Here are what the editors at HealthDay consider to be the most important developments in HIV & AIDS for October 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Switching From IV to Oral Meds Cuts Health Care Costs
MONDAY, Oct. 31 (HealthDay News) -- For patients who are clinically eligible for oral (PO) medication intake, switching from intravenous (IV) to oral medication can substantially reduce the annual cost of health care, according to a study published online Oct. 17 in Clinical Therapeutics.
qHPV Vaccine Efficacious in Anal Intraepithelial Neoplasia
WEDNESDAY, Oct. 26 (HealthDay News) -- Quadrivalent human papillomavirus (qHPV) vaccine is safe and efficacious against anal intraepithelial neoplasia in men who have sex with men, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.
Ghost Authorship Prevalent in About One-Fifth of Articles
WEDNESDAY, Oct. 26 (HealthDay News) -- The prevalence of articles with honorary authorship, ghost authorship, or both is 21 percent, which marks a significant decrease since 1996, according to a study published online Oct. 25 in BMJ.
CDC Recommends HPV Vaccination in Males
TUESDAY, Oct. 25 (HealthDay News) -- Young males should receive routine vaccination against human papillomavirus (HPV), according to a recommendation announced Oct. 25 by the U.S. Centers for Disease Control and Prevention.
Early Initiation of ART After TB Treatment Ups Survival
WEDNESDAY, Oct. 19 (HealthDay News) -- For patients with HIV and tuberculosis, initiation of antiretroviral therapy (ART) early after starting tuberculosis treatment improves survival in those with CD4+ T-cell counts of less than 50/mm³, according to three studies published in the Oct. 20 issue of the New England Journal of Medicine.
Readmission Risk Models Display Poor Predictive Ability
TUESDAY, Oct. 18 (HealthDay News) -- Most hospital readmission risk models have poor predictive ability, according to a review published in the Oct. 19 issue of the Journal of the American Medical Association.
Rare Disorders ID'd by NIH Undiagnosed Diseases Program
THURSDAY, Oct. 13 (HealthDay News) -- The extensive application of genomic technology under the U.S. National Institutes of Health Undiagnosed Diseases Program (NIH-UDP) helps diagnose complex and rare multisystem disorders, according to a report published online Sept. 26 in Genetics in Medicine.
Teen Sexual Activity Unchanged, but Condom Use Up Slightly
WEDNESDAY, Oct. 12 (HealthDay News) -- Sexual activity, contraceptive use, and sexual experiences in teenagers were similar in 2002 and in 2006-2010, according to a study published online Oct. 12 in the Vital and Health Statistics Series.
Financial Conflicts of Interest Prevalent, Under-Reported
WEDNESDAY, Oct. 12 (HealthDay News) -- Conflicts of interest (COI) are prevalent among members and chairs of guideline panels, and are under-reported, according to a study published online Oct. 11 in BMJ.
Septicemia Most Costly Reason for Hospitalization in 2009
MONDAY, Oct. 10 (HealthDay News) -- Septicemia was the single most expensive condition treated in U.S. hospitals in 2009, with expenditure totaling nearly $15.4 billion, according to an October statistical brief based on Healthcare Cost and Utilization Project (HCUP) data published by the Agency for Healthcare Research and Quality (AHRQ).
Improved Virologic Response After Triple Class Failure in HIV
MONDAY, Oct. 10 (HealthDay News) -- There has been a considerable improvement in viral load suppression and a decrease in the rate of AIDS for patients with HIV who had triple-class virological failure (TCVF) with the three original classes of antiretroviral drugs between 2000 and 2009, according to a study published online Oct. 10 in The Lancet Infectious Diseases.
Two HIV Variants Identified in HIV-Linked Dementia
FRIDAY, Oct. 7 (HealthDay News) -- Individuals with HIV-type 1 (HIV-1)-associated dementia (HAD) have two genetically distinct HIV-1 variants in their cerebrospinal fluid (CSF): CCR5-tropic (R5) T-cell-tropic and macrophage-tropic, which differ in terms of replication and evolution in the central nervous system (CNS), according to a study published online Oct. 6 in PLoS Pathogens.
More Minority Patients in Low-Quality, High-Cost Hospitals
THURSDAY, Oct. 6 (HealthDay News) -- Hospitals where the quality is low and costs high (worst hospitals) in the United States care for a higher proportion of elderly black, Hispanic, and Medicaid patients than high-quality, low-cost institutions (best hospitals), according to a study published in the October issue of Health Affairs.
Model Projects Smoking Will Up TB Cases, Deaths by 2050
WEDNESDAY, Oct. 5 (HealthDay News) -- Assuming that current smoking trends will continue, it is estimated that tobacco smoking will cause 18 million tuberculosis cases and 40 million deaths from tuberculosis worldwide from 2010 to 2050, according to a study published online Oct. 4 in BMJ.
Advance Directives Linked to Regional Medical Expenditures
TUESDAY, Oct. 4 (HealthDay News) -- Advance directives (living wills) specifying limitations in end-of-life care are associated with significantly lower levels of Medicare spending, lower likelihood of in-hospital death, and higher use of hospice care during the last six months of life for patients living in regions with high medical expenditures but not in other regions, according to a study published in the Oct. 5 issue of the Journal of the American Medical Association.
Hormonal Contraceptives May Up HIV-1 Acquisition by Women
TUESDAY, Oct. 4 (HealthDay News) -- Use of hormonal contraceptives is associated with an increased risk of HIV-1 acquisition by women, and an increased risk of HIV-1 transmission from HIV-infected women to HIV-1 seronegative men, according to a study published online Oct. 4 in The Lancet Infectious Diseases.
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