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Category: Internal Medicine | Monthly Briefing

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January 2012 Briefing - Internal Medicine

Last Updated: February 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for January 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Diabetes Drugs Affect Pancreatic Cancer Risk

TUESDAY, Jan. 31 (HealthDay News) -- Long-term use of the diabetes drug metformin is associated with a lower risk of pancreatic cancer only in women, while long-term use of sulfonylureas and insulin are associated with a significantly higher risk of pancreatic cancer, according to a study published online Jan. 31 in the American Journal of Gastroenterology.

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Fenofibrate Found Safe in Diabetes With Renal Impairment

TUESDAY, Jan. 31 (HealthDay News) -- Long-term daily use of fenofibrate is beneficial for patients with type 2 diabetes and moderate renal impairment and is not associated with an increase in drug-related safety concerns compared with those with mild renal impairment, according to research published in the February issue of Diabetes Care.

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Safety-Net Status Not Linked to ER Length of Stay

TUESDAY, Jan. 31 (HealthDay News) -- There is no significant difference in compliance with emergency department length-of-stay measures for admissions, discharges, observations, and transfers between safety-net and non-safety-net hospitals, according to a study published in the Feb. 1 issue of the Journal of the American Medical Association.

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Breast Reexcision Rates Vary With Surgeon, Institution

TUESDAY, Jan. 31 (HealthDay News) -- For women with invasive breast cancer who undergo partial mastectomy and have negative margins, reexcision rates vary substantially depending on the surgeon and institution, according to a retrospective chart review published in the Feb. 1 issue of the Journal of the American Medical Association.

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Physician Overweight/Obesity Impacts Obesity Care

TUESDAY, Jan. 31 (HealthDay News) -- Being overweight/obese has a significant impact on a physician's provision of obesity care, according to a study published online Jan. 19 in Obesity.

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Laparoscopy Acceptable for Staging Uterine Cancer

TUESDAY, Jan. 31 (HealthDay News) -- Comprehensive surgical staging of endometrial cancer can be performed laparoscopically with relatively small differences in recurrence rates compared to laparotomy, according to a study published online Jan. 30 in the Journal of Clinical Oncology.

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Site of Fatty Acid Storage in the Body Varies With Activity

TUESDAY, Jan. 31 (HealthDay News) -- During eating, free fatty acids are preferentially stored in upper-body fat in both men and women, but during walking they are preferentially stored in lower-body fat in women, according to a study published in the February issue of Diabetes.

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Cyberknife Effective in Treating Trigeminal Neuralgia

TUESDAY, Jan. 31 (HealthDay News) -- Cyberknife stereotactic radiosurgery is effective in the treatment of trigeminal neuralgia (TN), according to a small study published online Jan. 25 in the Journal of NeuroInterventional Surgery.

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High-Fiber Diet May Not Lower Risk of Diverticulosis

TUESDAY, Jan. 31 (HealthDay News) -- High dietary fiber intake was not associated with a lower prevalence of diverticulosis. In fact, people who ate a high-fiber diet and those having 15 or more bowel movements per week had a higher, not lower, prevalence of diverticulosis, according to research published in the February issue of Gastroenterology.

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Meta-Analysis: Statin Therapy Equally Effective in Women, Men

MONDAY, Jan. 30 (HealthDay News) -- Statin therapy is equally effective for decreasing cardiovascular events in women and men, according to a meta-analysis published in the Feb. 7 issue of the Journal of the American College of Cardiology.

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Antiretroviral Medications Linked to Cleft Deformities

MONDAY, Jan. 30 (HealthDay News) --Antiretroviral drugs prescribed for HIV-infected pregnant women to reduce risk of mother-to-child disease transmission may be linked to cleft lip and palate disorders in newborns, according to a study published in the January issue of Cleft Palate-Craniofacial Journal.

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Disc Degeneration More Likely in Overweight, Obese Adults

MONDAY, Jan. 30 (HealthDay News) -- Overweight and obese adults are significantly more likely to have lumbar disc degeneration compared with those who have a normal body mass index (BMI), according to a study published online Jan. 27 in Arthritis & Rheumatism.

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Education Reduces Distress During Breast Cancer Treatment

MONDAY, Jan. 30 (HealthDay News) -- Interventions such as telephone counseling can help women with early-stage breast cancer adjust to emotional distress stemming from the side effects of treatment, according to a study published in the February issue of Applied Nursing Research.

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Preventive Health Services Missed in Half of Patients

MONDAY, Jan. 30 (HealthDay News) -- During periodic health examinations (PHEs), a variety of patient, physician, and visit factors together affect the recommendation and delivery of evidence-based preventive health services, with patients receiving only about half of those services for which they are due, according to research published in the February issue of the American Journal of Preventive Medicine.

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Family Teamwork Gives Valued Boost to Senior Care

MONDAY, Jan. 30 (HealthDay News) -- Family companions involved in physician visits with older adults usually offer task assistance in activities of daily living (ADLs) and can help build patient-provider partnerships to efficiently manage senior health, according to a study published in the January issue of the Journal of the American Geriatrics Society.

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Bydureon Approved for Type 2 Diabetes

FRIDAY, Jan. 27 (HealthDay News) -- Bydureon (exenatide extended release), Amylin Pharmaceuticals' long-acting version of the diabetes drug Byetta, has been approved by the U.S. Food and Drug Administration.

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Self-Rated Health Status Predicts Mortality Among CVD Patients

FRIDAY, Jan. 27 (HealthDay News) -- Self-rated health status is a risk factor for future vascular events and mortality in patients with cardiovascular diseases, particularly in those with asymptomatic atherosclerotic disease, according to a study published online Jan. 18 in the Journal of Internal Medicine.

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Isoflurane Harmful to Mitochondrial Function in Mice

FRIDAY, Jan. 27 (HealthDay News) -- Anesthetics isoflurane and desflurane have distinct effects on mitochondrial function and learning and memory, according to an experimental study published online Jan. 19 in the Annals of Neurology.

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COPD Assessment Test Predicts Exacerbation Severity

FRIDAY, Jan. 27 (HealthDay News) -- The COPD Assessment Test (CAT) provides a reliable score of exacerbation severity in patients with chronic obstructive pulmonary disease (COPD), according to a study published online Jan. 26 in the American Journal of Respiratory and Critical Care Medicine.

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Steroid-Sparing Renal Transplant Yields Successful Outcomes

FRIDAY, Jan. 27 (HealthDay News) -- Rapid discontinuation of prednisone (RDP) five days after renal transplantation from a living (LD) or deceased donor (DD) yields acceptable 10-year patient and graft outcomes, according to research published online Jan. 26 in the Clinical Journal of the American Society of Nephrology.

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No Complications From Using Stored Red Blood Cells

FRIDAY, Jan. 27 (HealthDay News) -- There is no significant difference in early complications, including measures of pulmonary function, immunologic status, or coagulation status, after using fresh versus standard issue red blood cell (RBC) transfusions, according to a study published online Jan. 26 in the American Journal of Respiratory and Critical Care Medicine.

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Polypectomy Outcomes Similar to Surgical Resection

FRIDAY, Jan. 27 (HealthDay News) -- For patients with malignant colonic polyps who have similar clinical characteristics, management with either polypectomy or surgical resection results in comparable outcomes, according to a study published in the Feb. 1 issue of Cancer.

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Comparable Clinical Activity for Low-, High-Dose Clofarabine

FRIDAY, Jan. 27 (HealthDay News) -- Low and high doses of clofarabine have comparable clinical activity for the treatment of patients with higher-risk myelodysplastic syndrome (MDS), according to a study published in the Feb. 1 issue of Cancer.

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New PCR-Based Assay Better Predicts Lung Cancer Survival

FRIDAY, Jan. 27 (HealthDay News) -- A new quantitative polymerase chain reaction (PCR)-based assay can better identify which patients with early-stage non-small-cell lung cancer (NSCLC) are at higher risk of mortality after surgical resection, according to a study published online Jan. 27 in The Lancet.

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Warfarin Use Lowers Mortality in Septuagenarians With A-Fib

FRIDAY, Jan. 27 (HealthDay News) -- In a group of septuagenarian patients with atrial fibrillation, followed for up to six years, warfarin use is associated with a significant reduction in all-cause mortality, according to a study published in the Feb. 1 issue of The American Journal of Cardiology.

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More Than 40 Percent of Adults With RA Are Inactive

THURSDAY, Jan. 26 (HealthDay News) -- More than 40 percent of adults with rheumatoid arthritis (RA) are inactive, with lack of both strong motivation and belief in physical activity accounting for most of the excess inactivity, according to a study published online Jan. 25 in Arthritis Care & Research.

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Decline in Rate of Diabetic Lower-Extremity Amputation

THURSDAY, Jan. 26 (HealthDay News) -- From 1996 to 2008 there was a decline in the rates of hospitalization for nontraumatic lower-extremity amputation (NLEA) in the U.S. population with diabetes, according to a study published in the February issue of Diabetes Care.

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ACE Inhibitors Not Linked to Improved Outcomes After ACS

THURSDAY, Jan. 26 (HealthDay News) -- For patients with acute coronary syndrome (ACS), prior chronic use of an angiotensin-converting enzyme (ACE) inhibitor is not independently associated with improved in-hospital outcomes, according to a study published in the Feb. 1 issue of The American Journal of Cardiology.

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Oral HPV Infection Prevalence in U.S. Close to 7 Percent

THURSDAY, Jan. 26 (HealthDay News) -- In the United States, the prevalence of oral human papillomavirus (HPV) infection is 6.9 percent, with higher prevalence in men than women, according to a study published online Jan. 26 in the Journal of the American Medical Association.

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Survival Reduced for Patients With Cancer Who Have Diabetes

THURSDAY, Jan. 26 (HealthDay News) -- Patients with cancer generally have reduced survival if they also have type 2 diabetes, although this depends on the type of cancer and diabetes treatment, according to a study published online Jan. 20 in Diabetes Care.

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Long Working Hours Linked to Increased Risk of Depression

THURSDAY, Jan. 26 (HealthDay News) -- Working 11 or more hours a day is associated with a significant increase in the likelihood of a major depressive episode (MDE) among British civil servants, compared with working a seven to eight hour day, according to a study published online Jan. 25 in PLoS One.

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Deaths From Myocardial Infarction Halved in England

THURSDAY, Jan. 26 (HealthDay News) -- From 2002 to 2010 in England, there was a decrease of about half in the total mortality rate for acute myocardial infarction, according to a study published online Jan. 25 in BMJ.

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Mutations in IDH1/2 Seen in Intrahepatic Bile Duct Cancers

THURSDAY, Jan. 26 (HealthDay News) -- Mutations in genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are present in about a quarter of biliary tract carcinomas arising within the liver, according to a study published online Dec. 16 in The Oncologist.

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Exposure to Iodinated Contrast Media Affects Thyroid Function

THURSDAY, Jan. 26 (HealthDay News) -- Exposure to iodinated contrast media (ICM), which are frequently used during imaging procedures, is associated with changes in thyroid function, specifically an increased risk of developing incident hyperthyroidism and incident overt hypothyroidism, according to a study published in the Jan. 23 issue of the Archives of Internal Medicine.

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Positive Affirmation Improves Medication Adherence

THURSDAY, Jan. 26 (HealthDay News) -- Patient education (PE) enhanced with positive affirmation (PA) improves medication adherence over education alone in African-Americans with hypertension, but it does not lead to significant improvements in blood pressure (BP) reduction, according to a study published online Jan. 23 in the Archives of Internal Medicine.

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Risk-Factor Burden Impacts Lifetime Risk of Cardio Disease

WEDNESDAY, Jan. 25 (HealthDay News) -- Variation in risk-factor burden results in considerable differences in the lifetime risk of cardiovascular disease, and these differences are consistent across race and birth cohorts, according to a meta-analysis published in the Jan. 26 issue of the New England Journal of Medicine.

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Bevacizumab Efficacious for HER2-Negative Breast Cancer

WEDNESDAY, Jan. 25 (HealthDay News) -- For patients with human epidermal growth factor receptor 2 (HER2)-negative breast cancer, the addition of bevacizumab to neoadjuvant chemotherapy improves the pathological complete response (pCR), according to two studies published in the Jan. 26 issue of the New England Journal of Medicine.

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Men at Higher Risk for Mild Cognitive Impairment

WEDNESDAY, Jan. 25 (HealthDay News) -- The incidence of both amnestic and nonamnestic mild cognitive impairment (aMCI and naMCI) is higher in men than women, according to a study published online Jan. 25 in Neurology.

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Neurologists Should Routinely Assess Patients for Abuse

WEDNESDAY, Jan. 25 (HealthDay News) -- Neurologists should evaluate patients for abuse and neglect, according to a position statement issued by the American Academy of Neurology published online Jan. 25 in Neurology.

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Overuse of Health Care Services Understudied

WEDNESDAY, Jan. 25 (HealthDay News) -- Overuse of health care services in the United States is an understudied problem, with the majority of research limited to a few interventions, according to a review published in the Jan. 23 issue of the Archives of Internal Medicine.

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Sex Differences Exist in Disease-Linked Pain Intensity

WEDNESDAY, Jan. 25 (HealthDay News) -- Sex differences exist in specific disease-associated pain intensity, with women suffering a higher prevalence of pain for musculoskeletal, neuropathic, abdominal, and migraine-related conditions, according to a study published online Jan. 16 in The Journal of Pain.

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Oxaliplatin Improves Survival for Colorectal Cancer Patients

WEDNESDAY, Jan. 25 (HealthDay News) -- The addition of oxaliplatin to 5-fluorouracil (5-FU) improves survival for stage III colon cancer patients in diverse practice settings, including among older and minority patients, according to a study published online Jan. 20 in the Journal of the National Cancer Institute.

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Foods Fried in Olive Oil Not Linked to Heart Disease

WEDNESDAY, Jan. 25 (HealthDay News) -- Eating foods fried in olive or sunflower oil is not linked to heart disease or all-cause mortality, according to a Spanish study published online Jan. 24 in BMJ.

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BRCA Carriers Have Improved Survival in Ovarian Cancer

TUESDAY, Jan. 24 (HealthDay News) -- For patients with invasive epithelial ovarian cancer (EOC), BRCA1 and BRCA2 mutations are associated with improved five-year survival, according to a study published in the Jan. 25 issue of the Journal of the American Medical Association.

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Unemployed Have Poorer Mental and Physical Health

TUESDAY, Jan. 24 (HealthDay News) -- Unemployed adults are about half as likely to have health insurance as employed individuals; have poorer mental and physical health, regardless of their insurance status; and are less likely to receive needed medical care and prescriptions, according to a January data brief issued by the National Center for Health Statistics.

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Reduced [11C]PiB Uptake in Cognitively Active Elderly

TUESDAY, Jan. 24 (HealthDay News) -- Elderly individuals who keep their brains active through activities such as reading, writing, and playing games have reduced uptake of carbon 11-labeled Pittsburg Compound B ([11C]PiB), according to a study published online Jan. 23 in the Archives of Neurology.

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Dutasteride Delays Low-Risk Prostate Cancer Progression

TUESDAY, Jan. 24 (HealthDay News) -- For men with low-risk prostate cancer who undergo active surveillance, treatment with dutasteride delays the time to cancer progression, according to a study published online Jan. 24 in The Lancet.

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HealthGrades IDs Notable Hospitals for Clinical Excellence

TUESDAY, Jan. 24 (HealthDay News) -- The top 5 percent of U.S. hospitals has more than a 30 percent lower risk-adjusted mortality across 17 procedures and diagnoses, compared with other hospitals, according to the 10th annual HealthGrades Hospital Quality and Clinical Excellence study published online Jan. 24.

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Unhealthy Narcissism Linked to Elevated Cortisol in Men

TUESDAY, Jan. 24 (HealthDay News) -- Narcissism is associated with elevated levels of cortisol in men, according to a study published online Jan. 23 in PLoS One.

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Negative Social Interactions Linked to Inflammation

TUESDAY, Jan. 24 (HealthDay News) -- Everyday social interactions that are negative or competitive are associated with elevated levels of inflammatory cytokines, according to a study published online Jan. 23 in the Proceedings of the National Academy of Sciences.

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Statins May Reduce Risk for HCC in Hep B-Infected Patients

MONDAY, Jan. 23 (HealthDay News) -- For hepatitis B virus (HBV)-infected patients, statin use is associated with a reduction in the risk for hepatocellular carcinoma (HCC), in a dose-dependent manner, according to a study published online Jan. 23 in the Journal of Clinical Oncology.

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Sleep Disturbance Linked to Cardiometabolic Disease Risk

MONDAY, Jan. 23 (HealthDay News) -- Sleep duration and sleep disturbance are associated with cardiometabolic disease, according to a study published online Dec. 12 in the Journal of Sleep Research.

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Mild Traumatic Brain Injury in ~4 Percent of U.K. Troops

MONDAY, Jan. 23 (HealthDay News) -- Mild traumatic brain injury (mTBI) has a prevalence of 4.4 percent in U.K. troops returning from Iraq or Afghanistan, and 9.5 percent in those with a combat role, according to a study published in the January/February issue of the Journal of Head Trauma Rehabilitation.

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Substantial Minority Continue Smoking After Cancer Diagnosis

MONDAY, Jan. 23 (HealthDay News) -- A considerable minority of patients with lung and colorectal cancer continue smoking after being diagnosed, according to study published online Jan. 23 in Cancer.

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Mild-to-Moderate Asthma Frequently Non-Eosinophilic

MONDAY, Jan. 23 (HealthDay News) -- Approximately half of all patients with mild-to-moderate asthma are persistently non-eosinophilic, according to a study published online Jan. 20 in the American Journal of Respiratory and Critical Care Medicine.

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Gender, Family, Ambivalence Impact Live Liver Donation

MONDAY, Jan. 23 (HealthDay News) -- Gender, relationship to the recipient, and ambivalence toward donation all impact living liver donor's decisions, motives, and post-donation outcomes, according to a study published in the January issue of the American Journal of Transplantation.

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Inadequate Hep B Vaccinations for High-Risk Adults

MONDAY, Jan. 23 (HealthDay News) -- Approximately half of all adults at high risk of hepatitis B infection are vaccinated against hepatitis B, and more than half miss opportunities to be vaccinated, according to a study published online Jan. 12 in Infection.

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Dosing Errors Occur With IV Acetaminophen in Children

MONDAY, Jan. 23 (HealthDay News) -- Use of a new intravenous formulation of acetaminophen is associated with dosing errors in neonates, infants, and small children, and evaluation and management of these dosing errors are similar to oral overdose, according to a report published online Jan. 23 in Pediatrics.

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First Test Approved to Help Detect Risk of PML

FRIDAY, Jan. 20 (HealthDay News) -- The first test to help determine the risk of a rare brain infection among users of the drug Tysabri has been approved by the U.S. Food and Drug Administration.

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SSRIs Increase Fall Risk in Elderly Dementia Patients

FRIDAY, Jan. 20 (HealthDay News) -- Even at low doses, selective serotonin reuptake inhibitors (SSRIs) increase the risk of injuries due to falls in elderly dementia patients, and the risk increases further at higher doses and when hypnotics and sedatives are added, according to a study published online Jan. 18 in the British Journal of Clinical Pharmacology.

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Neuromodulators Reduce Pain in Rheumatoid Arthritis

FRIDAY, Jan. 20 (HealthDay News) -- Neuromodulators are superior to placebo for reducing pain in patients with rheumatoid arthritis (RA), but treatment is associated with adverse events; whereas muscle relaxants show no benefit for improving pain in RA, according to two reviews published online Jan. 18 in the Cochrane Database of Systematic Reviews.

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Matted Lymph Nodes ID Poor Oropharyngeal SCC Prognosis

FRIDAY, Jan. 20 (HealthDay News) -- Patients with oropharyngeal squamous cell carcinoma (SCC) who present with matted nodes have a worse prognosis than those without matted nodes, according to a study published online Jan. 13 in Head & Neck.

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Warfarin Patients With Head Trauma Need Second CT Scan

FRIDAY, Jan. 20 (HealthDay News) -- For patients on warfarin with minor head trauma who have an initial negative computed tomography (CT) scan, 24-hour observation followed by an additional CT scan identifies the majority of cases of delayed bleeding, according to a study published online Jan. 16 in the Annals of Emergency Medicine.

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HIV Risk-Related Behaviors Down in the United States

FRIDAY, Jan. 20 (HealthDay News) -- The number of men and women who reported engaging in HIV risk-related behaviors was lower in 2006 to 2010 compared with 2002, with the decline likely resulting from a decrease in sexual risk behaviors, according to a research published in the Jan. 19 issue of the U.S. Centers for Disease Control and Prevention's National Health Statistics Reports.

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No Autoimmune Safety Signal for Quadrivalent HPV Vaccine

FRIDAY, Jan. 20 (HealthDay News) -- For women vaccinated with the quadrivalent human papillomavirus vaccine (HPV4), there is no evidence of an autoimmune safety signal, according to a study published in the February issue of the Journal of Internal Medicine.

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Sleep Tied to Maintenance of Emotional Reactivity

FRIDAY, Jan. 20 (HealthDay News) -- Sleep is associated with enhanced emotional memory and maintenance of emotional reactivity compared with wake, according to a study published in the Jan. 18 issue of The Journal of Neuroscience.

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Taking Two or More Medications Increases Fall Rate

FRIDAY, Jan. 20 (HealthDay News) -- The use of two or more prescription medications is associated with an increased risk of falls and fall-related injuries at home among young and middle-aged adults, according to a study published online Jan. 16 in Injury Prevention.

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Sexual Activity Safe for Most Cardiovascular Disease Patients

THURSDAY, Jan. 19 (HealthDay News) -- For most individuals with stable cardiovascular disease (CVD), sexual activity is safe, according to a scientific statement from the American Heart Association published online Jan. 19 in Circulation.

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Worse Outcomes for Stroke Patients With Delirium

THURSDAY, Jan. 19 (HealthDay News) -- Stroke patients who develop delirium have worse outcomes, including higher mortality and longer hospitalizations, and are more likely to be discharged to a care facility, according to a review published online Jan. 19 in Stroke.

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Calcium Associated With Lower Risk of Prostate Cancer

THURSDAY, Jan. 19 (HealthDay News) -- Dietary calcium intake is inversely associated with prostate cancer risk, according to a study published online Jan. 12 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Cancer Prevention Guidelines Updated

THURSDAY, Jan. 19 (HealthDay News) -- The American Cancer Society (ACS) Nutrition and Physical Activity Guidelines were recently updated and published in the January/February issue of CA: A Cancer Journal for Clinicians.

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Cognitive Impairment Seen in Overweight Retired NFL Players

THURSDAY, Jan. 19 (HealthDay News) -- Overweight retired National Football League (NFL) players have decreased blood flow in certain areas of the brain as well as significant decreases in attention, cognitive proficiency, and memory, according to a study published online Jan. 17 in Translational Psychiatry.

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Osteoporotic Fracture Risk High in Systemic Mastocytosis

THURSDAY, Jan. 19 (HealthDay News) -- There is a high risk of osteoporotic fractures and osteoporosis in patients with indolent systemic mastocytosis (ISM), according to a study published online Jan. 9 in Allergy.

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SAMHSA: One in Five U.S. Adults Has Mental Illness

THURSDAY, Jan. 19 (HealthDay News) -- In the United States in 2010, the prevalence of any mental illness (AMI) in the past year was 20 percent, and that of serious mental illness (SMI) was 5 percent, for individuals aged 18 years or older, according to a report published online Jan. 19 by the Substance Abuse and Mental Health Services Administration (SAMHSA).

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Upper Normal BP Increases Risk for A-Fib in Men

THURSDAY, Jan. 19 (HealthDay News) -- Having blood pressure (BP) within the upper limits of normal can predict future atrial fibrillation (AF) in otherwise healthy, middle-aged men, according to a study published online Jan. 17 in Hypertension.

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Chronic Hepatitis C May Benefit From New Antivirals

THURSDAY, Jan. 19 (HealthDay News) -- Direct-acting antiviral agents may be effective for treating patients with chronic hepatitis C virus (HCV) genotype 1 who don't respond to peginterferon and ribavirin therapies, according to a study published in the Jan. 19 issue of the New England Journal of Medicine.

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Age-Related Intelligence Changes Linked to Genetics

WEDNESDAY, Jan. 18 (HealthDay News) -- Genetic factors account for some of the changes in intelligence that occur between childhood and old age, according to a letter published online Jan. 18 in Nature.

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Study IDs Optimal Interval Between Bone Density Tests

WEDNESDAY, Jan. 18 (HealthDay News) -- The recommended bone mineral density (BMD) screening interval is approximately 16 years for postmenopausal women with normal BMD, 4.5 years for women with moderate osteopenia, and one year for women with advanced osteopenia, according to a study published in the Jan. 19 issue of the New England Journal of Medicine.

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BRAF + MEK Inhibitor May Help Avoid Cutaneous Carcinomas

WEDNESDAY, Jan. 18 (HealthDay News) -- Combining the BRAF inhibitor vemurafenib with an MEK inhibitor may help prevent squamous-cell carcinomas in melanoma treatment, according to a study published in the Jan. 19 issue of the New England Journal of Medicine.

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Liver Transplant Stabilizes Lung Function in Cystic Fibrosis

WEDNESDAY, Jan. 18 (HealthDay News) -- For a select group of patients with cirrhosis due to cystic fibrosis liver disease (CFLD), liver transplantation can stabilize long-term lung function and nutritional status and reduce the need for intravenous antibiotics, according to a study published online Jan. 6 in the American Journal of Transplantation.

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Psychosocial Interventions Reduce Cancer Pain in Adults

WEDNESDAY, Jan. 18 (HealthDay News) -- For adults with cancer, psychosocial interventions have a positive effect on pain severity and pain interference, according to a meta-analysis published online Jan. 17 in the Journal of Clinical Oncology.

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Rates of Post-Arthroplasty Symptomatic VTE Identified

WEDNESDAY, Jan. 18 (HealthDay News) -- The rates of postoperative symptomatic venous thromboembolism (VTE) are 1.09 percent after total or partial knee arthroplasty (TPKA) and 0.53 percent after total or partial hip arthroplasty (TPHA), according to a review published in the Jan. 18 issue of the Journal of the American Medical Association.

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Cybercycling Improves Cognitive Function in Elderly

WEDNESDAY, Jan. 18 (HealthDay News) -- Virtual reality-enhanced exercise, or "exergames," such as cybercycling, is associated with a greater cognitive benefit for older adults than traditional exercise, according to a study published online Jan. 17 in the American Journal of Preventive Medicine.

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Platelet Inhibition Maintained With Pre-CABG Cangrelor

TUESDAY, Jan. 17 (HealthDay News) -- For patients who discontinue thienopyridine treatment before coronary artery bypass graft (CABG) surgery, the use of cangrelor as a bridge is associated with higher maintenance of platelet inhibition compared with placebo, according to a study published in the Jan. 18 issue of the Journal of the American Medical Association.

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No Long-Term Benefit of Caffeine for Apnea in Preemies

TUESDAY, Jan. 17 (HealthDay News) -- Neonatal caffeine therapy for apnea of prematurity is no longer associated with increased survival without disability when assessed at five-year follow-up, according to a study published in the Jan. 18 issue of the Journal of the American Medical Association.

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Prevalence of Obesity Unchanged in Adults/Children

TUESDAY, Jan. 17 (HealthDay News) -- The prevalence of obesity in adults and children/adolescents in the United States has remained unchanged in recent years, according to two studies published online Jan. 17 in the Journal of the American Medical Association.

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Abstract - Ogden
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Comorbidities Affect Hospital Costs After Hip Fracture

TUESDAY, Jan. 17 (HealthDay News) -- For older Americans with hip fracture, the presence of comorbidities is associated with increased cost of hospitalization, according to a study published in the Jan. 4 issue of The Journal of Bone & Joint Surgery.

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Untreated Sleep Apnea Linked to Cardio Mortality in Women

TUESDAY, Jan. 17 (HealthDay News) -- Untreated obstructive sleep apnea (OSA) is associated with increased cardiovascular mortality in women, but continuous positive airway pressure (CPAP) treatment reduces the risk of mortality, according to a study published in the Jan. 17 issue of the Annals of Internal Medicine.

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Low Doses of Insulin Induce an Elastogenic Effect

TUESDAY, Jan. 17 (HealthDay News) -- Insulin induces an elastogenic effect, with therapeutic doses of insulin stimulating the formation of elastic fibers in human aortic smooth muscle cell cultures, according to an experimental study published online Jan. 11 in The American Journal of Pathology.

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Endovascular Graft Approved for Tears of Aorta

MONDAY, Jan. 16 (HealthDay News) -- The U.S. Food and Drug Administration has expanded approval of an endovascular graft to include ruptures of the aorta.

tears of the aorta

Vitamin D Supplements Do Not Reduce COPD Exacerbations

MONDAY, Jan. 16 (HealthDay News) -- For patients with chronic obstructive pulmonary disease (COPD), high-dose vitamin D supplementation does not reduce the incidence of exacerbations, according to a study published in the Jan. 17 issue of the Annals of Internal Medicine.

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Patients With Breast Cancer Lack Knowledge of the Disease

MONDAY, Jan. 16 (HealthDay News) -- Many early-stage breast cancer survivors lack knowledge about their disease and report not being involved in treatment decisions, although most receive treatment consistent with their goals, according to a study published in the January issue of the Journal of the American College of Surgeons.

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Access to Quality Primary Care Reduces Mortality Risk

MONDAY, Jan. 16 (HealthDay News) -- Greater access to high-quality primary medical care that includes features of comprehensiveness, patient-centeredness, and extended office hours is associated with a reduced risk of death, according to a study published in the January/February issue of the Annals of Family Medicine.

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Practice Differs for Cardiac Screening in ADHD Treatment

MONDAY, Jan. 16 (HealthDay News) -- There is considerable variation in the attitudes, barriers, and practices of pediatricians for cardiac screening before initiation of stimulant treatment for attention-deficit/hyperactivity disorder (ADHD), according to a study published online Jan 16 in Pediatrics.

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Hyaluronic Acid Similar to Placebo for Ankle Arthritis

MONDAY, Jan. 16 (HealthDay News) -- A single intra-articular injection of hyaluronic acid was no more effective in treating osteoarthritis of the ankle than an injection of normal saline solution, according to a study published in the Jan. 4 issue of The Journal of Bone & Joint Surgery.

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Maternal Asthma Meds Not Linked to Most Birth Defects

MONDAY, Jan. 16 (HealthDay News) -- Use of asthma medications in early pregnancy is not associated with most birth defects, but positive associations are present for a few specific defects, including isolated esophageal and anorectal atresia and omphalocele, according to a study published online Jan. 16 in Pediatrics.

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Integrated Diabetes-Depression Treatment Improves Outcome

MONDAY, Jan. 16 (HealthDay News) -- Integrating the treatment of type 2 diabetes and depression improves outcomes, including glycemic control and depression, for patients in the primary care setting, according to a study published in the January/February issue of the Annals of Family Medicine.

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Young Women Often Perceive Their Weight Gain Inaccurately

FRIDAY, Jan. 13 (HealthDay News) -- For young women of reproductive age, self-perceptions of weight gain are often inaccurate, and are affected by race/ethnicity and contraceptive use, according to a study published online Dec. 2 in the Journal of Women's Health.

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Surgery Beats Non-Op Care for Intervertebral Disc Herniation

FRIDAY, Jan. 13 (HealthDay News) -- Surgery is more effective than nonoperative treatment for patients with intervertebral disc herniation (IDH), with marital status, joint prob

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