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Category: Pathology | Monthly Briefing

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December 2011 Briefing - Pathology

Last Updated: January 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Pathology for December 2011. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Three Gene Mutations Linked to Epithelial Thyroid Cancers

FRIDAY, Dec. 30 (HealthDay News) -- Cowden syndrome (CS)/CS-like patients with PTEN mutations, SDHx variations, and KLLN epimutations are at increased risk of epithelial thyroid cancers, according to a study published in the Dec. 1 issue of the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Age-Adjusted Thalamic Volume Associated With Disability in MS

THURSDAY, Dec. 29 (HealthDay News) -- Patients with multiple sclerosis (MS) have lower age- and lesion-independent thalamic volume than healthy individuals, and the loss in thalamic volume is associated with disability, according to a study published in the Nov. 16 issue of The Journal of Neuroscience.

Abstract
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High-Sensitivity CRP Predicts Mortality in A-Fib Patients

THURSDAY, Dec. 29 (HealthDay News) -- Higher levels of high-sensitivity C-reactive protein (hs-CRP) are associated with increased all-cause and cardiovascular mortality in patients with atrial fibrillation (AF), independent of other risk factors, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

Abstract
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Oseltamivir-Resistant H1N1 Identified in Australia

THURSDAY, Dec. 29 (HealthDay News) -- Oseltamivir-resistant prepandemic seasonal influenza 1 (H1N1) viruses with a neuraminidase substitution (H275Y) (A[H1N1]pdm09) have been identified in Australia, according to a letter published in the Dec. 29 issue of the New England Journal of Medicine.

Letter

Air Pollution Linked to Diabetes

THURSDAY, Dec. 29 (HealthDay News) -- Long-term exposure to air pollution from traffic is associated with a higher incidence of diabetes in adults, especially in nonsmokers, the physically active, and individuals who lead a healthy lifestyle, according to research published in the January issue of Diabetes Care.

Abstract
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Metformin Hikes B12 Deficiency in Type 2 Diabetes

THURSDAY, Dec. 29 (HealthDay News) -- The use of metformin therapy in adults with type 2 diabetes is linked to a biochemical B12 deficiency greater than that found in other adults with type 2 diabetes and adults without diabetes, and current over-the-counter supplements are not sufficient to correct the deficiency in either of these type 2 diabetes groups, according to research published online Dec. 16 in Diabetes Care.

Abstract
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Basal Cell Cancer Subtype May Often Be Misdiagnosed

THURSDAY, Dec. 29 (HealthDay News) -- Basal cell carcinoma (BCC) subtypes are often misidentified in standard punch and shave biopsy specimens, some of which are ultimately determined to have an aggressive component, according to research published in the January issue of the Journal of the American Academy of Dermatology.

Abstract
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Bevacizumab Ups Progression-Free Survival in Ovarian Cancer

WEDNESDAY, Dec. 28 (HealthDay News) -- For women with ovarian cancer, the addition of bevacizumab to standard chemotherapy results in significantly improved progression-free survival (PFS), according to two phase 3 studies published in the Dec. 29 issue of the New England Journal of Medicine.

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Acute Kidney Injury Shortens Survival in Alcoholic Hepatitis

WEDNESDAY, Dec. 28 (HealthDay News) -- In patients with alcoholic hepatitis (AH), acute kidney injury (AKI) during hospitalization decreases 90-day survival; and AKI detected by AKI network (AKIN) criteria is a better predictor of mortality than AKI detected by traditional criteria, according to research published in the January issue of Clinical Gastroenterology and Hepatology.

Abstract
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Rhinoviruses Frequently Cause ARIs in VLBW Premature Infants

WEDNESDAY, Dec. 28 (HealthDay News) -- More than half (55 percent) of very low birth weight (VLBW) infants with acute respiratory illness (ARI) have infection with human rhinoviruses (HRVs), according to a study published online Dec. 26 in Pediatrics.

Abstract
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Genetic Variants Found to Predispose to Weight Regain

WEDNESDAY, Dec. 28 (HealthDay News) -- Numerous genetic variants predispose people to weight loss (WL) as well as weight regain (WR) after intentional WL, according to research published online Dec. 16 in Diabetes Care.

Abstract
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Prevalence of High-Risk HPV, Cytologic Abnormalities ID'd

WEDNESDAY, Dec. 28 (HealthDay News) -- Estimates of the baseline prevalence of cytologic abnormalities, high-risk human papillomavirus (hrHPV; defined as 1 of 14 high-risk types of HPV including HPV 16 and HPV 18), HPV 16, HPV 18, and cervical intraepithelial neoplasia grade 2 (CIN2) or greater have been established using the Addressing the Need for Advanced HPV Diagnostics screening trial, according to a study published in the January issue of the American Journal of Obstetrics & Gynecology.

Abstract
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Risk of Gastrointestinal Cancer in Celiac Patients Low Overall

WEDNESDAY, Dec. 28 (HealthDay News) -- Patients with celiac disease, inflammation, or latent celiac disease have a low risk of developing gastrointestinal (GI) cancer, although the risk is higher in the first year following diagnosis, according to a study published in the January issue of Clinical Gastroenterology and Hepatology.

Abstract
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Chromosomal Abnormalities Signal CNS Involvement in AML

WEDNESDAY, Dec. 28 (HealthDay News) -- Cytogenetic analysis at the time of diagnosis in patients with acute myeloid leukemia (AML) shows higher rates of chromosomal abnormalities for patients with central nervous system (CNS) involvement than for those with no CNS involvement, and survival is typically poor for patients with AML and CNS disease, according to a study published in the Jan. 1 issue of Cancer.

Abstract
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Serial Change in hsTnI or cTnI Accurately Rule In/Out AMI

TUESDAY, Dec. 27 (HealthDay News) -- For patients admitted with suspected acute coronary syndrome (ACS), use of highly sensitive troponin I (hsTnI) or contemporary troponin I (cTnI) assays on admission, and changes in their levels within three hours, can confirm the diagnosis of acute myocardial infarction (AMI), according to a study published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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No Correlation ID'd Between CYP2C19 Genotype, CVD Events

TUESDAY, Dec. 27 (HealthDay News) -- Although CYP2C19 genotype correlates with clopidogrel response and platelet aggregation, there is no evidence of a clinically significant association between CYP2C19 genotype and cardiovascular disease (CVD) events, according to a meta-analysis published in the Dec. 28 issue of the Journal of the American Medical Association.

Abstract
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Obese Patients Have Worse Colon Cancer Outcomes

TUESDAY, Dec. 27 (HealthDay News) -- Obese patients with colon cancer are less likely to have deficient mismatch repair (dMMR) tumors and have a worse prognosis compared with normal-weight patients, independent of other tumor variables, according to a study published online Dec. 27 in the Journal of Clinical Oncology.

Abstract
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Trace Element Levels Linked to Pancreatic Cancer Risk

TUESDAY, Dec. 27 (HealthDay News) -- High bodily levels of the trace elements nickel and selenium may lower the risk of developing the most common type of pancreatic cancer, while high levels of lead, arsenic, and cadmium could increase the likelihood of developing the disease, according to a study published online Dec. 19 in Gut.

Abstract
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Smoking During Pregnancy Affects Children's Vasculature

TUESDAY, Dec. 27 (HealthDay News) -- Parental smoking during pregnancy affects children's arterial structure and function in early life; and interventions that encourage parents to quit smoking for their children's benefit may increase parental quit rates, according to two studies published online Dec. 26 in Pediatrics.

Abstract - Geerts
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Abstract - Rosen
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Simvastatin Beats Ezetimibe in Anti-inflammatory Effects

THURSDAY, Dec. 22 (HealthDay News) -- For patients with hypercholesterolemia, simvastatin is superior to ezetimibe for producing lymphocyte-suppression and systemic anti-inflammatory and endothelial protective effects, according to a study published in the January issue of the Journal of Internal Medicine.

Abstract
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Gene-Ligand System Positively Associated With Human Obesity

THURSDAY, Dec. 22 (HealthDay News) -- There is a positive association between the L-α-lysophosphatidylinositol (LPI) and GPR55 system and obesity in humans, according to a study published online Dec. 16 in Diabetes.

Abstract
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Psoriasis Pathogenesis Involves Dermal Dendritic Cells

THURSDAY, Dec. 22 (HealthDay News) -- Dermal dendritic cells (DCs) are involved in the pathogenesis of psoriasis, although the quantity of these cells does not appear to account for the preferential involvement of extensor skin, according to research published in the January issue of the Journal of the American Academy of Dermatology.

Abstract
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INF2 Mutations Cause Charcot-Marie Tooth Neuropathy

WEDNESDAY, Dec. 21 (HealthDay News) -- INF2 mutations are a major cause of Charcot-Marie-Tooth disease associated with focal segmental glomerulosclerosis (FSGS), according to a study published in the Dec. 22 issue of the New England Journal of Medicine.

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DICER1 Mutations ID'd in Non-Epithelial Ovarian Cancer

WEDNESDAY, Dec. 21 (HealthDay News) -- Somatic missense mutations in the region of DICER1, which encodes the RNase IIIb domain, are common in nonepithelial ovarian tumors, according to a study published online Dec. 21 in the New England Journal of Medicine.

Abstract
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Quantitative MRI Biomarker IDs Cognitive Decline Risk

WEDNESDAY, Dec. 21 (HealthDay News) -- Cognitively normal (CN) older adults with a low measure of Alzheimer's disease signature (ADsig), a quantitative magnetic resonance imaging (MRI) biomarker, are more likely to develop cognitive decline, according to a study published online Dec. 21 in Neurology.

Abstract
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Immunosuppression Evidence Identified in Septic Death

WEDNESDAY, Dec. 21 (HealthDay News) -- Patients who die with active severe sepsis have reduced cytokine secretion and other changes indicative of immunosuppression, according to a study published in the Dec. 21 issue of the Journal of the American Medical Association.

Abstract
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Increasing U.S. Renal Cancer Incidence Differs by Age

MONDAY, Dec. 19 (HealthDay News) -- The increase in renal cancer incidence seen from 1995 to 2006 in the United States differs by age, according to a study published in the January issue of The Journal of Urology.

Abstract
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Mutant U2AF1 ID'd in Acute Myeloid Leukemia

MONDAY, Dec. 19 (HealthDay News) -- Patients with myelodysplastic syndromes (MDS), with a missense mutation affecting the serine at codon 34 (Ser34) in U2AF1, may be more likely to progress to chemotherapy-resistant secondary acute myeloid leukemia (sAML), according to a letter published online Dec. 11 in Nature Genetics.

Abstract
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Rule of 7's Sensitive in ID'ing Low Risk of Lyme Meningitis

MONDAY, Dec. 19 (HealthDay News) -- The "Rule of 7's," a Lyme meningitis clinical prediction rule based on clinical and laboratory parameters, identifies children with cerebrospinal fluid (CSF) pleocytosis who are at low risk for Lyme meningitis with high sensitivity, according to a study published online Dec. 19 in Pediatrics.

Abstract
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Low Serum Iron Ups Blood Clot Risk in At-Risk Population

FRIDAY, Dec. 16 (HealthDay News) -- For patients with hereditary hemorrhagic telangiectasia, low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and the risk of venous thromboemboli (VTE), according to a study published online Dec. 14 in Thorax.

Abstract
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SNP in MTHFR Tied to Risk of Radiation Pneumonitis

FRIDAY, Dec. 16 (HealthDay News) -- In patients treated with thoracic radiation therapy for locally advanced lung cancer, a single-nucleotide polymorphism (SNP) in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with a clinically significant risk of radiation pneumonitis (RP), according to a study published online Dec. 5 in Cancer.

Abstract
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HPV DNA Testing Leads to Early Detection of Cervical Cancer

THURSDAY, Dec. 15 (HealthDay News) -- Human papillomavirus (HPV) DNA testing at a first screening results in detection of fewer cases of cervical intraepithelial neoplasia (CIN) grade 2 or worse, CIN grade 3 or worse, and cervical cancer at a second screening five years later, according to a study published online Dec. 15 in The Lancet Oncology.

Abstract
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Editorial (subscription or payment may be required)

Rising Adiponectin Levels Lower Diabetes Risk in Elderly

THURSDAY, Dec. 15 (HealthDay News) -- In older adults, increasing concentrations of total and high-molecular-weight (HMW) adiponectin up to 20 and 10 mg/L, respectively, are inversely associated with incident diabetes, according to a study published online Dec. 6 in Diabetes Care.

Abstract
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Liberal Transfusion Nonsuperior Post-Hip Fracture Surgery

WEDNESDAY, Dec. 14 (HealthDay News) -- A liberal blood transfusion strategy (maintenance at a threshold of 10 g/dL hemoglobin) is not superior to a restrictive strategy (transfusion at symptoms of anemia or <8 g/dL hemoglobin) for reducing death and inability to walk independently after hip fracture surgery, according to a study published online Dec. 14 in the New England Journal of Medicine.

Abstract
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Brain Atrophy Is Cognitive Biomarker in Parkinson's

WEDNESDAY, Dec. 14 (HealthDay News) -- Patients with Parkinson's disease (PD) with mild cognitive impairment (PD-MCI) and dementia-level cognitive deficits (PDD) have increased brain atrophy, compared with patients with PD with normal cognition (PD-NC), according to a study published in the December issue of the Archives of Neurology.

Abstract
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Gene Polymorphisms Not Tied to Flu Deaths in Young Adults

TUESDAY, Dec. 13 (HealthDay News) -- Influenza-related deaths among children and young adults are not associated with polymorphisms in the tumor necrosis factor (TNF) and mannose-binding lectin (MBL2) genes, according to a study published in the December issue of the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.

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Lower PSA Threshold Not Being Used to Recommend Biopsy

WEDNESDAY, Dec. 14 (HealthDay News) -- Men with prostate-specific antigen (PSA) levels of less than 4.0 ng/mL are rarely sent for biopsy, according to a study published online Dec. 13 in the American Journal of Preventive Medicine.

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Autologous Blood Donation Tied to Pre-Op Anemia, Blood Loss

WEDNESDAY, Dec. 14 (HealthDay News) -- Preoperative autologous blood donation (PABD) during posterior lumbar spinal surgery is associated with preoperative anemia and a lower transfusion threshold than allogeneic blood use, according to a study published in the Dec. 15 issue of Spine.

Abstract
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Myotonic Muscular Dystrophy Tied to Increased Cancer Risk

TUESDAY, Dec. 13 (HealthDay News) -- Patients diagnosed with myotonic muscular dystrophy (MMD) are at an increased risk of developing cancer, according to a study published in the Dec. 14 issue of the Journal of the American Medical Association.

Abstract
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Single First-Trimester Malaria Episode Ups Miscarriage Risk

TUESDAY, Dec. 13 (HealthDay News) -- There is an increased risk of miscarriage for women who have a single episode of Plasmodium falciparum or Plasmodium vivax malaria during their first trimester of pregnancy, according to a study published online Dec. 13 in The Lancet Infectious Diseases.

Abstract
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Peritoneal Carcinomatosis Tied to Poor Survival in CRC

TUESDAY, Dec. 13 (HealthDay News) -- For patients with metastatic colorectal cancer (mCRC), peritoneal carcinomatosis colorectal cancer (pcCRC) is associated with significantly shorter overall survival (OS) and progression-free survival (PFS), according to a study published online Dec. 12 in the Journal of Clinical Oncology.

Abstract
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Infection Prevention Up in VA, Non-Federal Hospitals

TUESDAY, Dec. 13 (HealthDay News) -- From 2005 to 2009, there was a significant increase in the use of hospital-acquired infection (HAI) prevention practices in non-federal and Veterans Affairs (VA) hospitals, according to a study published online Dec. 6 in the Journal of General Internal Medicine.

Abstract
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Dysfunctional Dynamics Seen in Pain Pathways in Migraine

MONDAY, Dec. 12 (HealthDay News) -- Patients with migraines have an interictal increase in resting state intrinsic connectivity between the periaqueductal gray matter (PAG) and both nociceptive and sensory processing pathways, according to a study published online Dec. 7 in the Annals of Neurology.

Abstract
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Low Vitamin D Levels Seen in Obese Children

FRIDAY, Dec. 9 (HealthDay News) -- Low levels of 25-hydroxyvitamin D (25[OH]D) have been seen in children with obesity and are associated with early signs of diabetes, according to research published online Nov. 9 in the Journal of Clinical Endocrinology & Metabolism.

Abstract
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Microbial Diversity ID'd in Gut of Low Birth Weight Infants

FRIDAY, Dec. 9 (HealthDay News) -- The gut-associated microbiome of extremely low birth weight (ELBW) infants has microbial diversity and includes fungal species, bacteria, molds, viruses, parasitic organisms, and roundworms, according to a study published online Dec. 8 in PLoS One.

Full Text

Bowel Screening Detects Early Cancer in Majority of Patients

FRIDAY, Dec. 9 (HealthDay News) -- The colorectal cancer screening program in England detects mainly early cancer, and has found that left-sided cancers are considerably more common than expected, according to a study published online Dec. 7 in Gut.

Abstract
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Post-Mastectomy Reconstruction Feasible for Older Women

FRIDAY, Dec. 9 (HealthDay News) -- Breast reconstruction after mastectomy is safe, feasible, and well tolerated in older women, according to a study published in the December issue of The American Surgeon.

Abstract
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Nephrology Referral Low Following Acute Kidney Injury

FRIDAY, Dec. 9 (HealthDay News) -- Following an acute kidney injury (AKI), most patients at risk for subsequent decline in kidney function are not referred to a kidney specialist, according to a study published online Dec. 8 in the Journal of the American Society of Nephrology.

Abstract
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Factors Affecting Micro-RNA Detection Accuracy Identified

FRIDAY, Dec. 9 (HealthDay News) -- Accurate detection and quantitation of circulating microRNAs (miRNAs) is affected by inherent differences in plasma samples, methods used for their collection and analysis, and the presence of specific inhibitors in plasma, according to a study published online Dec. 9 in the Journal of Molecular Diagnostics.

Abstract
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Similar Prognosis for BRCA1 Carriers, Sporadic Breast Cancer

THURSDAY, Dec. 8 (HealthDay News) -- The risks of distant recurrence and death are similar for BRCA1 mutation carriers and for those with sporadic breast cancer, whereas women with BRCA2 mutations have higher risks on univariable analysis, and similar risks on multivariable analysis, according to a study published online Dec. 5 in the Journal of Clinical Oncology.

Abstract
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Editorial

Laquinimod Ups Brain-Derived Neurotrophic Factor in MS

THURSDAY, Dec. 8 (HealthDay News) -- Treatment with laquinimod is associated with a significant increase in the serum levels of brain-derived neurotrophic factor (BDNF) in patients with multiple sclerosis (MS), and increases the severity of experimental autoimmune encephalomyelitis (EAE) in mice with BDNF deficiency versus wild-type mice, according to a study published online Dec. 8 in The American Journal of Pathology.

Abstract
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Role of Environmental Factors in Breast Cancer Explored

WEDNESDAY, Dec. 7 (HealthDay News) -- Women may be able to reduce their risk of breast cancer by avoiding exposure to certain environmental factors, according to a report published Dec. 7 by the Institute of Medicine.

More Information

Cortical Demyelination Prevalent in Early MS

WEDNESDAY, Dec. 7 (HealthDay News) -- In patients with early-stage multiple sclerosis, cortical demyelinating lesions are common, inflammatory, and linked to meningeal inflammation, according to a study published in the Dec. 8 issue of the New England Journal of Medicine.

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Childhood Maltreatment Linked to Reduced Gray Matter Volume

WEDNESDAY, Dec. 7 (HealthDay News) -- Exposure to childhood maltreatment (CM) is associated with reduced cerebral gray matter (GM) morphology in adolescents without psychiatric diagnoses, according to a study published in the December issue of the Archives of Pediatrics & Adolescent Medicine.

Abstract
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Randomized Controlled HCC Screening Trial Not Feasible

WEDNESDAY, Dec. 7 (HealthDay News) -- A randomized controlled trial (RCT) of hepatocellular carcinoma (HCC) screening is not feasible for informed patients with cirrhosis; and small HCC detection is not improved by ultrasonographic screening (US) every three versus six months, according to two studies published in the December issue of Hepatology.

Abstract - Poustchi
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Abstract - Trinchet
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Study Finds Mammography Cuts Breast Cancer Deaths

TUESDAY, Dec. 6 (HealthDay News) -- Breast cancer detection through mammography screening is effective in reducing breast cancer mortality, according to a case-control study published online Dec. 6 in Cancer Epidemiology, Biomarkers & Prevention.

Abstract
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Rice Consumption Linked to Arsenic Exposure

TUESDAY, Dec. 6 (HealthDay News) -- In pregnant women who report daily rice consumption, urinary excretion of arsenic is significantly elevated when compared with non-rice eaters, according to research published online Dec. 5 in the Proceedings of the National Academy of Sciences.

Abstract
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Specific Genetic Alterations Identified in ADHD

TUESDAY, Dec. 6 (HealthDay News) -- Researchers have identified alterations in specific genes involved in brain signaling pathways implicated in attention-deficit/hyperactivity disorder (ADHD), according to a report published online Dec. 4 in Nature Genetics.

Abstract
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HLA-B27 Prevalence in United States Calculated

TUESDAY, Dec. 6 (HealthDay News) -- In the first large-scale study on the prevalence of HLA-B27 reactivity in the general population, roughly 6 percent of the population was found to be positive for HLA-B27, and it was more common in non-Hispanic whites and appears to decrease in prevalence with age, according to recent research published online Dec. 2 in Arthritis & Rheumatism.

Abstract
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Transplant Patients Want a Role in Liver Quality Decisions

TUESDAY, Dec. 6 (HealthDay News) -- Patients waiting for liver transplantation want to be involved in decisions about organ quality, and the level of risk they are prepared to tolerate is influenced by the presentation format, according to a study published in the December issue of Liver Transplantation.

Abstract
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Medical Students Fail to ID Hand Hygiene Indications

MONDAY, Dec. 5 (HealthDay News) -- Medical students who are about to start the clinical phase of their education have a lack of knowledge regarding the correct indications for hand disinfection, according to a study published in the December issue of the American Journal of Infection Control.

Abstract
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Childhood Risk Exposure Tied to Weight Gain in Adolescence

MONDAY, Dec. 5 (HealthDay News) -- Early childhood cumulative risk exposure to sociodemographic, physical, and psychosocial stressors is associated with weight gain in adolescence, and these gains are mainly accounted for by deteriorated self-regulatory abilities in children exposed to risks, according to a study published online Dec. 5 in Pediatrics.

Abstract
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Green Tea Polyphenol Inhibits HCV Entry Into Hepatocytes

MONDAY, Dec. 5 (HealthDay News) -- Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, strongly inhibits the entry of hepatitis C virus (HCV) into primary human hepatocytes, according to a study published in the December issue of Hepatology.

Abstract
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Cold Sore Susceptibility Linked to SNPs on C21orf91

FRIDAY, Dec. 2 (HealthDay News) -- Single nucleotide polymorphisms (SNPs) on C21orf91 are associated with herpes simplex labialis (HSL) susceptibility, according to a study published in the Dec. 1 issue of the Journal of Infectious Diseases.

Abstract
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Editorial

Serum Glucose Levels Tied to Colorectal Cancer Risk in Women

FRIDAY, Dec. 2 (HealthDay News) -- Serum glucose levels, but not serum insulin or homeostasis model assessment, are associated with increased colorectal cancer risk in postmenopausal women, according to a study published online Nov. 29 in the British Journal of Cancer.

Abstract
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Lobular Breast Cancer Tied to Having Father With Cancer

FRIDAY, Dec. 2 (HealthDay News) -- Lobular breast cancer is associated with having a father diagnosed with cancer, most commonly prostate cancer; and this association is independent of a family history of breast cancer, according to a study published online Nov. 28 in BMC Cancer.

Abstract
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Biomarkers of Huntington's Disease Progression ID'd

FRIDAY, Dec. 2 (HealthDay News) -- The effect sizes of detectable Huntington's disease (HD)-related changes over 24 months can identify potential outcome measures for assessing HD progression in therapeutic trials, according to a study published online Dec. 2 in The Lancet Neurology.

Abstract
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F2-Isoprostanes Inversely Linked to Diabetes Risk

FRIDAY, Dec. 2 (HealthDay News) -- Urinary F2-isoprostanes (iPF2α-III, 2,3-dinor-iPF2α-III, and iPF2α-VI) show a significant inverse association with the risk of type 2 diabetes, according to a study published online Nov. 18 in Diabetes Care.

Abstract
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Salvianolic Acid B Suppress Maturation of Dendritic Cells

FRIDAY, Dec. 2 (HealthDay News) -- Salvianolic acid B (Sal B) -- a herb-derived, water-soluble antioxidant known to help prevent atherosclerosis -- effectively suppresses the maturation of human monocyte-derived dendritic cells (h-monDCs), according to a study published in the December issue of the British Journal of Pharmacology.

Abstract
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MicroRNAs Distinguish Tumors in Von Hippel-Lindau Syndrome

THURSDAY, Dec. 1 (HealthDay News) -- MicroRNA (miRNA), miR-9 and miR-200a, signatures facilitate distinction of hemangioblastomas from metastatic clear cell renal cell carcinomas (Met CCRCC) in Von Hippel-Lindau Syndrome, according to a study published online Nov. 15 in Brain Pathology.

Abstract
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Breast CA Mets Biopsy Viable; May Impact Management

THURSDAY, Dec. 1 (HealthDay News) -- Biopsy of breast cancer metastases for estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor 2 (HER2) status is feasible and alters management in 14 percent of patients, but receptor discordance is not associated with worse outcome, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

Abstract
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Parental CA Therapy Not Tied to Genetic Defects in Offspring

THURSDAY, Dec. 1 (HealthDay News) -- Neither prenatal chemotherapy nor preconception gonad irradiation are associated with genetic defects in children of cancer survivors, according to a study published online Nov. 28 in the Journal of Clinical Oncology.

Abstract
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Editorial

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