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Category: Endocrinology | Monthly Briefing

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December 2011 Briefing - Diabetes & Endocrinology

Last Updated: January 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for December 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Three Gene Mutations Linked to Epithelial Thyroid Cancers

FRIDAY, Dec. 30 (HealthDay News) -- Cowden syndrome (CS)/CS-like patients with PTEN mutations, SDHx variations, and KLLN epimutations are at increased risk of epithelial thyroid cancers, according to a study published in the Dec. 1 issue of the Journal of Clinical Endocrinology & Metabolism.

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Early Childhood Factors ID'd for Predicting Adult Obesity

THURSDAY, Dec. 29 (HealthDay News) -- Childhood growth patterns, childhood obesity, maternal body mass index (BMI), and father's employment are probable early markers for adult obesity, according to a study published online Dec. 16 in Obesity Reviews.

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Metabolic Syndrome Linked to Overactive Bladder in Females

THURSDAY, Dec. 29 (HealthDay News) -- Metabolic syndrome is significantly associated with overactive bladder in female patients, according to a study published in the January issue of Urology.

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More Fat Than Lean Mass Regained During Weight Regain

THURSDAY, Dec. 29 (HealthDay News) -- For postmenopausal women who regain weight in the year following intentional weight loss, fat mass is regained to a greater extent than lean mass, according to a study published in a recent issue of the American Journal of Clinical Nutrition.

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Metformin Hikes B12 Deficiency in Type 2 Diabetes

THURSDAY, Dec. 29 (HealthDay News) -- The use of metformin therapy in adults with type 2 diabetes is linked to a biochemical B12 deficiency greater than that found in other adults with type 2 diabetes and adults without diabetes, and current over-the-counter supplements are not sufficient to correct the deficiency in either of these type 2 diabetes groups, according to research published online Dec. 16 in Diabetes Care.

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Air Pollution Linked to Diabetes

THURSDAY, Dec. 29 (HealthDay News) -- Long-term exposure to air pollution from traffic is associated with a higher incidence of diabetes in adults, especially in nonsmokers, the physically active, and individuals who lead a healthy lifestyle, according to research published in the January issue of Diabetes Care.

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New Equation Accurately Predicts Body Fat Percentage

WEDNESDAY, Dec. 28 (HealthDay News) -- A new prediction equation estimates body fat percentage (BF%) in adults with a low error rate and acceptable accuracy and may be a good first-screening tool for identifying patients at cardiovascular and type 2 diabetes risk, according to research published online Dec. 16 in Diabetes Care.

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Genetic Variants Found to Predispose to Weight Regain

WEDNESDAY, Dec. 28 (HealthDay News) -- Numerous genetic variants predispose people to weight loss (WL) as well as weight regain (WR) after intentional WL, according to research published online Dec. 16 in Diabetes Care.

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Perceptions of Inappropriate Care Prevalent Among ICU Staff

TUESDAY, Dec. 27 (HealthDay News) -- Perceptions of inappropriate care are prevalent among intensive care unit (ICU) clinicians in Europe and Israel, according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

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Obese Patients Have Worse Colon Cancer Outcomes

TUESDAY, Dec. 27 (HealthDay News) -- Obese patients with colon cancer are less likely to have deficient mismatch repair (dMMR) tumors and have a worse prognosis compared with normal-weight patients, independent of other tumor variables, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

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Low Pegnancy Vitamin D Levels Up Child's Diabetes Risk

TUESDAY, Dec. 27 (HealthDay News) -- Lower maternal serum concentrations of 25-hydroxy-vitamin D (25-OH D) during pregnancy are associated with an increased risk of offspring developing type 1 diabetes during childhood, according to a study published in the January issue of Diabetes.

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Improved CVD Risk Prediction Model in Diabetes Identified

TUESDAY, Dec. 27 (HealthDay News) -- For patients with type 2 diabetes and no history of cardiovascular diseases (CVDs), the ability of the Framingham risk score (FRS) to predict development of CVD is improved by combining it with carotid intima-media thickness (IMT) measurement, according to a study published in the January issue of Diabetes Care.

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Mother-Child Relationship Contributes to Child Obesity

TUESDAY, Dec. 27 (HealthDay News) -- Children who have poor-quality early maternal-child relationships are 2.45 times more likely to experience adolescent obesity, according to a study published online Dec. 26 in Pediatrics.

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Postmenopausal HRT Improves Sexual Function

THURSDAY, Dec. 22 (HealthDay News) -- Twelve months of daily oral hormonal replacement therapy with estradiol plus dihydrogesterone (HRT), dehydroepiandrosterone (DHEA), or tibolone improves sexual function and frequency in early postmenopausal women, according to a study published in the December issue of Climacteric.

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CDC Outlines HPV and Hep B Vaccine Recommendations

THURSDAY, Dec. 22 (HealthDay News) -- Vaccination against human papillomavirus (HPV) in young males and hepatitis B in adults with diabetes mellitus is recommended by the Advisory Committee on Immunization Practices (ACIP) for infection control, according to two reports published in the Dec. 23 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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Simvastatin Beats Ezetimibe in Anti-inflammatory Effects

THURSDAY, Dec. 22 (HealthDay News) -- For patients with hypercholesterolemia, simvastatin is superior to ezetimibe for producing lymphocyte-suppression and systemic anti-inflammatory and endothelial protective effects, according to a study published in the January issue of the Journal of Internal Medicine.

Abstract
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Gene-Ligand System Positively Associated With Human Obesity

THURSDAY, Dec. 22 (HealthDay News) -- There is a positive association between the L-α-lysophosphatidylinositol (LPI) and GPR55 system and obesity in humans, according to a study published online Dec. 16 in Diabetes.

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ADA Updates Standards of Care for Driving With Diabetes

WEDNESDAY, Dec. 21 (HealthDay News) -- For people with diabetes, the eligibility to receive a driver's license should be an individual decision, based on clinical evidence and appropriate consideration of potential safety risks, according to a position statement from the American Diabetes Association published in a supplement to the January issue of Diabetes Care.

Diabetes and Driving Position Statement
Standard of Care Position Statement

Long-Term Increase in Resting Heart Rate Ups Mortality

TUESDAY, Dec. 20 (HealthDay News) -- An increase in resting heart rate (RHR) over a 10-year period is associated with an increased risk of dying from ischemic heart disease (IHD), according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

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Chlorthalidone Treatment Offers Long-Term Survival Benefits

TUESDAY, Dec. 20 (HealthDay News) -- Chlorthalidone treatment for isolated systolic hypertension, among participants of the Systolic Hypertension in the Elderly Program (SHEP) trial, is associated with improved cardiovascular mortality, according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

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Initial Wound Debridement Faster With Maggot Therapy

TUESDAY, Dec. 20 (HealthDay News) -- Compared with conventional therapy, wound debridement is significantly faster with maggot therapy during the first week of treatment, but there is no significant difference at day 15, according to a study published online Dec. 19 in the Archives of Dermatology.

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Blood Pressure in Middle Age Affects Lifetime CVD Risk

TUESDAY, Dec. 20 (HealthDay News) -- Changes in blood pressure (BP) during middle age significantly impact lifetime risk (LTR) for cardiovascular disease (CVD), with a possible dose-response effect for the number of years with high BP on the LTR of CVD, coronary heart disease, and stroke, according to research published online Dec. 19 in Circulation.

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Liver Transplants for NASH Up 600 Percent in 10 Years

TUESDAY, Dec. 20 (HealthDay News) -- The proportion of liver transplants performed in patients diagnosed with nonalcoholic steatohepatitis (NASH) increased dramatically from 1997-2003 to 2004-2010, but post-transplant survival in this population is excellent, with one-year survival rates near 88 percent, according to a study published online Sept. 19 in Liver Transplantation.

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Little Risk to Offspring From Maternal Inhaled Steroids

TUESDAY, Dec. 20 (HealthDay News) -- In pregnant women with asthma, the use of inhaled glucocorticoids does not increase the risk of most pediatric diseases in the offspring, though it may be a risk factor for endocrine and metabolic disorders, according to research published online Dec. 16 in the American Journal of Respiratory and Critical Care Medicine.

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Physician Opinions on Benefits of Open Visit Notes Vary

MONDAY, Dec. 19 (HealthDay News) -- Primary care physicians (PCPs) have varied opinions about open access to doctors' notes; and most users of a personal health record (PHR) system are interested in sharing access to their information, according to two studies published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Walker
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Abstract - Zulman
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Suboptimal Intensive Statin Therapy Use After ACS

MONDAY, Dec. 19 (HealthDay News) -- Intensive statin therapy (IST) use during hospitalization is suboptimal following acute coronary syndrome (ACS), and there is poor persistence after discharge, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Quitting Smoking Improves Happiness, Quality of Life

FRIDAY, Dec. 16 (HealthDay News) -- People who successfully quit smoking are happier and more satisfied with their lives than people who continue to smoke, according to a study published online Dec. 10 in the Annals of Behavioral Medicine.

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Intense Interval Training Impacts Diabetic Blood Glucose

FRIDAY, Dec. 16 (HealthDay News) -- Low-volume high-intensity interval training (HIT) lowers the 24-hour blood glucose concentration, and increases markers of skeletal muscle mitochondrial capacity in individuals with type 2 diabetes, according to a study published in the December issue of the Journal of Applied Physiology.

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High-Dose Aspirin Impacts Fibrin Network in Diabetes

FRIDAY, Dec. 16 (HealthDay News) -- Treatment with high-dose (320 mg), but not low-dose (75 mg), aspirin increases fibrin network permeability in patients with type 1 diabetes, according to a study published online Dec. 6 in Diabetes Care.

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AHA: U.S. Cardiovascular Disease Burden Still High

THURSDAY, Dec. 15 (HealthDay News) -- Despite a decrease in the rate of death attributable to cardiovascular disease and stroke, the burden of disease is still high, according to the American Heart Association's (AHA's) Heart Disease and Stroke Statistical Update 2012, published online Dec. 15 in Circulation.

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Statins Lower Death Risk in Adults Hospitalized With Flu

THURSDAY, Dec. 15 (HealthDay News) -- In adults hospitalized for influenza virus infections, administration of statins before or during the hospitalization is associated with a reduced risk of mortality, according to a study published online Dec. 13 in the Journal of Infectious Diseases.

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High Prevalence of Obesity Found Among Adults in Spain

THURSDAY, Dec. 15 (HealthDay News) -- The prevalence of obesity is high in the adult population of Spain and is affected by sociodemographic factors, including age and education levels, according to a study published online Dec. 12 in Obesity Reviews.

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Physical Activity Tied to Sexual Function in Young Men

THURSDAY, Dec. 15 (HealthDay News) -- For young, healthy men, leading a sedentary lifestyle is associated with increased sexual dysfunction on various domains of the International Index of Erectile Function (IIEF), according to a study published online Dec. 6 in The Journal of Sexual Medicine.

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School-Based Clinics Feasible for ID'ing Chronic Fatigue

THURSDAY, Dec. 15 (HealthDay News) -- School-based clinics can identify children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), and may be useful for diagnosing children with less severe symptoms, according to a study published online Dec. 12 in BMJ Open.

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Rising Adiponectin Levels Lower Diabetes Risk in Elderly

THURSDAY, Dec. 15 (HealthDay News) -- In older adults, increasing concentrations of total and high-molecular-weight (HMW) adiponectin up to 20 and 10 mg/L, respectively, are inversely associated with incident diabetes, according to a study published online Dec. 6 in Diabetes Care.

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Regional Rehospitalization Rate Tied to Overall Admissions

WEDNESDAY, Dec. 14 (HealthDay News) -- For patients with congestive heart failure or pneumonia, regional rates of rehospitalizations are substantially associated with overall admission rates at 30, 60, and 90 days, according to a study published in the Dec. 15 issue of the New England Journal of Medicine.

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CPAP Improves BP, Metabolic Abnormalities in Sleep Apnea

WEDNESDAY, Dec. 14 (HealthDay News) -- For patients with severe obstructive sleep apnea, three months of continuous positive airway pressure (CPAP) therapy is associated with reduced blood pressure, and partial reversal of metabolic abnormalities, according to a study published in the Dec. 15 issue of the New England Journal of Medicine.

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Risk Factors for Stillbirth ID'd at the Start of Pregnancy

TUESDAY, Dec. 13 (HealthDay News) -- Several risk factors that can be identified at the time of pregnancy confirmation correlate with stillbirth; and obstetric complications and placental abnormalities are the most common causes of stillbirth, and show racial discrepancies, according to two studies published in the Dec. 14 issue of the Journal of the American Medical Association.

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Over and Under Nutrition Tied to Increased Stroke Risk

TUESDAY, Dec. 13 (HealthDay News) -- Evidence suggests that under and over nutrition increase the risk of stroke, and questions the role of antioxidant, vitamin, and calcium supplements, according to a review published in the January issue of The Lancet Neurology.

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Infection Prevention Up in VA, Non-Federal Hospitals

TUESDAY, Dec. 13 (HealthDay News) -- From 2005 to 2009, there was a significant increase in the use of hospital-acquired infection (HAI) prevention practices in non-federal and Veterans Affairs (VA) hospitals, according to a study published online Dec. 6 in the Journal of General Internal Medicine.

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Meds Reduce Stroke Risk in Patients With Prehypertension

FRIDAY, Dec. 9 (HealthDay News) -- The administration of blood pressure-lowering medication to people in a prehypertensive range appears to significantly reduce their risk of stroke, according to research published online Dec. 8 in Stroke.

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Low Vitamin D Levels Seen in Obese Children

FRIDAY, Dec. 9 (HealthDay News) -- Low levels of 25-hydroxyvitamin D (25[OH]D) have been seen in children with obesity and are associated with early signs of diabetes, according to research published online Nov. 9 in the Journal of Clinical Endocrinology & Metabolism.

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Factors Affecting Micro-RNA Detection Accuracy Identified

FRIDAY, Dec. 9 (HealthDay News) -- Accurate detection and quantitation of circulating microRNAs (miRNAs) is affected by inherent differences in plasma samples, methods used for their collection and analysis, and the presence of specific inhibitors in plasma, according to a study published online Dec. 9 in the Journal of Molecular Diagnostics.

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Child Obesity Prevention Interventions Can Be Effective

FRIDAY, Dec. 9 (HealthDay News) -- Obesity prevention interventions in children can be effective, according to a review published online Dec. 7 in the Cochrane Database of Systematic Reviews.

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Few Parents Recall Being Told Their Child Is Overweight

THURSDAY, Dec. 8 (HealthDay News) -- Less than one-quarter of parents of overweight children recall being told by a doctor or other health care provider that their child is overweight, according to a study published online Dec. 5 in the Archives of Pediatrics & Adolescent Medicine.

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Risk of Dementia Up in Patients With Depression, Diabetes

THURSDAY, Dec. 8 (HealthDay News) -- Patients with diabetes who have comorbid depression have an increased risk for the development of dementia, compared to those with diabetes alone, according to a study published online Dec. 5 in the Archives of General Psychiatry.

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Acupuncture May Help Chemo-Induced Peripheral Neuropathy

WEDNESDAY, Dec. 7 (HealthDay News) -- The addition of acupuncture to best medical care for chemotherapy-induced peripheral neuropathy (CIPN) may have a positive effect, according to a pilot study published online Dec. 5 in Acupuncture in Medicine.

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Sympathetic Nervous System Activity Predicts Weight Loss

WEDNESDAY, Dec. 7 (HealthDay News) -- During hypocaloric dietary intervention in obese individuals, baseline muscle sympathetic nerve activity (MSNA), and post-prandial nutritional sympathetic nervous system (SNS) responsiveness, are positive predictors of weight loss, according to a study published online Nov. 16 in the Journal of Clinical Endocrinology & Metabolism.

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Androgen Deprivation in Prostate Cancer Not Tied to CVD Death

TUESDAY, Dec. 6 (HealthDay News) -- Use of androgen deprivation therapy (ADT) is not associated with cardiovascular death, but is correlated with significantly lower prostate cancer-specific mortality (PCSM) and all-cause mortality, according to a review and meta-analysis published in the Dec. 7 issue of the Journal of the American Medical Association.

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FDA and FTC Crack Down on Homeopathic Weight Loss Drug

TUESDAY, Dec. 6 (HealthDay News) -- Companies that market over-the-counter products containing human chorionic gonadotropin (HCG) and labeled as "homeopathic" for weight loss are violating federal law and have been issued warnings, according to a Dec. 6 announcement from the U.S. Food and Drug Administration and the Federal Trade Commission (FTC).

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Medical Students Fail to ID Hand Hygiene Indications

MONDAY, Dec. 5 (HealthDay News) -- Medical students who are about to start the clinical phase of their education have a lack of knowledge regarding the correct indications for hand disinfection, according to a study published in the December issue of the American Journal of Infection Control.

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Eating Little or No Fish Ups Young Women's CVD Risk

MONDAY, Dec. 5 (HealthDay News) -- Young and initially healthy women who consume little or no fish and long-chain n-3 polyunsaturated fatty acids (LCn3FAs) have an increased risk of cardiovascular disease, according to a study published online Dec. 5 in Hypertension.

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Childhood Risk Exposure Tied to Weight Gain in Adolescence

MONDAY, Dec. 5 (HealthDay News) -- Early childhood cumulative risk exposure to sociodemographic, physical, and psychosocial stressors is associated with weight gain in adolescence, and these gains are mainly accounted for by deteriorated self-regulatory abilities in children exposed to risks, according to a study published online Dec. 5 in Pediatrics.

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Serum Glucose Levels Tied to Colorectal Cancer Risk in Women

FRIDAY, Dec. 2 (HealthDay News) -- Serum glucose levels, but not serum insulin or homeostasis model assessment, are associated with increased colorectal cancer risk in postmenopausal women, according to a study published online Nov. 29 in the British Journal of Cancer.

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Eating Out of Home Linked to Higher Calorie and Fat Intake

FRIDAY, Dec. 2 (HealthDay News) -- Eating out of home (OH) is associated with higher total energy and fat intake, according to research published online Nov. 23 in Obesity Reviews.

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F2-Isoprostanes Inversely Linked to Diabetes Risk

FRIDAY, Dec. 2 (HealthDay News) -- Urinary F2-isoprostanes (iPF2α-III, 2,3-dinor-iPF2α-III, and iPF2α-VI) show a significant inverse association with the risk of type 2 diabetes, according to a study published online Nov. 18 in Diabetes Care.

Abstract
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Racial Disparities in U.S. Diet, Exercise, Weight Explained

FRIDAY, Dec. 2 (HealthDay News) -- Some of the racial/ethnic disparities in diet, exercise, and weight status among U.S. adults can be explained by socioeconomic status (SES), but very few are explained by nutrition- and health-related psychosocial factors (NHRPF), according to a study published in the December issue of the Journal of the American Dietetic Association.

Abstract
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Portal Thrombosis Preventable in Islet Transplantation

FRIDAY, Dec. 2 (HealthDay News) -- For patients undergoing percutaneous islet implantation, portal venous thrombosis (PVT) can be prevented by therapeutic anticoagulation, ablation of the portal catheter tract, and limiting packed cell volume (PCV), according to a study published in the December issue of the American Journal of Transplantation.

Abstract
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Basal Hyperglycemia Dominates at High A1C Levels

THURSDAY, Dec. 1 (HealthDay News) -- For patients with type 2 diabetes with hemoglobin A1c (A1C) levels of >7.0 percent, the contribution of basal hyperglycemia (BHG) to total hyperglycemic exposure is high, and is reduced following intensification of treatment and concomitant reduction of A1C levels, according to a study published in the December issue of Diabetes Care.

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Waist-to-Height Ratio Beats BMI for Cardiometabolic Risk

THURSDAY, Dec. 1 (HealthDay News) -- Waist-to-height ratio (WHtR) is superior to waist circumference (WC) and body mass index (BMI) for detecting cardiometabolic risk in men and women of different nationalities and ethnicities, according to a review published online Nov. 23 in Obesity Reviews.

Abstract
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MK-0941 Safe, Efficacious for Short-Term Glucose Control

THURSDAY, Dec. 1 (HealthDay News) -- For patients taking stable-dose insulin glargine, use of a glucokinase inhibitor (GKA), MK-0941, leads to significant improvement in glycemic control at week 14, which is not sustained by 30 weeks, according to a study published in the December issue of Diabetes Care.

Abstract
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Snack Timing Affects Fruit, Vegetable Intake, Weight Loss

THURSDAY, Dec. 1 (HealthDay News) -- The timing and frequency of snack meals can affect dietary intake of fruits, vegetables, and fiber, and can impede weight loss interventions, according to a study published in the December issue of the Journal of the American Dietetic Association.

Abstract
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