Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for October 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Preexisting Dementia in Stroke Patients Ups Disability
MONDAY, Oct. 31 (HealthDay News) -- For patients with stroke, preexisting dementia is associated with increased disability at discharge and lower likelihood of being discharged to prestroke domicile, according to a study published in the Nov. 1 issue of Neurology.
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Noncarriers of BRCA Do Not Have Increased Breast CA Risk
MONDAY, Oct. 31 (HealthDay News) -- Women testing negative for their family-specific BRCA1 or BRCA2 mutation (noncarriers) do not have an increased risk of breast cancer, according to a study published online Oct. 31 in the Journal of Clinical Oncology.
Momentary Positive Affect Tied to Improved Survival
MONDAY, Oct. 31 (HealthDay News) -- Positive affect (PA) is associated with survival, with high PA linked to considerably improved survival in older men and women, according to a study published online Oct. 31 in the Proceedings of the National Academy of Sciences.
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Proportion of MELD Exceptions Up From 2002 to 2010
MONDAY, Oct. 31 (HealthDay News) -- The proportion of liver transplant candidates who are model for end-stage liver disease (MELD) exceptions increased from 2002 to 2010, and since April 2005, exceptions have been associated with a reduced risk of wait-list mortality, according to a study published in the November issue of the American Journal of Transplantation.
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Switching From IV to Oral Meds Cuts Health Care Costs
MONDAY, Oct. 31 (HealthDay News) -- For patients who are clinically eligible for oral (PO) medication intake, switching from intravenous (IV) to oral medication can substantially reduce the annual cost of health care, according to a study published online Oct. 17 in Clinical Therapeutics.
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Pre-Op Erythropoietin Reduces Need for Peri-Op Transfusion
MONDAY, Oct. 31 (HealthDay News) -- Preoperative administration of erythropoietin and an iron supplement significantly reduces the requirement for perioperative transfusion in anemic patients undergoing valvular heart surgery, according to a study published in the November issue of Anesthesiology.
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Disc Herniation Symptom Duration Tied to Outcome
MONDAY, Oct. 31 (HealthDay News) -- Longer pretreatment symptom duration from lumbar disc herniation is associated with poorer outcomes after both surgical and nonsurgical intervention, according to a study published in the Oct. 19 issue of The Journal of Bone & Joint Surgery.
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Complete Remission for Many With Nonsyndromic Epilepsy
MONDAY, Oct. 31 (HealthDay News) -- More than half of young patients with nonsyndromic epilepsy (NSE) undergo complete remission, which usually persists, according to a study published in the October issue of the Annals of Neurology.
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Self-Reported Knee Function, Pain Worse Than Doc-Assessed
FRIDAY, Oct. 28 (HealthDay News) -- Following total knee arthroplasty, self-reported American Knee Society pain and function subscores are worse than clinician-assessed scores, but self- and clinician-assessment of the Oxford Knee Score is similar, according to a study published in the Oct. 19 issue of the Journal of Bone and Joint Surgery.
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Thalidomide Effective, Safe in GI Vascular Malformations
FRIDAY, Oct. 28 (HealthDay News) -- For patients with refractory bleeding from gastrointestinal vascular malformations, treatment with thalidomide is effective, according to a study published in the November issue of Gastroenterology.
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ATA: Thyroidectomy Improves Sleep Apnea Symptoms
FRIDAY, Oct. 28 (HealthDay News) -- Surgical reduction or removal of an enlarged thyroid gland improves obstructive sleep apnea (OSA) symptoms, including snoring, according to a study being presented in the annual meeting of the American Thyroid Association, held from Oct. 26 to 30 in Palm Springs, Calif.
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Long-Term Aspirin Use Lowers CRC Risk in Lynch Syndrome
FRIDAY, Oct. 28 (HealthDay News) -- Long-term use of aspirin reduces the risk for colorectal cancer in carriers of Lynch syndrome, according to a study published online Oct. 28 in The Lancet.
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Nonclinical Factors Impact Back Pain Treatment Decisions
FRIDAY, Oct. 28 (HealthDay News) -- Nonclinical factors, including gender, socioeconomic status, and patient presentation, influence physicians' treatment recommendations for acute nonspecific low back pain, with patient presentation the most influential factor, according to a study published in the Nov. 1 issue of Spine.
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Neurogenesis Indicative of Poor Colorectal Cancer Outcomes
FRIDAY, Oct. 28 (HealthDay News) -- Neurogenesis is associated with colorectal cancer progression, and is predictive of poor outcomes for patients, according to a study published in the Nov. 1 issue of Cancer.
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Fecal Assays Help Identify Food Hypersensitivity in IBS
FRIDAY, Oct. 28 (HealthDay News) -- A quarter of patients with irritable bowel syndrome (IBS) have food hypersensitivity (FH), which can be detected using fecal assays; most accurately with eosinophil cationic protein (ECP) assay, according to a study published in the November issue of Clinical Gastroenterology and Hepatology.
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Nipple-Sparing Mastectomy Safe for Selected Patients
FRIDAY, Oct. 28 (HealthDay News) -- Nipple-sparing mastectomy (NSM) can be safe when used for properly-selected women with breast cancer, according to a study published in the November issue of Plastic and Reconstructive Surgery.
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Weight Loss in Obese Tied to Low-Order Cognitive Upturn
FRIDAY, Oct. 28 (HealthDay News) -- Weight loss in obese individuals is associated with low-order significant improvements in executive/attention functioning and memory, according to a meta-analysis published in the November issue of Obesity Reviews.
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IBS Patient-Reported Outcomes Tied to Symptom Severity Ratings
FRIDAY, Oct. 28 (HealthDay News) -- Pain catastrophizing and somatization affect patients' judgments of pain, bloating, and/or bowel habits, which impact patient-reported outcomes (PROs) in irritable bowel syndrome (IBS), according to a study published in the November issue of Clinical Gastroenterology and Hepatology.
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Adipose Tissue Inflammation Tied to Fat Deposition
THURSDAY, Oct. 27 (HealthDay News) -- Subcutaneous adipose tissue (SAT) inflammation is not correlated with gender or ethnicity, and is associated with visceral adipose tissue (VAT) deposition, hepatic fat fraction (HFF), hyperinsulinemia, and stimulation of the nuclear factor-κB (NF-κB) stress pathway, according to a study published in the November issue of Diabetes.
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Cannabinoid Receptor Tied to Cognitive Chaos
THURSDAY, Oct. 27 (HealthDay News) -- Disrupted temporal coordination of hippocampal and medial prefrontal cortical networks (mPFC) due to systemic activation of the cannabinoid receptor is associated with impaired accuracy during working-memory task performance in rats, according to an experimental study published in the Oct. 26 issue of the Journal of Neuroscience.
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Low Income, Less Health Care Spending Ups Stroke Incidence
THURSDAY, Oct. 27 (HealthDay News) -- Lower per-capita gross domestic product and lower total health expenditure per capita are associated with increased stroke incidence, according to a study published online Oct. 27 in Stroke.
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Mice Study: Probiotics Do Not Alter Gut Microbiota Makeup
THURSDAY, Oct. 27 (HealthDay News) -- Consumption of a commercially available probiotic fermented milk product (FMP) does not induce significant changes in gut microbiota composition in human and gnotobiotic mice, but does induce changes in bacterial metabolic pathways, according to an experimental study published online Oct. 26 in Science Translational Medicine.
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Bedside Geriatric Assessment Feasible in Elderly With AML
THURSDAY, Oct. 27 (HealthDay News) -- Inpatient bedside geriatric assessment (GA) is feasible, and is useful for identifying multiple geriatric impairments in elderly patients initiating chemotherapy for acute myelogenous leukemia (AML), according to a study published in the October issue of the Journal of the American Geriatrics Society.
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Gene Variation Tied to Rate of Age-Related Mental Decline
THURSDAY, Oct. 27 (HealthDay News) -- A valine-to-methionine substitution at position 66 (val66met) of brain-derived neurotrophic factor (BDNF) is associated with the rate of decline in skilled task performance and age-dependent hippocampal volume changes in middle-aged and older healthy individuals, according to a study published online Oct. 25 in Translational Psychiatry.
Ovarian Stimulation Ups Risk of Ovarian Tumors in Later Life
THURSDAY, Oct. 27 (HealthDay News) -- Ovarian stimulation for in vitro fertilization (IVF) is associated with an increase in the risk of ovarian malignancies, especially borderline ovarian tumors, according to a study published online Oct. 26 in Human Reproduction.
Obesity Tied to Impaired Immunity After Flu Vaccine
THURSDAY, Oct. 27 (HealthDay News) -- Obese individuals have reduced levels of influenza antibody titers and decreased CD8+ T-cell responses 12 months after influenza vaccination, according to a study published online Oct. 25 in the International Journal of Obesity.
Briakinumab More Effective Than Methotrexate in Psoriasis
THURSDAY, Oct. 27 (HealthDay News) -- For patients with moderate to severe psoriasis, briakinumab is more effective than methotrexate, although serious infections and cancers occur more frequently with briakinumab, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.
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Long-Term Moderate, High Stress Ups Male Mortality Rate
THURSDAY, Oct. 27 (HealthDay News) -- Long-term moderate or high levels of stress in men are associated with higher mortality rates, independent of demographics and health behavior habits, according to a study published in the Journal of Aging Research.
Similar Clinical Impairments for Men, Women Who Binge Eat
THURSDAY, Oct. 27 (HealthDay News) -- Men and women who binge eat suffer similar levels of clinical impairment, despite an underrepresentation of men in treatment studies, according to a study published online Oct. 26 in the International Journal of Eating Disorders.
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Hormonal Alterations Persist One Year After Weight Loss
WEDNESDAY, Oct. 26 (HealthDay News) -- Altered levels of several peripheral hormones involved in the homeostatic regulation of body weight persist more than one year after initial weight reduction, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.
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No Lung Cancer Mortality Drop With Chest X-Ray Screening
WEDNESDAY, Oct. 26 (HealthDay News) -- Annual lung cancer screening with chest radiographs for four years does not significantly decrease lung cancer mortality compared to usual care, according to a study published online Oct. 26 in the Journal of the American Medical Association to coincide with presentation at the annual meeting of the American College of Chest Physicians, held from Oct. 22 to 26 in Honolulu.
qHPV Vaccine Efficacious in Anal Intraepithelial Neoplasia
WEDNESDAY, Oct. 26 (HealthDay News) -- Quadrivalent human papillomavirus (qHPV) vaccine is safe and efficacious against anal intraepithelial neoplasia in men who have sex with men, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.
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Bedtime Medications Offer Better BP Control in CKD
WEDNESDAY, Oct. 26 (HealthDay News) -- For patients with chronic kidney disease (CKD), taking at least one hypertension medication at bedtime results in better blood pressure (BP) control compared to morning medication, according to a study published online Oct. 24 in the Journal of the American Society of Nephrology.
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Small Airway Obstruction Heralds Emphysema in COPD
WEDNESDAY, Oct. 26 (HealthDay News) -- The number of airways with a diameter of 2 to 2.5 mm is significantly reduced in patients with chronic obstructive pulmonary disease (COPD), and the narrowing and disappearance of small-airways precedes emphysematous destruction, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.
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Newer Progestogen Types in the Pill Tied to Higher VTE Risk
WEDNESDAY, Oct. 26 (HealthDay News) -- Women who use oral contraceptives with desogestrel, gestodene, or drospirenone have an increased risk of first-ever venous thromboembolism (VTE), compared to users of oral contraceptives with levonorgestrel, according to a study published online Oct. 25 in BMJ.
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Evidence Suggests Variable Effectiveness for Flu Vaccine
WEDNESDAY, Oct. 26 (HealthDay News) -- Influenza vaccines provide variable effectiveness and efficacy in young children and adults, according to a study published online Oct. 26 in The Lancet Infectious Diseases.
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Smoking Rarely Cited As Cause of Death on Death Certificates
WEDNESDAY, Oct. 26 (HealthDay News) -- Doctors rarely cite smoking as the cause of death (COD) on death certificates, even in cases where there is a strong causal link to smoking, according to a study published online Oct. 24 in the Journal of Clinical Pathology.
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Yoga As Effective As Stretching for Chronic Low Back Pain
WEDNESDAY, Oct. 26 (HealthDay News) -- For primary care patients with chronic low back pain, yoga is as effective as conventional stretching exercises and more effective than a self-care book for improving function and reducing symptoms, according to a study published online Oct. 24 in the Archives of Internal Medicine.
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Ghost Authorship Prevalent in About One-Fifth of Articles
WEDNESDAY, Oct. 26 (HealthDay News) -- The prevalence of articles with honorary authorship, ghost authorship, or both is 21 percent, which marks a significant decrease since 1996, according to a study published online Oct. 25 in BMJ.
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FDA: Xigris Pulled From Global Market
TUESDAY, Oct. 25 (HealthDay News) -- Xigris (drotrecogin alfa [activated]), used in the treatment of patients with severe sepsis, is being voluntarily pulled from the market by its manufacturer, Eli Lilly and Company, after failing to show a survival benefit in these patients, according to a drug safety notification issued Oct. 25 by the U.S. Food and Drug Administration.
Clinical, Genetic Factors Linked to Early Stent Thrombosis
TUESDAY, Oct. 25 (HealthDay News) -- Both genetic and clinical factors are independently associated with early stent thrombosis, according to a study published in the Oct. 26 issue of the Journal of the American Medical Association.
Low-Dose Lung Cancer CT Screens May Help Identify COPD
TUESDAY, Oct. 25 (HealthDay News) -- Low-dose inspiratory and expiratory lung cancer screening computed tomography (CT) scans can be used to identify chronic obstructive pulmonary disease (COPD), according to a study published in the Oct. 26 issue of the Journal of the American Medical Association.
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Mortgage Default Associated With Worse Health Status
TUESDAY, Oct. 25 (HealthDay News) -- Falling behind in mortgage payments is correlated with elevated depressive symptoms, food insecurity, and cost-related medication nonadherence, according to a study published online Oct. 20 in the American Journal of Public Health.
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Radiographic Osteoarthritis Phenotypes Linked to Race
TUESDAY, Oct. 25 (HealthDay News) -- African-Americans are less likely to have hand radiographic osteoarthritis (rOA) phenotypes, but are more likely to have knee rOA phenotypes involving the tibiofemoral joints (TFJ), according to a study published online Oct. 20 in Arthritis & Rheumatism.
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Vandetanib Ups Survival in Medullary Thyroid Carcinoma
TUESDAY, Oct. 25 (HealthDay News) -- Administration of vandetanib to patients with advanced medullary thyroid carcinoma (MTC) improves progression-free survival (PFS) compared to placebo, according to a study published online Oct. 24 in the Journal of Clinical Oncology.
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Capecitabine First-Line Option in Advanced Breast Cancer Therapy
TUESDAY, Oct. 25 (HealthDay News) -- Capecitabine is a good first-line treatment alternative to cyclophosphamide, methotrexate, and fluorouracil (CMF) for some women with advanced breast cancer, according to a study published online Oct. 24 in the Journal of Clinical Oncology.
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New Estimates of Rotavirus-Attributable Diarrhea Mortality
TUESDAY, Oct. 25 (HealthDay News) -- Worldwide in 2008, 453,000 deaths in children younger than 5 years old resulted from diarrhea attributable to rotavirus, according to a meta-analysis published online Oct. 25 in The Lancet Infectious Diseases.
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First Versions of Generic Zyprexa Approved
MONDAY, Oct. 24 (HealthDay News) -- The first generic versions of Zyprexa (olanzapine) have been approved by the U.S. Food and Drug Administration to treat schizophrenia or bipolar disorder, the agency said Monday.
Pre-Op Regimen Tolerable for Esophageal Adenocarcinoma
MONDAY, Oct. 24 (HealthDay News) -- Use of neoadjuvant oxaliplatin, protracted-infusion fluorouracil (PI-FU), and external-beam radiation therapy (EBRT) is tolerable for esophageal adenocarcinoma, but fails to achieve the predefined pathologic complete response (pCR) rate, according to a study published online Oct. 24 in the Journal of Clinical Oncology.
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HPV Infection, Cardiovascular Disease in Women Linked
MONDAY, Oct. 24 (HealthDay News) -- Human papillomavirus (HPV) infection in women, especially tumor-associated oncogenic HPV, is correlated with an increased risk of cardiovascular disease (CVD), according to a study published in the Nov. 1 issue of the Journal of the American College of Cardiology.
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Insomnia Moderately Raises Risk of Myocardial Infarction
MONDAY, Oct. 24 (HealthDay News) -- Insomnia symptoms are associated with a moderate increase in the risk of acute myocardial infarction (AMI), according to a study published online Oct. 24 in Circulation.
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Excision Margin of 2 cm Safe in Melanoma Thicker Than 2 mm
MONDAY, Oct. 24 (HealthDay News) -- For patients with cutaneous melanoma thicker than 2 mm, a surgical excision margin of 2 cm is sufficient and has similar overall survival as with a 4-cm excision margin, according to a study published online Oct. 24 in The Lancet.
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Breast Reconstruction Ups Psychosocial, Sexual Health
MONDAY, Oct. 24 (HealthDay News) -- Women undergoing autologous tissue breast reconstruction experience significant gains in breast satisfaction, and psychological and sexual well-being as early as three weeks post surgery, according to a study published online Oct. 24 in Cancer.
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LABA Use Ups Risk of Serious Asthma Events in Children
MONDAY, Oct. 24 (HealthDay News) -- The use of long acting β²-adrenergic receptor agonists (LABAs) in children increases the risk for an excess of serious asthma-related events, according to a study published online Oct. 24 in Pediatrics.
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Immunotherapy-Chemo Combo Improves Survival in NSCLC
MONDAY, Oct. 24 (HealthDay News) -- For patients with advanced non-small-cell-lung cancer (NSCLC), combining TG4010 immunotherapy with standard chemotherapy improves six-month progression-free survival (PFS), according to a study published online Oct. 22 in The Lancet Oncology.
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Successful Pregnancy Feasible After Kidney Transplantation
MONDAY, Oct. 24 (HealthDay News) -- Pregnancy after kidney transplantation is associated with an increased live birth rate, lower miscarriage rate, and higher rate of complications compared to the general U.S. population, according to a study published online July 27 in the American Journal of Transplantation.
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New Method Improves Renal Transplant Biopsy Accuracy
MONDAY, Oct. 24 (HealthDay News) -- Adding molecular phenotyping to histological classification of kidney transplantation biopsies facilitates more accurate classification of borderline rejection biopsies, and helps eliminate this category in most cases, according to a study published online Oct. 12 in the American Journal of Transplantation.
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High Rate of Elevated BP Post Pediatric Liver Transplant
FRIDAY, Oct. 21 (HealthDay News) -- For children who undergo liver transplant (LT), there is a high prevalence of elevated blood pressure (BP) at five to 10 years post-transplant, and this can be predicted by age at LT, decreased calculated glomerular filtration rate (cGFR), and recent steroid use, according to a study published online Oct. 12 in the American Journal of Transplantation.
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Early Impact of RA on Women's Daily Activities, Occupation
FRIDAY, Oct. 21 (HealthDay News) -- For women with rheumatoid arthritis (RA), daily activities and occupational identity are affected in the first 12 months after diagnosis, according to a study published online Oct. 17 in Arthritis Care & Research.
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CLIP-170 Mediates Paclitaxel Sensitivity in Breast Cancer
FRIDAY, Oct. 21 (HealthDay News) -- CLIP-170 regulates paclitaxel sensitivity in breast cancer cells by mediating the effects of paclitaxel on microtubule assembly, mitosis, and apoptosis, according to a study published online Oct. 12 in The Journal of Pathology.
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Vulvar Lesions Should Always Be Indication for Treatment
FRIDAY, Oct. 20 (HealthDay News) -- Vulvar intraepithelial neoplasia (VIN), a problem that appears to be on the rise in women in their 40s, should always receive treatment, according to a joint committee opinion issued by the American College of Obstetricians and Gynecologists and the American Society for Colposcopy and Cervical Pathology and published in the November issue of Obstetrics & Gynecology.
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Cardiac Troponin Predicts Mortality in Acute Heart Failure
FRIDAY, Oct. 21 (HealthDay News) -- A sensitive cardiac troponin I (s-cTnI) assay can predict mortality risk for patients with acute heart failure, according to a study published online Oct. 11 in the Journal of Internal Medicine.
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Cough Predicts Idiopathic Lung Fibrosis Disease Progression
FRIDAY, Oct. 21 (HealthDay News) -- Cough is common in patients with idiopathic pulmonary fibrosis (IPF), and is an independent predictor of disease progression, according to a study published in the August issue of Respirology.
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Trabecular Bone Texture Predicts Arthritis Progression
FRIDAY, Oct. 21 (HealthDay News) -- Automated analysis of tibial trabecular bone (TB) texture in individuals with or without radiographic knee osteoarthritis shows promise for predicting progressive tibiofemoral joint space loss, according to a study published online Oct. 11 in Arthritis & Rheumatism.
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Letrozole Monotherapy Shows Breast CA Long-Term Benefits
FRIDAY, Oct. 21 (HealthDay News) -- For postmenopausal women with hormone receptor-positive early breast cancer, letrozole monotherapy reduces breast cancer recurrence and mortality in the long-term more effectively than tamoxifen monotherapy, according to a study published online Oct. 21 in The Lancet Oncology.
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No Link Found Between Cell Phone Use and Cancer
FRIDAY, Oct. 21 (HealthDay News) -- In what may be the largest study to date evaluating cancer risk in cell phone subscribers, Danish researchers have found no evidence of increased central nervous system tumor rates in long-term holders of cell phone subscriptions; their findings have been published online Oct. 20 in BMJ.
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Multiple Hormones Influence Breast Cancer Risk
FRIDAY, Oct. 21 (HealthDay News) -- High levels of sex and growth hormones are known to increase the risk of breast cancer, and it appears that other hormones circulating at high levels may also have a profound influence on the likelihood that a woman will develop postmenopausal breast cancer, according to research published online Oct. 21 in Breast Cancer Research.
Ultrasound, Shock Wave Not Effective for Low Back Pain
FRIDAY, Oct. 21 (HealthDay News) -- The available evidence does not support the effectiveness of ultrasound or shock wave for treating low back pain (LBP), according to a review published in the October issue of The Spine Journal.
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Local LV Remodeling Linked to Mitral Regurgitation
FRIDAY, Oct. 21 (HealthDay News) -- For patients with idiopathic dilated cardiomyopathy (IDC) and wide QRS durations, local left ventricular (LV) remodeling contributes toward development of mitral regurgitation (MR), which can be reduced by cardiac resynchronization therapy (CRT), according to a study published in the Nov. 1 issue of The American Journal of Cardiology.
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Article Collection Sheds Light on U.S. Melanoma Trends
THURSDAY, Oct. 20 (HealthDay News) -- Skin cancer is the most common form of cancer in the United States, and melanoma, the third-most common form of skin cancer, may strike more than 45,000 people annually, according to a recent supplement published in the November issue of the Journal of the American Academy of Dermatology.
Social Network Size Associated With Brain Structure
THURSDAY, Oct. 20 (HealthDay News) -- The size of a person's online social network is associated with the gray matter density of specific regions in the brain, and these regions are specific to Web-based networks rather than real-world social networks, according to a study published online Oct. 19 in the Proceedings of the Royal Society B.
Sodium-Sensitive Populations Fail to Curb Intake
THURSDAY, Oct. 20 (HealthDay News) -- Nearly half of all Americans should limit their sodium intake for the sake of their health, but less than 2 percent of those who meet the criteria for sodium limitation actually do so, and most Americans ingest too much sodium, according to research published in the Oct. 21 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
Drug-Eluting Stents With Abnormal ABI Tied to Mortality
THURSDAY, Oct. 20 (HealthDay News) -- For patients undergoing drug-eluting stent (DES) implantation, an abnormal ankle brachial index (ABI) is independently associated with one-year risk of total mortality and cardiovascular mortality, but not with risk of stroke, nonfatal acute coronary syndrome (ACS), or newer revascularization, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.
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3-D CT Useful for Classification of Ligament Ossification
THURSDAY, Oct. 20 (HealthDay News) -- Use of three-dimensional computed tomography (3-D CT) to visualize ossification of the posterior longitudinal ligament (OPLL) can aid with classification of lesions, according to a study published in the October issue of The Spine Journal.
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Intensive Lipid Therapy Lowers Plaque Lipid Content
THURSDAY, Oct. 20 (HealthDay News) -- Significant decreases are observed in carotid plaque lipids after one year of intensive lipid therapy and continue in the second year, according to a study published in the Sept. 1 issue of the Journal of the American College of Cardiology: Cardiovascular Imaging.
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IBD Increases Risk of Post-Op Thromboembolism
THURSDAY, Oct. 20 (HealthDay News) -- Patients with inflammatory bowel disease (IBD) have an increased risk of developing postoperative deep vein thrombosis (DVT) and pulmonary embolism (PE), with a higher risk in those undergoing nonintestinal surgery, according to a study published online Oct. 17 in the Archives of Surgery.
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Platelet-Rich Fibrin Matrix Shots Induce Cellular Changes
THURSDAY, Oct. 20 (HealthDay News) -- Administration of platelet-rich fibrin matrix (PRFM) into the deep dermis and immediate subdermis stimulates cellular changes, including activated fibroblasts, new collagen deposition, new blood vessel development, intradermal adipocyte collection, and subdermal adipocyte stimulation, according to a study published online Oct. 17 in the Archives of Facial Plastic Surgery.
Oropharyngeal Exam Confirms Obstructive Sleep Apnea
THURSDAY, Oct. 20 (HealthDay News) -- The Friedman tongue position (FTP) score on oropharyngeal examination confirms obstructive sleep apnea syndrome (OSAS) and is associated with its severity, according to a study published in the October issue of the Archives of Otolaryngology -- Head & Neck Surgery.
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Low Lethal Potential for Atypical Spitz Tumors
THURSDAY, Oct. 20 (HealthDay News) -- Atypical Spitz tumors (ASTs) are associated with a favorable prognosis, an increased melanoma risk, and a moderate risk of metastasis to regional nodes, according to a study published in the October issue of the Archives of Dermatology.
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Antidepressants Used by About 11 Percent of Americans
WEDNESDAY, Oct. 19 (HealthDay News) -- Approximately one out of 10 Americans aged 12 and over take antidepressant medications, the use of which is most prevalent in women aged 40 to 59, according to an October data brief released by the National Center for Health Statistics (NCHS).
Early Initiation of ART After TB Treatment Ups Survival
WEDNESDAY, Oct. 19 (HealthDay News) -- For patients with HIV and tuberculosis, initiation of antiretroviral therapy (ART) early after starting tuberculosis treatment improves survival in those with CD4+ T-cell counts of less than 50/mm³, according to three studies published in the Oct. 20 issue of the New England Journal of Medicine.
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Neighborhood Poverty Level Linked to Obesity, Diabetes
WEDNESDAY, Oct. 19 (HealthDay News) -- Moving from a neighborhood with a high level of poverty to one with a low level of poverty is associated with a slight reduction in the prevalence of extreme obesity and diabetes, according to a study published in the Oct. 20 issue of the New England Journal of Medicine.
Deletion in ADAM17 Connected to Skin, Bowel Disease
WEDNESDAY, Oct. 19 (HealthDay News) -- A deletion mutation in ADAM17 may be the cause of a neonatal-onset inflammatory skin and bowel disease, according to a study published in the Oct. 20 issue of the New England Journal of Medicine.
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Nicotine Dependence Underdiagnosed in U.S. Vets
WEDNESDAY, Oct. 19 (HealthDay News) -- U.S. veterans are more likely than the general population to have a nicotine dependency, especially if they've struggled with other substances, mental illness, or homelessness, but VA services may be underestimating the scope of the problem, according to research published in the November issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.
Different CD8+ T-Cell Targets in New, Established Diabetes
WEDNESDAY, Oct. 19 (HealthDay News) -- Autoreactive CD8+ T cells specific for preproinsulin (PPI) include central and effector memory cells and show different specificities for epitopes in patients with recent-onset and long-standing type 1 diabetes (T1D), according to a study published online Oct. 13 in Diabetes.
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Erectile Dysfunction After Colorectal CA Poorly Managed
WEDNESDAY, Oct. 19 (HealthDay News) -- Most men who experience erectile dysfunction after treatment for colorectal cancer feel profound distress, do not receive adequate information, and often feel they have been treated poorly by clinicians, according to a study published online Oct. 18 in BMJ.
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Distinct Risks for Superficial Spreading, Lentigo Melanomas
WEDNESDAY, Oct. 19 (HealthDay News) -- Lentigo maligna melanoma (LMM) and superficial spreading melanoma (SSM) have distinct risk profiles, with the strongest determinants of LMM and SSM being the number of solar lentigines and the number of nevi, respectively, according to a study published online Oct. 17 in the Archives of Dermatology.
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H. pylori Not Detected in Hyperplastic Adenoids
WEDNESDAY, Oct. 19 (HealthDay News) -- Helicobacter pylori (H. pylori) and other Helicobacteraceae family members do not majorly contribute toward development of hyperplastic adenoids in children, according to a study published in the October issue of the Archives of Otolaryngology -- Head & Neck Surgery.
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High Resource Use Ups Congenital Heart Surgery Risk
WEDNESDAY, Oct. 19 (HealthDay News) -- Adults with high resource use (HRU) undergoing congenital heart surgery in pediatric hospitals have higher mortality, according to a study published online Oct. 18 in Circulation: Cardiovascular Quality and Outcomes.
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Maternal ACE Inhibitor Use Not Tied to Congenital Defects
WEDNESDAY, Oct. 19 (HealthDay News) -- For pregnant women with hypertension, use of angiotensin-converting enzyme (ACE) inhibitors in the first trimester does not increase the risk of congenital heart defects in offspring compared to no treatment, according to a study published online Oct. 18 in BMJ.
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Heart Failure Hospitalizations Down From 1998 to 2008
TUESDAY, Oct. 18 (HealthDay News) -- Overall heart failure hospitalization rates in the United States declined significantly from 1998 to 2008, with black men showing the lowest rate of decline, according to a study published in the Oct. 19 issue of the Journal of the American Medical Association.
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E-Beam Sterilized Dialyzers Up Risk of Thrombocytopenia
TUESDAY, Oct. 18 (HealthDay News) -- Use of electron-beam (e-beam) sterilized hemodialysis membranes increases the risk of significant thrombocytopenia, according to a study published in the Oct. 19 issue of the Journal of the American Medical Association.
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Readmission Risk Models Display Poor Predictive Ability
TUESDAY, Oct. 18 (HealthDay News) -- Most hospital readmission risk models have poor predictive ability, according to a review published in the Oct. 19 issue of the Journal of the American Medical Association.
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Cardiac Device Lead Removal by Laser Safe for Octogenarians
TUESDAY, Oct. 18 (HealthDay News) -- Laser assisted extraction of leads from implanted cardiac devices (pacemakers and defibrillators) is safe and effective in the octogenarian population, with risks similar to those in the non-octogenarian population, according to a study published online Oct. 17 in Circulation: Arrhythmia and Electrophysiology.
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Addition of Dulanermin Doesn't Improve Outcomes in NSCLC
TUESDAY, Oct. 18 (HealthDay News) -- Addition of dulanermin to paclitaxel and carboplatin (PC) and bevacizumab (PCB) does not improve outcomes for patients with advanced squamous or nonsquamous non-small-cell lung cancer (NSCLC), according to a study published online Oct. 17 in the Journal of Clinical Oncology.
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