Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for December 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Anesthesia Boosts Colonoscopy Price Tag
THURSDAY, Dec. 29 (HealthDay News) -- In asymptomatic adults who undergo screening colonoscopies, the use of anesthesia significantly increases the cost of the procedure and is most likely to be ordered by a surgeon, according to research published in the January issue of Clinical Gastroenterology and Hepatology.
Benefits Beat Risks in Combo Therapy for Crohn's Disease
THURSDAY, Dec. 29 (HealthDay News) -- In Crohn's patients treated for one year in the Study of Biologic and Immunomodulator-Naive Patients With Crohn's Disease (SONIC), infection would have to occur at a rate of 20 percent or greater, and lymphoma at a rate of 3.9 percent or greater, for the risks of combination therapy with infliximab and azathioprine (IFX/AZA) to outweigh the benefits, when compared with IFX monotherapy, according to research published in the January issue of Clinical Gastroenterology and Hepatology.
Acute Kidney Injury Shortens Survival in Alcoholic Hepatitis
WEDNESDAY, Dec. 28 (HealthDay News) -- In patients with alcoholic hepatitis (AH), acute kidney injury (AKI) during hospitalization decreases 90-day survival; and AKI detected by AKI network (AKIN) criteria is a better predictor of mortality than AKI detected by traditional criteria, according to research published in the January issue of Clinical Gastroenterology and Hepatology.
Risk of Gastrointestinal Cancer in Celiac Patients Low Overall
WEDNESDAY, Dec. 28 (HealthDay News) -- Patients with celiac disease, inflammation, or latent celiac disease have a low risk of developing gastrointestinal (GI) cancer, although the risk is higher in the first year following diagnosis, according to a study published in the January issue of Clinical Gastroenterology and Hepatology.
Obese Patients Have Worse Colon Cancer Outcomes
TUESDAY, Dec. 27 (HealthDay News) -- Obese patients with colon cancer are less likely to have deficient mismatch repair (dMMR) tumors and have a worse prognosis compared with normal-weight patients, independent of other tumor variables, according to a study published online Dec. 27 in the Journal of Clinical Oncology.
Trace Element Levels Linked to Pancreatic Cancer Risk
TUESDAY, Dec. 27 (HealthDay News) -- High bodily levels of the trace elements nickel and selenium may lower the risk of developing the most common type of pancreatic cancer, while high levels of lead, arsenic, and cadmium could increase the likelihood of developing the disease, according to a study published online Dec. 19 in Gut.
Perceptions of Inappropriate Care Prevalent Among ICU Staff
TUESDAY, Dec. 27 (HealthDay News) -- Perceptions of inappropriate care are prevalent among intensive care unit (ICU) clinicians in Europe and Israel, according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.
Norway Shows Rise in Gastro-Oesophageal Reflux Symptoms
TUESDAY, Dec. 27 (HealthDay News) -- The prevalence of gastro-oesophageal reflux symptoms (GORS) in a Norwegian county increased substantially between 1995-7 and 2006-9, according to a study published online Dec. 21 in Gut.
Women With Endometriosis Have a Higher Risk of IBD
THURSDAY, Dec. 22 (HealthDay News) -- Women with endometriosis have a significantly increased risk of developing inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, compared to those without the reproductive disorder, according to a large Danish study published online Dec. 19 in Gut.
Aflibercept Shows Clinical Activity for Malignant Ascites
WEDNESDAY, Dec. 21 (HealthDay News) -- Aflibercept, a potent inhibitor of vascular endothelial growth factor (VEGF), shows clinical activity and increases the time to repeat paracentesis for patients with advanced chemo-resistant ovarian cancer and recurrent symptomatic malignant ascites, according to a study published online Dec. 21 in The Lancet Oncology.
U.S. CRC Mortality Racial Disparity Up in Last 20 Years
TUESDAY, Dec. 20 (HealthDay News) -- From 1985 to 2008, black-white disparities in U.S. colorectal cancer (CRC) mortality rates have increased for each disease stage, with trends in late-stage disease accounting for most of the overall disparity, according to a study published online Dec. 19 in the Journal of Clinical Oncology.
Liver Transplants for NASH Up 600 Percent in 10 Years
TUESDAY, Dec. 20 (HealthDay News) -- The proportion of liver transplants performed in patients diagnosed with nonalcoholic steatohepatitis (NASH) increased dramatically from 1997-2003 to 2004-2010, but post-transplant survival in this population is excellent, with one-year survival rates near 88 percent, according to a study published online Sept. 19 in Liver Transplantation.
Physician Opinions on Benefits of Open Visit Notes Vary
MONDAY, Dec. 19 (HealthDay News) -- Primary care physicians (PCPs) have varied opinions about open access to doctors' notes; and most users of a personal health record (PHR) system are interested in sharing access to their information, according to two studies published in the Dec. 20 issue of the Annals of Internal Medicine.
Routine Cancer Screening Common in Elderly Aged 75 Up
TUESDAY, Dec. 13 (HealthDay News) -- Many adults aged 75 years or older routinely undergo cancer screening, according to a study published in the Dec. 12/26 issue of the Archives of Internal Medicine.
Myotonic Muscular Dystrophy Tied to Increased Cancer Risk
TUESDAY, Dec. 13 (HealthDay News) -- Patients diagnosed with myotonic muscular dystrophy (MMD) are at an increased risk of developing cancer, according to a study published in the Dec. 14 issue of the Journal of the American Medical Association.
Peritoneal Carcinomatosis Tied to Poor Survival in CRC
TUESDAY, Dec. 13 (HealthDay News) -- For patients with metastatic colorectal cancer (mCRC), peritoneal carcinomatosis colorectal cancer (pcCRC) is associated with significantly shorter overall survival (OS) and progression-free survival (PFS), according to a study published online Dec. 12 in the Journal of Clinical Oncology.
Hispanic Race, Obesity Tied to Pediatric Gallbladder Disease
TUESDAY, Dec. 13 (HealthDay News) -- Hispanic ethnicity and obesity are strongly associated with symptomatic pediatric gallbladder disease, according to a study published online Dec. 12 in Pediatrics.
Infection Prevention Up in VA, Non-Federal Hospitals
TUESDAY, Dec. 13 (HealthDay News) -- From 2005 to 2009, there was a significant increase in the use of hospital-acquired infection (HAI) prevention practices in non-federal and Veterans Affairs (VA) hospitals, according to a study published online Dec. 6 in the Journal of General Internal Medicine.
Microbial Diversity ID'd in Gut of Low Birth Weight Infants
FRIDAY, Dec. 9 (HealthDay News) -- The gut-associated microbiome of extremely low birth weight (ELBW) infants has microbial diversity and includes fungal species, bacteria, molds, viruses, parasitic organisms, and roundworms, according to a study published online Dec. 8 in PLoS One.
Bowel Screening Detects Early Cancer in Majority of Patients
FRIDAY, Dec. 9 (HealthDay News) -- The colorectal cancer screening program in England detects mainly early cancer, and has found that left-sided cancers are considerably more common than expected, according to a study published online Dec. 7 in Gut.
Factors Affecting Micro-RNA Detection Accuracy Identified
FRIDAY, Dec. 9 (HealthDay News) -- Accurate detection and quantitation of circulating microRNAs (miRNAs) is affected by inherent differences in plasma samples, methods used for their collection and analysis, and the presence of specific inhibitors in plasma, according to a study published online Dec. 9 in the Journal of Molecular Diagnostics.
Intranasal Vaccine Effective Against Norwalk Virus Illness
WEDNESDAY, Dec. 7 (HealthDay News) -- Two doses of an intranasally delivered norovirus virus-like particle (VLP) vaccine with adjuvants (chitosan and monophosphoryl lipid A), provides protection against challenge with a homologous Norwalk virus in healthy adults, according to a study published in the Dec. 8 issue of the New England Journal of Medicine.
Randomized Controlled HCC Screening Trial Not Feasible
WEDNESDAY, Dec. 7 (HealthDay News) -- A randomized controlled trial (RCT) of hepatocellular carcinoma (HCC) screening is not feasible for informed patients with cirrhosis; and small HCC detection is not improved by ultrasonographic screening (US) every three versus six months, according to two studies published in the December issue of Hepatology.
Transplant Patients Want a Role in Liver Quality Decisions
TUESDAY, Dec. 6 (HealthDay News) -- Patients waiting for liver transplantation want to be involved in decisions about organ quality, and the level of risk they are prepared to tolerate is influenced by the presentation format, according to a study published in the December issue of Liver Transplantation.
Medical Students Fail to ID Hand Hygiene Indications
MONDAY, Dec. 5 (HealthDay News) -- Medical students who are about to start the clinical phase of their education have a lack of knowledge regarding the correct indications for hand disinfection, according to a study published in the December issue of the American Journal of Infection Control.
C. difficile Infection Ups Duration of Hospital Stay
MONDAY, Dec. 5 (HealthDay News) -- Hospital-acquired infection with Clostridium difficile (C. difficile) significantly and independently lengthens the duration of stay in the hospital, according to a study published online Dec. 5 in CMAJ, the journal of the Canadian Medical Association.
Green Tea Polyphenol Inhibits HCV Entry Into Hepatocytes
MONDAY, Dec. 5 (HealthDay News) -- Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, strongly inhibits the entry of hepatitis C virus (HCV) into primary human hepatocytes, according to a study published in the December issue of Hepatology.
High Incidence of Adverse Upper GI Events in MI Patients
MONDAY, Dec. 5 (HealthDay News) -- Patients with ST-segment elevation myocardial infarction, who undergo primary percutaneous coronary intervention and receive routine dual-antiplatelet therapy, have a high incidence of short- and long-term major adverse upper gastrointestinal events (MAUGIEs), according to a study published in the Dec. 15 issue of The American Journal of Cardiology.
Serum Glucose Levels Tied to Colorectal Cancer Risk in Women
FRIDAY, Dec. 2 (HealthDay News) -- Serum glucose levels, but not serum insulin or homeostasis model assessment, are associated with increased colorectal cancer risk in postmenopausal women, according to a study published online Nov. 29 in the British Journal of Cancer.
Satisfaction With Care Scale Validated for Patients With IBS
THURSDAY, Dec. 1 (HealthDay News) -- The irritable bowel syndrome (IBS) Satisfaction With Care Scale (IBS-SAT) is a validated measure of patient satisfaction with IBS care, which exhibits high internal consistency, and convergent and discriminant validity, according to a study published in the December issue of Clinical Gastroenterology and Hepatology.
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