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Category: Gynecology | Monthly Briefing

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December 2011 Briefing - OBGYN & Women’s Health

Last Updated: January 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in OBGYN & Women's Health for December 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Early Childhood Factors ID'd for Predicting Adult Obesity

THURSDAY, Dec. 29 (HealthDay News) -- Childhood growth patterns, childhood obesity, maternal body mass index (BMI), and father's employment are probable early markers for adult obesity, according to a study published online Dec. 16 in Obesity Reviews.

Abstract
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Metabolic Syndrome Linked to Overactive Bladder in Females

THURSDAY, Dec. 29 (HealthDay News) -- Metabolic syndrome is significantly associated with overactive bladder in female patients, according to a study published in the January issue of Urology.

Abstract
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Oseltamivir-Resistant H1N1 Identified in Australia

THURSDAY, Dec. 29 (HealthDay News) -- Oseltamivir-resistant prepandemic seasonal influenza 1 (H1N1) viruses with a neuraminidase substitution (H275Y) (A[H1N1]pdm09) have been identified in Australia, according to a letter published in the Dec. 29 issue of the New England Journal of Medicine.

Letter

More Fat Than Lean Mass Regained During Weight Regain

THURSDAY, Dec. 29 (HealthDay News) -- For postmenopausal women who regain weight in the year following intentional weight loss, fat mass is regained to a greater extent than lean mass, according to a study published in a recent issue of the American Journal of Clinical Nutrition.

Abstract
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Nutrition Tied to Cognitive Decline, Cerebral Volume Loss

WEDNESDAY, Dec. 28 (HealthDay News) -- In elderly adults with high intake of B vitamins; vitamins C, D, and E; and omega-3 fatty acids, cognitive testing and magnetic resonance imaging (MRI) demonstrate less cognitive decline and cerebral volume loss, while high-trans-fat diets have the opposite effects, according to research published online Dec. 28 in Neurology.

Abstract
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Bevacizumab Ups Progression-Free Survival in Ovarian Cancer

WEDNESDAY, Dec. 28 (HealthDay News) -- For women with ovarian cancer, the addition of bevacizumab to standard chemotherapy results in significantly improved progression-free survival (PFS), according to two phase 3 studies published in the Dec. 29 issue of the New England Journal of Medicine.

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Oral Olaparib Shows Efficacy in Advanced Ovarian Cancer

WEDNESDAY, Dec. 28 (HealthDay News) -- A new orally active poly (ADP-ribose) polymerase (PARP) inhibitor, olaparib, has been found to have similar efficacy to pegylated liposomal doxorubicin (PLD) for the treatment of patients with ovarian cancer that has recurred or progressed following treatment with platinum-based chemotherapy, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Editorial

New Equation Accurately Predicts Body Fat Percentage

WEDNESDAY, Dec. 28 (HealthDay News) -- A new prediction equation estimates body fat percentage (BF%) in adults with a low error rate and acceptable accuracy and may be a good first-screening tool for identifying patients at cardiovascular and type 2 diabetes risk, according to research published online Dec. 16 in Diabetes Care.

Abstract
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Genetic Variants Found to Predispose to Weight Regain

WEDNESDAY, Dec. 28 (HealthDay News) -- Numerous genetic variants predispose people to weight loss (WL) as well as weight regain (WR) after intentional WL, according to research published online Dec. 16 in Diabetes Care.

Abstract
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Prevalence of High-Risk HPV, Cytologic Abnormalities ID'd

WEDNESDAY, Dec. 28 (HealthDay News) -- Estimates of the baseline prevalence of cytologic abnormalities, high-risk human papillomavirus (hrHPV; defined as 1 of 14 high-risk types of HPV including HPV 16 and HPV 18), HPV 16, HPV 18, and cervical intraepithelial neoplasia grade 2 (CIN2) or greater have been established using the Addressing the Need for Advanced HPV Diagnostics screening trial, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Irradiation of Left Breast Linked to Coronary Stenosis Risk

WEDNESDAY, Dec. 28 (HealthDay News) -- Women with irradiated left sided breast cancer (BC) have an increased risk of high-grade coronary artery stenosis in the mid and distal left anterior descending artery and distal diagonal (mdLAD + dD), according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Editorial

Perceptions of Inappropriate Care Prevalent Among ICU Staff

TUESDAY, Dec. 27 (HealthDay News) -- Perceptions of inappropriate care are prevalent among intensive care unit (ICU) clinicians in Europe and Israel, according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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Vaginal Prolapse Outcomes Similar With or Without Mesh

TUESDAY, Dec. 27 (HealthDay News) -- Vaginal prolapse repair improves quality of life, with or without mesh, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Low Pegnancy Vitamin D Levels Up Child's Diabetes Risk

TUESDAY, Dec. 27 (HealthDay News) -- Lower maternal serum concentrations of 25-hydroxy-vitamin D (25-OH D) during pregnancy are associated with an increased risk of offspring developing type 1 diabetes during childhood, according to a study published in the January issue of Diabetes.

Abstract
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U.S. Spends Up to $34.4 Billion Annually on Uterine Fibroids

TUESDAY, Dec. 27 (HealthDay News) -- The total annual societal cost of uterine fibroids in the United States is estimated to range from $5.9 to $34.4 billion, based on direct and indirect costs, according to a study published online Dec. 12 in the American Journal of Obstetrics & Gynecology.

Abstract
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Smoking During Pregnancy Affects Children's Vasculature

TUESDAY, Dec. 27 (HealthDay News) -- Parental smoking during pregnancy affects children's arterial structure and function in early life; and interventions that encourage parents to quit smoking for their children's benefit may increase parental quit rates, according to two studies published online Dec. 26 in Pediatrics.

Abstract - Geerts
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Abstract - Rosen
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Extended Nevirapine Reduces Breastfeeding HIV Transmission

FRIDAY, Dec. 23 (HealthDay News) -- Prophylactic nevirapine is safe and can reduce mother-to-child Human Immunodeficiency Virus-1 (HIV-1) transmission during breastfeeding up to 6 months of age, according to a study published online Dec. 23 in The Lancet.

Abstract
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Postmenopausal HRT Improves Sexual Function

THURSDAY, Dec. 22 (HealthDay News) -- Twelve months of daily oral hormonal replacement therapy with estradiol plus dihydrogesterone (HRT), dehydroepiandrosterone (DHEA), or tibolone improves sexual function and frequency in early postmenopausal women, according to a study published in the December issue of Climacteric.

Abstract
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Women With Endometriosis Have a Higher Risk of IBD

THURSDAY, Dec. 22 (HealthDay News) -- Women with endometriosis have a significantly increased risk of developing inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, compared to those without the reproductive disorder, according to a large Danish study published online Dec. 19 in Gut.

Abstract
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Screening Mammography Over-Recommended in Terminally Ill

THURSDAY, Dec. 22 (HealthDay News) -- Over-recommendation of screening mammography for women with a terminal comorbidity is common, and is associated with physician and practice characteristics, including specialty, gender, race, and size of practice, according to a study published in the Jan. 1 issue of Cancer.

Abstract
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DICER1 Mutations ID'd in Non-Epithelial Ovarian Cancer

WEDNESDAY, Dec. 21 (HealthDay News) -- Somatic missense mutations in the region of DICER1, which encodes the RNase IIIb domain, are common in nonepithelial ovarian tumors, according to a study published online Dec. 21 in the New England Journal of Medicine.

Abstract
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Aflibercept Shows Clinical Activity for Malignant Ascites

WEDNESDAY, Dec. 21 (HealthDay News) -- Aflibercept, a potent inhibitor of vascular endothelial growth factor (VEGF), shows clinical activity and increases the time to repeat paracentesis for patients with advanced chemo-resistant ovarian cancer and recurrent symptomatic malignant ascites, according to a study published online Dec. 21 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Medical Team Training Program Cuts Surgical Morbidity Rate

WEDNESDAY, Dec. 21 (HealthDay News) -- The Veterans Health Administration Medical Team Training (MTT) program is associated with a significant decrease in the annual surgical morbidity rate, according to a study published in the December issue of the Archives of Surgery.

Abstract
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Editorial (subscription or payment may be required)

Increased Risk of Cutaneous Melanoma in Cancer Survivors

WEDNESDAY, Dec. 21 (HealthDay News) -- Patients with a previous diagnosis of cancer have an elevated risk of developing cutaneous melanoma (CM), according to a study published in the December issue of the Archives of Dermatology.

Abstract
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Vitamin D, Calcium Found to Cut Fracture, Cancer Risk

TUESDAY, Dec. 20 (HealthDay News) -- Vitamin D supplementation can reduce the risk of fracture and cancer; and although there is a biological association between vitamin D deficiency and cardiovascular disease (CVD), there is no evidence that vitamin D supplementation prevents CVD, according to two reviews published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Chung
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Abstract - Greevy and Williams
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Blood Pressure in Middle Age Affects Lifetime CVD Risk

TUESDAY, Dec. 20 (HealthDay News) -- Changes in blood pressure (BP) during middle age significantly impact lifetime risk (LTR) for cardiovascular disease (CVD), with a possible dose-response effect for the number of years with high BP on the LTR of CVD, coronary heart disease, and stroke, according to research published online Dec. 19 in Circulation.

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Little Risk to Offspring From Maternal Inhaled Steroids

TUESDAY, Dec. 20 (HealthDay News) -- In pregnant women with asthma, the use of inhaled glucocorticoids does not increase the risk of most pediatric diseases in the offspring, though it may be a risk factor for endocrine and metabolic disorders, according to research published online Dec. 16 in the American Journal of Respiratory and Critical Care Medicine.

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Weekly AMG 386 + Paclitaxel Well Tolerated in Recurrent Ovarian CA

MONDAY, Dec. 19 (HealthDay News) -- For patients with recurrent ovarian cancer, AMG 386, an investigational peptide-Fc fusion protein, combined with weekly paclitaxel is well-tolerated, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Ovarian Failure Risk Differs with Chemo Type in Hodgkin's

MONDAY, Dec. 19 (HealthDay News) -- For female survivors of Hodgkin's lymphoma, treatment with nonalkylating chemotherapy carries little risk of premature ovarian failure (POF) for those younger than 32 years, whereas alkylating chemotherapy carries a substantially increased risk of POF, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Physician Opinions on Benefits of Open Visit Notes Vary

MONDAY, Dec. 19 (HealthDay News) -- Primary care physicians (PCPs) have varied opinions about open access to doctors' notes; and most users of a personal health record (PHR) system are interested in sharing access to their information, according to two studies published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Walker
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Abstract - Zulman
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Editorial (subscription or payment may be required)

Higher Mortality Risk in Very Premature Males Than Females

MONDAY, Dec. 19 (HealthDay News) -- Male infants born extremely prematurely have a significantly higher risk of mortality and poorer long-term neurologic outcomes, but this gender difference loses significance at 27 weeks of gestation, according to a study published online Dec. 19 in Pediatrics.

Abstract
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Variation Seen in Accelerated Breast Irradiation Use

MONDAY, Dec. 19 (HealthDay News) -- In women with breast cancer, accelerated partial breast irradiation using brachytherapy (APBIb) after breast-conserving surgery varies by race, ethnicity, and region, particularly in patients who may not be suitable for the technique, according to research published online Dec. 16 in the Journal of the National Cancer Institute.

Abstract
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Quitting Smoking Improves Happiness, Quality of Life

FRIDAY, Dec. 16 (HealthDay News) -- People who successfully quit smoking are happier and more satisfied with their lives than people who continue to smoke, according to a study published online Dec. 10 in the Annals of Behavioral Medicine.

Abstract
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Vaginal Progesterone Cuts Preterm Birth, Neonatal Deaths

FRIDAY, Dec. 16 (HealthDay News) -- For asymptomatic women with a sonographically identified short cervix in the mid-trimester, treatment with vaginal progesterone reduces the risk of preterm birth and neonatal morbidity and mortality, according to a meta-analysis published online Dec. 12 in the American Journal of Obstetrics & Gynecology.

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Pre-Pregnancy Maternal BMI Impacts Baby's Birth Weight

FRIDAY, Dec. 16 (HealthDay News) -- Birth weight is influenced by both pre-pregnancy weight and weight gain during pregnancy, according to a study published online Nov. 14 in Acta Obstetricia et Gynecologica Scandinavica.

Abstract
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HPV DNA Testing Leads to Early Detection of Cervical Cancer

THURSDAY, Dec. 15 (HealthDay News) -- Human papillomavirus (HPV) DNA testing at a first screening results in detection of fewer cases of cervical intraepithelial neoplasia (CIN) grade 2 or worse, CIN grade 3 or worse, and cervical cancer at a second screening five years later, according to a study published online Dec. 15 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

High Prevalence of Obesity Found Among Adults in Spain

THURSDAY, Dec. 15 (HealthDay News) -- The prevalence of obesity is high in the adult population of Spain and is affected by sociodemographic factors, including age and education levels, according to a study published online Dec. 12 in Obesity Reviews.

Abstract
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Fetal Tracheal Occlusion Improves Neonatal Survival

WEDNESDAY, Dec. 14 (HealthDay News) -- Fetal endoscopic tracheal occlusion (FETO) is associated with improved neonatal survival in severe isolated congenital diaphragmatic hernia (CDH), according to a study published online Dec. 14 in Ultrasound in Obstetrics & Gynecology.

Abstract
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Routine Cancer Screening Common in Elderly Aged 75 Up

TUESDAY, Dec. 13 (HealthDay News) -- Many adults aged 75 years or older routinely undergo cancer screening, according to a study published in the Dec. 12/26 issue of the Archives of Internal Medicine.

Abstract
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Editorial (subscription or payment may be required)

Myotonic Muscular Dystrophy Tied to Increased Cancer Risk

TUESDAY, Dec. 13 (HealthDay News) -- Patients diagnosed with myotonic muscular dystrophy (MMD) are at an increased risk of developing cancer, according to a study published in the Dec. 14 issue of the Journal of the American Medical Association.

Abstract
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Risk Factors for Stillbirth ID'd at the Start of Pregnancy

TUESDAY, Dec. 13 (HealthDay News) -- Several risk factors that can be identified at the time of pregnancy confirmation correlate with stillbirth; and obstetric complications and placental abnormalities are the most common causes of stillbirth, and show racial discrepancies, according to two studies published in the Dec. 14 issue of the Journal of the American Medical Association.

Abstract 1
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Abstract 2
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Editorial (subscription or payment may be required)

Single First-Trimester Malaria Episode Ups Miscarriage Risk

TUESDAY, Dec. 13 (HealthDay News) -- There is an increased risk of miscarriage for women who have a single episode of Plasmodium falciparum or Plasmodium vivax malaria during their first trimester of pregnancy, according to a study published online Dec. 13 in The Lancet Infectious Diseases.

Abstract
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Histologic Chorioamnionitis Protects Against Sepsis

TUESDAY, Dec. 13 (HealthDay News) -- Histologic chorioamnionitis (HCA) has been implicated in preterm delivery and is a risk factor for early-onset sepsis, but may be protective against late-onset sepsis (LOS) by modulating postnatal immunity, according to research published online Dec. 12 in Pediatrics.

Abstract
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No Increase in Birth Defects for Offspring of Cancer Survivors

TUESDAY, Dec. 13 (HealthDay News) -- For survivors of childhood cancer treated with chemotherapy or gonadal radiation, there is no increased risk of congenital anomalies in their offspring, according to a study published online Dec. 12 in the Journal of Clinical Oncology.

Abstract
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Infection Prevention Up in VA, Non-Federal Hospitals

TUESDAY, Dec. 13 (HealthDay News) -- From 2005 to 2009, there was a significant increase in the use of hospital-acquired infection (HAI) prevention practices in non-federal and Veterans Affairs (VA) hospitals, according to a study published online Dec. 6 in the Journal of General Internal Medicine.

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Two Prognostic Models for Very Preterm Birth Validated

MONDAY, Dec. 12 (HealthDay News) -- Prognostic models for stillbirth and neonatal death in very preterm infants demonstrated good performance in the Netherlands, according to a study published online Dec. 12 in Pediatrics.

Abstract
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Preterm Birth Impairs Baroreflex Sensitivity in Infants

MONDAY, Dec. 12 (HealthDay News) -- Preterm birth alters the normal maturational increase in baroreflex sensitivity (BRS), which results in significantly reduced BRS during quiet sleep (QS), at a corrected age (CA) of 5 to 6 months, according to a study published online Dec. 12 in Pediatrics.

Abstract
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Chemo, Radiation Worsen Cognition in Breast CA Survivors

MONDAY, Dec. 12 (HealthDay News) -- Breast cancer survivors treated with chemotherapy plus radiation or radiation alone may experience poorer cognitive functioning over time, according to a study published online Dec. 12 in Cancer.

Abstract
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Microbial Diversity ID'd in Gut of Low Birth Weight Infants

FRIDAY, Dec. 9 (HealthDay News) -- The gut-associated microbiome of extremely low birth weight (ELBW) infants has microbial diversity and includes fungal species, bacteria, molds, viruses, parasitic organisms, and roundworms, according to a study published online Dec. 8 in PLoS One.

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Post-Mastectomy Reconstruction Feasible for Older Women

FRIDAY, Dec. 9 (HealthDay News) -- Breast reconstruction after mastectomy is safe, feasible, and well tolerated in older women, according to a study published in the December issue of The American Surgeon.

Abstract
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Breast Cancer Screening May Be Causing More Harm Than Good

FRIDAY, Dec. 9 (HealthDay News) -- Mammographic breast cancer screening may initially cause more harm than good when including the effects of harms in the analysis, according to a study published online Dec. 8 in BMJ.

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Factors Affecting Micro-RNA Detection Accuracy Identified

FRIDAY, Dec. 9 (HealthDay News) -- Accurate detection and quantitation of circulating microRNAs (miRNAs) is affected by inherent differences in plasma samples, methods used for their collection and analysis, and the presence of specific inhibitors in plasma, according to a study published online Dec. 9 in the Journal of Molecular Diagnostics.

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Urinary Incontinence Surgery Tied to Voiding Pressure

THURSDAY, Dec. 8 (HealthDay News) -- Successful surgical outcomes following stress urinary incontinence (SUI) surgery, with Burch colposuspension or autologous fascial sling, are associated with higher voiding pressures, but not with change in other urodynamic parameters, according to a study published in the December issue of Urology.

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Similar Prognosis for BRCA1 Carriers, Sporadic Breast Cancer

THURSDAY, Dec. 8 (HealthDay News) -- The risks of distant recurrence and death are similar for BRCA1 mutation carriers and for those with sporadic breast cancer, whereas women with BRCA2 mutations have higher risks on univariable analysis, and similar risks on multivariable analysis, according to a study published online Dec. 5 in the Journal of Clinical Oncology.

Abstract
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Editorial

Behavioral Problems ID'd in Moderately Preterm Children

THURSDAY, Dec. 8 (HealthDay News) -- Children born moderately preterm have a higher overall occurrence of behavioral and emotional problems than term-born controls, as well as a higher occurance of specific types of such problems, according to a study published online Dec. 6 in the Archives of Disease in Childhood.

Abstract
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Role of Environmental Factors in Breast Cancer Explored

WEDNESDAY, Dec. 7 (HealthDay News) -- Women may be able to reduce their risk of breast cancer by avoiding exposure to certain environmental factors, according to a report published Dec. 7 by the Institute of Medicine.

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Study Finds Mammography Cuts Breast Cancer Deaths

TUESDAY, Dec. 6 (HealthDay News) -- Breast cancer detection through mammography screening is effective in reducing breast cancer mortality, according to a case-control study published online Dec. 6 in Cancer Epidemiology, Biomarkers & Prevention.

Abstract
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Antenatal Steroids Useful for Infants Born at 23 to 25 Weeks

TUESDAY, Dec. 6 (HealthDay News) -- For infants born at 23 to 25 weeks of gestation, antenatal exposure to corticosteroids is associated with a lower rate of death or neurodevelopmental impairment at 18 to 22 months, according to a study published in the Dec. 7 issue of the Journal of the American Medical Association.

Abstract
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FDA and FTC Crack Down on Homeopathic Weight Loss Drug

TUESDAY, Dec. 6 (HealthDay News) -- Companies that market over-the-counter products containing human chorionic gonadotropin (HCG) and labeled as "homeopathic" for weight loss are violating federal law and have been issued warnings, according to a Dec. 6 announcement from the U.S. Food and Drug Administration and the Federal Trade Commission (FTC).

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Rice Consumption Linked to Arsenic Exposure

TUESDAY, Dec. 6 (HealthDay News) -- In pregnant women who report daily rice consumption, urinary excretion of arsenic is significantly elevated when compared with non-rice eaters, according to research published online Dec. 5 in the Proceedings of the National Academy of Sciences.

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Postpartum Psychiatric Episodes Predict Bipolar Disorder

TUESDAY, Dec. 6 (HealthDay News) -- Presentation of a psychiatric episode in the postpartum period predicts subsequent conversion to bipolar affective disorder, according to a study published online Dec. 5 in the Archives of General Psychiatry.

Abstract
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Medical Students Fail to ID Hand Hygiene Indications

MONDAY, Dec. 5 (HealthDay News) -- Medical students who are about to start the clinical phase of their education have a lack of knowledge regarding the correct indications for hand disinfection, according to a study published in the December issue of the American Journal of Infection Control.

Abstract
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Eating Little or No Fish Ups Young Women's CVD Risk

MONDAY, Dec. 5 (HealthDay News) -- Young and initially healthy women who consume little or no fish and long-chain n-3 polyunsaturated fatty acids (LCn3FAs) have an increased risk of cardiovascular disease, according to a study published online Dec. 5 in Hypertension.

Abstract
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Aggravating Circumstances in Most Youth Sexting Police Cases

MONDAY, Dec. 5 (HealthDay News) -- The majority of police-investigated youth sexting cases include aggravating circumstances, but few youth are arrested; and only a small percentage of youth appear in, create, or receive sexually explicit images, according to two studies published online Dec. 5 in Pediatrics.

Abstract - Wolak
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Abstract - Mitchell
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Risk Factors Identified for Pregnancy-Associated Suicide

FRIDAY, Dec. 2 (HealthDay News) -- The presence of an existing mental health diagnosis, current depressed mood, substance use, and intimate partner problems are risk factors which influence pregnancy-associated suicide, according to a study published online Nov. 3 in General Hospital Psychiatry.

Abstract
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Serum Glucose Levels Tied to Colorectal Cancer Risk in Women

FRIDAY, Dec. 2 (HealthDay News) -- Serum glucose levels, but not serum insulin or homeostasis model assessment, are associated with increased colorectal cancer risk in postmenopausal women, according to a study published online Nov. 29 in the British Journal of Cancer.

Abstract
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Lobular Breast Cancer Tied to Having Father With Cancer

FRIDAY, Dec. 2 (HealthDay News) -- Lobular breast cancer is associated with having a father diagnosed with cancer, most commonly prostate cancer; and this association is independent of a family history of breast cancer, according to a study published online Nov. 28 in BMC Cancer.

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Time of Operation Not Linked to Postoperative Mortality

FRIDAY, Dec. 2 (HealthDay News) -- The timing of general surgery and the moon phase are not associated with 30-day mortality after surgery, according to a study published in the December issue of Anesthesia & Analgesia.

Abstract
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Diet High in Antioxidants Cuts Stroke Risk for Women

THURSDAY, Dec. 1 (HealthDay News) -- Following a diet with high total antioxidant capacity (TAC) is associated with reduced incidence of total stroke among women with no history of cardiovascular disease (CVD) and hemorrhagic stroke in those with a CVD history, according to a study published online Dec. 1 in Stroke.

Abstract
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Risk Factors ID'd for Pressure Ulcers in Prolonged Surgery

THURSDAY, Dec. 1 (HealthDay News) -- Pressure ulcer development during surgical procedures that last more than three hours is significantly related to the type of positioning device, table surface, skin assessment, and gender; with use of a foam pad and a lower day-one Braden score significantly predictive of pressure ulcers, according to a study published in the December issue of the AORN Journal.

Abstract
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Breast CA Mets Biopsy Viable; May Impact Management

THURSDAY, Dec. 1 (HealthDay News) -- Biopsy of breast cancer metastases for estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor 2 (HER2) status is feasible and alters management in 14 percent of patients, but receptor discordance is not associated with worse outcome, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

Abstract
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Parental CA Therapy Not Tied to Genetic Defects in Offspring

THURSDAY, Dec. 1 (HealthDay News) -- Neither prenatal chemotherapy nor preconception gonad irradiation are associated with genetic defects in children of cancer survivors, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

Abstract
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Editorial

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