Create Account | Sign In: Author or Forum

 
 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 

 Headlines:

 

Category: Family Medicine | Gastroenterology | Internal Medicine | Critical Care | Emergency Medicine | Nursing | Pharmacy | Anesthesiology & Pain | Journal

Back to Journal Articles

Staggered Acetaminophen Overdose Tied to Poor Outcome

Last Updated: November 23, 2011.

 

Delayed presentation after overdose associated with death/liver transplantation

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Staggered acetaminophen overdose and delayed presentation after overdose are associated with adverse outcomes, according to a study published online Nov. 23 in the British Journal of Clinical Pharmacology.

WEDNESDAY, Nov. 23 (HealthDay News) -- Staggered acetaminophen overdose and delayed presentation after overdose are associated with adverse outcomes, according to a study published online Nov. 23 in the British Journal of Clinical Pharmacology.

Darren G.N. Craig, from the Royal Infirmary of Edinburgh in the United Kingdom, and colleagues examined the clinical impact of staggered acetaminophen overdoses and delayed presentation after an overdose. A total of 663 patients were admitted with acetaminophen-induced severe liver injury between 1992 and 2008, of whom 161 patients had taken a staggered overdose.

The investigators found that, compared with single time-point overdose patients, staggered overdose patients were significantly older and had a greater likelihood of alcohol abuse. They were also more likely to be encephalopathic on admission and to need mechanical ventilation or renal replacement therapy. Staggered overdose patients had significantly higher mortality rates (37.3 versus 27.8 percent), despite lower total ingested acetaminophen doses and lower admission serum alanine aminotransferase levels. However, staggered overdose was not an independent predictor of death. The most frequent reason for repeated supratherapeutic ingestion was relief of pain (58.2 percent). A total of 44.9 percent of single time-point overdose patients accessed medical services more than 24 hours after an overdose, with such delayed presentation being independently correlated with death/liver transplantation (odds ratio, 2.25).

"Both delayed presentation and staggered overdose pattern are associated with adverse outcomes following [acetaminophen] overdose. These patients are at increased risk of developing multiorgan failure," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2011 HealthDay. All rights reserved.


Previous: Recent Drop Seen in Oral, Pharyngeal Cancer Mortality Next: Prolonged LDL-Lowering Statin Treatment Beneficial, Safe

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

  • Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.