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Category: Endocrinology | Monthly Briefing

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October 2011 Briefing - Diabetes & Endocrinology

Last Updated: November 01, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for October 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Switching From IV to Oral Meds Cuts Health Care Costs

MONDAY, Oct. 31 (HealthDay News) -- For patients who are clinically eligible for oral (PO) medication intake, switching from intravenous (IV) to oral medication can substantially reduce the annual cost of health care, according to a study published online Oct. 17 in Clinical Therapeutics.

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Paternal Fetal IGF2 Variants Up Maternal Glucose Levels

FRIDAY, Oct. 28 (HealthDay News) -- Paternally transmitted fetal IGF2 variants are associated with increased maternal glucose concentrations in the third trimester of pregnancy, according to a study published in the November issue of Diabetes.

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ATA: Thyroidectomy Improves Sleep Apnea Symptoms

FRIDAY, Oct. 28 (HealthDay News) -- Surgical reduction or removal of an enlarged thyroid gland improves obstructive sleep apnea (OSA) symptoms, including snoring, according to a study being presented in the annual meeting of the American Thyroid Association, held from Oct. 26 to 30 in Palm Springs, Calif.

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Last Decade Saw Marked Drop in Diabetes-Linked Retinopathy

FRIDAY, Oct. 28 (HealthDay News) -- The prevalence of retinopathy in adolescents with type 1 diabetes decreased significantly from 1990 to 2009, according to a study published in the November issue of Diabetes Care.

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Weight Loss in Obese Tied to Low-Order Cognitive Upturn

FRIDAY, Oct. 28 (HealthDay News) -- Weight loss in obese individuals is associated with low-order significant improvements in executive/attention functioning and memory, according to a meta-analysis published in the November issue of Obesity Reviews.

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Adipose Tissue Inflammation Tied to Fat Deposition

THURSDAY, Oct. 27 (HealthDay News) -- Subcutaneous adipose tissue (SAT) inflammation is not correlated with gender or ethnicity, and is associated with visceral adipose tissue (VAT) deposition, hepatic fat fraction (HFF), hyperinsulinemia, and stimulation of the nuclear factor-κB (NF-κB) stress pathway, according to a study published in the November issue of Diabetes.

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Pancreatic Islet Cells Express Serotonergic Genes in Mice

THURSDAY, Oct. 27 (HealthDay News) -- Pancreatic islet cells express all the genes responsible for synthesis, packaging, and secretion of serotonin, including the serotonergic transcription factor Pet1, according to an experimental study published online Oct. 19 in Diabetes.

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Obesity Tied to Impaired Immunity After Flu Vaccine

THURSDAY, Oct. 27 (HealthDay News) -- Obese individuals have reduced levels of influenza antibody titers and decreased CD8+ T-cell responses 12 months after influenza vaccination, according to a study published online Oct. 25 in the International Journal of Obesity.

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Ovarian Stimulation Ups Risk of Ovarian Tumors in Later Life

THURSDAY, Oct. 27 (HealthDay News) -- Ovarian stimulation for in vitro fertilization (IVF) is associated with an increase in the risk of ovarian malignancies, especially borderline ovarian tumors, according to a study published online Oct. 26 in Human Reproduction.

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Bedtime Medications Offer Better BP Control in CKD

WEDNESDAY, Oct. 26 (HealthDay News) -- For patients with chronic kidney disease (CKD), taking at least one hypertension medication at bedtime results in better blood pressure (BP) control compared to morning medication, according to a study published online Oct. 24 in the Journal of the American Society of Nephrology.

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Hormonal Alterations Persist One Year After Weight Loss

WEDNESDAY, Oct. 26 (HealthDay News) -- Altered levels of several peripheral hormones involved in the homeostatic regulation of body weight persist more than one year after initial weight reduction, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.

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Ghost Authorship Prevalent in About One-Fifth of Articles

WEDNESDAY, Oct. 26 (HealthDay News) -- The prevalence of articles with honorary authorship, ghost authorship, or both is 21 percent, which marks a significant decrease since 1996, according to a study published online Oct. 25 in BMJ.

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Vandetanib Ups Survival in Medullary Thyroid Carcinoma

TUESDAY, Oct. 25 (HealthDay News) -- Administration of vandetanib to patients with advanced medullary thyroid carcinoma (MTC) improves progression-free survival (PFS) compared to placebo, according to a study published online Oct. 24 in the Journal of Clinical Oncology.

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Predictors of Infant Adiposity in GDM Tied to Fetal Sex

FRIDAY, Oct. 21 (HealthDay News) -- For women with gestational diabetes mellitus (GDM), the determinants of neonatal adiposity differ according to gender, with glycemia and maternal body mass index (BMI) being primary predictors of adiposity in male and female infants, respectively, according to a study published online Oct. 12 in Diabetes Care.

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Multiple Hormones Influence Breast Cancer Risk

FRIDAY, Oct. 21 (HealthDay News) -- High levels of sex and growth hormones are known to increase the risk of breast cancer, and it appears that other hormones circulating at high levels may also have a profound influence on the likelihood that a woman will develop postmenopausal breast cancer, according to research published online Oct. 21 in Breast Cancer Research.

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Sodium-Sensitive Populations Fail to Curb Intake

THURSDAY, Oct. 20 (HealthDay News) -- Nearly half of all Americans should limit their sodium intake for the sake of their health, but less than 2 percent of those who meet the criteria for sodium limitation actually do so, and most Americans ingest too much sodium, according to research published in the Oct. 21 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Neighborhood Poverty Level Linked to Obesity, Diabetes

WEDNESDAY, Oct. 19 (HealthDay News) -- Moving from a neighborhood with a high level of poverty to one with a low level of poverty is associated with a slight reduction in the prevalence of extreme obesity and diabetes, according to a study published in the Oct. 20 issue of the New England Journal of Medicine.

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Different CD8+ T-Cell Targets in New, Established Diabetes

WEDNESDAY, Oct. 19 (HealthDay News) -- Autoreactive CD8+ T cells specific for preproinsulin (PPI) include central and effector memory cells and show different specificities for epitopes in patients with recent-onset and long-standing type 1 diabetes (T1D), according to a study published online Oct. 13 in Diabetes.

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Readmission Risk Models Display Poor Predictive Ability

TUESDAY, Oct. 18 (HealthDay News) -- Most hospital readmission risk models have poor predictive ability, according to a review published in the Oct. 19 issue of the Journal of the American Medical Association.

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Bariatric Surgery Offers Health Benefits to Patients' Family

TUESDAY, Oct. 18 (HealthDay News) -- Adult family members and children of patients undergoing Roux-en-Y gastric bypass surgery experience weight loss and improved healthy behaviors one year following surgery, according to a study published in the October issue of the Archives of Surgery.

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Urinary Marker ID'd for Long-Term Mortality in Diabetes

TUESDAY, Oct. 18 (HealthDay News) -- For patients with type 2 diabetes, urinary excretion of the marker of the RNA oxidation (8-oxo-7,8-dihydroguanosine [8-oxoGuo]) predicts long term all-cause and diabetes-related mortality, but excretion of markers of DNA oxidation (8-oxo-7,8-dihydro-2'-deoxyguanosine [8-oxodG]) do not, according to a study published online Oct. 12 in Diabetes Care.

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Evidence Suggests Obesity Tied to Altered Iron Metabolism

MONDAY, Oct. 17 (HealthDay News) -- Evidence suggests that obesity is associated with higher hemoglobin and ferritin concentrations and lower transferrin saturation, according to a review published online Oct. 9 in Obesity Reviews.

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Hypoglycemic Brain Function Different in Type 1 Diabetes

FRIDAY, Oct. 14 (HealthDay News) -- During hypoglycemia, patients with type 1 diabetes (T1D) who perform a working-memory task (WMT) have more activation of brain regions and less deactivation of the default-mode network (DMN) than control subjects, according to a study published online Oct. 7 in Diabetes.

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Polycystic Ovarian Syndrome Makes Pregnancy Difficult

FRIDAY, Oct. 14 (HealthDay News) -- Women with polycystic ovarian syndrome (PCOS) may be at higher risk for difficult pregnancies and deliveries, according to research published online Oct. 13 in BMJ.

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No Metabolic Dysfunction for LGA Delivery Without GDM

FRIDAY, Oct. 14 (HealthDay News) -- Women without gestational diabetes mellitus (GDM) who have a large-for-gestational-age (LGA) delivery (nonGDM-LGA) do not have postpartum metabolic dysfunction typically seen in women with GDM, according to a study published online Oct. 4 in Diabetes Care.

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CDC: Coronary Heart Disease Rates Continue to Fall

THURSDAY, Oct. 13 (HealthDay News) -- Coronary heart disease (CHD) is continuing its steady decline in the United States, according to self-reported data; but there is variation in prevalence by sex, race, education level, and geography, according to research published in the Oct. 14 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Rare Disorders ID'd by NIH Undiagnosed Diseases Program

THURSDAY, Oct. 13 (HealthDay News) -- The extensive application of genomic technology under the U.S. National Institutes of Health Undiagnosed Diseases Program (NIH-UDP) helps diagnose complex and rare multisystem disorders, according to a report published online Sept. 26 in Genetics in Medicine.

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Poorly Controlled Diabetes Benefits From Interventions

THURSDAY, Oct. 13 (HealthDay News) -- Behavioral and educational interventions effectively improve glycemic control for patients with poorly controlled diabetes, according to three studies published online Oct. 10 in the Archives of Internal Medicine.

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Parental History of Heart Disease for Women With PCOS

THURSDAY, Oct. 13 (HealthDay News) -- Parents of women with polycystic ovary syndrome (PCOS) are more likely to suffer from chronic cardiovascular diseases than parents of women without the condition, according to a study published online Oct. 4 in PLoS One.

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Raw Fruit and Vegetable Intake Modifies 9p21 CVD Risk

WEDNESDAY, Oct. 12 (HealthDay News) -- Following a diet high in raw vegetables and fruits modifies the influence of chromosome 9p21 single nucleotide polymorphisms (SNPs) on myocardial infarction (MI) and cardiovascular disease (CVD), according to a study published online Oct. 11 in PLoS Medicine.

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Financial Conflicts of Interest Prevalent, Under-Reported

WEDNESDAY, Oct. 12 (HealthDay News) -- Conflicts of interest (COI) are prevalent among members and chairs of guideline panels, and are under-reported, according to a study published online Oct. 11 in BMJ.

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Physical Activity Cuts Mortality Risk in Metabolic Syndrome

TUESDAY, Oct. 11 (HealthDay News) -- For individuals with metabolic syndrome, physical activity is associated with a reduced risk of mortality from all causes and from cardiovascular causes, according to a study published online Sept. 29 in BMC Medicine.

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Glycemic Extremes Affect Brain Development in Type 1 Diabetes

TUESDAY, Oct. 11 (HealthDay News) -- For patients with type 1 diabetes (T1DM), more exposure to hyperglycemia is associated with a decrease in whole brain gray matter, and severe hypoglycemia is associated with greater decreases in occipital/parietal white matter volume, according to a study published online Sept. 27 in Diabetes.

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Septicemia Most Costly Reason for Hospitalization in 2009

MONDAY, Oct. 10 (HealthDay News) -- Septicemia was the single most expensive condition treated in U.S. hospitals in 2009, with expenditure totaling nearly $15.4 billion, according to an October statistical brief based on Healthcare Cost and Utilization Project (HCUP) data published by the Agency for Healthcare Research and Quality (AHRQ).

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Poor Methods Used to Develop Diabetes Risk Prediction Models

MONDAY, Oct. 10 (HealthDay News) -- Methodological deficiencies and poor reporting of data are seen in studies which attempt to develop risk prediction models for type 2 diabetes, according to a review published online Sept. 8 in BMC Medicine.

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Exercise Offers Modest Cut in Chronic Disease Risk for Obese

MONDAY, Oct. 10 (HealthDay News) -- Physical activity has no more than a modest beneficial effect of lowering risk of chronic disease in obese individuals, according to a review published online Sept. 26 in Obesity Reviews.

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Shift Work Ups Cortisol Levels, BMI in Young Adults

MONDAY, Oct. 10 (HealthDay News) -- For young adults, shift work (work performed out of standard working hours) is associated with long-term elevated cortisol levels and increased body mass index (BMI), according to a study published online Aug. 31 in the Journal of Clinical Endocrinology & Metabolism.

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Elevated Liver Function Enzymes Tied to Diabetes Risk

MONDAY, Oct. 10 (HealthDay News) -- Elevated liver alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) are potentially useful for predicting the risk of young adults developing diabetes, according to a study published online Sept. 27 in Diabetes Care.

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Juvisync Approved for Type 2 Diabetics With High Cholesterol

FRIDAY, Oct. 7 (HealthDay News) -- Juvisync (sitagliptin and simvastatin) has been approved by the U.S. Food and Drug Administration for people with type 2 diabetes who also have high cholesterol.

American Diabetes Association

Men Are Diagnosed With Type 2 Diabetes at Lower BMIs

FRIDAY, Oct. 7 (HealthDay News) -- Men are diagnosed with type 2 diabetes at a lower body mass index (BMI) than women, with a steeper inverse relationship between BMI and age at diagnosis for women, according to a study published online Sept. 30 in Diabetologia.

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Anti-TNF-α Use Cuts Diabetes Risk in Rheumatoid Arthritis

FRIDAY, Oct. 7 (HealthDay News) -- Patients with rheumatoid arthritis (RA) who are treated with anti-tumor necrosis factor-α (TNF-α) therapy have a reduced risk of developing diabetes, according to a study published online Oct. 3 in Arthritis Care & Research.

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Use of Oral Steroids Linked to Vitamin D Deficiency

THURSDAY, Oct. 6 (HealthDay News) -- The use of oral steroids is associated with serum 25-hydroxyvitamin D (25[OH]D) deficiency, according to a study published online Sept. 28 in the Journal of Clinical Endocrinology & Metabolism.

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More Minority Patients in Low-Quality, High-Cost Hospitals

THURSDAY, Oct. 6 (HealthDay News) -- Hospitals where the quality is low and costs high (worst hospitals) in the United States care for a higher proportion of elderly black, Hispanic, and Medicaid patients than high-quality, low-cost institutions (best hospitals), according to a study published in the October issue of Health Affairs.

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Novel Algorithm for Mealtime Insulin Dose Estimation ID'd

TURSDAY, Oct. 4 (HealthDay News) -- In patients with type 1 diabetes using intensive insulin pump therapy, a novel food insulin index (FII)-based algorithm improves acute postprandial glycemia compared with the use of carbohydrate counting, according to a study published in the October issue of Diabetes Care.

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Clinically Meaningful Weight Loss From Behavioral Therapy

TUESDAY, Oct. 4 (HealthDay News) -- Although health-outcome data are sparse, behavioral interventions are effective in yielding clinically meaningful weight loss in overweight and obese individuals, according to a study published in the Oct. 4 issue of the Annals of Internal Medicine.

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Poor Footwear Ups Impairment, Disability in Chronic Gout

MONDAY, Oct. 3 (HealthDay News) -- Use of poor footwear is common among patients with chronic gout, and is associated with foot-related disability and impairment, according to a study published online Oct. 3 in Arthritis Care & Research.

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