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Category: Internal Medicine | Monthly Briefing

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December 2011 Briefing - Internal Medicine

Last Updated: January 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for December 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Three Gene Mutations Linked to Epithelial Thyroid Cancers

FRIDAY, Dec. 30 (HealthDay News) -- Cowden syndrome (CS)/CS-like patients with PTEN mutations, SDHx variations, and KLLN epimutations are at increased risk of epithelial thyroid cancers, according to a study published in the Dec. 1 issue of the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Age-Adjusted Thalamic Volume Associated With Disability in MS

THURSDAY, Dec. 29 (HealthDay News) -- Patients with multiple sclerosis (MS) have lower age- and lesion-independent thalamic volume than healthy individuals, and the loss in thalamic volume is associated with disability, according to a study published in the Nov. 16 issue of The Journal of Neuroscience.

Abstract
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Anesthesia Boosts Colonoscopy Price Tag

THURSDAY, Dec. 29 (HealthDay News) -- In asymptomatic adults who undergo screening colonoscopies, the use of anesthesia significantly increases the cost of the procedure and is most likely to be ordered by a surgeon, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

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Early Childhood Factors ID'd for Predicting Adult Obesity

THURSDAY, Dec. 29 (HealthDay News) -- Childhood growth patterns, childhood obesity, maternal body mass index (BMI), and father's employment are probable early markers for adult obesity, according to a study published online Dec. 16 in Obesity Reviews.

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High-Sensitivity CRP Predicts Mortality in A-Fib Patients

THURSDAY, Dec. 29 (HealthDay News) -- Higher levels of high-sensitivity C-reactive protein (hs-CRP) are associated with increased all-cause and cardiovascular mortality in patients with atrial fibrillation (AF), independent of other risk factors, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

Abstract
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Metabolic Syndrome Linked to Overactive Bladder in Females

THURSDAY, Dec. 29 (HealthDay News) -- Metabolic syndrome is significantly associated with overactive bladder in female patients, according to a study published in the January issue of Urology.

Abstract
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Early Palliative Care Improves Quality of Life in NSCLC

THURSDAY, Dec. 29 (HealthDay News) -- Early palliative care for patients with terminal non-small-cell lung cancer (NSCLC) improves the timing of final chemotherapy administration and is associated with an earlier transition to hospice care, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Editorial

Oseltamivir-Resistant H1N1 Identified in Australia

THURSDAY, Dec. 29 (HealthDay News) -- Oseltamivir-resistant prepandemic seasonal influenza 1 (H1N1) viruses with a neuraminidase substitution (H275Y) (A[H1N1]pdm09) have been identified in Australia, according to a letter published in the Dec. 29 issue of the New England Journal of Medicine.

Letter

Updated Tool Helps Predict Outcome in Brain Metastases

THURSDAY, Dec. 29 (HealthDay News) -- The updated Graded Prognostic Assessment (GPA), a diagnosis-specific, predictive index for cancer patients with brain metastases, helps clinicians estimate survival, select appropriate treatment, and stratify patients for clinical trials, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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More Fat Than Lean Mass Regained During Weight Regain

THURSDAY, Dec. 29 (HealthDay News) -- For postmenopausal women who regain weight in the year following intentional weight loss, fat mass is regained to a greater extent than lean mass, according to a study published in a recent issue of the American Journal of Clinical Nutrition.

Abstract
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Metformin Hikes B12 Deficiency in Type 2 Diabetes

THURSDAY, Dec. 29 (HealthDay News) -- The use of metformin therapy in adults with type 2 diabetes is linked to a biochemical B12 deficiency greater than that found in other adults with type 2 diabetes and adults without diabetes, and current over-the-counter supplements are not sufficient to correct the deficiency in either of these type 2 diabetes groups, according to research published online Dec. 16 in Diabetes Care.

Abstract
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Air Pollution Linked to Diabetes

THURSDAY, Dec. 29 (HealthDay News) -- Long-term exposure to air pollution from traffic is associated with a higher incidence of diabetes in adults, especially in nonsmokers, the physically active, and individuals who lead a healthy lifestyle, according to research published in the January issue of Diabetes Care.

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Benefits Beat Risks in Combo Therapy for Crohn's Disease

THURSDAY, Dec. 29 (HealthDay News) -- In Crohn's patients treated for one year in the Study of Biologic and Immunomodulator-Naive Patients With Crohn's Disease (SONIC), infection would have to occur at a rate of 20 percent or greater, and lymphoma at a rate of 3.9 percent or greater, for the risks of combination therapy with infliximab and azathioprine (IFX/AZA) to outweigh the benefits, when compared with IFX monotherapy, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

Abstract
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Bevacizumab Ups Progression-Free Survival in Ovarian Cancer

WEDNESDAY, Dec. 28 (HealthDay News) -- For women with ovarian cancer, the addition of bevacizumab to standard chemotherapy results in significantly improved progression-free survival (PFS), according to two phase 3 studies published in the Dec. 29 issue of the New England Journal of Medicine.

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Enoxaparin Doesn't Reduce Death Rate for Acutely Ill

WEDNESDAY, Dec. 28 (HealthDay News) -- For hospitalized, acutely ill medical patients, use of enoxaparin plus elastic stockings with graduated compressions, does not reduce the rate of death from any cause at 30 days, according to a study published in the Dec. 29 issue of the New England Journal of Medicine.

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Nutrition Tied to Cognitive Decline, Cerebral Volume Loss

WEDNESDAY, Dec. 28 (HealthDay News) -- In elderly adults with high intake of B vitamins; vitamins C, D, and E; and omega-3 fatty acids, cognitive testing and magnetic resonance imaging (MRI) demonstrate less cognitive decline and cerebral volume loss, while high-trans-fat diets have the opposite effects, according to research published online Dec. 28 in Neurology.

Abstract
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Acute Kidney Injury Shortens Survival in Alcoholic Hepatitis

WEDNESDAY, Dec. 28 (HealthDay News) -- In patients with alcoholic hepatitis (AH), acute kidney injury (AKI) during hospitalization decreases 90-day survival; and AKI detected by AKI network (AKIN) criteria is a better predictor of mortality than AKI detected by traditional criteria, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

Abstract
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Drugs ID'd in Mice to Possibly Treat Angelman Syndrome

WEDNESDAY, Dec. 28 (HealthDay News) -- Reactivating the functional but silenced paternal allele of the ubiquitin protein ligase E3A (Ube3a) may offer a possible treatment strategy for the severe neurodevelopmental disorder known as Angelman syndrome, according to an experimental study published online Dec. 21 in Nature.

Abstract
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Prevalence of High-Risk HPV, Cytologic Abnormalities ID'd

WEDNESDAY, Dec. 28 (HealthDay News) -- Estimates of the baseline prevalence of cytologic abnormalities, high-risk human papillomavirus (hrHPV; defined as 1 of 14 high-risk types of HPV including HPV 16 and HPV 18), HPV 16, HPV 18, and cervical intraepithelial neoplasia grade 2 (CIN2) or greater have been established using the Addressing the Need for Advanced HPV Diagnostics screening trial, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Genetic Variants Found to Predispose to Weight Regain

WEDNESDAY, Dec. 28 (HealthDay News) -- Numerous genetic variants predispose people to weight loss (WL) as well as weight regain (WR) after intentional WL, according to research published online Dec. 16 in Diabetes Care.

Abstract
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New Equation Accurately Predicts Body Fat Percentage

WEDNESDAY, Dec. 28 (HealthDay News) -- A new prediction equation estimates body fat percentage (BF%) in adults with a low error rate and acceptable accuracy and may be a good first-screening tool for identifying patients at cardiovascular and type 2 diabetes risk, according to research published online Dec. 16 in Diabetes Care.

Abstract
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Study Assesses Fusion Failure After Anterior Screw Fixation

WEDNESDAY, Dec. 28 (HealthDay News) -- Risk of fusion failure following anterior odontoid screw fixation increases with both delays in surgery and fracture gaps larger than 2 mm, according to a study published in the Jan. 1 issue of Spine.

Abstract
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Irradiation of Left Breast Linked to Coronary Stenosis Risk

WEDNESDAY, Dec. 28 (HealthDay News) -- Women with irradiated left sided breast cancer (BC) have an increased risk of high-grade coronary artery stenosis in the mid and distal left anterior descending artery and distal diagonal (mdLAD + dD), according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Editorial

Risk of Gastrointestinal Cancer in Celiac Patients Low Overall

WEDNESDAY, Dec. 28 (HealthDay News) -- Patients with celiac disease, inflammation, or latent celiac disease have a low risk of developing gastrointestinal (GI) cancer, although the risk is higher in the first year following diagnosis, according to a study published in the January issue of Clinical Gastroenterology and Hepatology.

Abstract
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Serial Change in hsTnI or cTnI Accurately Rule In/Out AMI

TUESDAY, Dec. 27 (HealthDay News) -- For patients admitted with suspected acute coronary syndrome (ACS), use of highly sensitive troponin I (hsTnI) or contemporary troponin I (cTnI) assays on admission, and changes in their levels within three hours, can confirm the diagnosis of acute myocardial infarction (AMI), according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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Obese Patients Have Worse Colon Cancer Outcomes

TUESDAY, Dec. 27 (HealthDay News) -- Obese patients with colon cancer are less likely to have deficient mismatch repair (dMMR) tumors and have a worse prognosis compared with normal-weight patients, independent of other tumor variables, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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No Correlation ID'd Between CYP2C19 Genotype, CVD Events

TUESDAY, Dec. 27 (HealthDay News) -- Although CYP2C19 genotype correlates with clopidogrel response and platelet aggregation, there is no evidence of a clinically significant association between CYP2C19 genotype and cardiovascular disease (CVD) events, according to a meta-analysis published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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Trace Element Levels Linked to Pancreatic Cancer Risk

TUESDAY, Dec. 27 (HealthDay News) -- High bodily levels of the trace elements nickel and selenium may lower the risk of developing the most common type of pancreatic cancer, while high levels of lead, arsenic, and cadmium could increase the likelihood of developing the disease, according to a study published online Dec. 19 in Gut.

Abstract
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Perceptions of Inappropriate Care Prevalent Among ICU Staff

TUESDAY, Dec. 27 (HealthDay News) -- Perceptions of inappropriate care are prevalent among intensive care unit (ICU) clinicians in Europe and Israel, according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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Vaginal Prolapse Outcomes Similar With or Without Mesh

TUESDAY, Dec. 27 (HealthDay News) -- Vaginal prolapse repair improves quality of life, with or without mesh, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Congenital Facial Disfigurement Has Limited Psych Impact

TUESDAY, Dec. 27 (HealthDay News) -- Adults born with severe congenital facial disfigurement have relatively normal psychological functioning, but are more prone to internalizing problems, according to a study published in the January issue of Plastic and Reconstructive Surgery.

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Norway Shows Rise in Gastro-Oesophageal Reflux Symptoms

TUESDAY, Dec. 27 (HealthDay News) -- The prevalence of gastro-oesophageal reflux symptoms (GORS) in a Norwegian county increased substantially between 1995-7 and 2006-9, according to a study published online Dec. 21 in Gut.

Abstract
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Improved CVD Risk Prediction Model in Diabetes Identified

TUESDAY, Dec. 27 (HealthDay News) -- For patients with type 2 diabetes and no history of cardiovascular diseases (CVDs), the ability of the Framingham risk score (FRS) to predict development of CVD is improved by combining it with carotid intima-media thickness (IMT) measurement, according to a study published in the January issue of Diabetes Care.

Abstract
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Risk Factors for Post-Spinal Fusion Visual Loss Identified

TUESDAY, Dec. 27 (HealthDay News) -- Significant risk factors for ischemic optic neuropathy (ION) after spinal fusion surgery include male gender, obesity, Wilson frame use, longer anesthetic duration, greater estimated blood loss, and lower percent colloid administration, according to a study published in the January issue of Anesthesiology.

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Smoking During Pregnancy Affects Children's Vasculature

TUESDAY, Dec. 27 (HealthDay News) -- Parental smoking during pregnancy affects children's arterial structure and function in early life; and interventions that encourage parents to quit smoking for their children's benefit may increase parental quit rates, according to two studies published online Dec. 26 in Pediatrics.

Abstract - Geerts
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Abstract - Rosen
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Study Compares Onset of Action of Two Types of Botulinum Toxin

MONDAY, Dec. 26 (HealthDay News) -- Two botulinum neuromodulators demonstrate early improvements in the appearance of lateral orbital rhytids (crow's feet), but abobotulinumtoxinA results in greater improvement than onabotulinumtoxinA, according to a study published online Dec. 19 in the Archives of Facial Plastic Surgery.

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Coronary MRI Good Alternative to SPECT for CHD Diagnosis

MONDAY, Dec. 26 (HealthDay News) -- For patients with suspected coronary heart disease, a multiparametric cardiovascular magnetic resonance (CMR) protocol has better sensitivity and negative predictive value, and similar specificity as single-photon emission computed tomography (SPECT), according to a study published online Dec. 23 in The Lancet.

Abstract
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Editorial (subscription or payment may be required)

Poor Compliance With Sunscreen Advice Found in Adult Skiers

FRIDAY, Dec. 23 (HealthDay News) -- Very few adult skiers and snowboarders show full compliance with sunscreen advice, especially with the advice to reapply sunscreen after two hours, according to a study published in the January issue of the Journal of the American Academy of Dermatology.

Abstract
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Postmenopausal HRT Improves Sexual Function

THURSDAY, Dec. 22 (HealthDay News) -- Twelve months of daily oral hormonal replacement therapy with estradiol plus dihydrogesterone (HRT), dehydroepiandrosterone (DHEA), or tibolone improves sexual function and frequency in early postmenopausal women, according to a study published in the December issue of Climacteric.

Abstract
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CDC Outlines HPV and Hep B Vaccine Recommendations

THURSDAY, Dec. 22 (HealthDay News) -- Vaccination against human papillomavirus (HPV) in young males and hepatitis B in adults with diabetes mellitus is recommended by the Advisory Committee on Immunization Practices (ACIP) for infection control, according to two reports published in the Dec. 23 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

Full Text - HPV
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Correcting Anemia Reduces Odds of Renal Transplant Failure

THURSDAY, Dec. 22 (HealthDay News) -- Complete correction of anemia (hemoglobin, ≥13 g/dL) in kidney transplant recipients slows progression to chronic allograft nephropathy, according to a study published online Dec. 22 in the Journal of the American Society of Nephrology.

Abstract
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Simvastatin Beats Ezetimibe in Anti-inflammatory Effects

THURSDAY, Dec. 22 (HealthDay News) -- For patients with hypercholesterolemia, simvastatin is superior to ezetimibe for producing lymphocyte-suppression and systemic anti-inflammatory and endothelial protective effects, according to a study published in the January issue of the Journal of Internal Medicine.

Abstract
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Screening Mammography Over-Recommended in Terminally Ill

THURSDAY, Dec. 22 (HealthDay News) -- Over-recommendation of screening mammography for women with a terminal comorbidity is common, and is associated with physician and practice characteristics, including specialty, gender, race, and size of practice, according to a study published in the Jan. 1 issue of Cancer.

Abstract
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Tobacco Smoke Ups Aspirin-Exacerbated Respiratory Disease

THURSDAY, Dec. 22 (HealthDay News) -- Active smoking, and combined childhood and adulthood exposure to environmental tobacco smoke (ETS) are associated with significantly higher odds of developing aspirin-exacerbated respiratory disease (AERD), according to a study published in the January issue of the Annals of Allergy, Asthma & Immunology.

Abstract
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Gene-Ligand System Positively Associated With Human Obesity

THURSDAY, Dec. 22 (HealthDay News) -- There is a positive association between the L-α-lysophosphatidylinositol (LPI) and GPR55 system and obesity in humans, according to a study published online Dec. 16 in Diabetes.

Abstract
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Left Auditory Cortex Less Responsive in Dyslexia

THURSDAY, Dec. 22 (HealthDay News) -- For individuals with dyslexia, the left auditory cortex may be less responsive at frequencies of approximately 30 Hz, according to a study published in the Dec. 22 issue of Neuron.

Abstract
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Recurrent Cutaneous Melanoma Hazard Rates Vary With Stage

THURSDAY, Dec. 22 (HealthDay News) -- The hazard rates (HRs) for recurrent and secondary cutaneous melanoma (CM) after incident stage IA melanoma are low, while the HRs of recurrence after incident stage IB, II, and III CM are high, according to a study published in the January issue of the Journal of the American Academy of Dermatology.

Abstract
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Platinum Treatment for Testicular Cancer Ups Neurotoxicity

THURSDAY, Dec. 22 (HealthDay News) -- Long-term serum levels of residual platinum correlate with the severity of neurotoxicity five to 20 years after chemotherapy in testicular cancer (TC) survivors, even after adjusting for initial cisplatin dose, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Women With Endometriosis Have a Higher Risk of IBD

THURSDAY, Dec. 22 (HealthDay News) -- Women with endometriosis have a significantly increased risk of developing inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, compared to those without the reproductive disorder, according to a large Danish study published online Dec. 19 in Gut.

Abstract
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Mindfulness Program Curbs Distress in Rheumatic Disease

THURSDAY, Dec. 22 (HealthDay News) -- In adults with inflammatory rheumatic joint diseases, a mindfulness-based group intervention reduces psychological distress, pain, and fatigue as compared to individual use of home exercises, according to research published online Dec. 20 in the Annals of the Rheumatic Diseases.

Abstract
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Isentress Approval Expanded to Include Children and Teens

WEDNESDAY, Dec. 21 (HealthDay News) -- Approval for the HIV drug Isentress (raltegravir) has been expanded to include children and adolescents ages 2 to 18, the U.S. Food and Drug Administration said Wednesday.

HIV/AIDS

INF2 Mutations Cause Charcot-Marie Tooth Neuropathy

WEDNESDAY, Dec. 21 (HealthDay News) -- INF2 mutations are a major cause of Charcot-Marie-Tooth disease associated with focal segmental glomerulosclerosis (FSGS), according to a study published in the Dec. 22 issue of the New England Journal of Medicine.

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Quantitative MRI Biomarker IDs Cognitive Decline Risk

WEDNESDAY, Dec. 21 (HealthDay News) -- Cognitively normal (CN) older adults with a low measure of Alzheimer's disease signature (ADsig), a quantitative magnetic resonance imaging (MRI) biomarker, are more likely to develop cognitive decline, according to a study published online Dec. 21 in Neurology.

Abstract
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Editorial (subscription or payment may be required)

Increased Risk of Cutaneous Melanoma in Cancer Survivors

WEDNESDAY, Dec. 21 (HealthDay News) -- Patients with a previous diagnosis of cancer have an elevated risk of developing cutaneous melanoma (CM), according to a study published in the December issue of the Archives of Dermatology.

Abstract
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Trauma Quality Indicators Linked to Clinical Outcomes

WEDNESDAY, Dec. 21 (HealthDay News) -- Several of the American College of Surgeons Committee on Trauma (ACSCOT) quality indicators have significant associations with in-hospital mortality and the composite outcome of death or major complications, according to a study published online Dec. 19 in the Archives of Surgery.

Abstract
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NCHS: Poisonings Are Leading Cause of Injury Deaths

WEDNESDAY, Dec. 21 (HealthDay News) -- From 1980 to 2008, the number of poisoning deaths increased almost six-fold, and became the leading cause of injury deaths (death attributable to a force external to the body), according to research published online Dec. 20 by the National Center for Health Statistics.

More Information

Poor Adherence to Imaging Guidelines for Prostate Cancer

WEDNESDAY, Dec. 21 (HealthDay News) -- Many men with low-risk prostate cancer receive inappropriate imaging for staging of their disease, while a large percentage in the high-risk group go without appropriate imaging, according to research published in the January issue of The Journal of Urology.

Abstract
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Majority of Practitioners in U.K. Advise Time Off for Back Pain

WEDNESDAY, Dec. 21 (HealthDay News) -- Despite guidelines for the clinical management of patients with low back pain (LBP) that encourage patients to stay active and return to work, the majority of practitioners advise patients to take a break from work to recover, according to a study published in the December issue of Pain.

Abstract
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Aflibercept Shows Clinical Activity for Malignant Ascites

WEDNESDAY, Dec. 21 (HealthDay News) -- Aflibercept, a potent inhibitor of vascular endothelial growth factor (VEGF), shows clinical activity and increases the time to repeat paracentesis for patients with advanced chemo-resistant ovarian cancer and recurrent symptomatic malignant ascites, according to a study published online Dec. 21 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

ADA Updates Standards of Care for Driving With Diabetes

WEDNESDAY, Dec. 21 (HealthDay News) -- For people with diabetes, the eligibility to receive a driver's license should be an individual decision, based on clinical evidence and appropriate consideration of potential safety risks, according to a position statement from the American Diabetes Association published in a supplement to the January issue of Diabetes Care.

Diabetes and Driving Position Statement
Standard of Care Position Statement

Immunosuppression Evidence Identified in Septic Death

WEDNESDAY, Dec. 21 (HealthDay News) -- Patients who die with active severe sepsis have reduced cytokine secretion and other changes indicative of immunosuppression, according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Antiarrythmic Drug Associated With Adverse Cardiac Events

TUESDAY, Dec. 20 (HealthDay News) -- The heart drug Multaq (dronedarone) should not be prescribed to patients with permanent atrial fibrillation because of an increased risk of serious cardiovascular events, including death, according to a Dec. 19 Drug Safety Communication from the U.S. Food and Drug Administration.

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Sleep Disorders Tied to Adverse Health Outcomes for Police

TUESDAY, Dec. 20 (HealthDay News) -- Sleep disorders are common among police officers and are associated with adverse health, safety, and performance outcomes, according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

Abstract
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Chlorthalidone Treatment Offers Long-Term Survival Benefits

TUESDAY, Dec. 20 (HealthDay News) -- Chlorthalidone treatment for isolated systolic hypertension, among participants of the Systolic Hypertension in the Elderly Program (SHEP) trial, is associated with improved cardiovascular mortality, according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

Abstract
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Sunless Tanning Product Use Tied to Reduced UV Exposure

TUESDAY, Dec. 20 (HealthDay News) -- Use of sunless tanning products is associated with decreased exposure to ultraviolet (UV) radiation tanning methods, especially among women who use such products frequently, according to a study published online Dec. 19 in the Archives of Dermatology.

Abstract
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Long-Term Increase in Resting Heart Rate Ups Mortality

TUESDAY, Dec. 20 (HealthDay News) -- An increase in resting heart rate (RHR) over a 10-year period is associated with an increased risk of dying from ischemic heart disease (IHD), according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

Abstract
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Vitamin D, Calcium Found to Cut Fracture, Cancer Risk

TUESDAY, Dec. 20 (HealthDay News) -- Vitamin D supplementation can reduce the risk of fracture and cancer; and although there is a biological association between vitamin D deficiency and cardiovascular disease (CVD), there is no evidence that vitamin D supplementation prevents CVD, according to two reviews published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Chung
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Abstract - Greevy and Williams
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Initial Wound Debridement Faster With Maggot Therapy

TUESDAY, Dec. 20 (HealthDay News) -- Compared with conventional therapy, wound debridement is significantly faster with maggot therapy during the first week of treatment, but there is no significant difference at day 15, according to a study published online Dec. 19 in the Archives of Dermatology.

Abstract
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Favorable Survival for Incidental Renal Cell Cancer Detection

TUESDAY, Dec. 20 (HealthDay News) -- Patients with incidentally diagnosed renal cell carcinoma have improved survival compared with those who have symptomatic tumors, according to a study published in the January issue of The Journal of Urology.

Abstract
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U.S. CRC Mortality Racial Disparity Up in Last 20 Years

TUESDAY, Dec. 20 (HealthDay News) -- From 1985 to 2008, black-white disparities in U.S. colorectal cancer (CRC) mortality rates have increased for each disease stage, with trends in late-stage disease accounting for most of the overall disparity, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Editorial

Liver Transplants for NASH Up 600 Percent in 10 Years

TUESDAY, Dec. 20 (HealthDay News) -- The proportion of liver transplants performed in patients diagnosed with nonalcoholic steatohepatitis (NASH) increased dramatically from 1997-2003 to 2004-2010, but post-transplant survival in this population is excellent, with one-year survival rates near 88 percent, according to a study published online Sept. 19 in Liver Transplantation.

Abstract
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Blood Pressure in Middle Age Affects Lifetime CVD Risk

TUESDAY, Dec. 20 (HealthDay News) -- Changes in blood pressure (BP) during middle age significantly impact lifetime risk (LTR) for cardiovascular disease (CVD), with a possible dose-response effect for the number of years with high BP on the LTR of CVD, coronary heart disease, and stroke, according to research published online Dec. 19 in Circulation.

Abstract
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Little Risk to Offspring From Maternal Inhaled Steroids

TUESDAY, Dec. 20 (HealthDay News) -- In pregnant women with asthma, the use of inhaled glucocorticoids does not increase the risk of most pediatric diseases in the offspring, though it may be a risk factor for endocrine and metabolic disorders, according to research published online Dec. 16 in the American Journal of Respiratory and Critical Care Medicine.

Full Text

Inhaled Dry Powder Mannitol Improves Lung Function in CF

TUESDAY, Dec. 20 (HealthDay News) -- Adding the inhaled dry powder mannitol to standard therapy for cystic fibrosis produces sustained improvement in lung function for up to 52 weeks, according to a study published online Dec. 16 in the American Journal of Respiratory and Critical Care Medicine.

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Weekly AMG 386 + Paclitaxel Well Tolerated in Recurrent Ovarian CA

MONDAY, Dec. 19 (HealthDay News) -- For patients with recurrent ovarian cancer, AMG 386, an investigational peptide-Fc fusion protein, combined with weekly paclitaxel is well-tolerated, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Physician Opinions on Benefits of Open Visit Notes Vary

MONDAY, Dec. 19 (HealthDay News) -- Primary care physicians (PCPs) have varied opinions about open access to doctors' notes; and most users of a personal health record (PHR) system are interested in sharing access to their information, according to two studies published in the Dec. 20 issue of the Annals of Internal Medicine.

Abstract - Walker
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Abstract - Zulman
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Editorial (subscription or payment may be required)

Ovarian Failure Risk Differs with Chemo Type in Hodgkin's

MONDAY, Dec. 19 (HealthDay News) -- For female survivors of Hodgkin's lymphoma, treatment with nonalkylating chemotherapy carries little risk of premature ovarian failure (POF) for those younger than 32 years, whereas alkylating chemotherapy carries a substantially increased risk of POF, according to a study published online Dec. 19 in the Journal of Clinical Oncology.

Abstract
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Combo Therapies in Psoriasis More Effective Than Monotherapy

MONDAY, Dec. 19 (HealthDay News) -- Many combination topical therapies for psoriasis are more effective than topical monotherapies, and adding phototherapy to topical monotherapy generally improves psoriasis clearance, compared to monotherapy alone, according to a meta-analysis published online Dec. 19 in the Archives of Dermatology.

Abstract
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Nearly One-Half of Short-Term PCI Deaths Occur Post-Discharge

MONDAY, Dec. 19 (HealthDay News) -- Nearly 40 percent of all post-percutaneous coronary intervention (PCI) short-term deaths occur after discharge and within 30 days of the procedure, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Increasing U.S. Renal Cancer Incidence Differs by Age

MONDAY, Dec. 19 (HealthDay News) -- The increase in renal cancer incidence seen from 1995 to 2006 in the United States differs by age, according to a study published in the January issue of The Journal of Urology.

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Mutant U2AF1 ID'd in Acute Myeloid Leukemia

MONDAY, Dec. 19 (HealthDay News) -- Patients with myelodysplastic syndromes (MDS), with a missense mutation affecting the serine at codon 34 (Ser34) in U2AF1, may be more likely to progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML), according to a letter published online Dec. 11 in Nature Genetics.

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Suboptimal Intensive Statin Therapy Use After ACS

MONDAY, Dec. 19 (HealthDay News) -- Intensive statin therapy (IST) use during hospitalization is suboptimal following acute coronary syndrome (ACS), and there is poor persistence after discharge, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Variation Seen in Accelerated Breast Irradiation Use

MONDAY, Dec. 19 (HealthDay News) -- In women with breast cancer, accelerated partial breast irradiation using brachytherapy (APBIb) after breast-conserving surgery varies by race, ethnicity, and region, particularly in patients who may not be suitable for the technique, according to research published online Dec. 16 in the Journal of the National Cancer Institute.

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Omega-3 Index Not Linked to Bleeding in Acute MI

MONDAY, Dec. 19 (HealthDay News) -- For patients with acute myocardial infarction (AMI), there is no association between the omega-3 fatty acid index (red blood cell eicosapentaenoic acid plus docosahexaenoic acid) and bleeding, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Cumulative Prevalence of Arrest Up in U.S. Youth

MONDAY, Dec. 19 (HealthDay News) -- Since the 1960s, there has been a substantial increase in the cumulative prevalence of arrest among U.S. youth aged 8 to 23 years, according to a study published online Dec. 19 in Pediatrics.

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Patient Isolation During Hospitalization Tied to Delirium

FRIDAY, Dec. 16 (HealthDay News) -- Patients who are newly placed under contact precautions during hospitalization are at a higher risk for delirium, according to a study published in the January issue of Infection Control and Hospital Epidemiology.

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Quitting Smoking Improves Happiness, Quality of Life

FRIDAY, Dec. 16 (HealthDay News) -- People who successfully quit smoking are happier and more satisfied with their lives than people who continue to smoke, according to a study published online Dec. 10 in the Annals of Behavioral Medicine.

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Asthma Strongly Associated With Chronic Rhinosinusitis

FRIDAY, Dec. 16 (HealthDay News) -- Asthma is strongly associated with chronic rhinosinusitis and its prevalence varies widely across Europe, according to the results of a multicenter, international study published in the January issue of Allergy.

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Training Improves Physical Function After Hip Replacement

FRIDAY, Dec. 16 (HealthDay News) -- For patients with osteoarthritis who undergo total hip arthroplasty (THA), a walking skill training program performed three to five months after THA improves physical functioning, according to a study published online Dec. 14 in Arthritis Care & Research.

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Low Serum Iron Ups Blood Clot Risk in At-Risk Population

FRIDAY, Dec. 16 (HealthDay News) -- For patients with hereditary hemorrhagic telangiectasia, low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and the risk of venous thromboemboli (VTE), according to a study published online Dec. 14 in Thorax.

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Sexual Problems Highly Prevalent Among Older Men

FRIDAY, Dec. 16 (HealthDay News) -- Sexual problems are highly prevalent in older men, according to a study published online Dec. 6 in The Journal of Sexual Medicine.

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Intense Interval Training Impacts Diabetic Blood Glucose

FRIDAY, Dec. 16 (HealthDay News) -- Low-volume high-intensity interval training (HIT) lowers the 24-hour blood glucose concentration, and increases markers of skeletal muscle mitochondrial capacity in individuals with type 2 diabetes, according to a study published in the December issue of the Journal of Applied Physiology.

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SNP in MTHFR Tied to Risk of Radiation Pneumonitis

FRIDAY, Dec. 16 (HealthDay News) -- In patients treated with thoracic radiation therapy for locally advanced lung cancer, a single-nucleotide polymorphism (SNP) in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with a clinically significant risk of radiation pneumonitis

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