Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for November 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
IL-2 Tied to Regulatory T-Cell Expansion in Graft-Versus-Host
WEDNESDAY, Nov. 30 (HealthDay News) -- Daily low-dose interleukin-2 is safe and induces regulatory T (Treg) cell expansion with suppression of clinical manifestations in patients with chronic graft-versus-host disease (GVHD), and is also associated with Treg recovery and clinical improvement in patients with hepatitis C virus (HCV)-induced vasculitis, according to two studies published in the Dec. 1 issue of the New England Journal of Medicine.
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Delayed Acyclovir in Neonates With Herpes Ups Mortality
WEDNESDAY, Nov. 30 (HealthDay News) -- Delayed initiation of acyclovir therapy in neonates with herpes simplex virus (HSV) infection is associated with in-hospital mortality, according to a study published online Nov. 28 in Pediatrics.
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Viral Suppression Low in U.S. Adults With HIV
TUESDAY, Nov. 29 (HealthDay News) -- Although viral suppression is high in HIV-infected individuals who receive ongoing medical care and anti-retroviral treatment (ART), researchers estimate only 28 percent of U.S. adults living with HIV have control over their infection, according to a report published in the Nov. 29 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.
Opioid Rx for Chronic Abdominal Pain Up Over Last Decade
TUESDAY, Nov. 29 (HealthDay News) -- The prevalence of opioid prescriptions for chronic abdominal pain more than doubled between 1997 and 2008 in the United States, with prescriptions most common for patients aged 25 to 40 years, according to a study published in the December issue of Clinical Gastroenterology and Hepatology.
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Concomitant MMRV With PCV-7 Highly Immunogenic, Safe
TUESDAY, Nov. 29 (HealthDay News) -- Concomitant administration of a combined measles, mumps, rubella, and varicella vaccine (MMRV) and pneumococcal 7-valent conjugate vaccine (PCV-7) is immunogenic and safe for healthy 12- to 15-month-old children, according to a study published online Nov. 28 in Pediatrics.
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NSAID, Statin Use Cuts Cancer Risk in Barrett's Esophagus
TUESDAY, Nov. 29 (HealthDay News) -- For patients with Barrett's esophagus, use of nonsteroidal anti-inflammatory drugs (NSAIDs) and statins reduces the risk of neoplastic progression, with combined use giving additional protection, according to a study published in the December issue of Gastroenterology.
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Intensified Immunochemotherapy Benefits B-Cell Lymphoma
TUESDAY, Nov. 29 (HealthDay News) -- For patients with untreated diffuse large B-cell lymphoma, intensified immunochemotherapy with rituximab, doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (R-ACVBP) is associated with improved survival compared to standard therapy with rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisone (R-CHOP), according to a study published in the Nov. 26 issue of The Lancet.
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New Treatment for Radiation Toxicities May Be Feasible
MONDAY, Nov. 28 (HealthDay News) -- In mice with extensive radiation exposure, a combination of a fluoroquinolone antibiotic and recombinant bactericidal/permeability-increasing protein fragment (rBPI21) improves survival, speeds up hematopoietic recovery, and promotes expansion of stem and progenitor cells, according to an experimental study published in the Nov. 23 issue of Science Translational Medicine.
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Chronic Disease Management Ups Smoking Abstinence
MONDAY, Nov. 28 (HealthDay News) -- A chronic disease management approach is associated with increased short- and long-term abstinence from smoking; and nicotine replacement therapy (NT) during a practice quit attempt (PQA) correlates with increased incidence of any quit attempt, according to two studies published in the Nov. 28 issue of the Archives of Internal Medicine.
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High-Performing Docs Learn Equally From Success, Failure
MONDAY, Nov. 28 (HealthDay News) -- Among physicians making decisions in a medically-framed learning task, high and low performers show distinct behavioral and neural patterns of learning, according to a study published online Nov. 23 in PLoS One.
Many Pediatricians OK With Alternative Vaccine Schedules
MONDAY, Nov. 28 (HealthDay News) -- Pediatricians in Washington State are frequently asked to use alternative childhood immunization schedules (ACISs), and the majority are comfortable using them, according to a study published online Nov. 28 in Pediatrics.
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GIP Identified As Bifunctional Blood Glucose Stabilizer
MONDAY, Nov. 28 (HealthDay News) -- Infusion of glucose-dependent insulinotropic polypeptide (GIP) increases glucagon responses during hypoglycemia and euglycemia, with no effect on insulin secretion, and more than doubles the insulin secretion rate during hyperglycemia, with no effect on glucagon responses, according to a study published in the December issue of Diabetes.
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Everolimus Ups Survival in Carcinoid Syndrome
MONDAY, Nov. 28 (HealthDay News) -- For patients with low- or intermediate-grade advanced neuroendocrine tumors (carcinoids), everolimus plus octreotide long-acting repeatable (LAR) improves progression-free survival versus placebo plus octreotide LAR, according to a study published online Nov. 25 in The Lancet.
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Afternoon Shots Up Post-Immunization Sleep Duration
MONDAY, Nov. 28 (HealthDay News) -- Infants who have immunizations in the afternoon, or have an increased temperature in response to vaccines, have increased sleep duration after immunization, according to a study published online Nov. 28 in Pediatrics.
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Drugs ID'd in Most Older Adult Emergency Hospitalizations
WEDNESDAY, Nov. 23 (HealthDay News) -- Adverse drug events from commonly used medications, including warfarin, insulin, oral antiplatelet agents, and oral hypoglycemic agents, account for the majority of emergency hospitalizations in older adults in the United States, according to a study published in the Nov. 24 issue of the New England Journal of Medicine.
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Dabigatran Poses Challenge in Treating Injured Patients
WEDNESDAY, Nov. 23 (HealthDay News) -- Dabigatran etexilate, a new oral direct thrombin inhibitor, should be used with caution due to a lack of readily available methods to assess the degree of anticoagulation or reverse its effects, posing a threat of fatal bleeding complications for injured patients, according to a letter published in the Nov. 24 issue of the New England Journal of Medicine.
Similar Asthma Outcomes With Daily, Intermittent Budesonide
WEDNESDAY, Nov. 23 (HealthDay News) -- Daily low-dose budesonide therapy is not superior to intermittent high-dose therapy for reducing asthma exacerbations in children, according to a study published in the Nov. 24 issue of the New England Journal of Medicine.
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Continuous Glucose Monitoring Improves Glycemic Control
WEDNESDAY, Nov. 23 (HealthDay News) -- For patients with type 2 diabetes not taking prandial insulin, 12 weeks of intermittent real-time continuous glucose monitoring (RT-CGM) significantly improves and sustains glycemic control compared with use of self-monitoring of blood glucose (SMBG), according to a study published online Nov. 18 in Diabetes Care.
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Alendronate Ups BMD in Patients Taking Steroids for Skin Diseases
WEDNESDAY, Nov. 23 (HealthDay News) -- Alendronate therapy is associated with significantly increased bone mineral density (BMD) at the lumbar spine and femoral neck at 12 months in patients with immunobullous skin diseases and glucocorticoid-induced osteoporosis, according to a study published online Nov. 21 in the Archives of Dermatology.
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Staggered Acetaminophen Overdose Tied to Poor Outcome
WEDNESDAY, Nov. 23 (HealthDay News) -- Staggered acetaminophen overdose and delayed presentation after overdose are associated with adverse outcomes, according to a study published online Nov. 23 in the British Journal of Clinical Pharmacology.
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Prolonged LDL-Lowering Statin Treatment Beneficial, Safe
WEDNESDAY, Nov. 23 (HealthDay News) -- Prolonged statin treatment reduces low-density lipoprotein (LDL) cholesterol and is accompanied by a proportional decrease in vascular events, according to a study published online Nov. 23 in The Lancet.
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Adjuvant Capecitabine Does Not Improve Breast Cancer Survival
WEDNESDAY, Nov. 23 (HealthDay News) -- The addition of capecitabine to a regimen with docetaxel, epirubicin, and cyclophosphamide does not significantly improve recurrence-free survival (RFS) in women with early breast cancer, according to a study published online Nov. 21 in the Journal of Clinical Oncology.
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Breast CA, Tenderness Linked in Women on Combo HRT
TUESDAY, Nov. 22 (HealthDay News) -- For women, use of conjugated equine estrogen (CEE) and medroxyprogesterone (MPA) is associated with new-onset breast tenderness, which correlates with increased breast cancer risk, according to a study published online Nov. 1 in Breast Cancer Research and Treatment.
Process Attributes Most Impact Psoriasis Therapy Choice
TUESDAY, Nov. 22 (HealthDay News) -- Patients with psoriasis attach greater importance to process attributes (treatment location, frequency, duration, delivery method, and individual cost) than to outcome attributes (probability, magnitude and duration of benefit, and probability, severity, and reversibility of adverse effects) when choosing a treatment option for psoriasis, according to a study published in the November issue of the Archives of Dermatology.
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Oral Antibiotic Use in Acne Tied to Reported Pharyngitis
MONDAY, Nov. 21 (HealthDay News) -- Use of oral antibiotics for treatment of acne is associated with a more than three-fold increased risk of reported pharyngitis, according to a study published online Nov. 21 in the Archives of Dermatology.
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Grape Seed Extract Lowers Squamous Cell Carcinoma Risk
MONDAY, Nov. 21 (HealthDay News) -- Use of grape seed extract is associated with a reduced risk of cutaneous squamous cell carcinoma (SCC), according to a study published in the December issue of the Journal of the American Academy of Dermatology.
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Nonpunitive Method Improves Medical Error Reporting
MONDAY, Nov. 21 (HealthDay News) -- Medical error reporting in an academic pediatric ambulatory practice can be improved by a voluntary, nonpunitive, error-reporting system, according to a study published online Nov. 21 in Pediatrics.
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Post-Bat Exposure Prophylaxis Up in New York
FRIDAY, Nov. 18 (HealthDay News) -- During a 10-year period of reporting concurrent with implementation of revised post-exposure prophylaxis (PEP) guidelines for bat rabies, there were increases in the number of bats submitted for testing, reports of exposure, and instances of human PEP, according to a letter published online Nov. 16 in the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.
Erwinaze Approved for Acute Lymphoblastic Leukemia
FRIDAY, Nov. 18 (HealthDay News) -- Erwinaze (asparaginase Erwinia chrysanthemi) has been approved by the U.S. Food and Drug Administration to treat Acute Lymphoblastic Leukemia (ALL) among people who have developed an allergy to more standard treatments.
FDA Revokes Avastin Breast Cancer Indication
FRIDAY, Nov. 18 (HealthDay News) -- The U.S. Food and Drug Administration is revoking its accelerated approval of Avastin for the treatment of breast cancer after finding the drug neither safe nor effective for that indication, according to a Nov. 18 press release from the agency.
Growth Hormone Replacement Ups Diabetes Incidence
FRIDAY, Nov. 18 (HealthDay News) -- Growth hormone (GH) replacement therapy (GHRT) in adult patients with GH deficiency increases the risk of developing diabetes, according to a study published online Nov. 10 in Diabetes Care.
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Rapid Safety Monitoring of H1N1 Vaccine Feasible
FRIDAY, Nov. 18 (HealthDay News) -- A rapid safety surveillance system using modern technology is feasible for monitoring new H1N1 vaccines given or offered to large numbers of patients under normal conditions within a short period of time, according to a study published online Nov. 15 in the British Journal of Clinical Pharmacology.
Minoxidil Foam Is Effective in Androgenic Alopecia
FRIDAY, Nov. 18 (HealthDay News) -- For women with androgenic alopecia, hair growth can be stimulated effectively with once-daily 5 percent minoxidil topical foam (MTF), according to a study published in the December issue of the Journal of the American Academy of Dermatology.
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Tyrosine Isoforms Involved in Concomitant Tumor Resistance
FRIDAY, Nov. 18 (HealthDay News) -- The ortho- and meta-isoforms of tyrosine are associated with concomitant tumor resistance (CR), according to an experimental study published in the Nov. 15 issue of Cancer Research.
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Long-Term Antiepileptic Drug Therapy Ups Atherosclerosis
FRIDAY, Nov. 18 (HealthDay News) -- For patients with epilepsy, long-term monotherapy with carbamazepine (CBZ), phenytoin (PHT), or valproic acid (VPA), but not lamotrigine (LTG), is associated with increased common carotid artery intima media thickness (CCA IMT) and altered circulatory markers of vascular risk, according to a study published online Nov. 15 in Epilepsia.
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Hib Vaccine Has Cut H. influenzae Incidence Dramatically
THURSDAY, Nov. 17 (HealthDay News) -- The introduction of the Haemophilus influenzae (H. influenzae) serotype b vaccine (Hib) has significantly reduced the incidence of invasive disease, according to a study published in the Dec. 15 issue of Clinical Infectious Diseases.
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Tamoxifen Discontinuation Rate High in Male Breast Cancer
THURSDAY, Nov. 17 (HealthDay News) -- Male patients with breast cancer have a high rate of tamoxifen discontinuation due to drug-related side effects, according to a study published online Nov. 15 in the Annals of Oncology.
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Mycophenolate Mofetil Beats Azathioprine in Lupus Nephritis
WEDNESDAY, Nov. 16 (HealthDay News) -- For patients with lupus nephritis who have a clinical response to induction therapy, mycophenolate mofetil is superior to azathioprine for maintaining a renal response to treatment and preventing relapse, according to a study published in the Nov. 17 issue of the New England Journal of Medicine.
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Breast Cancer Survivors Have Impaired Neurological Function
WEDNESDAY, Nov. 16 (HealthDay News) -- Breast cancer (BC) survivors have significantly reduced activation of the prefrontal cortex, with additional reductions in prefrontal function and poorer executive functioning for women treated with chemotherapy, according to a study published in the November issue of the Archives of Neurology.
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Denosumab Improves Bone-Metastasis-Free Survival
WEDNESDAY, Nov. 16 (HealthDay News) -- For men with high-risk castration-resistant prostate cancer, treatment with a fully human anti-receptor activator of nuclear factor kappa-B ligand (RANKL) monoclonal antibody, denosumab, significantly improves bone-metastasis-free survival, according to a study published online Nov. 16 in The Lancet.
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U.S. Oncologists Rate Selves Highly in Pain Management
TUESDAY, Nov. 15 (HealthDay News) -- Although U.S oncologists rate their specialty highly in terms of pain management, they acknowledge treatment barriers to optimal care, and consider their training to be poor, according to a study published online Nov. 14 in the Journal of Clinical Oncology.
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Global Oral Contraceptive Use Tied to Prostate Cancer Incidence
TUESDAY, Nov. 15 (HealthDay News) -- Population-based use of oral contraceptives (OC) is significantly associated with increased prostate cancer incidence and mortality, according to a study published online Nov. 14 in BMJ Open.
Delayed Acyclovir Ups Hospital Stay for Eczema Herpeticum
MONDAY, Nov. 14 (HealthDay News) -- For children hospitalized for eczema herpeticum, a delay in acyclovir initiation increases the length of stay (LOS), according to a study published online Nov. 14 in Pediatrics.
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U.S. Teen Vaccination Coverage Up From 2006 to 2009
MONDAY, Nov. 14 (HealthDay News) -- Adolescent vaccination coverage in the United States increased from 2006 to 2009, and could be further improved, according to a study published online Nov. 14 in Pediatrics.
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Diazoxide Lowers Glucose Production in Humans, Rats
FRIDAY, Nov. 11 (HealthDay News) -- Oral administration of diazoxide, a hypothalamic ATP-sensitive potassium (KATP) channel activator, decreases endogenous glucose production (EGP) in humans without diabetes and in rats, according to an experimental study published online Nov. 7 in the Journal of Clinical Investigation.
Methamphetamine Linked to Increased Schizophrenia Risk
FRIDAY, Nov. 11 (HealthDay News) -- Individuals with methamphetamine-related conditions have an increased risk of developing schizophrenia compared to other drug use disorders, and a similar risk to those with cannabis-use disorders, according to a study published online Nov. 8 in The American Journal of Psychiatry.
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About 15,000 Intentional Poisoning ER Visits in 2009
FRIDAY, Nov. 11 (HealthDay News) -- In 2009, there were an estimated 14,720 emergency department visits due to intentional drug poisoning, with alcohol and drug combinations involved in 60 percent of these cases, according to a report published online Nov. 3 by the Substance Abuse and Mental Health Services Administration (SAMHSA).
Estimated Flu Incidence of 90 Million for 2008 in Under-5s
FRIDAY, Nov. 11 (HealthDay News) -- In 2008, there were an estimated 90 million new cases of influenza in children younger than 5 years of age, according to a review published online Nov. 11 in The Lancet.
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Community-Based Treatment Improves Pneumonia Outcomes
FRIDAY, Nov. 11 (HealthDay News) -- Implementation of community case management by lady health workers (LHWs) is associated with decreased treatment failure rates for children with severe pneumonia in Pakistan, according to a study published online Nov. 11 in The Lancet.
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Zostavax Still Recommended Only for Those 60 and Over
THURSDAY, Nov. 10 (HealthDay News) -- Despite the U.S. Food and Drug Administration's expansion of the indication for herpes zoster vaccination to include a younger cohort, the Advisory Committee on Immunization Practices (ACIP) still recommends the vaccine only for adults 60 and older, according to a report published in the Nov. 9 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.
Adipotide Reduces White Adipose Tissue in Obese Monkeys
THURSDAY, Nov. 10 (HealthDay News) -- The ligand-directed peptidomimetic CKGGRAKDC-GG-D(KLAKLAK)2 (adipotide) reduces white adipose tissue in obese monkeys, according to an experimental study published in the Nov. 9 issue of Science Translational Medicine.
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Epigenetic Therapy Shows Promise in Progressive NSCLC
THURSDAY, Nov. 10 (HealthDay News) -- Epigenetic therapy combined with low-dose azacitidine and entinostat is well-tolerated and provides an improvement in median survival similar to existing therapies for patients with metastatic non-small-cell lung cancer (NSCLC), according to a study published online Nov. 9 in Cancer Discovery.
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Glove Use Linked to Reduced Hand Hygiene Compliance
THURSDAY, Nov. 10 (HealthDay News) -- Glove usage among healthcare workers is often inappropriate, and hand hygiene compliance is worse when gloves are worn, according to a study published online Oct. 17 in Infection Control and Hospital Epidemiology.
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Pre-Knee Replacement Use of Opioids Tied to Complications
THURSDAY, Nov. 10 (HealthDay News) -- Use of chronic opioid analgesia prior to total knee arthroplasty is associated with significantly increased prevalence of complications and poorer clinical outcomes, according to a study published in the Nov. 2 issue of The Journal of Bone & Joint Surgery.
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Evidence Shows Reduced Sodium Intake Lowers BP
THURSDAY, Nov. 10 (HealthDay News) -- Reduced sodium intake is associated with a significant decrease in blood pressure (BP), and a concomitant increase in plasma levels of renin, aldosterone, adrenaline, noradrenaline, cholesterol, and triglycerides, according to a review published online Nov. 9 in the American Journal of Hypertension.
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Trilipix Not Found to Reduce Risk of Coronary Events
WEDNESDAY, Nov. 9 (HealthDay News) -- Trilipix (fenofibric acid), a cholesterol-lowering medication, may not reduce the risk of heart attack or stroke, and physicians should consider the risks and benefits of the drug before prescribing it to patients, according to a safety communication issued Nov. 9 by the U.S. Food and Drug Administration.
Alcoholic Hepatitis Combo Meds Don't Help Six-Month Survival
WEDNESDAY, Nov. 9 (HealthDay News) -- For patients with severe acute alcoholic hepatitis, prednisolone plus N-acetylcysteine therapy does not improve six-month survival, but early liver transplant after a first episode of severe alcoholic hepatitis not responding to medical therapy does, according to two studies published in the Nov. 10 issue of the New England Journal of Medicine.
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TNF-α Antagonists Do Not Up Infection Hospitalizations
WEDNESDAY, Nov. 9 (HealthDay News) -- For patients with autoimmune diseases, tumor necrosis factor (TNF)-α antagonist use is not associated with a significant increase in serious infections requiring hospitalization, compared to nonbiologic medication use, according to a study published online Nov. 6 in the Journal of the American Medical Association.
Biolimus Stents Noninferior to Sirolimus Stents
WEDNESDAY, Nov. 9 (HealthDay News) -- Biodegradable biolimus-eluting stents (BES) are noninferior to durable polymer sirolimus-eluting stents (SES) in coronary artery disease (CAD), according to a study published online Nov. 9 in The Lancet to coincide with its presentation at the Transcatheter Cardiovascular Therapeutics meeting, held from Nov. 7 to 11 in San Francisco.
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Wait-and-See Policy Feasible for Some With Rectal Cancer
WEDNESDAY, Nov. 9 (HealthDay News) -- For patients who have complete clinical response (cCR) following chemoradiotherapy for rectal cancer, a wait-and-see-policy is feasible and promising if strict selection criteria and follow-up are implemented, according to a study published online Nov. 7 in the Journal of Clinical Oncology.
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HPV-16/18 Efficacious Against CIN3+, Adenocarcinoma in Situ
WEDNESDAY, Nov. 9 (HealthDay News) -- The human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine shows excellent efficacy against CIN3+ and adenocarcinoma in situ (AIS), and cross-protective efficacy against four oncogenic non-vaccine HPV types, according to two studies published online Nov. 9 in The Lancet Oncology.
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Adjuvant Bevacizumab Feasible in Ovarian Cancer
WEDNESDAY, Nov. 9 (HealthDay News) -- Addition of bevacizumab to first-line intraperitoneal (IP) chemotherapy is feasible in ovarian cancer but increases the risk of bowel obstruction/perforation, according to a study published online Nov. 7 in the Journal of Clinical Oncology.
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Varying Response to Etanercept in Juvenile Arthritis
WEDNESDAY, Nov. 9 (HealthDay News) -- For patients with juvenile idiopathic arthritis (JIA), the treatment response to etanercept varies, with excellent response associated with lower baseline disability scores, fewer pretreatment disease-modifying antirheumatic drugs (DMARDs), and younger age of onset, according to a study published online Nov. 6 in the Journal of the American Medical Association.
No Added Benefits of Cranial Bypass in Stroke Prevention
TUESDAY, Nov. 8 (HealthDay News) -- Extracranial-intracranial (EC-IC) bypass surgery in addition to medical therapy offers no additional benefit over medical therapy alone in preventing recurrent stroke in recent symptomatic atherosclerotic internal carotid artery occlusion (AICAO), according to a study published in the Nov. 9 issue of the Journal of the American Medical Association.
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Poxviral Vaccine Benefits Some With Ovarian, Breast Cancer
TUESDAY, Nov. 8 (HealthDay News) -- Use of the recombinant poxviral vaccine (PANVAC) may be beneficial for some patients with metastatic breast and ovarian cancers with limited tumor burden and minimal exposure to chemotherapy, according to a study published online Nov. 8 in Clinical Cancer Research.
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Substance Use, Abuse Highest Among Native American Teens
TUESDAY, Nov. 8 (HealthDay News) -- Substance use varies according to race/ethnicity, with Native American adolescents having the highest prevalence of use and substance-related disorders, according to a study published in the November issue of the Archives of General Psychiatry.
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Ridaforolimus Promising for Treating Advanced Sarcomas
TUESDAY, Nov. 8 (HealthDay News) -- Ridaforolimus treatment is associated with promising clinical benefit response (CBR) and progression-free survival (PFS) for patients with advanced sarcomas, according to a study published online Nov. 7 in the Journal of Clinical Oncology.
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Evidence Lacking for Pridopidine Efficacy in Huntington's Disease
TUESDAY, Nov. 8 (HealthDay News) -- Pridopidine may have some effect on the motor phenotype of Huntington's disease, although it does not reach the prespecificed α level in a phase 3 trial, according to a study published online Nov. 7 in The Lancet Neurology.
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Erbitux Approval Expanded to Include Head and Neck Cancer
MONDAY, Nov. 7 (HealthDay News) -- U.S. Food and Drug Administration approval of Erbitux (cetuximab) has been expanded to include late-stage (metastatic) head and neck cancer, the agency announced Monday.
Great Achievement at Young Age Function of Time, Not Field
MONDAY, Nov. 7 (HealthDay News) -- The frequency of great scientific achievements at young age is a function of time, and not related to the field, according to a study published online Nov. 7 in the Proceedings of the National Academy of Sciences.
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Impact of Exercise Lessened by Metformin in Prediabetes
MONDAY, Nov. 7 (HealthDay News) -- For men and women with prediabetes, insulin sensitivity increases to a similar extent with exercise training, metformin, or a combination of the two, with metformin impacting slightly on the effect of exercise, according to a study published online Oct. 31 in Diabetes Care.
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K2 Linked to Cases of ST-Elevation Myocardial Infarction
MONDAY, Nov. 7 (HealthDay News) -- Use of K2, a synthetic cannabinoid, among adolescents is associated with ST-segment elevation-myocardial infarction (MI), according to a study published online Nov. 7 in Pediatrics.
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Causal Link Suggested Between Acetaminophen Use, Asthma
MONDAY, Nov. 7 (HealthDay News) -- The use of acetaminophen in children with asthma or at risk of asthma should be avoided until the drug's safety is established, as observations suggest a causative association between acetaminophen use and increased asthma prevalence in children, according to a report published online Nov. 7 in Pediatrics.
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Exenatide Tied to Modest Weight Loss for Obese Women
MONDAY, Nov. 7 (HealthDay News) -- For obese women without diabetes, short-term treatment with exenetide is associated with modest weight loss and decreased waist circumference, with a subset of women benefiting from significant weight loss, according to a study published online Oct. 31 in Diabetes Care.
FDA Enhancing Surveillance for Anti-TNF Malignancy
FRIDAY, Nov. 4 (HealthDay News) -- The U.S. Food and Drug Administration is stepping up their safety surveillance of tumor necrosis factor (TNF) inhibitors, such as infliximab and adalimumab, amidst ongoing reports of hepatosplenic T-cell lymphoma in children and young adults, according to a safety alert issued Nov. 4 by the agency.
Statin Use in BAV Stenosis Tied to Ascending Aortic Size
FRIDAY, Nov. 4 (HealthDay News) -- Statin treatment in patients with bicuspid aortic valve (BAV) stenosis is associated with significantly lower ascending aortic size, according to a study published in the Nov. 15 issue of The American Journal of Cardiology.
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Varenicline Tied to Increased Risk of Suicidal Behavior
FRIDAY, Nov. 4 (HealthDay News) -- Patients taking varenicline for smoking cessation have a significantly increased risk for reported suicidal/self-injurious behavior or depression, compared to those taking bupropion or nicotine replacement products, according to a study published online Nov. 2 in PLoS One.
Receptionists Contribute to Safety of Repeat Prescriptions
FRIDAY, Nov. 4 (HealthDay News) -- Receptionists and administrative staff of general practices in the United Kingdom make important contributions to quality and safety in repeat prescribing, which are often unknown to clinicians, according to a study published online Nov. 3 in BMJ.
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EGFR Level Predicts Survival Benefit of Cetuximab in NSCLC
FRIDAY, Nov. 4 (HealthDay News) -- For patients with advanced non-small-cell lung cancer (NSCLC), high epidermal growth factor receptor (EGFR) expression can predict the survival benefit for the addition of cetuximab to first-line chemotherapy, according to a study published online Nov. 4 in The Lancet Oncology.
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Rooms of Patients With A. baumannii Often Contaminated
FRIDAY, Nov. 4 (HealthDay News) -- A considerable proportion of rooms of patients colonized or infected with multidrug-resistant Acinetobacter baumannii (A. baumannii) (MDR-AB) have surfaces which are positive for A. baumannii, even in patients with a remote history of infection, according to a study published in the November issue of the American Journal of Infection Control.
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Carisoprodol-Related Emergency Visits Up in United States
THURSDAY, Nov. 3 (HealthDay News) -- Carisoprodol misuse- or abuse-related emergency department visits increased in the United States between 2004 and 2009, with the majority of visits involving other pharmaceuticals, according to a report published online Nov. 3 by the Substance Abuse and Mental Health Services Administration (SAMHSA).
ZDN/IFN-α Ups Survival in T-Cell Leukemia/Lymphoma
THURSDAY, Nov. 3 (HealthDay News) -- Use of zidovudine (ZDN) and interferon alfa (IFN-α) with chemotherapy (combined first-line therapy) prolongs survival in patients with adult T-cell leukemia/lymphoma (ATLL), according to a study published online Oct. 31 in the Journal of Clinical Oncology.
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No Concerning Patterns Seen With H1N1 Vaccine in Pregnancy
THURSDAY, Nov. 3 (HealthDay News) -- Administration of the influenza A (H1N1) vaccine to pregnant women seems to be safe and is not associated with an increase in adverse maternal or fetal outcomes, according to a study published in the November issue of the American Journal of Obstetrics & Gynecology.
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Ivacaftor Safe, Efficacious for Cystic Fibrosis
WEDNESDAY, Nov. 2 (HealthDay News) -- Use of ivacaftor is associated with improved lung function in cystic fibrosis, according to a study published in the Nov. 3 issue of the New England Journal of Medicine.
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Caspase 9-Induced Apoptosis Shows Promise for Cell Therapy
WEDNESDAY, Nov. 2 (HealthDay News) -- Incorporation of inducible caspase 9 (iCasp9) into a transgene facilitates rapid induction of apoptosis of cells expressing the transgene with use of a dimerizing drug (AP1903), according to a study published in the Nov. 3 issue of the New England Journal of Medicine.
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Prophylactic Therapy Reduces Bleeding in Hemophilia A
WEDNESDAY, Nov. 2 (HealthDay News) -- For patients with severe hemophilia A, anti-inhibitor coagulant complex (AICC) prophylaxis is safe and significantly reduces bleeding episodes compared with on-demand therapy, according to a study published in the Nov. 3 issue of the New England Journal of Medicine.
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HPV Testing in Self-Collected Samples Has High Sensitivity
WEDNESDAY, Nov. 2 (HealthDay News) -- Human papillomavirus (HPV) DNA testing of self-collected vaginal specimens is more sensitive than clinic-based cervical cytology for detection of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 2 or worse, but has lower positive predictive value, according to a study published online Nov. 3 in The Lancet.
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CDC: Opioid Overdoses Have Reached Epidemic Proportions
WEDNESDAY, Nov. 2 (HealthDay News) -- Opioid pain relievers (OPR) are involved in most drug overdose deaths; and OPR-related deaths, sales, and treatment admissions have increased in the last decade, according to a report published in the Nov. 1 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
Ocrelizumab Safe, Promising for Relapsing-Remitting MS
TUESDAY, Nov. 1 (HealthDay News) -- Ocrelizumab administered in doses of 600 and 2,000 mg in patients with relapsing-remitting multiple sclerosis (MS) is safe, and reduces the total number of gadolinium-enhancing lesions (GEL) on T1-weighted magnetic resonance imaging (MRI), according to a study published online Nov. 1 in The Lancet.
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Omental Adipocytes Play Key Role in Ovarian CA Metastasis
TUESDAY, Nov. 1 (HealthDay News) -- Primary human omental adipocytes promote homing, migration, and invasion of ovarian cancer cells to the omentum, and fatty-acid binding protein 4 (FABP4) seems to have a role in metastatic ovarian tumor growth, according to a letter published online Oct. 30 in Nature Medicine.
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ADHD Drug Use Not Tied to Serious Cardiovascular Events
TUESDAY, Nov. 1 (HealthDay News) -- Current use of attention deficit-hyperactivity disorder (ADHD) drugs is not associated with a significantly increased risk of serious cardiovascular events, according to a study published online Nov. 1 in the New England Journal of Medicine.
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