverse Outcomes Tied to SSRI Use in Elderly

WEDNESDAY, Aug. 3 (HealthDay News) -- In older individuals with depression, use of selective serotonin reuptake inhibitors (SSRIs) and certain other antidepressants is associated with higher risk of adverse outcomes than tricyclic antidepressants (TCAs), according to a study published online Aug. 2 in BMJ.

Abstract
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Prognostic Value of p53 in Early Urothelial Cancers Unconfirmed

WEDNESDAY, Aug. 3 (HealthDay News) -- In patients with pT1/T2N0M0 urothelial bladder cancer, the predictive value of p53 and the benefit of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) adjuvant chemotherapy could not be demonstrated, according to a study published online Aug. 1 in the Journal of Clinical Oncology.

Abstract
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High Doses of Zinc Found to Reduce Common Cold Duration

WEDNESDAY, Aug. 3 (HealthDay News) -- In individuals with natural common cold infections, use of lozenges containing a daily zinc dose of over 75 mg significantly reduces cold symptoms, but use of a daily total of less than 75 mg shows no effect, according to a meta-analysis published online June 23 in the Open Respiratory Medicine Journal.

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Functional Gene Profiling IDs Breast CA Therapeutic Targets

TUESDAY, Aug. 2 (HealthDay News) -- The large-scale functional profiling of genes validates established targets for breast cancer therapy and identifies potential new therapeutic targets, including those for PTEN-mutated and estrogen receptor (ER)-positive breast cancers, according to a study published online Aug. 2 in Cancer Discovery.

Abstract
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Risperidone Not Effective for Military-Related PTSD

TUESDAY, Aug. 2 (HealthDay News) -- The second-generation antipsychotic risperidone is not an effective treatment for veterans with chronic military-related posttraumatic stress disorder (PTSD) not responding to serotonin reuptake-inhibitors (SRIs) treatment, according to a study published in the Aug. 3 violence/human rights-themed issue of the Journal of the American Medical Association.

Abstract
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Cetuximab Effective, Safe for Squamous Cell Skin Carcinoma

TUESDAY, Aug. 2 (HealthDay News) -- In patients with unresectable squamous cell carcinoma of the skin (SCCS), first-line treatment with single-agent cetuximab has an overall disease control rate (DCR) of 69 percent, according to a study published online Aug. 1 in the Journal of Clinical Oncology.

Abstract
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Bortezomib Combo Effective in Advanced Follicular Lymphoma

TUESDAY, Aug. 2 (HealthDay News) -- Bortezomib, given in combination with rituximab, cyclophosphamide, vincristine, and prednisone (BR-CVP), is feasible for treating patients with advanced-stage follicular lymphoma (FL), and the combination of bortezomib, bendamustine, and rituximab is active in patients with FL who have received previous treatment, according to two studies published online Aug. 1 in the Journal of Clinical Oncology.

Abstract - Sehn
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Abstract - Fowler
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Editorial

Lower Risk of Repeat Vascular Events in Young Adults on Statins

TUESDAY, Aug. 2 (HealthDay News) -- Young adults treated with a statin for an ischemic stroke of unknown etiology are at lower risk for subsequent vascular events than were those who are untreated, according to a study published in the Aug. 2 issue of Neurology.

Abstract
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DHA Intake in Pregnancy Tied to Fewer Colds in Infants

MONDAY, Aug. 1 (HealthDay News) -- Maternal docosahexaenoic acid (DHA) supplementation during pregnancy is associated with reduced occurrence of cold symptoms in infants at 1 month, and influences the duration of certain illness symptoms at 1, 3, and 6 months, according to a study published online Aug. 1 in Pediatrics.

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Tamoxifen Chemoprophylaxis Offers Cost-Effective Benefits

MONDAY, Aug. 1 (HealthDay News) -- Tamoxifen chemoprophylaxis is a cost-effective policy which reduces breast cancer incidence, and improves life expectancy for postmenopausal women younger than 55 years, following active treatment, according to a study published in the Aug. 1 issue of Cancer.

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