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Category: Endocrinology | Monthly Briefing

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January 2012 Briefing - Diabetes & Endocrinology

Last Updated: February 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for January 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Fenofibrate Found Safe in Diabetes With Renal Impairment

TUESDAY, Jan. 31 (HealthDay News) -- Long-term daily use of fenofibrate is beneficial for patients with type 2 diabetes and moderate renal impairment and is not associated with an increase in drug-related safety concerns compared with those with mild renal impairment, according to research published in the February issue of Diabetes Care.

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Diabetes Drugs Affect Pancreatic Cancer Risk

TUESDAY, Jan. 31 (HealthDay News) -- Long-term use of the diabetes drug metformin is associated with a lower risk of pancreatic cancer only in women, while long-term use of sulfonylureas and insulin are associated with a significantly higher risk of pancreatic cancer, according to a study published online Jan. 31 in the American Journal of Gastroenterology.

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Fructose Linked to Increased Cardiometabolic Risk in Teens

TUESDAY, Jan. 31 (HealthDay News) -- In adolescents, consumption of fructose is associated with multiple markers of cardiometabolic risk, and this association seems to be mediated by visceral adipose tissue (VAT), according to a study published in the Feb. 1 issue of the Journal of Nutrition.

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Site of Fatty Acid Storage in the Body Varies With Activity

TUESDAY, Jan. 31 (HealthDay News) -- During eating, free fatty acids are preferentially stored in upper-body fat in both men and women, but during walking they are preferentially stored in lower-body fat in women, according to a study published in the February issue of Diabetes.

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Physician Overweight/Obesity Impacts Obesity Care

TUESDAY, Jan. 31 (HealthDay News) -- Being overweight/obese has a significant impact on a physician's provision of obesity care, according to a study published online Jan. 19 in Obesity.

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Prenatal Testosterone Levels a Risk Factor for Language Delay

FRIDAY, Jan. 27 (HealthDay News) -- High prenatal testosterone levels are associated with an increased risk of clinically significant language delay in the first three years of life for male children, but are associated with a reduced risk of language delay for female children, according to research published online Jan. 26 in the Journal of Child Psychology and Psychiatry.

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Bydureon Approved for Type 2 Diabetes

FRIDAY, Jan. 27 (HealthDay News) -- Bydureon (exenatide extended release), Amylin Pharmaceuticals' long-acting version of the diabetes drug Byetta, has been approved by the U.S. Food and Drug Administration.

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Steroid-Sparing Renal Transplant Yields Successful Outcomes

FRIDAY, Jan. 27 (HealthDay News) -- Rapid discontinuation of prednisone (RDP) five days after renal transplantation from a living (LD) or deceased donor (DD) yields acceptable 10-year patient and graft outcomes, according to research published online Jan. 26 in the Clinical Journal of the American Society of Nephrology.

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Many Obesity Interventions Cost-Effective in Long-Term

FRIDAY, Jan. 27 (HealthDay News) -- The majority of obesity prevention interventions are cost-effective in the long-term, with the most favorable interventions being those which modify a target population's environment, according to a review published online Jan. 17 in Obesity Reviews.

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Better Dysglycemia Screening With Fasting Triglyceride Levels

FRIDAY, Jan. 27 (HealthDay News) -- The addition of fasting triglyceride levels to current American Diabetes Association (ADA) screening models improves the diagnostic accuracy of dysglycemia in overweight or obese children, according to a study published online Jan. 23 in Diabetes Care.

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Decline in Rate of Diabetic Lower-Extremity Amputation

THURSDAY, Jan. 26 (HealthDay News) -- From 1996 to 2008 there was a decline in the rates of hospitalization for nontraumatic lower-extremity amputation (NLEA) in the U.S. population with diabetes, according to a study published in the February issue of Diabetes Care.

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Positive Affirmation Improves Medication Adherence

THURSDAY, Jan. 26 (HealthDay News) -- Patient education (PE) enhanced with positive affirmation (PA) improves medication adherence over education alone in African-Americans with hypertension, but it does not lead to significant improvements in blood pressure (BP) reduction, according to a study published online Jan. 23 in the Archives of Internal Medicine.

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Exposure to Iodinated Contrast Media Affects Thyroid Function

THURSDAY, Jan. 26 (HealthDay News) -- Exposure to iodinated contrast media (ICM), which are frequently used during imaging procedures, is associated with changes in thyroid function, specifically an increased risk of developing incident hyperthyroidism and incident overt hypothyroidism, according to a study published in the Jan. 23 issue of the Archives of Internal Medicine.

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Survival Reduced for Patients With Cancer Who Have Diabetes

THURSDAY, Jan. 26 (HealthDay News) -- Patients with cancer generally have reduced survival if they also have type 2 diabetes, although this depends on the type of cancer and diabetes treatment, according to a study published online Jan. 20 in Diabetes Care.

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Risk-Factor Burden Impacts Lifetime Risk of Cardio Disease

WEDNESDAY, Jan. 25 (HealthDay News) -- Variation in risk-factor burden results in considerable differences in the lifetime risk of cardiovascular disease, and these differences are consistent across race and birth cohorts, according to a meta-analysis published in the Jan. 26 issue of the New England Journal of Medicine.

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Foods Fried in Olive Oil Not Linked to Heart Disease

WEDNESDAY, Jan. 25 (HealthDay News) -- Eating foods fried in olive or sunflower oil is not linked to heart disease or all-cause mortality, according to a Spanish study published online Jan. 24 in BMJ.

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Overuse of Health Care Services Understudied

WEDNESDAY, Jan. 25 (HealthDay News) -- Overuse of health care services in the United States is an understudied problem, with the majority of research limited to a few interventions, according to a review published in the Jan. 23 issue of the Archives of Internal Medicine.

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Unemployed Have Poorer Mental and Physical Health

TUESDAY, Jan. 24 (HealthDay News) -- Unemployed adults are about half as likely to have health insurance as employed individuals; have poorer mental and physical health, regardless of their insurance status; and are less likely to receive needed medical care and prescriptions, according to a January data brief issued by the National Center for Health Statistics.

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Parental Role in Successful Child Weight Loss Unclear

TUESDAY, Jan. 24 (HealthDay News) -- Parents should be involved in weight loss treatment programs for their obese children, but more research is needed to identify specific approaches that enable parents and adult caregivers (PACs) to be more effective agents in assisting obese children with weight loss, according to a new scientific statement from the American Heart Association published online Jan. 23 in Circulation.

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Negative Social Interactions Linked to Inflammation

TUESDAY, Jan. 24 (HealthDay News) -- Everyday social interactions that are negative or competitive are associated with elevated levels of inflammatory cytokines, according to a study published online Jan. 23 in the Proceedings of the National Academy of Sciences.

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Sleep Disturbance Linked to Cardiometabolic Disease Risk

MONDAY, Jan. 23 (HealthDay News) -- Sleep duration and sleep disturbance are associated with cardiometabolic disease, according to a study published online Dec. 12 in the Journal of Sleep Research.

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Four Novel Biomarkers May Predict Diabetic Kidney Damage

FRIDAY, Jan. 20 (HealthDay News) -- In patients with type 1 diabetes, a panel of four novel protein biomarkers may predict early kidney damage, according to a study published online Jan. 11 in Diabetes Care.

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Design Flaws Cast Doubt on Million Woman Study

THURSDAY, Jan. 19 (HealthDay News) -- The largest study linking hormone replacement therapy (HRT) to breast cancer, the Million Women Study (MWS), had flaws in its design and the findings do not satisfy the principles of causation, according to an evidence review published online Jan. 16 in the Journal of Family Planning & Reproductive Health Care.

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Osteoporotic Fracture Risk High in Systemic Mastocytosis

THURSDAY, Jan. 19 (HealthDay News) -- There is a high risk of osteoporotic fractures and osteoporosis in patients with indolent systemic mastocytosis (ISM), according to a study published online Jan. 9 in Allergy.

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New Equation Accurately Predicts Body Fat Percentage

WEDNESDAY, Jan. 18 (HealthDay News) -- The Clinica Universidad de Navarra body adiposity estimator (CUN-BAE) is an effective clinical tool for the prediction of body fat percentage (BF%), according to a study published online Dec. 16 in Diabetes Care.

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Prevalence of Obesity Unchanged in Adults/Children

TUESDAY, Jan. 17 (HealthDay News) -- The prevalence of obesity in adults and children/adolescents in the United States has remained unchanged in recent years, according to two studies published online Jan. 17 in the Journal of the American Medical Association.

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Superior Weight Loss With Roux-en-Y Gastric Bypass

TUESDAY, Jan. 17 (HealthDay News) -- Compared with laparoscopic gastric banding (GB), the Roux-en-Y gastric bypass (RYGBP) surgical procedure results in better weight loss and fewer long-term complications, according to a study published online Jan. 16 in the Archives of Surgery.

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Excess Weight Found to Double the Odds of Acne in Teen Girls

TUESDAY, Jan. 17 (HealthDay News) -- Overweight and obese girls are twice as likely to have moderate to severe acne, but this is not the case for overweight boys, according to a study published in the January issue of the Archives of Dermatology.

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Low Doses of Insulin Induce an Elastogenic Effect

TUESDAY, Jan. 17 (HealthDay News) -- Insulin induces an elastogenic effect, with therapeutic doses of insulin stimulating the formation of elastic fibers in human aortic smooth muscle cell cultures, according to an experimental study published online Jan. 11 in The American Journal of Pathology.

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Coffee May Inhibit Human Islet Amyloid Aggregation

TUESDAY, Jan. 17 (HealthDay News) -- The major components of coffee are able to inhibit the toxic aggregation of human islet amyloid polypeptide (hIAPP), according to a study published in the Dec. 28 issue of the Journal of Agricultural and Food Chemistry.

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Access to Quality Primary Care Reduces Mortality Risk

MONDAY, Jan. 16 (HealthDay News) -- Greater access to high-quality primary medical care that includes features of comprehensiveness, patient-centeredness, and extended office hours is associated with a reduced risk of death, according to a study published in the January/February issue of the Annals of Family Medicine.

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Parents Are Primary Target for Pediatric Obesity Programs

MONDAY, Jan. 16 (HealthDay News) -- Parents are the primary agents of change in most family- and home-based pediatric overweight and obesity intervention programs, according to research published online Jan. 6 in Obesity Reviews.

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SNP on CD36 Linked to Fat Gustatory Perception

MONDAY, Jan. 16 (HealthDay News) -- Variation at a single nuclear polymorphism (SNP) in the CD36 gene is associated with fat gustatory perception, with lower oral detection thresholds for oleic acid and triolein for obese individuals homozygous for the G-allele, according to a study published online Dec. 31 in the Journal of Lipid Research.

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Integrated Diabetes-Depression Treatment Improves Outcome

MONDAY, Jan. 16 (HealthDay News) -- Integrating the treatment of type 2 diabetes and depression improves outcomes, including glycemic control and depression, for patients in the primary care setting, according to a study published in the January/February issue of the Annals of Family Medicine.

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Cut Points Established for the Diabetes Distress Scale

FRIDAY, Jan. 13 (HealthDay News) -- Using the curvilinear relationship between the 17-item Diabetes Distress Scale (DDS17) and diabetes variables (hemoglobin A1c [HbA1c], self-efficacy, diet, and physical activity), distress cut points can be established, according to a study published online Jan. 6 in Diabetes Care.

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U.S. Health Care Expenditure Still Unevenly Distributed

FRIDAY, Jan. 13 (HealthDay News) -- Health care expenditure in the United States is still unevenly distributed, with 1 percent of the population accounting for approximately 20 percent of expenditure in 2008 and 2009, according to a January statistical brief published by the Agency for Healthcare Research and Quality (AHRQ).

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Increased CD4+ T Cells in Peripheral Blood of Obese

FRIDAY, Jan. 13 (HealthDay News) -- Morbidly obese individuals have a selective increase in CD4+ T cells in the peripheral blood T-cell compartment, according to a study published online Jan. 6 in Diabetes.

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Novel Anticancer Agents ID'd From NIH Drug Collection

THURSDAY, Jan. 12 (HealthDay News) -- Quantitative high-throughput screening (qHTS) of a large pharmaceutical collection can identify novel agents with anticancer activity, according to a study published online Dec. 14 in the Journal of Clinical Endocrinology & Metabolism.

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Stem Cell Therapy Shows Promise for Type 1 Diabetes

THURSDAY, Jan. 12 (HealthDay News) -- "Re-educating" lymphocytes from patients with type 1 diabetes through exposure to cord blood-derived multipotent stem cells (CB-SCs) is safe and may reverse autoimmunity, according to a study published online Jan. 10 in BMC Medicine.

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Physical Activity in Work or Leisure Tied to Lower MI Risk

THURSDAY, Jan. 12 (HealthDay News) -- Physical activity during work or leisure time is associated with a significantly lower risk of myocardial infarction (MI), according to a multinational study published online Jan. 11 in the European Heart Journal.

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CDC: 2010 Saw Decrease in Age-Adjusted Death Rates

WEDNESDAY, Jan. 11 (HealthDay News) -- From 2009 to 2010, age-adjusted death rates decreased and life expectancy increased, according to a Jan. 11 report published by the U.S. Centers for Disease Control and Prevention.

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Surgeons Aged 35 to 50 Years Perform Best Thyroidectomies

WEDNESDAY, Jan. 11 (HealthDay News) -- Surgeons aged 35 to 50 years appear to perform thyroidectomies better than their younger or older colleagues, according to a study published online Jan. 11 in BMJ.

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GLP-1R Agonists Found Effective for Weight Loss

WEDNESDAY, Jan. 11 (HealthDay News) -- Treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists for at least 20 weeks leads to weight loss in obese or overweight patients with or without type 2 diabetes mellitus, according to a study published online Jan. 11 in BMJ.

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Complications Increase With Delay of BP Control in Diabetes

WEDNESDAY, Jan. 11 (HealthDay News) -- For middle-aged patients with newly-diagnosed type 2 diabetes, the impact of a delay in controlling systolic blood pressure depends on the length of the delay, according to a study published online Jan. 4 in the Journal of General Internal Medicine.

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Gestational Hypothyroidism Higher Than Estimated

TUESDAY, Jan. 10 (HealthDay News) -- Nearly one in six pregnant women who are tested suffer from gestational hypothyroidism, but less than a quarter of pregnant women undergo screening, according to a study published online Dec. 14 in the Journal of Clinical Endocrinology & Metabolism.

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Long-Term Prognostic Value of Dobutamine Stress Echo Limited

TUESDAY, Jan. 10 (HealthDay News) -- Dobutamine stress echocardiography (DSE) has limited long-term predictive value for patients with diabetes who are unable to perform an exercise stress test, particularly during the first seven years after initial testing, according to a study published online Jan. 6 in Diabetes Care.

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Diabetes Lifestyle Intervention Program Could Save Billions

TUESDAY, Jan. 10 (HealthDay News) -- Modeling suggests that a lifestyle intervention program could prevent thousands of cases of diabetes and save billions of dollars; and wide-scale implementation of evidence-based interventions may be able to curb diabetes and its complications, according to two studies published in the January issue of Health Affairs.

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Statins Increase Diabetes Risk for Postmenopausal Women

MONDAY, Jan. 9 (HealthDay News) -- Postmenopausal women taking statin medications have an increased risk of incident diabetes mellitus (DM), according to an analysis published online Jan. 9 in the Archives of Internal Medicine.

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Biomarker Patterns Indicative of Weight Loss Benefits

MONDAY, Jan. 9 (HealthDay News) -- Biomarker patterns reflect both the short-term benefits of weight reduction and the long-term cumulative benefits of healthful eating, despite partial weight regain, according to a study published online Dec. 21 in Diabetes Care.

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Larger Trabecular Holes Explain Bone Fragility in Diabetes

MONDAY, Jan. 9 (HealthDay News) -- The higher fracture risk observed in women with type 2 diabetes mellitus (T2DM) may be due, in part, to the larger average hole size and, consequently, the more porous nature of their trabecular bone microarchitecture, according to a study published in the January issue of Arthritis Care & Research.

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Glucose-Lowering Algorithm Safe in Coronary Care Unit

FRIDAY, Jan. 6 (HealthDay News) -- In coronary care unit (CCU) patients, a paper-based glucose-lowering algorithm with target serum glucose levels of 5.0 to 6.5 mmol/L (90 to 117 mg/dL) can be safely implemented, but further studies are needed to assess cardiovascular outcomes, according to research published in the January issue of Diabetes Care.

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New Criteria ID Fewer Cases of Post-Op Diabetes Remission

FRIDAY, Jan. 6 (HealthDay News) -- Fewer patients with type 2 diabetes achieve diabetes remission following weight loss surgery, when employing the new, stricter criteria for diabetes remission issued by the American Diabetes Association (ADA), according to a study published in the January issue of the British Journal of Surgery.

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Hypoglycemia in Intensive Diabetes Control May Up Survival

FRIDAY, Jan. 6 (HealthDay News) -- For adults with type 2 diabetes, recognized and unrecognized hypoglycemia is more common in those with intensive blood sugar control, and is associated with a small but significant reduction in the risk of mortality, according to a study published online Dec. 16 in Diabetes Care.

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Exercise Benefits Insulin-Treated Obese Patients With Diabetes

FRIDAY, Jan. 6 (HealthDay News) -- Supervised mixed (aerobic and resistance) exercise is effective in improving hemoglobin A1c (HbA1c) and cardiovascular disease (CVD) risk related to insulin treatment in overweight and obese patients with type 2 diabetes, according to a study published in the January issue of Diabetes Care.

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Few With Diabetes Risk See Need for Lifestyle Counseling

FRIDAY, Jan. 6 (HealthDay News) -- Many patients who are at risk for developing type 2 diabetes do not perceive the need for lifestyle counseling, and even among those who see the need for counseling, less than half actually attend lifestyle interventions, according to a study published online Dec. 21 in Diabetes Care.

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TACSTD2 Gene May Affect Postnatal Growth, Fat Mass

FRIDAY, Jan. 6 (HealthDay News) -- Altered expression of the TACSTD2 gene may be associated with postnatal growth and childhood fat mass, although lack of association between postnatal growth or fat mass and a methylation proxy SNP in this gene may indicate confounding, according to a study published online Dec. 21 in Diabetes.

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Poor Sleep Worsens Health in Youth With Type 1 Diabetes

FRIDAY, Jan. 6 (HealthDay News) -- Young people with type 1 diabetes mellitus (T1DM) may have difficulty getting a good night's sleep, resulting in difficulty controlling blood sugar and decreased performance in school, according to a study published in the January issue of SLEEP.

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In-Hospital, 30-Day Standardized Mortality Measures Differ

THURSDAY, Jan. 5 (HealthDay News) -- The mean risk-standardized mortality rates (RSMRs) differ for in-hospital and 30-day models, with wide variability across U.S. hospitals, according to a study published in the Jan. 3 issue of the Annals of Internal Medicine.

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Hyperuricemia Is Independent Risk Factor for Incident CKD

THURSDAY, Jan. 5 (HealthDay News) -- Patients with type 2 diabetes and normal kidney function are twice as likely to develop incident chronic kidney disease (CKD) if they have hyperuricemia, according to a study published in the January issue of Diabetes Care.

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Cancer Incidence, Mortality Higher in Adults With Diabetes

THURSDAY, Jan. 5 (HealthDay News) -- The incidence of cancer and the mortality rate due to cancer is higher in people with type 2 diabetes compared to those without the condition, according to a study published in the January issue of Diabetes Care.

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Dietary Protein Affects Energy Expenditure, Not Body Fat

TUESDAY, Jan. 3 (HealthDay News) -- For individuals in a controlled setting, the protein content of a diet affects energy expenditure and storage of lean mass, but does not impact body fat storage, according to a study published in the Jan. 4 issue of the Journal of the American Medical Association.

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Most Type 2 Diabetes, CAD Patients Present With Angina

WEDNESDAY, Jan. 4 (HealthDay News) -- A large proportion of patients with type 2 diabetes mellitus and documented stable coronary artery disease have symptoms of angina, and the nature of symptom presentation may be associated with the type of previous revascularization, according to a study published in the Jan. 1 issue of The American Journal of Cardiology.

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Usual Care Doesn't Stop Muscle Loss in Idiopathic Fracture

WEDNESDAY, Jan. 4 (HealthDay News) -- Routine management of men with idiopathic vertebral fracture has no effect on observed muscle loss; and patients still have significantly lower physical functioning and quality of life than controls after six years of follow-up, according to a study published in the January issue of Arthritis Care & Research.

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Burden of Treatment in Diabetes Rarely Addressed

WEDNESDAY, Jan. 4 (HealthDay News) -- Although the burden of diabetes treatments is discussed in more than 90 percent of primary care office visits, problem-solving efforts are made in only about one-third of cases, according to a study published in the January issue of Diabetes Care.

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Bariatric Surgery Tied to Reduced CVD Events, Mortality

TUESDAY, Jan. 3 (HealthDay News) -- For obese individuals, bariatric surgery is associated with significantly reduced incidence of cardiovascular events, and decreased cardiovascular death, versus usual care, according to a study published in the Jan. 4 issue of the Journal of the American Medical Association.

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Epidural Steroids Temporarily Up Blood Glucose in Diabetes

TUESDAY, Jan. 3 (HealthDay News) -- Epidural steroid injections (ESIs) significantly increase the blood glucose levels in patients with diabetes mellitus, but the effect lasts less than two days, according to a study published in the Jan. 1 issue of Spine.

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Traditional, Disease Risk Factors ID'd in SLE Osteoporosis

TUESDAY, Jan. 3 (HealthDay News) -- For patients with systemic lupus erythematosus (SLE), the etiology of osteoporosis is multifactorial, encompassing traditional risk factors and SLE-related factors; and there is an increased fracture risk, according to a review published in the January issue of Arthritis Care & Research.

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Maternal Diabetes, Low Income Up ADHD Risk in Children

TUESDAY, Jan. 3 (HealthDay News) -- Children exposed to maternal gestational diabetes mellitus (GDM) and low socioeconomic status (SES), especially in combination, are at an increased risk of developing childhood attention-deficit/hyperactivity disorder (ADHD), according to a study published online Jan. 2 in the Archives of Pediatrics & Adolescent Medicine.

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Lack of Resources Barrier to Vets' Weight-Management Plan

TUESDAY, Jan. 3 (HealthDay News) -- Successful implementation of the MOVE! weight-management program in Veterans Health Administration medical facilities depends upon organizational readiness and an innovation champion, according to a study published in the January issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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GLP-1 Plays Role in Glucose Control After Gastric Bypass

TUESDAY, Jan. 3 (HealthDay News) -- There is a positive association between glucagon-like peptide-1 (GLP-1) concentrations and insulin concentrations following gastric bypass (GBP) surgery in patients with type 2 diabetes, suggesting a role for GLP-1 in glucose control, according to a study published in the January issue of Diabetes Care.

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