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Category: Pharmacy | Monthly Briefing

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September 2011 Briefing - Pharmacy

Last Updated: October 03, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for September 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Topiramate Effective in Post-Traumatic Stress Disorder

FRIDAY, Sept. 30 (HealthDay News) -- Topiramate effectively improves avoidance/numbing symptom clusters and re-experiencing of symptoms in patients with post-traumatic stress disorder (PTSD), according to a study published in the October issue of CNS Neuroscience & Therapeutics.

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Aspirin Resistance Is Relatively Common Phenomenon

FRIDAY, Sept. 30 (HealthDay News) -- Aspirin resistance is common, but poor compliance may contribute to a substantial number of cases of apparent resistance, according to a study published in the October issue of Cardiovascular Therapeutics.

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Activated Protein C Inhibitor Effective in Hemophilia A

FRIDAY, Sept. 30 (HealthDay News) -- Specific activated protein C (APC) inhibitor PNASN-1 significantly increases thrombin generation in the blood and plasma of individuals with congenital hemophilia A, with and without factor VIII (FVIII) deficiency, according to a study published online Sept. 15 in the Journal of Thrombosis and Haemostasis.

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Surfactants Feasible for Self-Breathing Preterm Infants

FRIDAY, Sept. 30 (HealthDay News) -- Application of surfactant to spontaneously breathing preterm infants stabilized with continuous positive airway pressure (CPAP) is feasible, and reduces the need for mechanical ventilation, according to a study published online Sept. 30 in The Lancet.

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Single High-Dose Psilocybin Linked to Increase in Openness

FRIDAY, Sept. 30 (HealthDay News) -- A single dose of psilocybin is sufficient to produce significant increases in the personality domain of openness, which persists after a year, according to a study published online Sept. 28 in the Journal of Psychopharmacology.

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Tamoxifen Use Tied to Diabetes Risk in Breast Cancer Survivors

FRIDAY, Sept. 30 (HealthDay News) -- Current tamoxifen therapy is associated with a significantly increased incidence of diabetes in older breast cancer survivors, according to a study published online Sept. 20 in Cancer.

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SSRI With Antiplatelet Therapy Ups Post-MI Bleeding Risk

THURSDAY, Sept. 29 (HealthDay News) -- Combined use of selective serotonin reuptake inhibitors (SSRIs) with antiplatelet agents, including acetylsalicylic acid (ASA), clopidogrel, or both, is associated with an increased risk of bleeding following acute myocardial infarction (MI), according to a study published online Sept. 26 in CMAJ, the journal of the Canadian Medical Association.

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Slow, Steady Rise in Stimulant Use for ADHD Since 1996

THURSDAY, Sept. 29 (HealthDay News) -- The use of stimulant medications for the treatment of attention deficit hyperactivity disorder (ADHD) has increased consistently since 1996, with greater use in adolescents and decreasing use in preschoolers, according to a study published online Sept. 28 in the American Journal of Psychiatry.

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Cytisine More Effective Than Placebo for Smoking Cessation

WEDNESDAY, Sept. 28 (HealthDay News) -- Cytisine is more effective for smoking cessation than a placebo, with a better 12-month abstinence rate and seven-day point prevalence of abstinence, according to a study published in the Sept. 29 issue of the New England Journal of Medicine.

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DNA Repair Capacity IDs Non-Small-Cell Lung Cancer Survival

WEDNESDAY, Sept. 28 (HealthDay News) -- DNA repair capacity (DRC) in peripheral lymphocytes is a significant, independent predictor of survival for patients with non-small-cell lung cancer (NSCLC) treated with platinum-based chemotherapy, according to a study published online Sept. 26 in the Journal of Clinical Oncology.

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Increasing Dose of Saw Palmetto No Better Than Placebo in BPH

WEDNESDAY, Sept. 28 (HealthDay News) -- Saw palmetto fruit extract (Serenoa repens) at doses up to three times the standard daily dose has no greater effect than placebo on lower urinary tract symptoms (LUTS) attributable to benign prostatic hyperplasia (BPH), according to a study published the Sept. 28 issue of the Journal of the American Medical Association.

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DMARDs Found to Be Effective Treatment for Juvenile Arthritis

WEDNESDAY, Sept. 28 (HealthDay News) -- Disease-modifying anti-rheumatic drugs (DMARDs) may be more effective than ibuprofen or steroids in controlling juvenile idiopathic arthritis (JIA), but there is little strong evidence to support their long-term use, according to a new report released by the U.S. Department of Health and Human Service's Agency for Healthcare Research and Quality (AHRQ).

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Quadrivalent HPV Vaccine More Cost-Effective Than Bivalent

WEDNESDAY, Sept. 28 (HealthDay News) -- Due to different efficacy and protection offered by the bivalent and quadrivalent human papillomavirus (HPV) vaccines, the bivalent vaccine would need to be cheaper than the quadrivalent in order to be equally cost-effective, according to a study published online Sept. 27 in BMJ.

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Cognition Similar for Standard, Intensive Glycemic Control

WEDNESDAY, Sept. 28 (HealthDay News) -- Intensive glycemic lowering is not better than standard glycemic control for preventing cognitive decline in patients with type 2 diabetes, despite a higher total brain volume, according to a study published online Sept. 28 in The Lancet Neurology.

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Calcineurin-Inhibitor-Sparing Regimens Improve Outcomes

WEDNESDAY, Sept. 28 (HealthDay News) -- Use of calciuneurin-inhibitor-sparing regimens immediately after kidney transplantation is associated with improved outcomes, including less delayed graft function, improved graft function, and less new-onset diabetes, according to a meta-analysis published online Sept. 23 in the Journal of the American Society of Nephrology.

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Benefits, Harms With Off-Label Atypical Antipsychotic Use

TUESDAY, Sept. 27 (HealthDay News) -- There are varying benefits and adverse effects from using atypical antipsychotic medications for conditions which do not have labeling and marketing approval by the U.S. Food and Drug Administration (off-label), according to a meta-analysis published in the Sept. 28 issue of the Journal of the American Medical Association.

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Cell of Origin Key in Relapsed B-Cell Lymphoma Prognosis

TUESDAY, Sept. 27 (HealthDay News) -- Patients with relapsed/refractory germinal center B (GCB)-like diffuse large B-cell lymphoma (DLBCL) have improved outcomes when treated with rituximab, dexamethasone, high-dose cytarabine, and cisplatin (R-DHAP), according to a study published online Sept. 26 in the Journal of Clinical Oncology.

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ESR1 Expression Predicts Tamoxifen Benefit in Breast CA

TUESDAY, Sept. 27 (HealthDay News) -- Expression of ESR1 predicts tamoxifen benefit in estrogen receptor (ER)-positive breast cancer, with low levels of expression indicative of tamoxifen resistance, according to a study published online Sept. 26 in the Journal of Clinical Oncology.

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Asthma Prevalence Elevated in Youth With Diabetes

TUESDAY, Sept. 27 (HealthDay News) -- Asthma is more prevalent in youth with diabetes compared to the general U.S. population, and is associated with poor glycemic control in youth with type 1 diabetes, especially if untreated, according to a study published online Sept. 26 in Pediatrics.

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Tdap Safe After Tetanus-, Diphtheria-Containing Products

MONDAY, Sept. 26 (HealthDay News) -- The use of tetanus toxoid, reduced-content diphtheria toxoid, and acellular pertussis vaccine (Tdap) is safe, with no excess reactogenecity and no need for caution regarding Tdap use within any interval of a tetanus- or diphtheria-containing toxoid product, according to a policy statement published online Sept. 26 in Pediatrics.

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Remicade Approved for Ulcerative Colitis in Children

MONDAY, Sept. 26 (HealthDay News) -- Remicade (infliximab) has been approved by the U.S. Food and Drug Administration to treat moderate-to-severe active episodes of ulcerative colitis in children aged six and older who haven't responded to other therapies.

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Updated Guides Compare Treatments for GERD

MONDAY, Sept. 26 (HealthDay News) -- Updated, evidence-based, reader-friendly reports comparing treatments for gastroesophageal reflux disease (GERD) have been released by the Agency for Healthcare Research and Quality (AHRQ) to help guide patient and physician decision-making in treating this condition that affects up to 4 percent of Americans.

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GLCCI1 SNP Lowers Response to Inhaled Steroids in Asthma

MONDAY, Sept. 26 (HealthDay News) -- Expression of a single nucleotide polymorphism (SNP) at rs37973 correlates with decreased glucocorticoid-induced transcript 1 gene (GLCCI1) expression, which is associated with a reduced response to inhaled glucocorticoids in patients with asthma, according to a study published online Sept. 26 in the New England Journal of Medicine to coincide with late-breaking presentations at the European Respiratory Society Congress, held from Sept. 24 to 28 in Amsterdam, Netherlands.

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Adjuvant Zoledronic Acid Not Beneficial in Breast Cancer

MONDAY, Sept. 26 (HealthDay News) -- For patients with early-stage breast cancer, the addition of zoledronic acid to standard adjuvant therapy does not offer any benefit for disease-free or overall survival, according to a study published in the New England Journal of Medicine to coincide with presentation at the 2011 European Multidisciplinary Cancer Congress, held from Sept. 23 to 27 in Stockholm, Sweden.

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Generic Tacrolimus Safe for Liver, Kidney Recipients

MONDAY, Sept. 26 (HealthDay News) -- Patients who have undergone liver or kidney transplants may safely switch from brand-name to generic tacrolimus with no change in the indices of liver or kidney function or rejection, according to a study published in the September issue of the American Journal of Transplantation.

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Evidence for Nondrug Childhood Constipation Therapies Limited

MONDAY, Sept. 26 (HealthDay News) -- Although there is a lack of high-quality evidence for nonpharmacologic treatments for childhood constipation, there is some evidence of effectiveness of fiber supplements, but not for effectiveness of fluid supplements, prebiotics, probiotics, or behavioral interventions, according to a review published online Sept. 26 in Pediatrics.

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Glucagon-Like Peptide-1 Therapy Ups Pancreatitis Risk

FRIDAY, Sept. 23 (HealthDay News) -- The use of exenatide and sitagliptin for type 2 diabetes is associated with a higher odds ratio of pancreatitis and increased reports of pancreatic cancer, according to a study published in the July issue of Gastroenterology.

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FDA Expands Age Indication for Boostrix

THURSDAY, Sept. 22 (HealthDay News) -- The U.S. Food and Drug Administration has expanded the age indications for Boostrix, the tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap), to include people 65 and older, according to an article published in the Sept. 23 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Tyrosine Kinase Inhibitor Safe, Effective in Pulmonary Fibrosis

WEDNESDAY, Sept. 21 (HealthDay News) -- In patients with idiopathic pulmonary fibrosis, treatment with 150 mg of the tyrosine kinase inhibitor BIBF 1120 twice daily is safe, reduces lung function decline with fewer acute exacerbations, and preserves quality of life, according to a study published in the Sept. 22 issue of the New England Journal of Medicine.

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Rotavirus Vaccine Introduction Cut Health Care Use, Costs

WEDNESDAY, Sept. 21 (HealthDay News) -- Since the introduction of rotavirus vaccine (RV5) in 2006, diarrhea-related health care utilization and medical expenditures for U.S. children younger than 5 years old decreased considerably in the rotavirus seasons, according to a study published in the Sept. 22 issue of the New England Journal of Medicine.

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Age, Treating Physician Tied to Pediatric Psoriasis Treatment

WEDNESDAY, Sept. 21 (HealthDay News) -- Treatment for pediatric psoriasis varies according to treating physician and children's age, according to a study published online Sept. 19 in the Archives of Dermatology.

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F1+2, VEGF, D-Dimer Levels Up in Nonallergic Asthma

WEDNESDAY, Sept. 21 (HealthDay News) -- Patients with nonallergic asthma exhibit autoreactivity as well as increased levels of coagulation and angiogenesis markers, according to a study published in the October issue of Allergy.

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2006/2007 U.S. Flu Vaccination Policy Lowers Morbidity

WEDNESDAY, Sept. 21 (HealthDay News) -- The 2006/2007 influenza vaccination policy change in the United States to include healthy children aged 24 to 59 months has reduced influenza morbidity in the United States, as evident by reduction in the emergency department visits in the United States versus Canada, according to a study published in the Sept. 20 issue of the CMAJ, the journal of the Canadian Medical Association.

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Mortality Up in Hospitals With More Minority Trauma Patients

WEDNESDAY, Sept. 21 (HealthDay News) -- The odds of in-hospital mortality for trauma patients are associated with the proportion of minority patients in the hospital, according to a study published online Sept. 19 in the Archives of Surgery.

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Cognitive Behavior Therapy, SRIs Improve OCD Treatment

TUESDAY, Sept. 20 (HealthDay News) -- Cognitive behavior therapy (CBT) together with serotonin reuptake inhibitors (SRIs) is a better treatment for pediatric obsessive-compulsive disorder (OCD) than medication management alone, according to a study published in the Sept. 21 issue of the Journal of the American Medical Association.

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Progression-Free Survival Not Tied to R-CHOP Dose Density

TUESDAY, Sept. 20 (HealthDay News) -- There is no significant difference in progression-free survival (PFS) for patients with indolent B-cell lymphoma treated with rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) along with granulocyte colony-stimulating factor (G-CSF) every three weeks (R-CHOP-21) or every two weeks (R-CHOP-14), according to a study published online Sept. 19 in the Journal of Clinical Oncology.

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Mycophenolate Mofetil Safe, Effective for Refractory Lupus

TUESDAY, Sept. 20 (HealthDay News) -- Use of mycophenolate mofetil (MMF) in conjunction with standard therapy is well tolerated and effective for the treatment of antimalarial-resistant cutaneous lupus erythematosus (CLE), according to a study published in the October issue of the Journal of the American Academy of Dermatology.

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Payer Status Affects Health Care Quality and Outcomes

TUESDAY, Sept. 20 (HealthDay News) -- Patients with heart failure who have no insurance, or have Medicaid or Medicare, have lower quality of care and worse outcomes than those with private/health maintenance organization (HMO) insurance, according to a study published in the Sept. 27 issue of the Journal of the American College of Cardiology.

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Lower Sudden Death Risk With Add-On Antiepileptic Therapy

TUESDAY, Sept. 20 (HealthDay News) -- Patients with refractory epilepsy who are treated with adjunctive antiepileptic drugs (AEDs) at efficacious doses may have lower incidence of sudden unexpected death in epilepsy (SUDEP) compared with those receiving a placebo, according to a meta-analysis published online Sept. 20 in The Lancet Neurology.

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Tasquinimod Ups Castration-Resistant Prostate CA Survival

TUESDAY, Sept. 20 (HealthDay News) -- In men with castration-resistant prostate cancer (CRPC), treatment with tasquinimod (TASQ) significantly delays disease progression and improves progression-free survival (PFS) with an acceptable adverse event (AE) profile, according to a study published online Sept. 19 in the Journal of Clinical Oncology.

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Prolia Approval Expanded to Fracture Prevention in Cancer

MONDAY, Sept. 19 (HealthDay News) -- The U.S. Food and Drug Administration has expanded approval for the Amgen bone-building drug Prolia (denosumab) to include prostate cancer or breast cancer patients who are taking certain hormonal therapies.

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Enoxaparin Bests Unfractionated Heparin in Occlusive PAD

MONDAY, Sept. 19 (HealthDay News) -- Intravenous enoxaparin is safe and more effective than unfractionated heparin (UFH) for treating peripheral arterial occlusive disease (PAOD), according to a study published online Sept. 12 in the Journal of Thrombosis and Haemostasis.

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Fluoroquinolones Up Risk of Post-Biopsy Acute Prostatitis

FRIDAY, Sept. 16 (HealthDay News) -- In patients who undergo transrectal prostate biopsy, prior use of fluoroquinolones is the most significant risk factor for developing post-procedure acute prostatitis, according to a study published in the September issue of Urology.

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Child Self-Exposure to Meds Explains Most Drug Poisoning

FRIDAY, Sept. 16 (HealthDay News) -- Child self-exposure to prescription medications was responsible for 95 percent of the cases of pediatric pharmaceutical poisonings between 2001 and 2008, with the greatest resource use and morbidity due to self-ingestion of prescription products, including opioids, sedative-hypnotics, and cardiovascular agents, according to a study published online Sept. 16 in The Journal of Pediatrics.

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Statins After Ischemic Stroke Not Tied to Brain Hemorrhage

FRIDAY, Sept. 16 (HealthDay News) -- Exposure to statins after acute ischemic stroke is not associated with intracerebral hemorrhage (ICH), according to a study published online Sept. 12 in the Archives of Neurology.

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CDC: MRSA USA300 Strain Resistant to Topical Antibiotics

FRIDAY, Sept. 16 (HealthDay News) -- Most methicillin-resistant Staphylococcus aureus (MRSA) isolates are susceptible to bacitracin, but MRSA USA300 isolates show resistance to bacitracin and neomycin, according to a study published online Sept. 14 in the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

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Anti-Nausea Drug May Lead to Dangerous Heart Rhythms

THURSDAY, Sept. 15 (HealthDay News) -- Zofran (ondansetron), used to prevent nausea in patients receiving cancer treatment, is undergoing an ongoing safety review and labeling change by the U.S. Food and Drug Administration because it may cause potentially fatal changes in heart rhythm, according to a Sept. 15 FDA safety alert.

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CDC: Risk Factors ID'd in Most C. difficile Diarrhea Cases

THURSDAY, Sept. 15 (HealthDay News) -- The majority of patients with diarrhea caused by Clostridium difficile (C. difficile) infection (CDI) have recognized risk factors or a co-infection with another pathogen, according to a study published online Sept. 14 in the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

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CDC: Recent Influenza Activity Relatively Low

THURSDAY, Sept. 15 (HealthDay News) -- Influenza activity was relatively low worldwide over the summer of 2011, but vaccination remains an important criteria for keeping influenza under control and preventing potentially serious, even fatal, complications, according to two articles published in the Sept. 16 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Specific Pain Reduction Seen With Transdermal Buprenorphine

THURSDAY, Sept. 15 (HealthDay News) -- Transdermal buprenorphine, but not fentanyl, significantly reduces pain in experimentally induced bone-associated pain and primary hyperalgesia, according to a study published in the October issue of the British Journal of Pharmacology.

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Long-Term Nonaspirin NSAID Use Ups Renal Cell Cancer Risk

WEDNESDAY, Sept. 14 (HealthDay News) -- Use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs), but not aspirin and acetaminophen, is associated with an increased risk of renal cell cancer (RCC), with increased duration of use correlated with an elevated risk, according to a study published in the Sept. 12 issue of the Archives of Internal Medicine.

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Reduced Treatment Time Noninferior for Some With Hep C

WEDNESDAY, Sept. 14 (HealthDay News) -- Sustained virologic response for some patients who have chronic hepatitis C virus (HCV) was found to be noninferior when treating for 24 weeks versus 48 weeks, according to a study published in the Sept. 15 issue of the New England Journal of Medicine.

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No Benefit of Long-Term Azithromycin for Rhinosinusitis

WEDNESDAY, Sept. 14 (HealthDay News) -- For patients with persistent chronic rhinosinusitis (CRS), low-dose, long-term treatment with azithromycin (AZM) for 11 weeks offers no significant benefit, according to a study published online Sept. 2 in Allergy.

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Many Mistakenly Believe FDA OKs Only Safe, Effective Drugs

WEDNESDAY, Sept. 14 (HealthDay News) -- A considerable proportion of the U.S. public mistakenly believes that the U.S. Food and Drug Administration approves only effective and safe drugs, but providing consumer explanations can lead to better drug choices, according to a study published in the Sept. 12 issue of the Archives of Internal Medicine.

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Sorafenib Plus DEB-TACE Safe, Tolerated in Unresectable HCC

WEDNESDAY, Sept. 14 (HealthDay News) -- In patients with unresectable hepatocellular carcinoma (HCC), combined treatment with transarterial chemoembolization (TACE) with doxorubicin-eluting beads (DEB) and sorafenib is well tolerated and safe, according to a study published online Sept. 12 in the Journal of Clinical Oncology.

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Erectile Dysfunction Ups Risk of Cardiovascular Disease

WEDNESDAY, Sept. 14 (HealthDay News) -- Erectile dysfunction (ED) significantly increases the risk of cardiovascular disease (CVD), coronary heart disease, stroke, and all-cause mortality, according to a meta-analysis published in the Sept. 20 issue of the Journal of the American College of Cardiology.

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Insulin Therapy May Slow Alzheimer's Progression

TUESDAY, Sept. 13 (HealthDay News) -- Intranasal administration of insulin may delay or improve cognitive decline, functional ability, and cerebral glucose metabolism in adults with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease, according to research published online Sept. 12 in the Archives of Neurology.

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Dalcetrapib Use Safe, Possibly Beneficial in Atherosclerosis

TUESDAY, Sept. 13 (HealthDay News) -- Dalcetrapib is safe and reduces change in total vessel area and most-diseased-segment target-to-background ratio (TBR) as revealed by magnetic resonance imaging (MRI) and positron emission tomography-computed tomography (PET/CT), according to a study published online Sept. 12 in The Lancet.

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Venlafaxine, Clonidine Reduce Hot Flashes in Breast Cancer

TUESDAY, Sept. 13 (HealthDay News) -- Venlafaxine and clonidine effectively manage hot flashes in patients with breast cancer, with hot flash scores reducing more immediately with venlafaxine than clonidine, and reducing more significantly with clonidine during week 12 of treatment than with venlafaxine, according to a study published online Sept. 12 in the Journal of Clinical Oncology.

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TNF Inhibitors for RA Do Not Increase Malignancy Risk

MONDAY, Sept. 12 (HealthDay News) -- Treatment of rheumatoid arthritis (RA) with tumor necrosis factor inhibitors (TNFi) does not increase risk of malignancy, including lymphoma, but it may increase the risk of non-melanoma skin cancer and melanoma, according to a meta-analysis published online Sept. 1 in the Annals of Rheumatic Diseases.

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Clopidogrel Adherence Tied to Daily Pre-PCI Med Adherence

MONDAY, Sept. 12 (HealthDay News) -- Low patient adherence to daily medication regimens before percutaneous coronary intervention (PCI) is a good predictor of low clopidogrel adherence after PCI, according to a study published in the Sept. 15 issue of The American Journal of Cardiology.

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Opioid Delivery to Olfactory Region Ups Therapeutic Effects

FRIDAY, Sept. 9 (HealthDay News) -- Administration of opioids directly to the nasal olfactory region results in a larger fraction of drug being delivered to the central nervous system (CNS) and a significantly higher therapeutic effect without an increase in plasma drug exposure compared to drug delivery to the nasal respiratory region in rats, according to an experimental study published in the September issue of Anesthesia & Analgesia.

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Oxycodone No Safer Than Codeine During Breastfeeding

FRIDAY, Sept. 9 (HealthDay News) -- Neonates breastfed by mothers with postpartum oxycodone exposure have a higher incidence of central nervous system (CNS) depression than neonates breastfed by mothers exposed to codeine, according to a study published online Sept. 1 in The Journal of Pediatrics.

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SAMHSA Assesses Recent Trends in Illicit Drug Use

THURSDAY, Sept. 8 (HealthDay News) -- The use of illicit drugs and alcohol remained similar between 2009 and 2010, but was higher than in 2008, according to the 2010 National Survey on Drug Use and Health, published Sept. 8 by the Substance Abuse and Mental Health Services Administration (SAMHSA) at the start of the 22nd annual National Recovery Month held in September in United States.

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Comparative Efficacy Proposed for European Drug Approval

WEDNESDAY, Sept. 7 (HealthDay News) -- New drugs should be compared with existing treatments instead of placebo before their approval in Europe, according to a report published online Sept. 6 in the BMJ.

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FDA Announces Label Change to Warnings for TNFα Blockers

WEDNESDAY, Sept. 7 (HealthDay News) -- Labels for all tumor necrosis factor-alpha (TNFα) blockers have been revised to include the risk of infection from Legionella and Listeria, according to a safety alert issued Sept. 7 by the U.S. Food and Drug Administration.

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Many Hospital Staff Uniforms Contaminated With Bacteria

WEDNESDAY, Sept. 7 (HealthDay News) -- More than 60 percent of hospital staff uniforms are contaminated with potentially pathogenic bacteria, including drug-resistant species, according to a study published in the September issue of the American Journal of Infection Control.

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Gestational NSAID Intake Tied to Spontaneous Abortion Risk

WEDNESDAY, Sept. 7 (HealthDay News) -- Exposure to any type or dosage of nonaspirin nonsteroidal anti-inflammatory drug (NSAID) in early pregnancy increases the risk of spontaneous abortion, according to a study published online Sept. 6 in CMAJ, the journal of the Canadian Medical Association.

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Hospitalized Children Exposed to Considerable Polypharmacy

TUESDAY, Sept. 6 (HealthDay News) -- A considerable proportion of hospitalized children are exposed to polypharmacy, with exposure to more drugs significantly more likely among those with rare conditions, according to a study published online Sept. 5 in the Archives of Pediatrics & Adolescent Medicine.

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Immunoadsorption Therapy Effective in E. coli-Induced HUS

TUESDAY, Sept. 6 (HealthDay News) -- Immunoadsorption of immunoglobulin G (IgG) antibodies can safely be used to treat neurological complications in patients with Escherichia coli (E. coli) O104:H4-induced hemolytic uremic syndrome (HUS), according to a study published online Sept. 5 in The Lancet.

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Vaccine Rates Increase Among Children Aged 11 to 12 Years

TUESDAY, Sept. 6 (HealthDay News) -- Vaccine compliance at ages 11 to 12 years has increased among children, but they often do not receive all indicated vaccines during vaccination visits, according to a study published in the September issue of the Archives of Pediatrics & Adolescent Medicine.

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Temp Staff Errors More Harmful Than Those of Permanent Staff

MONDAY, Sept. 5 (HealthDay News) -- Emergency department medication errors associated with temporary staff are more likely to reach the patient and result in harm compared with errors associated with permanent staff, according to a study published in the July/August issue of the Journal for Healthcare Quality.

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FDA: New Contraindication, Updated Warning for Reclast

FRIDAY, Sept. 2 (HealthDay News) -- The drug label for Reclast (zoledronic acid) has been updated to reflect the risk of kidney failure, according to a safety alert issued Sept. 1 by the U.S. Food and Drug Administration.

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FDA: Antipsychotic Drug May Cause Severe Allergic Reaction

FRIDAY, Sept. 2 (HealthDay News) -- The drug label for Saphris (asenapine maleate), an antipsychotic medication, has been revised to warn of the risk of serious allergic reaction in patients with hypersensitivity to the drug, according to a safety alert issued Sept. 1 by the U.S. Food and Drug Administration.

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Simvastatin Neuroprotective for Spinal Cord Ischemia in Rats

FRIDAY, Sept. 2 (HealthDay News) -- Simvastatin significantly reduces hindlimb motor dysfunction, and reduces white- and gray-matter injury 24 to 48 hours after reperfusion in rats with spinal cord ischemia, according to an experimental study published in the September issue of Anesthesia & Analgesia.

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Antibiotic Prescriptions Down for Pediatric Patients

FRIDAY, Sept. 2 (HealthDay News) -- The rate of antibiotic prescriptions flowing from pediatric offices has dropped by nearly a quarter since 1993, but the U.S. Centers for Disease Control and Prevention says this is not enough to address the problem of antibiotic resistance in the United States, according to a report published in the Sept. 2 issue of the CDC's Morbidity and Mortality Weekly Report.

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Pediatric Vaccination Rates High in United States

THURSDAY, Sept. 1 (HealthDay News) -- Overall vaccination rates in children are high and have remained stable or have increased since 2009, though disparities persist among the economically underprivileged, according to a report published in the Sept. 2 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Success With Valproic Acid for Glioblastoma With TMZ Therapy

THURSDAY, Sept. 1 (HealthDay News) -- Patients with glioblastoma requiring antiepileptic drugs (AEDs) during temozolomide (TMZ)-based chemoradiotherapy have an improved overall survival with valproic acid (VPA) than with an enzyme-inducing antiepileptic drug (EIAED), according to a study published online Aug. 31 in Neurology.

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