Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for October 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Exparel Approved for Post-Surgery Pain
MONDAY, Oct. 31 (HealthDay News) -- Exparel (bupivacaine liposome injectable suspension) has been approved by the U.S. Food and Drug Administration to treat post-surgical pain, maker Pacira Pharmaceuticals said Monday.
Switching From IV to Oral Meds Cuts Health Care Costs
MONDAY, Oct. 31 (HealthDay News) -- For patients who are clinically eligible for oral (PO) medication intake, switching from intravenous (IV) to oral medication can substantially reduce the annual cost of health care, according to a study published online Oct. 17 in Clinical Therapeutics.
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Complete Remission for Many With Nonsyndromic Epilepsy
MONDAY, Oct. 31 (HealthDay News) -- More than half of young patients with nonsyndromic epilepsy (NSE) undergo complete remission, which usually persists, according to a study published in the October issue of the Annals of Neurology.
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Pre-Op Erythropoietin Reduces Need for Peri-Op Transfusion
MONDAY, Oct. 31 (HealthDay News) -- Preoperative administration of erythropoietin and an iron supplement significantly reduces the requirement for perioperative transfusion in anemic patients undergoing valvular heart surgery, according to a study published in the November issue of Anesthesiology.
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S100A10 Key for Recruitment of Macrophages to Tumor Sites
MONDAY, Oct. 31 (HealthDay News) -- The plasminogen receptor S100A10 is involved in facilitating movement of macrophages to tumor sites, according to an experimental study published online Oct. 31 in Cancer Research.
Universal Teen Substance Use Approach Recommended
MONDAY, Oct. 31 (HealthDay News) -- The American Academy of Pediatrics recommends implementing universal screening for substance use, brief intervention, and/or referral to treatment (SBIRT) in order to help pediatricians treat substance use in adolescents, according to a scientific statement published online Oct. 31 in Pediatrics.
Thalidomide Effective, Safe in GI Vascular Malformations
FRIDAY, Oct. 28 (HealthDay News) -- For patients with refractory bleeding from gastrointestinal vascular malformations, treatment with thalidomide is effective, according to a study published in the November issue of Gastroenterology.
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Long-Term Aspirin Use Lowers CRC Risk in Lynch Syndrome
FRIDAY, Oct. 28 (HealthDay News) -- Long-term use of aspirin reduces the risk for colorectal cancer in carriers of Lynch syndrome, according to a study published online Oct. 28 in The Lancet.
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Nonclinical Factors Impact Back Pain Treatment Decisions
FRIDAY, Oct. 28 (HealthDay News) -- Nonclinical factors, including gender, socioeconomic status, and patient presentation, influence physicians' treatment recommendations for acute nonspecific low back pain, with patient presentation the most influential factor, according to a study published in the Nov. 1 issue of Spine.
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Study Finds Statins Don't Slow Atherosclerosis in Pediatric SLE
THURSDAY, Oct. 27 (HealthDay News) -- Atorvastatin therapy for three years has no significant effect on atherosclerosis progression, as measured by mean-mean common carotid intima-media thickening (CIMT), in a pediatric population with systemic lupus erythematosus (SLE), according to a study published online Oct. 26 in Arthritis & Rheumatism.
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Cannabinoid Receptor Tied to Cognitive Chaos
THURSDAY, Oct. 27 (HealthDay News) -- Disrupted temporal coordination of hippocampal and medial prefrontal cortical networks (mPFC) due to systemic activation of the cannabinoid receptor is associated with impaired accuracy during working-memory task performance in rats, according to an experimental study published in the Oct. 26 issue of the Journal of Neuroscience.
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CDC to Discontinue Provision of Botulinum Toxoid Vaccine
THURSDAY, Oct. 27 (HealthDay News) -- The U.S. Centers for Disease Control and Prevention will stop providing botulinum toxoid (PBT) for the vaccination of people whose occupations put them at risk for exposure to botulinum serotypes A, B, C, D, and E, according to a report published in the Oct. 28 issue of the CDC's Morbidity and Mortality Weekly Report.
Bedside Geriatric Assessment Feasible in Elderly With AML
THURSDAY, Oct. 27 (HealthDay News) -- Inpatient bedside geriatric assessment (GA) is feasible, and is useful for identifying multiple geriatric impairments in elderly patients initiating chemotherapy for acute myelogenous leukemia (AML), according to a study published in the October issue of the Journal of the American Geriatrics Society.
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Briakinumab More Effective Than Methotrexate in Psoriasis
THURSDAY, Oct. 27 (HealthDay News) -- For patients with moderate to severe psoriasis, briakinumab is more effective than methotrexate, although serious infections and cancers occur more frequently with briakinumab, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.
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Ovarian Stimulation Ups Risk of Ovarian Tumors in Later Life
THURSDAY, Oct. 27 (HealthDay News) -- Ovarian stimulation for in vitro fertilization (IVF) is associated with an increase in the risk of ovarian malignancies, especially borderline ovarian tumors, according to a study published online Oct. 26 in Human Reproduction.
Obesity Tied to Impaired Immunity After Flu Vaccine
THURSDAY, Oct. 27 (HealthDay News) -- Obese individuals have reduced levels of influenza antibody titers and decreased CD8+ T-cell responses 12 months after influenza vaccination, according to a study published online Oct. 25 in the International Journal of Obesity.
Bedtime Medications Offer Better BP Control in CKD
WEDNESDAY, Oct. 26 (HealthDay News) -- For patients with chronic kidney disease (CKD), taking at least one hypertension medication at bedtime results in better blood pressure (BP) control compared to morning medication, according to a study published online Oct. 24 in the Journal of the American Society of Nephrology.
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qHPV Vaccine Efficacious in Anal Intraepithelial Neoplasia
WEDNESDAY, Oct. 26 (HealthDay News) -- Quadrivalent human papillomavirus (qHPV) vaccine is safe and efficacious against anal intraepithelial neoplasia in men who have sex with men, according to a study published in the Oct. 27 issue of the New England Journal of Medicine.
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Ghost Authorship Prevalent in About One-Fifth of Articles
WEDNESDAY, Oct. 26 (HealthDay News) -- The prevalence of articles with honorary authorship, ghost authorship, or both is 21 percent, which marks a significant decrease since 1996, according to a study published online Oct. 25 in BMJ.
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Evidence Suggests Variable Effectiveness for Flu Vaccine
WEDNESDAY, Oct. 26 (HealthDay News) -- Influenza vaccines provide variable effectiveness and efficacy in young children and adults, according to a study published online Oct. 26 in The Lancet Infectious Diseases.
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Newer Progestogen Types in the Pill Tied to Higher VTE Risk
WEDNESDAY, Oct. 26 (HealthDay News) -- Women who use oral contraceptives with desogestrel, gestodene, or drospirenone have an increased risk of first-ever venous thromboembolism (VTE), compared to users of oral contraceptives with levonorgestrel, according to a study published online Oct. 25 in BMJ.
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Clinical, Genetic Factors Linked to Early Stent Thrombosis
TUESDAY, Oct. 25 (HealthDay News) -- Both genetic and clinical factors are independently associated with early stent thrombosis, according to a study published in the Oct. 26 issue of the Journal of the American Medical Association.
FDA: Xigris Pulled From Global Market
TUESDAY, Oct. 25 (HealthDay News) -- Xigris (drotrecogin alfa [activated]), used in the treatment of patients with severe sepsis, is being voluntarily pulled from the market by its manufacturer, Eli Lilly and Company, after failing to show a survival benefit in these patients, according to a drug safety notification issued Oct. 25 by the U.S. Food and Drug Administration.
CDC Recommends HPV Vaccination in Males
TUESDAY, Oct. 25 (HealthDay News) -- Young males should receive routine vaccination against human papillomavirus (HPV), according to a recommendation announced Oct. 25 by the U.S. Centers for Disease Control and Prevention.
Vandetanib Ups Survival in Medullary Thyroid Carcinoma
TUESDAY, Oct. 25 (HealthDay News) -- Administration of vandetanib to patients with advanced medullary thyroid carcinoma (MTC) improves progression-free survival (PFS) compared to placebo, according to a study published online Oct. 24 in the Journal of Clinical Oncology.
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Capecitabine First-Line Option in Advanced Breast Cancer Therapy
TUESDAY, Oct. 25 (HealthDay News) -- Capecitabine is a good first-line treatment alternative to cyclophosphamide, methotrexate, and fluorouracil (CMF) for some women with advanced breast cancer, according to a study published online Oct. 24 in the Journal of Clinical Oncology.
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First Versions of Generic Zyprexa Approved
MONDAY, Oct. 24 (HealthDay News) -- The first generic versions of Zyprexa (olanzapine) have been approved by the U.S. Food and Drug Administration to treat schizophrenia or bipolar disorder, the agency said Monday.
Pre-Op Regimen Tolerable for Esophageal Adenocarcinoma
MONDAY, Oct. 24 (HealthDay News) -- Use of neoadjuvant oxaliplatin, protracted-infusion fluorouracil (PI-FU), and external-beam radiation therapy (EBRT) is tolerable for esophageal adenocarcinoma, but fails to achieve the predefined pathologic complete response (pCR) rate, according to a study published online Oct. 24 in the Journal of Clinical Oncology.
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Onfi Approved to Treat Severe Seizures
MONDAY, Oct. 24 (HealthDay News) -- Onfi (clobazam) tablets have been approved by the U.S. Food and Drug Administration as an add-on treatment for severe seizures associated with Lennox-Gastaut syndrome in people 2 years and older, the agency said Monday in a news release.
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LABA Use Ups Risk of Serious Asthma Events in Children
MONDAY, Oct. 24 (HealthDay News) -- The use of long acting β²-adrenergic receptor agonists (LABAs) in children increases the risk for an excess of serious asthma-related events, according to a study published online Oct. 24 in Pediatrics.
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Immunotherapy-Chemo Combo Improves Survival in NSCLC
MONDAY, Oct. 24 (HealthDay News) -- For patients with advanced non-small-cell-lung cancer (NSCLC), combining TG4010 immunotherapy with standard chemotherapy improves six-month progression-free survival (PFS), according to a study published online Oct. 22 in The Lancet Oncology.
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CLIP-170 Mediates Paclitaxel Sensitivity in Breast Cancer
FRIDAY, Oct. 21 (HealthDay News) -- CLIP-170 regulates paclitaxel sensitivity in breast cancer cells by mediating the effects of paclitaxel on microtubule assembly, mitosis, and apoptosis, according to a study published online Oct. 12 in The Journal of Pathology.
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Dopamine Polymorphisms Tied to Methylphenidate Response
FRIDAY, Oct. 21 (HealthDay News) -- Dopamine transporter (DAT) and dopamine receptor D4 (DRD4) polymorphisms may be correlated with dose-response variability to methylphenidate (MPH) in children with attention-deficit/hyperactivity disorder (ADHD), according to a study published online Sept. 19 in the Journal of the American Academy of Child & Adolescent Psychiatry.
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Letrozole Monotherapy Shows Breast CA Long-Term Benefits
FRIDAY, Oct. 21 (HealthDay News) -- For postmenopausal women with hormone receptor-positive early breast cancer, letrozole monotherapy reduces breast cancer recurrence and mortality in the long-term more effectively than tamoxifen monotherapy, according to a study published online Oct. 21 in The Lancet Oncology.
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Postnatal Steroids Mar Preterm Infant Cerebellar Growth
THURSDAY, Oct. 20 (HealthDay News) -- Postnatal glucocorticoid exposure increases the risk of cerebellar growth impairment in preterm neonates; and a small molecular agonist of the Sonic hedgehog-Smoothened (Shh-Smo) signaling pathway (SAG) protects against postnatal glucocorticoid-induced cerebellar injury in neonatal mice, according to two studies published in the Oct. 19 issue of Science Translational Medicine.
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Tdap Vaccinations Recommended for Families With Newborns
THURSDAY, Oct. 20 (HealthDay News) -- Infants 2 years old and younger cannot be vaccinated against pertussis, so other strategies are needed to protect this age group from the potentially fatal condition; therefore, tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) booster vaccines are being recommended for those who have close contact with infants, according to a report published in the Oct. 21 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
Drug-Eluting Stents With Abnormal ABI Tied to Mortality
THURSDAY, Oct. 20 (HealthDay News) -- For patients undergoing drug-eluting stent (DES) implantation, an abnormal ankle brachial index (ABI) is independently associated with one-year risk of total mortality and cardiovascular mortality, but not with risk of stroke, nonfatal acute coronary syndrome (ACS), or newer revascularization, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.
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Intensive Lipid Therapy Lowers Plaque Lipid Content
THURSDAY, Oct. 20 (HealthDay News) -- Significant decreases are observed in carotid plaque lipids after one year of intensive lipid therapy and continue in the second year, according to a study published in the Sept. 1 issue of the Journal of the American College of Cardiology: Cardiovascular Imaging.
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Antidepressants Used by About 11 Percent of Americans
WEDNESDAY, Oct. 19 (HealthDay News) -- Approximately one out of 10 Americans aged 12 and over take antidepressant medications, the use of which is most prevalent in women aged 40 to 59, according to an October data brief released by the National Center for Health Statistics (NCHS).
Early Initiation of ART After TB Treatment Ups Survival
WEDNESDAY, Oct. 19 (HealthDay News) -- For patients with HIV and tuberculosis, initiation of antiretroviral therapy (ART) early after starting tuberculosis treatment improves survival in those with CD4+ T-cell counts of less than 50/mm³, according to three studies published in the Oct. 20 issue of the New England Journal of Medicine.
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Maternal ACE Inhibitor Use Not Tied to Congenital Defects
WEDNESDAY, Oct. 19 (HealthDay News) -- For pregnant women with hypertension, use of angiotensin-converting enzyme (ACE) inhibitors in the first trimester does not increase the risk of congenital heart defects in offspring compared to no treatment, according to a study published online Oct. 18 in BMJ.
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Adjuvant S-1 Improves Five-Year Outcomes in Gastric Cancer
WEDNESDAY, Oct. 19 (HealthDay News) -- Postoperative adjuvant therapy with oral fluoropyrimidine derivative, S-1, improves overall and relapse-free survival at five years in patients with stage II or III gastric cancer who undergo D2 gastrectomy, according to a study published online Oct. 17 in the Journal of Clinical Oncology.
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Readmission Risk Models Display Poor Predictive Ability
TUESDAY, Oct. 18 (HealthDay News) -- Most hospital readmission risk models have poor predictive ability, according to a review published in the Oct. 19 issue of the Journal of the American Medical Association.
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Addition of Dulanermin Doesn't Improve Outcomes in NSCLC
TUESDAY, Oct. 18 (HealthDay News) -- Addition of dulanermin to paclitaxel and carboplatin (PC) and bevacizumab (PCB) does not improve outcomes for patients with advanced squamous or nonsquamous non-small-cell lung cancer (NSCLC), according to a study published online Oct. 17 in the Journal of Clinical Oncology.
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Topotecan Induction Feasible for High-Risk Neuroblastoma
TUESDAY, Oct. 18 (HealthDay News) -- Addition of dose-intensive topotecan and cyclophosphamide to induction therapy is feasible for patients with newly diagnosed high-risk neuroblastoma (HRNB), according to a study published online Oct. 17 in the Journal of Clinical Oncology.
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Exercise Shows Potential for Migraine Prophylaxis
MONDAY, Oct. 17 (HealthDay News) -- Exercising for 40 minutes three times a week shows similar efficacy for preventing migraines as topiramate, or relaxation, according to a study published in the October issue of Cephalalgia.
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Aspirin Response in Acute Coronary Syndrome Up Post PCI
FRIDAY, Oct. 14 (HealthDay News) -- The laboratory response to aspirin improves significantly in patients with acute coronary syndrome (ACS) following percutaneous coronary intervention (PCI) and clopidogrel loading, and correlates with improved clinical outcomes, according to a study published in the Oct. 15 issue of The American Journal of Cardiology.
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Patients Remain Seizure-Free Long After Epilepsy Surgery
FRIDAY, Oct. 14 (HealthDay News) -- Approximately half of patients with refractory focal epilepsy who undergo surgery remain seizure-free in the long term following epilepsy surgery, with seizure recurrence varying with the type of surgery, according to a study published in the Oct. 15 issue of The Lancet.
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No Effect of Prophylaxis Type on Pulmonary Embolism Rate
FRIDAY, Oct. 14 (HealthDay News) -- The rate of pulmonary embolism after total hip arthroplasty does not differ by the type of prophylaxis or anesthesia used, according to a study published in the Oct. 5 issue of The Journal of Bone & Joint Surgery.
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Pediatric Asthma Drug Prescriptions on the Upswing
THURSDAY, Oct. 13 (HealthDay News) -- Among children, the use of medications to control asthma nearly doubled in the last decade, while costs associated with all asthma medications more than quadrupled, according to a September statistical brief published by the Agency for Healthcare Research and Quality (AHRQ).
Vitamin D Dependent Pathway Key in Immunity Against TB
THURSDAY, Oct. 13 (HealthDay News) -- Interferon-γ (IFN-γ) released by T cells induces multiple macrophage responses to Mycobacterium tuberculosis in in a vitamin D-dependent pathway, according to a study published in the Oct. 12 issue of Science Translational Medicine.
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Polytherapy With Valproate Ups Fetal Malformation Risk
WEDNESDAY, Oct. 12 (HealthDay News) -- The risk of malformations among infants born to women exposed to antiepileptic drug (AED) polytherapy with carbamazepine or lamotrigine in their first trimester is significantly higher than the risk for those treated with the corresponding monotherapies, but only when valproate is included in the polytherapy, according to a study published in the October issue of the Archives of Neurology.
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Flu Vaccine With Adjuvant MF59 Efficacious in Infants
WEDNESDAY, Oct. 12 (HealthDay News) -- Administration of trivalent inactivated influenza vaccine (TIV) with the oil-in-water-based adjuvant MF59 is efficacious against confirmed influenza in young children and infants, according to a study published in the Oct. 13 issue of the New England Journal of Medicine.
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Long-Term Vitamin E Use Increases Prostate Cancer Risk
WEDNESDAY, Oct. 12 (HealthDay News) -- Long-term vitamin E supplementation is associated with an increased risk of prostate cancer in healthy men, according to a study published in the Oct. 12 issue of the Journal of the American Medical Association.
Financial Conflicts of Interest Prevalent, Under-Reported
WEDNESDAY, Oct. 12 (HealthDay News) -- Conflicts of interest (COI) are prevalent among members and chairs of guideline panels, and are under-reported, according to a study published online Oct. 11 in BMJ.
Prenatal Folic Acid Cuts Severe Language Delay in Offspring
WEDNESDAY, Oct. 12 (HealthDay News) -- Maternal use of prenatal folic acid supplementation before conception and in early pregnancy is correlated with a reduced risk of severe language delay in offspring at age 3 years, according to a study published in the Oct. 12 issue of the Journal of the American Medical Association.
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Gantenerumab Lowers Brain Amyloid Levels in Alzheimer's
TUESDAY, Oct. 11 (HealthDay News) -- Gantenerumab therapy induces dose-dependent reduction of brain amyloid levels in patients with Alzheimer's disease (AD), possibly by phagocytosis, according to a study published online Oct. 10 in the Archives of Neurology.
Leukemia Drug May Cause Pulmonary Arterial Hypertension
TUESDAY, Oct. 11 (HealthDay News) -- Sprycel (dasatinib), a drug administered to certain leukemia patients, may increase the rare but serious risk of pulmonary arterial hypertension (PAH), according to an Oct. 11 safety announcement from the U.S. Food and Drug Administration.
Colon Inflammation Markers Lower With Ginger Extract
TUESDAY, Oct. 11 (HealthDay News) -- For individuals at normal risk for colon cancer, ginger extract may decrease certain markers of colon inflammation, including prostaglandin E2 (PGE2) and 5-, 12-, and 15-hydroxyeicosatetraenoic acid (5-, 12-, and 15-HETE), when the eicosanoids are normalized to free arachidonic acid, according to a study published online Oct. 11 in Cancer Prevention Research.
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Some Dietary Supplements Up Mortality Risk in Older Women
TUESDAY, Oct. 11 (HealthDay News) -- Intake of certain common dietary vitamin and mineral supplements among older women is associated with increased mortality risk, according to a study published in the Oct. 10 issue of the Archives of Internal Medicine.
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Fludarabine, Alemtuzumab Combo Ups Survival in CLL
TUESDAY, Oct. 11 (HealthDay News) -- The use of fludarabine plus alemtuzumab in patients with previously treated chronic lymphocytic leukemia (CLL) results in better survival, but is associated with more adverse events (AEs) than fludarabine monotherapy, according to a study published online Oct. 11 in The Lancet Oncology.
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High Yield of Viral Diagnoses for RT-PCR in Respiratory Infection
TUESDAY, Oct. 11 (HealthDay News) -- Real-time polymerase chain reaction (RT-PCR) testing has a high yield of viral diagnoses, but rapid communication of results to clinicians has no positive impact on hospital admissions, length of hospital stay, or duration of antibiotic use for children with acute respiratory infections (ARI), according to a study published online Oct. 10 in Pediatrics.
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Septicemia Most Costly Reason for Hospitalization in 2009
MONDAY, Oct. 10 (HealthDay News) -- Septicemia was the single most expensive condition treated in U.S. hospitals in 2009, with expenditure totaling nearly $15.4 billion, according to an October statistical brief based on Healthcare Cost and Utilization Project (HCUP) data published by the Agency for Healthcare Research and Quality (AHRQ).
High Chocolate Consumption Tied to Lower Risk of Stroke
MONDAY, Oct. 10 (HealthDay News) -- Consumption of high levels of chocolate is associated with a reduced risk of stroke, according to a letter published in the Oct. 18 issue of the Journal of the American College of Cardiology.
Natalizumab Effective for Relapsing-Remitting MS
MONDAY, Oct. 10 (HealthDay News) -- Natalizumab (NTZ) is well tolerated and reduces relapses and disability at two years in patients with relapsing-remitting multiple sclerosis (RRMS), according to a review published online Oct. 5 in the Cochrane Database of Systematic Reviews.
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Improved Virologic Response After Triple Class Failure in HIV
MONDAY, Oct. 10 (HealthDay News) -- There has been a considerable improvement in viral load suppression and a decrease in the rate of AIDS for patients with HIV who had triple-class virological failure (TCVF) with the three original classes of antiretroviral drugs between 2000 and 2009, according to a study published online Oct. 10 in The Lancet Infectious Diseases.
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Upfront Zoledronic Acid Ups Bone Density in Breast Cancer
MONDAY, Oct. 10 (HealthDay News) -- For postmenopausal women with early breast cancer receiving aromatase inhibitors, treatment with upfront adjuvant zoledronic acid significantly increases bone mineral density (BMD) compared to delayed-start treatment, according to a study published online Oct. 10 in Cancer.
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Juvisync Approved for Type 2 Diabetics With High Cholesterol
FRIDAY, Oct. 7 (HealthDay News) -- Juvisync (sitagliptin and simvastatin) has been approved by the U.S. Food and Drug Administration for people with type 2 diabetes who also have high cholesterol.
Infliximab Improves Clinical Outcome in Ulcerative Colitis
FRIDAY, Oct. 7 (HealthDay News) -- For patients with ulcerative colitis treated with infliximab, mucosal healing after eight weeks is associated with improved long-term clinical outcomes and a reduced likelihood of progressing to colectomy, according to a study published in the October issue of Gastroenterology.
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Cialis Approved to Treat Benign Prostatic Hyperplasia
FRIDAY, Oct. 7 (HealthDay News) -- The erectile dysfunction drug Cialis (tadalafil) has received new approval from the U.S. Food and Drug Administration to treat benign prostatic hyperplasia (BPH).
Anti-TNF-α Use Cuts Diabetes Risk in Rheumatoid Arthritis
FRIDAY, Oct. 7 (HealthDay News) -- Patients with rheumatoid arthritis (RA) who are treated with anti-tumor necrosis factor-α (TNF-α) therapy have a reduced risk of developing diabetes, according to a study published online Oct. 3 in Arthritis Care & Research.
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Use of Oral Steroids Linked to Vitamin D Deficiency
THURSDAY, Oct. 6 (HealthDay News) -- The use of oral steroids is associated with serum 25-hydroxyvitamin D (25[OH]D) deficiency, according to a study published online Sept. 28 in the Journal of Clinical Endocrinology & Metabolism.
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Prolonged Exposure, Cognitive Therapy Prevent Chronic PTSD
THURSDAY, Oct. 6 (HealthDay News) -- Prolonged exposure (PE), delayed PE, and cognitive therapy (CT) reduce the prevalence of chronic post-traumatic stress disorder (PTSD) in survivors of traumatic events, according to a study published online Oct. 3 in the Archives of General Psychiatry.
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Nonanthracycline Trastuzumab Regimen Safe and Effective
THURSDAY, Oct. 6 (HealthDay News) -- A nonanthracycline regimen with adjuvant trastuzumab is safe and effective for women with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, according to a study published in the Oct. 6 issue of the New England Journal of Medicine.
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More Minority Patients in Low-Quality, High-Cost Hospitals
THURSDAY, Oct. 6 (HealthDay News) -- Hospitals where the quality is low and costs high (worst hospitals) in the United States care for a higher proportion of elderly black, Hispanic, and Medicaid patients than high-quality, low-cost institutions (best hospitals), according to a study published in the October issue of Health Affairs.
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Oral Acyclovir Improves Outcomes in Neonatal Herpes
THURSDAY, Oct. 6 (HealthDay News) -- The neurodevelopmental outcomes in neonates with herpes simplex virus (HSV) infection and central nervous system (CNS) involvement improve with six months of acyclovir suppressive therapy, according to a study published in the Oct. 6 issue of the New England Journal of Medicine.
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Oral Teriflunomide Effective in Relapsing Multiple Sclerosis
WEDNESDAY, Oct. 5 (HealthDay News) -- For patients with relapsing multiple sclerosis (MS), oral teriflunomide significantly reduces relapse rates, disability progression, and magnetic resonance imaging (MRI) evidence of disease, according to a study published in the Oct. 6 issue of the New England Journal of Medicine.
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Health Risks for Women Exposed to DES in Utero
WEDNESDAY, Oct. 5 (HealthDay News) -- Women who were exposed in utero to diethylstilbestrol (DES) have a higher lifetime risk for several adverse health outcomes, according to a study published in the Oct. 6 issue of the New England Journal of Medicine.
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Feasible to Stop Post-Renal Transplant Anti-Rejection Meds
WEDNESDAY, Oct. 5 (HealthDay News) -- Most patients undergoing human leukocyte antigen (HLA)-matched kidney-transplantation are able to discontinue anti-rejection medications, after receiving enriched CD34+ hematopoietic progenitor cells, total lymphoid irradiation, and anti-T-cell antibodies, according to a letter published in the Oct. 6 issue of the New England Journal of Medicine.
High Children's Asthma Care Compliance in Peds Hospitals
TUESDAY, Oct. 4 (HealthDay News) -- For children admitted with asthma to pediatric hospitals, there are high levels of hospital compliance with Children's Asthma Care (CAC) quality measures for receiving asthma relievers (CAC-1) and systemic corticosteroids (CAC-2), and moderate compliance for discharge with a home-management care plan (CAC-3), according to a study published in the Oct. 5 issue of the Journal of the American Medical Association.
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Hormonal Contraceptives May Up HIV-1 Acquisition by Women
TUESDAY, Oct. 4 (HealthDay News) -- Use of hormonal contraceptives is associated with an increased risk of HIV-1 acquisition by women, and an increased risk of HIV-1 transmission from HIV-infected women to HIV-1 seronegative men, according to a study published online Oct. 4 in The Lancet Infectious Diseases.
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Prior DNA Priming Ups Influenza Vaccine Effectiveness
TUESDAY, Oct. 4 (HealthDay News) -- H5-DNA priming 24 weeks prior to H5N1 monovalent inactivated vaccine (MIV) is safe, enhances H5-specific antibody titers, and induces protective hemagglutination inhibition (HAI) titers, according to a study published online Oct. 4 in The Lancet Infectious Diseases.
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CERT Expression of Prognostic Utility in Breast Cancer
MONDAY, Oct. 3 (HealthDay News) -- Following paclitaxel exposure in breast cancer, multidrug sensitization due to depletion of a ceramide transporter (CERT) augments autophagy, resulting in lysosomal-associated membrane protein 2 (LAMP-2)-dependent death of multinucleated cells, according to a study published online Sept. 26 in The Journal of Pathology.
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About One in 10 Parents Use Alternate Vaccination Schedule
MONDAY, Oct. 3 (HealthDay News) -- More than 10 percent of parents of young children follow an alternative vaccination schedule for their child, and approximately a quarter of parents think delaying vaccines is safer or disagree with the recommended schedule, according to a study published online Oct. 3 in Pediatrics.
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Flibanserin Effective Therapy for Hypoactive Sexual Desire
MONDAY, Oct. 3 (HealthDay News) -- Flibanserin is a safe and effective treatment for premenopausal women with hypoactive sexual desire disorder (HSDD), according to a study published online Sept. 20 in The Journal of Sexual Medicine.
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