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Category: Oncology | Monthly Briefing

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October 2011 Briefing - Hematology & Oncology

Last Updated: November 01, 2011.

 

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for October 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Noncarriers of BRCA Do Not Have Increased Breast CA Risk

MONDAY, Oct. 31 (HealthDay News) -- Women testing negative for their family-specific BRCA1 or BRCA2 mutation (noncarriers) do not have an increased risk of breast cancer, according to a study published online Oct. 31 in the Journal of Clinical Oncology.

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Switching From IV to Oral Meds Cuts Health Care Costs

MONDAY, Oct. 31 (HealthDay News) -- For patients who are clinically eligible for oral (PO) medication intake, switching from intravenous (IV) to oral medication can substantially reduce the annual cost of health care, according to a study published online Oct. 17 in Clinical Therapeutics.

Abstract
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Proportion of MELD Exceptions Up From 2002 to 2010

MONDAY, Oct. 31 (HealthDay News) -- The proportion of liver transplant candidates who are model for end-stage liver disease (MELD) exceptions increased from 2002 to 2010, and since April 2005, exceptions have been associated with a reduced risk of wait-list mortality, according to a study published in the November issue of the American Journal of Transplantation.

Abstract
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Pre-Op Erythropoietin Reduces Need for Peri-Op Transfusion

MONDAY, Oct. 31 (HealthDay News) -- Preoperative administration of erythropoietin and an iron supplement significantly reduces the requirement for perioperative transfusion in anemic patients undergoing valvular heart surgery, according to a study published in the November issue of Anesthesiology.

Abstract
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S100A10 Key for Recruitment of Macrophages to Tumor Sites

MONDAY, Oct. 31 (HealthDay News) -- The plasminogen receptor S100A10 is involved in facilitating movement of macrophages to tumor sites, according to an experimental study published online Oct. 31 in Cancer Research.

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Thalidomide Effective, Safe in GI Vascular Malformations

FRIDAY, Oct. 28 (HealthDay News) -- For patients with refractory bleeding from gastrointestinal vascular malformations, treatment with thalidomide is effective, according to a study published in the November issue of Gastroenterology.

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Long-Term Aspirin Use Lowers CRC Risk in Lynch Syndrome

FRIDAY, Oct. 28 (HealthDay News) -- Long-term use of aspirin reduces the risk for colorectal cancer in carriers of Lynch syndrome, according to a study published online Oct. 28 in The Lancet.

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Nipple-Sparing Mastectomy Safe for Selected Patients

FRIDAY, Oct. 28 (HealthDay News) -- Nipple-sparing mastectomy (NSM) can be safe when used for properly-selected women with breast cancer, according to a study published in the November issue of Plastic and Reconstructive Surgery.

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Neurogenesis Indicative of Poor Colorectal Cancer Outcomes

FRIDAY, Oct. 28 (HealthDay News) -- Neurogenesis is associated with colorectal cancer progression, and is predictive of poor outcomes for patients, according to a study published in the Nov. 1 issue of Cancer.

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Bedside Geriatric Assessment Feasible in Elderly With AML

THURSDAY, Oct. 27 (HealthDay News) -- Inpatient bedside geriatric assessment (GA) is feasible, and is useful for identifying multiple geriatric impairments in elderly patients initiating chemotherapy for acute myelogenous leukemia (AML), according to a study published in the October issue of the Journal of the American Geriatrics Society.

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Ovarian Stimulation Ups Risk of Ovarian Tumors in Later Life

THURSDAY, Oct. 27 (HealthDay News) -- Ovarian stimulation for in vitro fertilization (IVF) is associated with an increase in the risk of ovarian malignancies, especially borderline ovarian tumors, according to a study published online Oct. 26 in Human Reproduction.

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No Lung Cancer Mortality Drop With Chest X-Ray Screening

WEDNESDAY, Oct. 26 (HealthDay News) -- Annual lung cancer screening with chest radiographs for four years does not significantly decrease lung cancer mortality compared to usual care, according to a study published online Oct. 26 in the Journal of the American Medical Association to coincide with presentation at the annual meeting of the American College of Chest Physicians, held from Oct. 22 to 26 in Honolulu.

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qHPV Vaccine Efficacious in Anal Intraepithelial Neoplasia

WEDNESDAY, Oct. 26 (HealthDay News) -- Quadrivalent human papillomavirus (qHPV) vaccine is safe and efficacious against anal intraepithelial neoplasia in men who have sex with men, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.

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Smoking Rarely Cited As Cause of Death on Death Certificates

WEDNESDAY, Oct. 26 (HealthDay News) -- Doctors rarely cite smoking as the cause of death (COD) on death certificates, even in cases where there is a strong causal link to smoking, according to a study published online Oct. 24 in the Journal of Clinical Pathology.

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Ghost Authorship Prevalent in About One-Fifth of Articles

WEDNESDAY, Oct. 26 (HealthDay News) -- The prevalence of articles with honorary authorship, ghost authorship, or both is 21 percent, which marks a significant decrease since 1996, according to a study published online Oct. 25 in BMJ.

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Capecitabine First-Line Option in Advanced Breast Cancer Therapy

TUESDAY, Oct. 25 (HealthDay News) -- Capecitabine is a good first-line treatment alternative to cyclophosphamide, methotrexate, and fluorouracil (CMF) for some women with advanced breast cancer, according to a study published online Oct. 24 in the Journal of Clinical Oncology.

Abstract
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Vandetanib Ups Survival in Medullary Thyroid Carcinoma

TUESDAY, Oct. 25 (HealthDay News) -- Administration of vandetanib to patients with advanced medullary thyroid carcinoma (MTC) improves progression-free survival (PFS) compared to placebo, according to a study published online Oct. 24 in the Journal of Clinical Oncology.

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HPV Infection, Cardiovascular Disease in Women Linked

MONDAY, Oct. 24 (HealthDay News) -- Human papillomavirus (HPV) infection in women, especially tumor-associated oncogenic HPV, is correlated with an increased risk of cardiovascular disease (CVD), according to a study published in the Nov. 1 issue of the Journal of the American College of Cardiology.

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Pre-Op Regimen Tolerable for Esophageal Adenocarcinoma

MONDAY, Oct. 24 (HealthDay News) -- Use of neoadjuvant oxaliplatin, protracted-infusion fluorouracil (PI-FU), and external-beam radiation therapy (EBRT) is tolerable for esophageal adenocarcinoma, but fails to achieve the predefined pathologic complete response (pCR) rate, according to a study published online Oct. 24 in the Journal of Clinical Oncology.

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Immunotherapy-Chemo Combo Improves Survival in NSCLC

MONDAY, Oct. 24 (HealthDay News) -- For patients with advanced non-small-cell-lung cancer (NSCLC), combining TG4010 immunotherapy with standard chemotherapy improves six-month progression-free survival (PFS), according to a study published online Oct. 22 in The Lancet Oncology.

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Excision Margin of 2 cm Safe in Melanoma Thicker Than 2 mm

MONDAY, Oct. 24 (HealthDay News) -- For patients with cutaneous melanoma thicker than 2 mm, a surgical excision margin of 2 cm is sufficient and has similar overall survival as with a 4-cm excision margin, according to a study published online Oct. 24 in The Lancet.

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Breast Reconstruction Ups Psychosocial, Sexual Health

MONDAY, Oct. 24 (HealthDay News) -- Women undergoing autologous tissue breast reconstruction experience significant gains in breast satisfaction, and psychological and sexual well-being as early as three weeks post surgery, according to a study published online Oct. 24 in Cancer.

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CLIP-170 Mediates Paclitaxel Sensitivity in Breast Cancer

FRIDAY, Oct. 21 (HealthDay News) -- CLIP-170 regulates paclitaxel sensitivity in breast cancer cells by mediating the effects of paclitaxel on microtubule assembly, mitosis, and apoptosis, according to a study published online Oct. 12 in The Journal of Pathology.

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Vulvar Lesions Should Always Be Indication for Treatment

FRIDAY, Oct. 20 (HealthDay News) -- Vulvar intraepithelial neoplasia (VIN), a problem that appears to be on the rise in women in their 40s, should always receive treatment, according to a joint committee opinion issued by the American College of Obstetricians and Gynecologists and the American Society for Colposcopy and Cervical Pathology and published in the November issue of Obstetrics & Gynecology.

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Multiple Hormones Influence Breast Cancer Risk

FRIDAY, Oct. 21 (HealthDay News) -- High levels of sex and growth hormones are known to increase the risk of breast cancer, and it appears that other hormones circulating at high levels may also have a profound influence on the likelihood that a woman will develop postmenopausal breast cancer, according to research published online Oct. 21 in Breast Cancer Research.

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No Link Found Between Cell Phone Use and Cancer

FRIDAY, Oct. 21 (HealthDay News) -- In what may be the largest study to date evaluating cancer risk in cell phone subscribers, Danish researchers have found no evidence of increased central nervous system tumor rates in long-term holders of cell phone subscriptions; their findings have been published online Oct. 20 in BMJ.

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Letrozole Monotherapy Shows Breast CA Long-Term Benefits

FRIDAY, Oct. 21 (HealthDay News) -- For postmenopausal women with hormone receptor-positive early breast cancer, letrozole monotherapy reduces breast cancer recurrence and mortality in the long-term more effectively than tamoxifen monotherapy, according to a study published online Oct. 21 in The Lancet Oncology.

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Article Collection Sheds Light on U.S. Melanoma Trends

THURSDAY, Oct. 20 (HealthDay News) -- Skin cancer is the most common form of cancer in the United States, and melanoma, the third-most common form of skin cancer, may strike more than 45,000 people annually, according to a recent supplement published in the November issue of the Journal of the American Academy of Dermatology.

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Breast Cancer Recurrence Halved by Radiation

THURSDAY, Oct. 20 (HealthDay News) -- The use of radiotherapy appears to dramatically reduce the risk of breast cancer recurrence, and somewhat reduce the risk of death from breast cancer, in women who receive radiation after breast-conserving surgery, according to the results of a meta-analysis published online Oct. 20 in The Lancet.

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IBD Increases Risk of Post-Op Thromboembolism

THURSDAY, Oct. 20 (HealthDay News) -- Patients with inflammatory bowel disease (IBD) have an increased risk of developing postoperative deep vein thrombosis (DVT) and pulmonary embolism (PE), with a higher risk in those undergoing nonintestinal surgery, according to a study published online Oct. 17 in the Archives of Surgery.

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Low Lethal Potential for Atypical Spitz Tumors

THURSDAY, Oct. 20 (HealthDay News) -- Atypical Spitz tumors (ASTs) are associated with a favorable prognosis, an increased melanoma risk, and a moderate risk of metastasis to regional nodes, according to a study published in the October issue of the Archives of Dermatology.

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Adjuvant S-1 Improves Five-Year Outcomes in Gastric Cancer

WEDNESDAY, Oct. 19 (HealthDay News) -- Postoperative adjuvant therapy with oral fluoropyrimidine derivative, S-1, improves overall and relapse-free survival at five years in patients with stage II or III gastric cancer who undergo D2 gastrectomy, according to a study published online Oct. 17 in the Journal of Clinical Oncology.

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Distinct Risks for Superficial Spreading, Lentigo Melanomas

WEDNESDAY, Oct. 19 (HealthDay News) -- Lentigo maligna melanoma (LMM) and superficial spreading melanoma (SSM) have distinct risk profiles, with the strongest determinants of LMM and SSM being the number of solar lentigines and the number of nevi, respectively, according to a study published online Oct. 17 in the Archives of Dermatology.

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Erectile Dysfunction After Colorectal CA Poorly Managed

WEDNESDAY, Oct. 19 (HealthDay News) -- Most men who experience erectile dysfunction after treatment for colorectal cancer feel profound distress, do not receive adequate information, and often feel they have been treated poorly by clinicians, according to a study published online Oct. 18 in BMJ.

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Hair Professionals Are Potential Skin Cancer Educators

TUESDAY, Oct. 18 (HealthDay News) -- A considerable proportion of hair professionals are looking for lesions on their customers' scalp, neck, and face; and their personal self-reported health communication practices are significantly associated with the frequency of observation of lesions, according to a study published in the October issue of the Archives of Dermatology.

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E-Beam Sterilized Dialyzers Up Risk of Thrombocytopenia

TUESDAY, Oct. 18 (HealthDay News) -- Use of electron-beam (e-beam) sterilized hemodialysis membranes increases the risk of significant thrombocytopenia, according to a study published in the Oct. 19 issue of the Journal of the American Medical Association.

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Readmission Risk Models Display Poor Predictive Ability

TUESDAY, Oct. 18 (HealthDay News) -- Most hospital readmission risk models have poor predictive ability, according to a review published in the Oct. 19 issue of the Journal of the American Medical Association.

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Triple-Negative Breast Cancer Characteristics Identified

TUESDAY, Oct. 18 (HealthDay News) -- There are unique characteristics associated with triple-negative breast cancer (TNBC) in both BRCA1 mutation carriers and non-carriers, according to a study published online Oct. 17 in the Journal of Clinical Oncology.

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Addition of Dulanermin Doesn't Improve Outcomes in NSCLC

TUESDAY, Oct. 18 (HealthDay News) -- Addition of dulanermin to paclitaxel and carboplatin (PC) and bevacizumab (PCB) does not improve outcomes for patients with advanced squamous or nonsquamous non-small-cell lung cancer (NSCLC), according to a study published online Oct. 17 in the Journal of Clinical Oncology.

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Topotecan Induction Feasible for High-Risk Neuroblastoma

TUESDAY, Oct. 18 (HealthDay News) -- Addition of dose-intensive topotecan and cyclophosphamide to induction therapy is feasible for patients with newly diagnosed high-risk neuroblastoma (HRNB), according to a study published online Oct. 17 in the Journal of Clinical Oncology.

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Evidence Favors Cytology, Not HPV Screening, for Cervical CA

MONDAY, Oct. 17 (HealthDay News) -- Evidence favors the use of liquid-based cytology (LBC) or conventional cytology rather than human papillomavirus (HPV) screening for cervical cancer; and cervical cancer screening should begin at age 21 years and end at age 65 years, according to two reviews published online Oct. 17 in the Annals of Internal Medicine.

Abstract - Whitlock
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Abstract - Vesco
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False-Positive Recall for Most After 10 Years of Mammograms

MONDAY, Oct. 17 (HealthDay News) -- After 10 years of annual mammography screening for breast cancer, more than 60 percent of women will receive at least one false-positive recall; and, breast cancer detection rates in women aged 50 to 79 years are similar with digital or film-screen mammography, according to two studies published in the Oct. 18 issue of the Annals of Internal Medicine.

Abstract - Hubbard
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Abstract - Kerlikowske
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Single Kidney Outcome Similar With Nephrectomy, Ablation

MONDAY, Oct. 17 (HealthDay News) -- For patients with a tumor in a solitary kidney, short-term renal function outcomes are similar for treatment with partial nephrectomy or percutaneous ablation, according to a study published in the November issue of The Journal of Urology.

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Oral Microflora Tied to Chronic Pancreatitis, Pancreatic Cancer

MONDAY, Oct. 17 (HealthDay News) -- Variations in salivary microbiota are associated with pancreatic cancer and chronic pancreatitis, according to a study published online Oct. 12 in Gut.

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Evidence Suggests Obesity Tied to Altered Iron Metabolism

MONDAY, Oct. 17 (HealthDay News) -- Evidence suggests that obesity is associated with higher hemoglobin and ferritin concentrations and lower transferrin saturation, according to a review published online Oct. 9 in Obesity Reviews.

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Aspirin Response in Acute Coronary Syndrome Up Post PCI

FRIDAY, Oct. 14 (HealthDay News) -- The laboratory response to aspirin improves significantly in patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI) and clopidogrel loading, and correlates with improved clinical outcomes, according to a study published in the Oct. 15 issue of The American Journal of Cardiology.

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Ferriprox Approved to Treat 'Iron Overload'

FRIDAY, Oct. 14 (HealthDay News) -- Ferriprox (deferiprone) has been approved by the U.S. Food and Drug Administration to treat excess blood iron among people who require frequent transfusions.

iron overload

New Enrichment Technique for Detecting Mutant DNA ID'd

FRIDAY, Oct. 14 (HealthDay News) -- Mutant enrichment with 3'-modified oligonucleotides (MEMO) is a highly sensitive technique for detecting cancer mutations, according to a study published online Oct. 5 in The Journal of Molecular Diagnostics.

Abstract
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Blacks Fare Worse Than Whites Despite Same Colon CA Therapy

FRIDAY, Oct. 14 (HealthDay News) -- In patients with resected stage II and III colon cancer treated with identical adjuvant therapy, blacks have worse overall and recurrence-free survival than whites, but a similar recurrence-free interval, according to a study published online Oct. 12 in the Journal of the National Cancer Institute.

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Obesity Ups Esophageal Cancer Mortality in Never Smokers

THURSDAY, Oct. 13 (HealthDay News) -- For never smokers with esophageal adenocarcinoma (EAC), obesity is independently associated with deterioration of disease-specific survival (DSS), disease-free survival (DFS), and overall survival (OS) after esophagectomy, according to a study published online Oct. 11 in the Journal of Clinical Oncology.

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Rare Disorders ID'd by NIH Undiagnosed Diseases Program

THURSDAY, Oct. 13 (HealthDay News) -- The extensive application of genomic technology under the U.S. National Institutes of Health Undiagnosed Diseases Program (NIH-UDP) helps diagnose complex and rare multisystem disorders, according to a report published online Sept. 26 in Genetics in Medicine.

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One in Five With Cerebral Glioma Develops Depression

THURSDAY, Oct. 13 (HealthDay News) -- Approximately 20 percent of patients with cerebral glioma have major depressive disorder (MDD) in the six months after starting radiotherapy, with a previous history of functional impairment or depression predicting MDD, according to a study published online Oct. 11 in the Journal of Clinical Oncology.

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Incidence of Adenocarcinoma with Barrett's Esophagus Estimated

WEDNESDAY, Oct. 12 (HealthDay News) -- The relative risk of esophageal adenocarcinoma is significantly higher in patients with Barrett's esophagus compared to the general population, with an annual risk of 0.12 percent, according to a study published in the Oct. 13 issue of the New England Journal of Medicine.

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PTSD Symptoms Persist in Some Long-Term NHL Survivors

WEDNESDAY, Oct. 12 (HealthDay News) -- More than one third of the long-term survivors of non-Hodgkin's lymphoma (NHL) experience persistence or worsening of the symptoms of post-traumatic stress disorder (PTSD), according to a study published online Oct. 11 in the Journal of Clinical Oncology.

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Long-Term Vitamin E Use Increases Prostate Cancer Risk

WEDNESDAY, Oct. 12 (HealthDay News) -- Long-term vitamin E supplementation is associated with an increased risk of prostate cancer in healthy men, according to a study published in the Oct. 12 issue of the Journal of the American Medical Association.

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High False-Negative Rate for HER2 Status Using Oncotype DX

WEDNESDAY, Oct. 12 (HealthDay News) -- Genomic Health's (GHI) Oncotype DX test, a human epidermal growth factor receptor 2 (HER2) assay for breast cancer that uses a method of reverse transcription polymerase chain reaction (RT-PCR), has an unacceptable false-negative rate, according to a study published online Oct. 11 in the Journal of Clinical Oncology.

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BRCA2 Mutations Indicate Better Ovarian Cancer Survival

WEDNESDAY, Oct. 12 (HealthDay News) -- For women with high-grade serous ovarian cancer, BRCA2, but not BRCA1 mutation is associated with significantly better overall survival (OS), progression-free survival (PFS), and chemotherapy response than BRCA wild-type, according to a study published in the Oct. 12 issue of the Journal of the American Medical Association.

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Financial Conflicts of Interest Prevalent, Under-Reported

WEDNESDAY, Oct. 12 (HealthDay News) -- Conflicts of interest (COI) are prevalent among members and chairs of guideline panels, and are under-reported, according to a study published online Oct. 11 in BMJ.

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Women Remain Distress-Free Long After Genetic Test Results

TUESDAY, Oct. 11 (HealthDay News) -- Most women do not experience distress several years after receiving BRCA1 and BRCA2 (BRCA1/2) genetic test results, but mutation carriers are significantly more likely to experience distress, according to a study published online Oct. 10 in the Journal of Clinical Oncology.

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Leukemia Drug May Cause Pulmonary Arterial Hypertension

TUESDAY, Oct. 11 (HealthDay News) -- Sprycel (dasatinib), a drug administered to certain leukemia patients, may increase the rare but serious risk of pulmonary arterial hypertension (PAH), according to an Oct. 11 safety announcement from the U.S. Food and Drug Administration.

More Information

Colon Inflammation Markers Lower With Ginger Extract

TUESDAY, Oct. 11 (HealthDay News) -- For individuals at normal risk for colon cancer, ginger extract may decrease certain markers of colon inflammation, including prostaglandin E2 (PGE2) and 5-, 12-, and 15-hydroxyeicosatetraenoic acid (5-, 12-, and 15-HETE), when the eicosanoids are normalized to free arachidonic acid, according to a study published online Oct. 11 in Cancer Prevention Research.

Abstract
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Fludarabine, Alemtuzumab Combo Ups Survival in CLL

TUESDAY, Oct. 11 (HealthDay News) -- The use of fludarabine plus alemtuzumab in patients with previously treated chronic lymphocytic leukemia (CLL) results in better survival, but is associated with more adverse events (AEs) than fludarabine monotherapy, according to a study published online Oct. 11 in The Lancet Oncology.

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Children More Likely to Have SLN Mets Than Young Adults

TUESDAY, Oct. 11 (HealthDay News) -- Children and adolescents are more likely to have sentinel lymph node (SLN) metastases than young adults, and SLN biopsy use is predicted by tumor thickness and ulceration, according to a study published online Oct. 5 in Cancer.

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Septicemia Most Costly Reason for Hospitalization in 2009

MONDAY, Oct. 10 (HealthDay News) -- Septicemia was the single most expensive condition treated in U.S. hospitals in 2009, with expenditure totaling nearly $15.4 billion, according to an October statistical brief based on Healthcare Cost and Utilization Project (HCUP) data published by the Agency for Healthcare Research and Quality (AHRQ).

Report

Upfront Zoledronic Acid Ups Bone Density in Breast Cancer

MONDAY, Oct. 10 (HealthDay News) -- For postmenopausal women with early breast cancer receiving aromatase inhibitors, treatment with upfront adjuvant zoledronic acid significantly increases bone mineral density (BMD) compared to delayed-start treatment, according to a study published online Oct. 10 in Cancer.

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Electronic Records Enhance Care Transitions for Elderly

MONDAY, Oct. 10 (HealthDay News) -- Implementation of electronic health care record (EHR) systems is likely to enhance communication and patient care during care transitions, particularly for older patients, according to a study published in the October issue of the AORN Journal.

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Adding HLA-C Matching Cuts Cord Blood Transplant Death

FRIDAY, Oct. 7 (HealthDay News) -- Umbilical-cord blood transplantation-related deaths can be reduced by matching donor units with recipients at the human leukocyte antigen (HLA)-C locus in addition to the HLA-A, B, and DRB1 loci, even if there is a single mismatch at these loci, according to a study published online Oct. 7 in The Lancet Oncology.

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Increase in Older Cancer Survivor Population Anticipated

THURSDAY, Oct. 6 (HealthDay News) -- Based on current cancer incidence and survival trends and U.S. population projections, there is likely to be an increase in the population of older adult cancer survivors in the future, according to a study published in the October issue of Cancer Epidemiology, Biomarkers & Prevention.

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Nonanthracycline Trastuzumab Regimen Safe and Effective

THURSDAY, Oct. 6 (HealthDay News) -- A nonanthracycline regimen with adjuvant trastuzumab is safe and effective for women with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, according to a study published in the Oct. 6 issue of the New England Journal of Medicine.

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More Minority Patients in Low-Quality, High-Cost Hospitals

THURSDAY, Oct. 6 (HealthDay News) -- Hospitals where the quality is low and costs high (worst hospitals) in the United States care for a higher proportion of elderly black, Hispanic, and Medicaid patients than high-quality, low-cost institutions (best hospitals), according to a study published in the October issue of Health Affairs.

Abstract
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Pre-Op Anemia Ups Mortality After Non-Cardiac Surgery

THURSDAY, Oct. 6 (HealthDay News) -- For patients undergoing non-cardiac surgery, even a mild degree of preoperative anemia is independently associated with an increased risk of 30-day morbidity and mortality, according to a study published online Oct. 6 in The Lancet.

Abstract
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Health Risks for Women Exposed to DES in Utero

WEDNESDAY, Oct. 5 (HealthDay News) -- Women who were exposed in utero to diethylstilbestrol (DES) have a higher lifetime risk for several adverse health outcomes, according to a study published in the Oct. 6 issue of the New England Journal of Medicine.

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Advance Directives Linked to Regional Medical Expenditures

TUESDAY, Oct. 4 (HealthDay News) -- Advance directives (living wills) specifying limitations in end-of-life care are associated with significantly lower levels of Medicare spending, lower likelihood of in-hospital death, and higher use of hospice care during the last six months of life for patients living in regions with high medical expenditures but not in other regions, according to a study published in the Oct. 5 issue of the Journal of the American Medical Association.

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Lower Overall Survival for Men Than Women With Breast Cancer

TUESDAY, Oct. 4 (HealthDay News) -- Male patients with breast cancer have later onset and more advanced disease, and worse overall survival than female patients, according to a study published online Oct. 3 in the Journal of Clinical Oncology.

Abstract
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Breast Cancer Deaths Falling in United States

TUESDAY, Oct. 4 (HealthDay News) -- In the United States, the rate of death from breast cancer has fallen faster for wealthier women than for poor women, who are less likely to get screened for breast cancer, according to a report published online Oct. 3 in CA: A Cancer Journal for Clinicians.

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HPV 16 Diagnostic Tests Vary in Accuracy, Prognostic Value

TUESDAY, Oct. 4 (HealthDay News) -- Diagnostic tests for human papillomavirus-16 (HPV16) in oropharyngeal squamous cell carcinoma (OPSCC) differ in accuracy and prognostic value, with a combination of p16 immunohistochemistry (p16 IHC) and DNA quantitative polymerase chain reaction (qPCR) proving to be the best discriminator of favorable outcome, according to a study published in the Oct. 1 issue of Clinical Cancer Research.

Abstract
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Recent Rise in Oropharyngeal Cancer Incidence Due to HPV

MONDAY, Oct. 3 (HealthDay News) -- The recent increase in population-level incidence and survival of oropharyngeal squamous cell carcinomas (OPSCCs) in the United States from 1984 to 2004 is due to human papillomavirus (HPV) infection, according to a study published online Oct. 3 in the Journal of Clinical Oncology.

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CERT Expression of Prognostic Utility in Breast Cancer

MONDAY, Oct. 3 (HealthDay News) -- Following paclitaxel exposure in breast cancer, multidrug sensitization due to depletion of a ceramide transporter (CERT) augments autophagy, resulting in lysosomal-associated membrane protein 2 (LAMP-2)-dependent death of multinucleated cells, according to a study published online Sept. 26 in The Journal of Pathology.

Abstract
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Sevoflurane Anesthesia Does Not Up Incident Cancer Risk

MONDAY, Oct. 3 (HealthDay News) -- In cancer-free patients who undergo surgery under sevoflurane anesthesia, neither the duration of anesthesia (TANESTH) nor the time measured with the bispectral index (BIS) under 45 (TBIS<45) are associated with the risk of new malignant disease within five years, according to a study published in the October issue of Anesthesia & Analgesia.

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