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Category: Neurology | Monthly Briefing

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January 2012 Briefing - Neurology

Last Updated: February 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Neurology for January 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Cyberknife Effective in Treating Trigeminal Neuralgia

TUESDAY, Jan. 31 (HealthDay News) -- Cyberknife stereotactic radiosurgery is effective in the treatment of trigeminal neuralgia (TN), according to a small study published online Jan. 25 in the Journal of NeuroInterventional Surgery.

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Early Maternal Support Ups Hippocampal Volume in Children

TUESDAY, Jan. 31 (HealthDay News) -- Maternal support during the preschool years has a positive effect on healthy hippocampal development, which is key to memory and stress modulation, according to an article published online Jan. 30 in the Proceedings of the National Academy of Sciences.

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Hemi-CC7 Transfer Poor Option for Brachial Plexus Injury

MONDAY, Jan. 30 (HealthDay News) -- The use of hemi-contralateral C7 (CC7) transfer alone for either restoration of shoulder function or transfer to the median nerve is not recommended in patients with posttraumatic brachial plexus injury, according to a study published in the Jan. 18 issue of The Journal of Bone & Joint Surgery.

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Eye Contact Abnormal in Infants at Risk for Autism

MONDAY, Jan. 30 (HealthDay News) -- Infants at risk for developing autism spectrum disorders already show abnormalities in their patterns of eye contact in their first year, which may allow earlier intervention, according to a study published online Jan. 26 in Current Biology.

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Differing Arm Blood Pressure Linked to Vascular Disease, Death

MONDAY, Jan. 30 (HealthDay News) -- Systolic blood pressure that differs by more than 10 or 15 mm Hg between arms is associated with a higher risk of vascular problems and death, according to a study published online Jan. 30 in The Lancet.

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Self-Rated Health Status Predicts Mortality Among CVD Patients

FRIDAY, Jan. 27 (HealthDay News) -- Self-rated health status is a risk factor for future vascular events and mortality in patients with cardiovascular diseases, particularly in those with asymptomatic atherosclerotic disease, according to a study published online Jan. 18 in the Journal of Internal Medicine.

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Isoflurane Harmful to Mitochondrial Function in Mice

FRIDAY, Jan. 27 (HealthDay News) -- Anesthetics isoflurane and desflurane have distinct effects on mitochondrial function and learning and memory, according to an experimental study published online Jan. 19 in the Annals of Neurology.

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Testing Patterns to Diagnose Neuropathy Vary Widely

FRIDAY, Jan. 27 (HealthDay News) -- Patients diagnosed with peripheral neuropathy undergo a median of four tests, with variability seen in testing patterns, according to a study published in the Jan. 23 issue of the Archives of Internal Medicine.

Abstract
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Low Birth Weight May Be Risk Factor for Autism

THURSDAY, Jan. 26 (HealthDay News) -- Low birth weight may be among potential environmental risk factors for autism spectrum disorder (ASD), according to a study of same-sex twins published online Dec. 2 in Psychological Medicine.

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Positive Affirmation Improves Medication Adherence

THURSDAY, Jan. 26 (HealthDay News) -- Patient education (PE) enhanced with positive affirmation (PA) improves medication adherence over education alone in African-Americans with hypertension, but it does not lead to significant improvements in blood pressure (BP) reduction, according to a study published online Jan. 23 in the Archives of Internal Medicine.

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Men at Higher Risk for Mild Cognitive Impairment

WEDNESDAY, Jan. 25 (HealthDay News) -- The incidence of both amnestic and nonamnestic mild cognitive impairment (aMCI and naMCI) is higher in men than women, according to a study published online Jan. 25 in Neurology.

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Neurologists Should Routinely Assess Patients for Abuse

WEDNESDAY, Jan. 25 (HealthDay News) -- Neurologists should evaluate patients for abuse and neglect, according to a position statement issued by the American Academy of Neurology published online Jan. 25 in Neurology.

Position Statement

Overuse of Health Care Services Understudied

WEDNESDAY, Jan. 25 (HealthDay News) -- Overuse of health care services in the United States is an understudied problem, with the majority of research limited to a few interventions, according to a review published in the Jan. 23 issue of the Archives of Internal Medicine.

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Reduced Brain Activity Seen in Prereaders With Dyslexia Risk

WEDNESDAY, Jan. 25 (HealthDay News) -- Prereading children with a family history of developmental dyslexia (DD) show reduced activity in the bilateral occipitotemporal and left temporoparietal brain regions during phonological processing exercises, according to a study published online Jan. 23 in the Proceedings of the National Academy of Sciences.

Abstract
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Sex Differences Exist in Disease-Linked Pain Intensity

WEDNESDAY, Jan. 25 (HealthDay News) -- Sex differences exist in specific disease-associated pain intensity, with women suffering a higher prevalence of pain for musculoskeletal, neuropathic, abdominal, and migraine-related conditions, according to a study published online Jan. 16 in The Journal of Pain.

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Reduced [11C]PiB Uptake in Cognitively Active Elderly

TUESDAY, Jan. 24 (HealthDay News) -- Elderly individuals who keep their brains active through activities such as reading, writing, and playing games have reduced uptake of carbon 11-labeled Pittsburg Compound B ([11C]PiB), according to a study published online Jan. 23 in the Archives of Neurology.

Abstract
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Unemployed Have Poorer Mental and Physical Health

TUESDAY, Jan. 24 (HealthDay News) -- Unemployed adults are about half as likely to have health insurance as employed individuals; have poorer mental and physical health, regardless of their insurance status; and are less likely to receive needed medical care and prescriptions, according to a January data brief issued by the National Center for Health Statistics.

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HealthGrades IDs Notable Hospitals for Clinical Excellence

TUESDAY, Jan. 24 (HealthDay News) -- The top 5 percent of U.S. hospitals has more than a 30 percent lower risk-adjusted mortality across 17 procedures and diagnoses, compared with other hospitals, according to the 10th annual HealthGrades Hospital Quality and Clinical Excellence study published online Jan. 24.

Report

Effects of Severe, Childhood Brain Injury Long Lasting

MONDAY, Jan. 23 (HealthDay News) -- There is a high risk of persisting deficits following severe, childhood traumatic brain injury (TBI), according to a study published online Jan. 23 in Pediatrics.

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Mild Traumatic Brain Injury in ~4 Percent of U.K. Troops

MONDAY, Jan. 23 (HealthDay News) -- Mild traumatic brain injury (mTBI) has a prevalence of 4.4 percent in U.K. troops returning from Iraq or Afghanistan, and 9.5 percent in those with a combat role, according to a study published in the January/February issue of the Journal of Head Trauma Rehabilitation.

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Sleep Disturbance Linked to Cardiometabolic Disease Risk

MONDAY, Jan. 23 (HealthDay News) -- Sleep duration and sleep disturbance are associated with cardiometabolic disease, according to a study published online Dec. 12 in the Journal of Sleep Research.

Abstract
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Co-Occurring Conditions Impact Change in Autism Disorders

MONDAY, Jan. 23 (HealthDay News) -- For children with autism spectrum disorder (ASD), the presence of co-occurring neurodevelopmental and psychiatric conditions is associated with a change in ASD diagnosis, and these conditions vary with the age of the child, according to a study published online Jan. 23 in Pediatrics.

Abstract
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Sleep Tied to Maintenance of Emotional Reactivity

FRIDAY, Jan. 20 (HealthDay News) -- Sleep is associated with enhanced emotional memory and maintenance of emotional reactivity compared with wake, according to a study published in the Jan. 18 issue of The Journal of Neuroscience.

Abstract
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Warfarin Patients With Head Trauma Need Second CT Scan

FRIDAY, Jan. 20 (HealthDay News) -- For patients on warfarin with minor head trauma who have an initial negative computed tomography (CT) scan, 24-hour observation followed by an additional CT scan identifies the majority of cases of delayed bleeding, according to a study published online Jan. 16 in the Annals of Emergency Medicine.

Abstract
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Worse Outcomes for Stroke Patients With Delirium

THURSDAY, Jan. 19 (HealthDay News) -- Stroke patients who develop delirium have worse outcomes, including higher mortality and longer hospitalizations, and are more likely to be discharged to a care facility, according to a review published online Jan. 19 in Stroke.

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Cognitive Impairment Seen in Overweight Retired NFL Players

THURSDAY, Jan. 19 (HealthDay News) -- Overweight retired National Football League (NFL) players have decreased blood flow in certain areas of the brain as well as significant decreases in attention, cognitive proficiency, and memory, according to a study published online Jan. 17 in Translational Psychiatry.

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Meningitis B Vaccine Immunogenic in Adolescents

WEDNESDAY, Jan. 18 (HealthDay News) -- Two doses of the four-component Neisseria meningitidis serogroup B (4CMenB) vaccine is highly immunogenic in adolescents, according to a study published online Jan. 18 in The Lancet.

Abstract
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Cybercycling Improves Cognitive Function in Elderly

WEDNESDAY, Jan. 18 (HealthDay News) -- Virtual reality-enhanced exercise, or "exergames," such as cybercycling, is associated with a greater cognitive benefit for older adults than traditional exercise, according to a study published online Jan. 17 in the American Journal of Preventive Medicine.

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Bevacizumab Combo Improves Colorectal Cancer Survival

WEDNESDAY, Jan. 18 (HealthDay News) -- The addition of bevacizumab to combination chemotherapy for the treatment of stage IV colorectal cancer increases overall survival, particularly for patients receiving irinotecan-based chemotherapy regimens, but is associated with increased rates of strokes and gastrointestinal (GI) perforations, according to a study published online Jan. 17 in the Journal of Clinical Oncology.

Abstract
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Editorial

Surgery Beats Non-Op Care for Intervertebral Disc Herniation

FRIDAY, Jan. 13 (HealthDay News) -- Surgery is more effective than nonoperative treatment for patients with intervertebral disc herniation (IDH), with marital status, joint problems, and symptom trend at baseline identified as significant modifiers of treatment effect, according to a study published in the Jan. 15 issue of Spine.

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Impaired White Matter ID'd in Internet Addiction Disorder

FRIDAY, Jan. 13 (HealthDay News) -- Teenagers with internet addiction disorder (IAD) show impaired white matter structure, indicated by reductions in fractional anisotropy (FA), according to a study published online Jan. 11 in PLoS One.

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U.S. Health Care Expenditure Still Unevenly Distributed

FRIDAY, Jan. 13 (HealthDay News) -- Health care expenditure in the United States is still unevenly distributed, with 1 percent of the population accounting for approximately 20 percent of expenditure in 2008 and 2009, according to a January statistical brief published by the Agency for Healthcare Research and Quality (AHRQ).

Report

PEDF Has Tumor-Suppressive and Neuroprotective Functions

THURSDAY, Jan. 12 (HealthDay News) -- Pigment epithelium-derived factor (PEDF) rapidly suppresses experimental brain metastases and protects the brain from tumor-induced damage in a mouse model, according to a study published in the Jan. 1 issue of Cancer Research.

Abstract
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Foot Tapping Assesses Motor Function in Cervical Myelopathy

THURSDAY, Jan. 12 (HealthDay News) -- The foot tapping test (FTT) can be used to quantitatively assess lower extremity motor function in patients with cervical myelopathy, according to a study published in the Jan. 15 issue of Spine.

Abstract
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APOE Status, Exercise Combo Impact Amyloid Deposition

THURSDAY, Jan. 12 (HealthDay News) -- For cognitively normal carriers of APOE ε4, a sedentary lifestyle is associated with an increased risk of amyloid deposition, according to a study published online Jan. 9 in the Archives of Neurology.

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CDC: 2010 Saw Decrease in Age-Adjusted Death Rates

WEDNESDAY, Jan. 11 (HealthDay News) -- From 2009 to 2010, age-adjusted death rates decreased and life expectancy increased, according to a Jan. 11 report published by the U.S. Centers for Disease Control and Prevention.

Report

Dementia Associated With More Hospital Admissions

TUESDAY, Jan. 10 (HealthDay News) -- Hospital admission rates for all causes, and for ambulatory care-sensitive conditions (ACSCs), are significantly higher among patients with dementia compared to older patients without dementia, according to a study published in the Jan. 11 issue of the Journal of the American Medical Association.

Abstract
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Editorial (subscription or payment may be required)

Occasional Marijuana Use Not Tied to Adverse Lung Function

TUESDAY, Jan. 10 (HealthDay News) -- Occasional and low cumulative marijuana use does not adversely affect lung function, according to a study published in the Jan. 11 issue of the Journal of the American Medical Association.

Abstract
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Memantine Has No Impact on Cognition in Down's Syndrome

TUESDAY, Jan. 10 (HealthDay News) -- Memantine does not prevent a decline in cognition or function in adults with Down's syndrome, according to a study published online Jan. 10 in The Lancet.

Abstract
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Benefit of Aspirin in Primary Prevention Questioned

TUESDAY, Jan. 10 (HealthDay News) -- For individuals without prior cardiovascular disease (CVD), aspirin prophylaxis does not reduce cardiovascular death or cancer mortality, although it is associated with reductions in nonfatal myocardial infarction (MI), according to a meta-analysis published online Jan. 9 in the Archives of Internal Medicine.

Abstract
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Transdermal Nicotine May Benefit Cognitive Impairment

TUESDAY, Jan. 10 (HealthDay News) -- For nonsmokers with amnestic mild cognitive impairment (MCI), use of a transdermal nicotine patch for six months is associated with improved cognitive test performance, but not clinical global impression of change, according to a pilot study published in the Jan. 10 issue of Neurology.

Abstract
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Acupuncture May Have Minor Effect in Migraine Prevention

MONDAY, Jan. 9 (HealthDay News) -- For patients with migraine, acupuncture may have a minor clinical prophylactic effect, compared with sham acupuncture, according to a study published online Jan. 9 in CMAJ, the journal of the Canadian Medical Association.

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Adiponectin Tied to Dementia, Alzheimer's Risk in Women

MONDAY, Jan. 9 (HealthDay News) -- Plasma levels of adiponectin are an independent risk factor for all-cause dementia and Alzheimer's disease (AD) in women, according to a study published online Jan. 2 in the Archives of Neurology.

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Brain Changes Seen After First-Episode Psychosis in Teens

MONDAY, Jan. 9 (HealthDay News) -- Children and adolescents with schizophrenia have significantly greater brain gray matter (GM) volume loss and increased frontal lobe cerebrospinal fluid (CSF) volume compared with adolescents without a diagnosis of psychosis, according to a study published in the January issue of the Archives of General Psychiatry.

Abstract
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Three Novel Multiple Sclerosis Susceptibility Loci Identified

FRIDAY, Jan. 6 (HealthDay News) -- Three novel multiple sclerosis (MS) genetic susceptibility loci have been identified, according to a meta-analysis published in the December issue of the Annals of Neurology.

Abstract
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Cognitive Decline May Begin As Early As Age 45

FRIDAY, Jan. 6 (HealthDay News) -- Cognitive functioning, including memory, reasoning, and comprehension skills, can start to deteriorate as early as age 45 and declines even faster in men and women over age 65, according to a large, prospective study published online Jan. 5 in BMJ.

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In-Hospital, 30-Day Standardized Mortality Measures Differ

THURSDAY, Jan. 5 (HealthDay News) -- The mean risk-standardized mortality rates (RSMRs) differ for in-hospital and 30-day models, with wide variability across U.S. hospitals, according to a study published in the Jan. 3 issue of the Annals of Internal Medicine.

Abstract
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Epilepsy, HIV Drug Combination Therapies Require Caution

THURSDAY, Jan. 5 (HealthDay News) -- Antiepileptic drugs (AEDs) should be used with caution in individuals with HIV/AIDS, due to potential interactions between AEDs and antiretroviral agents (ARVs), according to new guidelines issued by the American Academy of Neurology, published online Jan. 4 in Neurology.

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Vibratory Sense Unimpaired in Knee-Injured Patients

THURSDAY, Jan. 5 (HealthDay News) -- For knee-injured patients, the vibratory perception threshold (VPT) is not impaired in those at high risk of knee osteoarthritis, according to a study published in the January issue of Arthritis Care & Research.

Abstract
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Neurostimulation Improves Swallowing After Stroke

WEDNESDAY, Jan. 4 (HealthDay News) -- A new neurostimulation technique called paired associated stimulation (PAS), which combines peripheral stimulation of the targeted muscle with cortical stimulation of the targeted muscle's representational area, may be useful in the rehabilitation of patients with dysphagia due to stroke, according to a study published in the January issue of Gastroenterology.

Abstract
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Bariatric Surgery Tied to Reduced CVD Events, Mortality

TUESDAY, Jan. 3 (HealthDay News) -- For obese individuals, bariatric surgery is associated with significantly reduced incidence of cardiovascular events, and decreased cardiovascular death, versus usual care, according to a study published in the Jan. 4 issue of the Journal of the American Medical Association.

Abstract
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Cannabis Impacts Brain During Attentional Salience

TUESDAY, Jan. 3 (HealthDay News) -- The psychotic effects of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol are mediated through distinct modulation of prefrontal, striatal, and hippocampal function during attentional salience processing, according to a study published in the January issue of the Archives of General Psychiatry.

Abstract
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Infarcts, Hippocampal Volume Independently Linked to Memory

TUESDAY, Jan. 3 (HealthDay News) -- In elderly individuals without dementia, the presence of brain infarcts and a smaller hippocampal volume are independently associated with poor memory, according to a study published in the Jan 3. issue of Neurology.

Abstract
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