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Category: Oncology | Monthly Briefing

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December 2011 Briefing - Hematology & Oncology

Last Updated: January 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for December 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Three Gene Mutations Linked to Epithelial Thyroid Cancers

FRIDAY, Dec. 30 (HealthDay News) -- Cowden syndrome (CS)/CS-like patients with PTEN mutations, SDHx variations, and KLLN epimutations are at increased risk of epithelial thyroid cancers, according to a study published in the Dec. 1 issue of the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Updated Tool Helps Predict Outcome in Brain Metastases

THURSDAY, Dec. 29 (HealthDay News) -- The updated Graded Prognostic Assessment (GPA), a diagnosis-specific, predictive index for cancer patients with brain metastases, helps clinicians estimate survival, select appropriate treatment, and stratify patients for clinical trials, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Oseltamivir-Resistant H1N1 Identified in Australia

THURSDAY, Dec. 29 (HealthDay News) -- Oseltamivir-resistant prepandemic seasonal influenza 1 (H1N1) viruses with a neuraminidase substitution (H275Y) (A[H1N1]pdm09) have been identified in Australia, according to a letter published in the Dec. 29 issue of the New England Journal of Medicine.

Letter

Early Palliative Care Improves Quality of Life in NSCLC

THURSDAY, Dec. 29 (HealthDay News) -- Early palliative care for patients with terminal non-small-cell lung cancer (NSCLC) improves the timing of final chemotherapy administration and is associated with an earlier transition to hospice care, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Editorial

Bevacizumab Ups Progression-Free Survival in Ovarian Cancer

WEDNESDAY, Dec. 28 (HealthDay News) -- For women with ovarian cancer, the addition of bevacizumab to standard chemotherapy results in significantly improved progression-free survival (PFS), according to two phase 3 studies published in the Dec. 29 issue of the New England Journal of Medicine.

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Enoxaparin Doesn't Reduce Death Rate for Acutely Ill

WEDNESDAY, Dec. 28 (HealthDay News) -- For hospitalized, acutely ill medical patients, use of enoxaparin plus elastic stockings with graduated compressions, does not reduce the rate of death from any cause at 30 days, according to a study published in the Dec. 29 issue of the New England Journal of Medicine.

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Oral Olaparib Shows Efficacy in Advanced Ovarian Cancer

WEDNESDAY, Dec. 28 (HealthDay News) -- A new orally active poly (ADP-ribose) polymerase (PARP) inhibitor, olaparib, has been found to have similar efficacy to pegylated liposomal doxorubicin (PLD) for the treatment of patients with ovarian cancer that has recurred or progressed following treatment with platinum-based chemotherapy, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Editorial

Prevalence of High-Risk HPV, Cytologic Abnormalities ID'd

WEDNESDAY, Dec. 28 (HealthDay News) -- Estimates of the baseline prevalence of cytologic abnormalities, high-risk human papillomavirus (hrHPV; defined as 1 of 14 high-risk types of HPV including HPV 16 and HPV 18), HPV 16, HPV 18, and cervical intraepithelial neoplasia grade 2 (CIN2) or greater have been established using the Addressing the Need for Advanced HPV Diagnostics screening trial, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Chromosomal Abnormalities Signal CNS Involvement in AML

WEDNESDAY, Dec. 28 (HealthDay News) -- Cytogenetic analysis at the time of diagnosis in patients with acute myeloid leukemia (AML) shows higher rates of chromosomal abnormalities for patients with central nervous system (CNS) involvement than for those with no CNS involvement, and survival is typically poor for patients with AML and CNS disease, according to a study published in the Jan. 1 issue of Cancer.

Abstract
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Risk of Gastrointestinal Cancer in Celiac Patients Low Overall

WEDNESDAY, Dec. 28 (HealthDay News) -- Patients with celiac disease, inflammation, or latent celiac disease have a low risk of developing gastrointestinal (GI) cancer, although the risk is higher in the first year following diagnosis, according to a study published in the January issue of Clinical Gastroenterology and Hepatology.

Abstract
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Irradiation of Left Breast Linked to Coronary Stenosis Risk

WEDNESDAY, Dec. 28 (HealthDay News) -- Women with irradiated left sided breast cancer (BC) have an increased risk of high-grade coronary artery stenosis in the mid and distal left anterior descending artery and distal diagonal (mdLAD + dD), according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Editorial

Obese Patients Have Worse Colon Cancer Outcomes

TUESDAY, Dec. 27 (HealthDay News) -- Obese patients with colon cancer are less likely to have deficient mismatch repair (dMMR) tumors and have a worse prognosis compared with normal-weight patients, independent of other tumor variables, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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No Correlation ID'd Between CYP2C19 Genotype, CVD Events

TUESDAY, Dec. 27 (HealthDay News) -- Although CYP2C19 genotype correlates with clopidogrel response and platelet aggregation, there is no evidence of a clinically significant association between CYP2C19 genotype and cardiovascular disease (CVD) events, according to a meta-analysis published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Trace Element Levels Linked to Pancreatic Cancer Risk

TUESDAY, Dec. 27 (HealthDay News) -- High bodily levels of the trace elements nickel and selenium may lower the risk of developing the most common type of pancreatic cancer, while high levels of lead, arsenic, and cadmium could increase the likelihood of developing the disease, according to a study published online Dec. 19 in Gut.

Abstract
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Perceptions of Inappropriate Care Prevalent Among ICU Staff

TUESDAY, Dec. 27 (HealthDay News) -- Perceptions of inappropriate care are prevalent among intensive care unit (ICU) clinicians in Europe and Israel, according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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Poor Compliance With Sunscreen Advice Found in Adult Skiers

FRIDAY, Dec. 23 (HealthDay News) -- Very few adult skiers and snowboarders show full compliance with sunscreen advice, especially with the advice to reapply sunscreen after two hours, according to a study published in the January issue of the Journal of the American Academy of Dermatology.

Abstract
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Correcting Anemia Reduces Odds of Renal Transplant Failure

THURSDAY, Dec. 22 (HealthDay News) -- Complete correction of anemia (hemoglobin, ≥13 g/dL) in kidney transplant recipients slows progression to chronic allograft nephropathy, according to a study published online Dec. 22 in the Journal of the American Society of Nephrology.

Abstract
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Screening Mammography Over-Recommended in Terminally Ill

THURSDAY, Dec. 22 (HealthDay News) -- Over-recommendation of screening mammography for women with a terminal comorbidity is common, and is associated with physician and practice characteristics, including specialty, gender, race, and size of practice, according to a study published in the Jan. 1 issue of Cancer.

Abstract
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Recurrent Cutaneous Melanoma Hazard Rates Vary With Stage

THURSDAY, Dec. 22 (HealthDay News) -- The hazard rates (HRs) for recurrent and secondary cutaneous melanoma (CM) after incident stage IA melanoma are low, while the HRs of recurrence after incident stage IB, II, and III CM are high, according to a study published in the January issue of the Journal of the American Academy of Dermatology.

Abstract
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Platinum Treatment for Testicular Cancer Ups Neurotoxicity

THURSDAY, Dec. 22 (HealthDay News) -- Long-term serum levels of residual platinum correlate with the severity of neurotoxicity five to 20 years after chemotherapy in testicular cancer (TC) survivors, even after adjusting for initial cisplatin dose, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Paxil Use Linked to Obesity in Childhood Cancer Survivors

THURSDAY, Dec. 22 (HealthDay News) -- Treatment, lifestyle, and the use of specific antidepressants may contribute to obesity among survivors of childhood cancer, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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DICER1 Mutations ID'd in Non-Epithelial Ovarian Cancer

WEDNESDAY, Dec. 21 (HealthDay News) -- Somatic missense mutations in the region of DICER1, which encodes the RNase IIIb domain, are common in nonepithelial ovarian tumors, according to a study published online Dec. 21 in the New England Journal of Medicine.

Abstract
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Increased Risk of Cutaneous Melanoma in Cancer Survivors

WEDNESDAY, Dec. 21 (HealthDay News) -- Patients with a previous diagnosis of cancer have an elevated risk of developing cutaneous melanoma (CM), according to a study published in the December issue of the Archives of Dermatology.

Abstract
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Aflibercept Shows Clinical Activity for Malignant Ascites

WEDNESDAY, Dec. 21 (HealthDay News) -- Aflibercept, a potent inhibitor of vascular endothelial growth factor (VEGF), shows clinical activity and increases the time to repeat paracentesis for patients with advanced chemo-resistant ovarian cancer and recurrent symptomatic malignant ascites, according to a study published online Dec. 21 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Immunosuppression Evidence Identified in Septic Death

WEDNESDAY, Dec. 21 (HealthDay News) -- Patients who die with active severe sepsis have reduced cytokine secretion and other changes indicative of immunosuppression, according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

Abstract
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Cixutumumab Tolerated for Pediatric Refractory Solid Tumors

WEDNESDAY, Dec. 21 (HealthDay News) -- Cixutumumab is well tolerated in children with refractory solid tumors, but limited single-agent activity is seen in Ewing sarcoma (ES), according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Sunless Tanning Product Use Tied to Reduced UV Exposure

TUESDAY, Dec. 20 (HealthDay News) -- Use of sunless tanning products is associated with decreased exposure to ultraviolet (UV) radiation tanning methods, especially among women who use such products frequently, according to a study published online Dec. 19 in the Archives of Dermatology.

Abstract
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Vitamin D, Calcium Found to Cut Fracture, Cancer Risk

TUESDAY, Dec. 20 (HealthDay News) -- Vitamin D supplementation can reduce the risk of fracture and cancer; and although there is a biological association between vitamin D deficiency and cardiovascular disease (CVD), there is no evidence that vitamin D supplementation prevents CVD, according to two reviews published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Chung
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Abstract - Greevy and Williams
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U.S. CRC Mortality Racial Disparity Up in Last 20 Years

TUESDAY, Dec. 20 (HealthDay News) -- From 1985 to 2008, black-white disparities in U.S. colorectal cancer (CRC) mortality rates have increased for each disease stage, with trends in late-stage disease accounting for most of the overall disparity, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Editorial

Favorable Survival for Incidental Renal Cell Cancer Detection

TUESDAY, Dec. 20 (HealthDay News) -- Patients with incidentally diagnosed renal cell carcinoma have improved survival compared with those who have symptomatic tumors, according to a study published in the January issue of The Journal of Urology.

Abstract
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Weekly AMG 386 + Paclitaxel Well Tolerated in Recurrent Ovarian CA

MONDAY, Dec. 19 (HealthDay News) -- For patients with recurrent ovarian cancer, AMG 386, an investigational peptide-Fc fusion protein, combined with weekly paclitaxel is well-tolerated, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Physician Opinions on Benefits of Open Visit Notes Vary

MONDAY, Dec. 19 (HealthDay News) -- Primary care physicians (PCPs) have varied opinions about open access to doctors' notes; and most users of a personal health record (PHR) system are interested in sharing access to their information, according to two studies published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Walker
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Abstract - Zulman
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Editorial (subscription or payment may be required)

Ovarian Failure Risk Differs with Chemo Type in Hodgkin's

MONDAY, Dec. 19 (HealthDay News) -- For female survivors of Hodgkin's lymphoma, treatment with nonalkylating chemotherapy carries little risk of premature ovarian failure (POF) for those younger than 32 years, whereas alkylating chemotherapy carries a substantially increased risk of POF, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Variation Seen in Accelerated Breast Irradiation Use

MONDAY, Dec. 19 (HealthDay News) -- In women with breast cancer, accelerated partial breast irradiation using brachytherapy (APBIb) after breast-conserving surgery varies by race, ethnicity, and region, particularly in patients who may not be suitable for the technique, according to research published online Dec. 16 in the Journal of the National Cancer Institute.

Abstract
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Omega-3 Index Not Linked to Bleeding in Acute MI

MONDAY, Dec. 19 (HealthDay News) -- For patients with acute myocardial infarction (AMI), there is no association between the omega-3 fatty acid index (red blood cell eicosapentaenoic acid plus docosahexaenoic acid) and bleeding, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

Abstract
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Increasing U.S. Renal Cancer Incidence Differs by Age

MONDAY, Dec. 19 (HealthDay News) -- The increase in renal cancer incidence seen from 1995 to 2006 in the United States differs by age, according to a study published in the January issue of The Journal of Urology.

Abstract
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Mutant U2AF1 ID'd in Acute Myeloid Leukemia

MONDAY, Dec. 19 (HealthDay News) -- Patients with myelodysplastic syndromes (MDS), with a missense mutation affecting the serine at codon 34 (Ser34) in U2AF1, may be more likely to progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML), according to a letter published online Dec. 11 in Nature Genetics.

Abstract
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Quitting Smoking Improves Happiness, Quality of Life

FRIDAY, Dec. 16 (HealthDay News) -- People who successfully quit smoking are happier and more satisfied with their lives than people who continue to smoke, according to a study published online Dec. 10 in the Annals of Behavioral Medicine.

Abstract
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Patient Isolation During Hospitalization Tied to Delirium

FRIDAY, Dec. 16 (HealthDay News) -- Patients who are newly placed under contact precautions during hospitalization are at a higher risk for delirium, according to a study published in the January issue of Infection Control and Hospital Epidemiology.

Abstract
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SNP in MTHFR Tied to Risk of Radiation Pneumonitis

FRIDAY, Dec. 16 (HealthDay News) -- In patients treated with thoracic radiation therapy for locally advanced lung cancer, a single-nucleotide polymorphism (SNP) in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with a clinically significant risk of radiation pneumonitis (RP), according to a study published online Dec. 5 in Cancer.

Abstract
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Adjuvant Bevacizumab Feasible for Nasopharyngeal Cancer

FRIDAY, Dec. 16 (HealthDay News) -- For patients with stage IIB to IVB locoregionally advanced nasopharyngeal carcinoma, the addition of bevacizumab to standard chemoradiation therapy is safe and effective, according to a study published online Dec. 16 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Low Serum Iron Ups Blood Clot Risk in At-Risk Population

FRIDAY, Dec. 16 (HealthDay News) -- For patients with hereditary hemorrhagic telangiectasia, low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and the risk of venous thromboemboli (VTE), according to a study published online Dec. 14 in Thorax.

Abstract
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High-Dose Aspirin Impacts Fibrin Network in Diabetes

FRIDAY, Dec. 16 (HealthDay News) -- Treatment with high-dose (320 mg), but not low-dose (75 mg), aspirin increases fibrin network permeability in patients with type 1 diabetes, according to a study published online Dec. 6 in Diabetes Care.

Abstract
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Smoking Linked to Non-Melanoma Skin Cancer

THURSDAY, Dec. 15 (HealthDay News) -- Non-melanoma skin cancer (NMSC) patients are twice as likely to have ever smoked compared to those with no past or present history of skin cancer, according to research published online Nov. 19 in Cancer Causes and Control.

Abstract
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HPV DNA Testing Leads to Early Detection of Cervical Cancer

THURSDAY, Dec. 15 (HealthDay News) -- Human papillomavirus (HPV) DNA testing at a first screening results in detection of fewer cases of cervical intraepithelial neoplasia (CIN) grade 2 or worse, CIN grade 3 or worse, and cervical cancer at a second screening five years later, according to a study published online Dec. 15 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Chemotherapy Options ID'd for Cisplatin-Unfit Urothelial Cancer

THURSDAY, Dec. 15 (HealthDay News) -- For patients with urothelial cancer who are ineligible for cisplatin therapy, treatment with gemcitabine/carboplatin (GC) or methotrexate/carboplatin/vinblastine (M-CAVI) regimens show similar efficacy, according to a study published online Dec. 12 in the Journal of Clinical Oncology.

Abstract
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Liberal Transfusion Nonsuperior Post-Hip Fracture Surgery

WEDNESDAY, Dec. 14 (HealthDay News) -- A liberal blood transfusion strategy (maintenance at a threshold of 10 g/dL hemoglobin) is not superior to a restrictive strategy (transfusion at symptoms of anemia or <8 g/dL hemoglobin) for reducing death and inability to walk independently after hip fracture surgery, according to a study published online Dec. 14 in the New England Journal of Medicine.

Abstract
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Editorial

Autologous Blood Donation Tied to Pre-Op Anemia, Blood Loss

WEDNESDAY, Dec. 14 (HealthDay News) -- Preoperative autologous blood donation (PABD) during posterior lumbar spinal surgery is associated with preoperative anemia and a lower transfusion threshold than allogeneic blood use, according to a study published in the Dec. 15 issue of Spine.

Abstract
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Lower PSA Threshold Not Being Used to Recommend Biopsy

WEDNESDAY, Dec. 14 (HealthDay News) -- Men with prostate-specific antigen (PSA) levels of less than 4.0 ng/mL are rarely sent for biopsy, according to a study published online Dec. 13 in the American Journal of Preventive Medicine.

Full Text

Myotonic Muscular Dystrophy Tied to Increased Cancer Risk

TUESDAY, Dec. 13 (HealthDay News) -- Patients diagnosed with myotonic muscular dystrophy (MMD) are at an increased risk of developing cancer, according to a study published in the Dec. 14 issue of the Journal of the American Medical Association.

Abstract
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Routine Cancer Screening Common in Elderly Aged 75 Up

TUESDAY, Dec. 13 (HealthDay News) -- Many adults aged 75 years or older routinely undergo cancer screening, according to a study published in the Dec. 12/26 issue of the Archives of Internal Medicine.

Abstract
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Peritoneal Carcinomatosis Tied to Poor Survival in CRC

TUESDAY, Dec. 13 (HealthDay News) -- For patients with metastatic colorectal cancer (mCRC), peritoneal carcinomatosis colorectal cancer (pcCRC) is associated with significantly shorter overall survival (OS) and progression-free survival (PFS), according to a study published online Dec. 12 in the Journal of Clinical Oncology.

Abstract
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Editorial

Infection Prevention Up in VA, Non-Federal Hospitals

TUESDAY, Dec. 13 (HealthDay News) -- From 2005 to 2009, there was a significant increase in the use of hospital-acquired infection (HAI) prevention practices in non-federal and Veterans Affairs (VA) hospitals, according to a study published online Dec. 6 in the Journal of General Internal Medicine.

Abstract
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No Increase in Birth Defects for Offspring of Cancer Survivors

TUESDAY, Dec. 13 (HealthDay News) -- For survivors of childhood cancer treated with chemotherapy or gonadal radiation, there is no increased risk of congenital anomalies in their offspring, according to a study published online Dec. 12 in the Journal of Clinical Oncology.

Abstract
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Editorial

Early PET Predicts Survival Outcomes in B-Cell Lymphoma

TUESDAY, Dec. 13 (HealthDay News) -- An interim [18F] fluorodeoxyglucose positron emission tomography (PET) can effectively predict the survival outcomes of patients with diffuse large B-cell lymphoma (DLBCL) after two cycles of anthracycline-based chemotherapy plus rituximab, according to a study published online Dec. 12 in the Journal of Clinical Oncology.

Abstract
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Breast Cancer Survivors Prefer Oncologist Follow-Up

MONDAY, Dec. 12 (HealthDay News) -- In breast cancer survivors participating in a survivorship study, follow-up visits with an oncologist as compared to other types of clinicians are perceived to minimize stress around the visit, decrease worrying about cancer, and improve the self-perceived impact of follow-up visits on cancer survival, according to research published online Dec. 12 in the Journal of Clinical Oncology.

Abstract
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Chemo, Radiation Worsen Cognition in Breast CA Survivors

MONDAY, Dec. 12 (HealthDay News) -- Breast cancer survivors treated with chemotherapy plus radiation or radiation alone may experience poorer cognitive functioning over time, according to a study published online Dec. 12 in Cancer.

Abstract
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Breast Cancer Screening May Be Causing More Harm Than Good

FRIDAY, Dec. 9 (HealthDay News) -- Mammographic breast cancer screening may initially cause more harm than good when including the effects of harms in the analysis, according to a study published online Dec. 8 in BMJ.

Full Text

Post-Mastectomy Reconstruction Feasible for Older Women

FRIDAY, Dec. 9 (HealthDay News) -- Breast reconstruction after mastectomy is safe, feasible, and well tolerated in older women, according to a study published in the December issue of The American Surgeon.

Abstract
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Bowel Screening Detects Early Cancer in Majority of Patients

FRIDAY, Dec. 9 (HealthDay News) -- The colorectal cancer screening program in England detects mainly early cancer, and has found that left-sided cancers are considerably more common than expected, according to a study published online Dec. 7 in Gut.

Abstract
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Factors Affecting Micro-RNA Detection Accuracy Identified

FRIDAY, Dec. 9 (HealthDay News) -- Accurate detection and quantitation of circulating microRNAs (miRNAs) is affected by inherent differences in plasma samples, methods used for their collection and analysis, and the presence of specific inhibitors in plasma, according to a study published online Dec. 9 in the Journal of Molecular Diagnostics.

Abstract
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Similar Prognosis for BRCA1 Carriers, Sporadic Breast Cancer

THURSDAY, Dec. 8 (HealthDay News) -- The risks of distant recurrence and death are similar for BRCA1 mutation carriers and for those with sporadic breast cancer, whereas women with BRCA2 mutations have higher risks on univariable analysis, and similar risks on multivariable analysis, according to a study published online Dec. 5 in the Journal of Clinical Oncology.

Abstract
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Editorial

Role of Environmental Factors in Breast Cancer Explored

WEDNESDAY, Dec. 7 (HealthDay News) -- Women may be able to reduce their risk of breast cancer by avoiding exposure to certain environmental factors, according to a report published Dec. 7 by the Institute of Medicine.

More Information

Acupuncture May Help Chemo-Induced Peripheral Neuropathy

WEDNESDAY, Dec. 7 (HealthDay News) -- The addition of acupuncture to best medical care for chemotherapy-induced peripheral neuropathy (CIPN) may have a positive effect, according to a pilot study published online Dec. 5 in Acupuncture in Medicine.

Abstract
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Randomized Controlled HCC Screening Trial Not Feasible

WEDNESDAY, Dec. 7 (HealthDay News) -- A randomized controlled trial (RCT) of hepatocellular carcinoma (HCC) screening is not feasible for informed patients with cirrhosis; and small HCC detection is not improved by ultrasonographic screening (US) every three versus six months, according to two studies published in the December issue of Hepatology.

Abstract - Poustchi
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Abstract - Trinchet
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Androgen Deprivation in Prostate Cancer Not Tied to CVD Death

TUESDAY, Dec. 6 (HealthDay News) -- Use of androgen deprivation therapy (ADT) is not associated with cardiovascular death, but is correlated with significantly lower prostate cancer-specific mortality (PCSM) and all-cause mortality, according to a review and meta-analysis published in the Dec. 7 issue of the Journal of the American Medical Association.

Abstract
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Study Finds Mammography Cuts Breast Cancer Deaths

TUESDAY, Dec. 6 (HealthDay News) -- Breast cancer detection through mammography screening is effective in reducing breast cancer mortality, according to a case-control study published online Dec. 6 in Cancer Epidemiology, Biomarkers & Prevention.

Abstract
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Transplant Patients Want a Role in Liver Quality Decisions

TUESDAY, Dec. 6 (HealthDay News) -- Patients waiting for liver transplantation want to be involved in decisions about organ quality, and the level of risk they are prepared to tolerate is influenced by the presentation format, according to a study published in the December issue of Liver Transplantation.

Abstract
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Medical Students Fail to ID Hand Hygiene Indications

MONDAY, Dec. 5 (HealthDay News) -- Medical students who are about to start the clinical phase of their education have a lack of knowledge regarding the correct indications for hand disinfection, according to a study published in the December issue of the American Journal of Infection Control.

Abstract
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Serum Glucose Levels Tied to Colorectal Cancer Risk in Women

FRIDAY, Dec. 2 (HealthDay News) -- Serum glucose levels, but not serum insulin or homeostasis model assessment, are associated with increased colorectal cancer risk in postmenopausal women, according to a study published online Nov. 29 in the British Journal of Cancer.

Abstract
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Lobular Breast Cancer Tied to Having Father With Cancer

FRIDAY, Dec. 2 (HealthDay News) -- Lobular breast cancer is associated with having a father diagnosed with cancer, most commonly prostate cancer; and this association is independent of a family history of breast cancer, according to a study published online Nov. 28 in BMC Cancer.

Abstract
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Most Non-Mobile Spinal Mets Patients Walk Post-Surgery

FRIDAY, Dec. 2 (HealthDay News) -- The majority of nonambulatory patients with epidural spinal metastasis become ambulatory postoperatively, according to a study published in the November issue of The Spine Journal.

Abstract
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Parental CA Therapy Not Tied to Genetic Defects in Offspring

THURSDAY, Dec. 1 (HealthDay News) -- Neither prenatal chemotherapy nor preconception gonad irradiation are associated with genetic defects in children of cancer survivors, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

Abstract
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Editorial

Breast CA Mets Biopsy Viable; May Impact Management

THURSDAY, Dec. 1 (HealthDay News) -- Biopsy of breast cancer metastases for estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor 2 (HER2) status is feasible and alters management in 14 percent of patients, but receptor discordance is not associated with worse outcome, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

Abstract
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Anticoagulant Self-Monitoring Safe Option for Suitable Patients

THURSDAY, Dec. 1 (HealthDay News) -- Self-monitoring and self-management of oral coagulation is associated with a significant reduction in thromboembolic events and is a safe option for suitable patients of all ages, according to a review published online Dec. 1 in The Lancet.

Abstract
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