Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Family Medicine | Internal Medicine | Critical Care | Emergency Medicine | Neurology | Nursing | Psychiatry | Surgery | Anesthesiology & Pain | Journal

Back to Journal Articles

Brain Hypoxia Tied to Poor Post-Traumatic Injury Outcome

Last Updated: November 11, 2011.

 

Indicative of poor prognosis independent of intracranial, perfusion pressures, severity of injury

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Brain hypoxia, or reduced brain oxygen, is independently associated with poor short-term outcomes in severe traumatic brain injury, according to a study published in the November issue of Neurosurgery.

FRIDAY, Nov. 11 (HealthDay News) -- Brain hypoxia (BH), or reduced brain oxygen (Pbto2), is independently associated with poor short-term outcomes in severe traumatic brain injury (TBI), according to a study published in the November issue of Neurosurgery.

Mauro Oddo, M.D., from the University of Pennsylvania Medical Center in Philadelphia, and colleagues analyzed the relationship between Pbto2, intracranial pressure (ICP), and cerebral perfusion pressure (CPP). A total of 103 patients with TBI who had more than 24 hours of ICP and Pbto2 monitoring were selected. The duration of BH, ICP greater than 20 mm Hg, and CPP less than 60 mm Hg were calculated and their correlations with outcome within 30 days were evaluated.

The investigators found that patients with unfavorable outcomes (Glasgow Coma Scale score, 1 to 3) had significantly longer duration of BH than those with favorable outcomes (Glasgow Coma Scale score, 4 to 5). For patients with intracranial hypertension, BH was associated with significantly fewer favorable outcomes (46 versus 81 percent). Compared to patients with low CPP and normal Pbto2, those with low CPP and BH had a significantly reduced likelihood of having a favorable outcome (39 versus 83 percent). BH was significantly and independently associated with poor prognosis after controlling for ICP, CPP, age, Glasgow Coma Scale score, Marshall computed tomography grade, and Acute Physiology and Chronic Health Evaluation II score (adjusted odds ratio for favorable outcome, 0.89 per hour of BH).

"BH is associated with poor short-term outcome after severe TBI independently of elevated ICP, low CPP, and injury severity," the authors write.

Two of the study authors disclosed financial ties to Integra Lifesciences.

Abstract
Full Text

Copyright © 2011 HealthDay. All rights reserved.


Previous: Methamphetamine Linked to Increased Schizophrenia Risk Next: Recurrent Pelvic Inflammation Ups Infertility, Pelvic Pain

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.