Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Endocrinology | Family Medicine | Geriatrics | Internal Medicine | Emergency Medicine | Nursing | Orthopedics | Rheumatology | Journal

Back to Journal Articles

Traditional, Disease Risk Factors ID’d in SLE Osteoporosis

Last Updated: January 03, 2012.

 

Fracture occurrence nearly five-fold higher for women with systemic lupus erythematosus

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
For patients with systemic lupus erythematosus (SLE), the etiology of osteoporosis is multifactorial, encompassing traditional risk factors and SLE-related factors; and there is an increased fracture risk, according to a review published in the January issue of Arthritis Care & Research.

TUESDAY, Jan. 3 (HealthDay News) -- For patients with systemic lupus erythematosus (SLE), the etiology of osteoporosis is multifactorial, encompassing traditional risk factors and SLE-related factors; and there is an increased fracture risk, according to a review published in the January issue of Arthritis Care & Research.

Irene E.M. Bultink, M.D., Ph.D., from the VU University Medical Center in Amsterdam, Netherlands investigated the etiology of bone loss and fractures in patients with SLE, and reviewed measures for the prevention and treatment of these complications.

The investigator found that osteopenia was reported in 25 to 74 percent, and osteoporosis in 1.4 to 68 percent, of patients with SLE. The etiology was multifactorial, including traditional risk factors, as well as inflammation; medication-induced adverse events; and metabolic, hormonal, and serologic factors. In a population-based cohort, fracture occurrence was nearly five-fold higher in women with SLE. Risk factors for symptomatic fractures included age, postmenopausal status, disease duration, and reduced bone mineral density (BMD). Glucocorticoid treatment is predictive of osteoporotic fractures, with increased duration of use linked with the time from SLE diagnosis to fracture. Vertebral fractures are prevalent in 20 to 26.1 percent of patients with SLE; and 20 to 35.8 percent of these patients had normal BMD. Lifestyle measures, adequate calcium intake and serum levels, and prescription of immunosuppressive medications to reduce inflammation-induced bone loss are recommended for prevention and treatment of osteoporosis and fractures.

"Additional vertebral fracture assessment must be considered since vertebral fractures are frequent in SLE," the author writes. "Moreover, osteoporosis screening should also be considered in subgroups of SLE patients without glucocorticoid treatment."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Cannabis Impacts Brain During Attentional Salience Next: Epidural Steroids Temporarily Up Blood Glucose in Diabetes

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.