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Category: Endocrinology | Monthly Briefing

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March 2012 Briefing - Diabetes & Endocrinology

Last Updated: April 02, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for March 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Swimming Improves Vascular Function, BP in Older Adults

FRIDAY, March 30 (HealthDay News) -- Swimming exercise is associated with a decrease in blood pressure (BP) and improvements in vascular function in older adults with early hypertension, according to a study published in the April 1 issue of The American Journal of Cardiology.

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Nanobodies Noninvasively Detect Atherosclerosis in Mice

FRIDAY, March 30 (HealthDay News) -- A radiolabeled antibody fragment targeting vascular cell adhesion molecule-1 (VCAM1) can noninvasively and specifically detect atherosclerotic plaques in mice, according to an experimental study published in the March 30 issue of Circulation Research.

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Lasers Remove Inches From Fat Trouble Spots

FRIDAY, March 30 (HealthDay News) -- Low-level laser therapy (LLLT) is effective for body slimming, according to a study published in the March issue of Lasers in Surgery and Medicine.

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Genetic Variants Confer Susceptibility to Fatty Liver

FRIDAY, March 30 (HealthDay News) -- Single nucleotide polymorphisms (SNPs) in two genes, coding for glucokinase regulatory protein (GCKR) and patatin-like phospholipase 3 (PNPLA3), act together to increase the susceptibility of obese children and adolescents to fatty liver disease, according to research published in the March issue of Hepatology.

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Poor Health-Related Function, Diabetes Combo Ups Death Risk

FRIDAY, March 30 (HealthDay News) -- The combination of type 2 diabetes and impaired health-related functioning (HRF) is associated with an increased risk of cardiovascular disease (CVD) mortality, according to a study published online March 23 in Diabetes Care.

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Statin Discontinuation Linked to Mortality in RA Patients

THURSDAY, March 29 (HealthDay News) -- Patients with rheumatoid arthritis are at higher risk of death from cardiovascular and non-cardiovascular causes if they discontinue statin treatment, according to a study published online March 29 in Arthritis Care & Research.

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High Fruit Consumption Not Linked to Gestational Diabetes

THURSDAY, March 29 (HealthDay News) -- Higher consumption of whole fruits prior to pregnancy is not associated with increased risk of gestational diabetes mellitus (GDM), and the association between fruit juice consumption and GDM appears to be nonlinear, according to a study published online March 23 in Diabetes Care.

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Chemo-Linked Factors May Impact Weight in Breast Cancer

THURSDAY, March 29 (HealthDay News) -- Adjuvant chemotherapy for early-stage breast cancer can induce weight gain and a variety of metabolic changes that may be associated with a poor prognosis for some patients, according to research published in the April issue of Obesity Reviews.

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Lifestyle Intervention Helps Overweight Diabetes Patients

WEDNESDAY, March 28 (HealthDay News) -- An intensive lifestyle intervention leads to a significant reduction in the risk of mobility-related disability in overweight type 2 diabetes patients, as compared with diabetes support and education, according to a study published in the March 29 issue of the New England Journal of Medicine.

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Moderate Drinking Cuts Mortality in MI Survivors

WEDNESDAY, March 28 (HealthDay News) -- Men who have survived a myocardial infarction (MI) benefit from moderate alcohol consumption, with long-term consumption inversely associated with all-cause and cardiovascular mortality, according to a study published online March 27 in the European Heart Journal.

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Extended-Release Niacin Raises Fasting Glucose Levels

WEDNESDAY, March 28 (HealthDay News) -- The combination of extended-release niacin (N) with ezetimibe plus simvastatin (E/S) to treat hyperlipidemia is associated with increased fasting glucose (FG) levels compared with E/S alone, but these cases tend to be transient and remit without intervention, according to research published in the April issue of Diabetes Care.

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Non-HDL Cholesterol Tied to Risk of Cardiovascular Event

TUESDAY, March 27 (HealthDay News) -- On-treatment levels of non-high-density lipoprotein cholesterol (non-HDL-C) and, to a lesser extent, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) are each associated with risk of future major cardiovascular events for patients on statin therapy, according to a study published in the March 28 issue of the Journal of the American Medical Association.

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Chocolate Consumption Tied to Lower Body Mass Index

TUESDAY, March 27 (HealthDay News) -- More frequent chocolate intake is linked to a lower body mass index (BMI), according to a research letter published in the March 26 issue of the Archives of Internal Medicine.

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Prolonged Sitting Increases All-Cause Mortality Risk

TUESDAY, March 27 (HealthDay News) -- People over the age of 45 years who sit for prolonged periods of time each day are at an increased risk of death due to all causes, compared with those who sit for less than four hours/day, according to research published in the March 26 issue of the Archives of Internal Medicine.

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Insulin Resistance Increases Risk of Colorectal Adenomas

TUESDAY, March 27 (HealthDay News) -- Insulin resistance (IR) and central obesity, as measured by waist to hip ratio (WHR), are associated with a significantly increased risk of colorectal adenomas, especially in men, according to a study published in the April 1 issue of Cancer.

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Common Blood Pressure Drugs Help Prevent Diabetes

FRIDAY, March 23 (HealthDay News) -- A common class of oral high blood pressure drugs is associated with improved survival of insulin-producing pancreatic β-cells and improved glucose homeostasis, according to a study published in the April issue of Diabetes.

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Simple, Realistic Diet and Exercise Guidelines Needed

FRIDAY, March 23 (HealthDay News) -- Consumers need to be provided with simple, clearly written, realistic, and tailored guidelines for healthy eating, physical activity, and weight-related recommendations, according to research published online March 8 in Obesity Reviews.

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Fewer Mitochondria in Offspring of Parents With Diabetes

FRIDAY, March 23 (HealthDay News) -- Normal-weight, insulin-resistant individuals whose parents have type 2 diabetes have fewer mitochondria in their muscles due to lower expression of lipoprotein lipase (LPL), according to a study published in the April issue of Diabetes.

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In Older Adults, Extra Fat Tied to Poor Cognitive Function

FRIDAY, March 23 (HealthDay News) -- In older adults (aged 60 to ≤70 years), obesity and high visceral adiposity are associated with poor cognitive function, according to a study published online March 22 in Age and Ageing.

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Prostaglandin D2 Linked to Hair Loss in Androgenetic Alopecia

FRIDAY, March 23 (HealthDay News) -- Prostaglandin D2 (PGD2) plays a role in inhibition of hair growth in androgenetic alopecia (AGA), according to a study published in the March 21 issue of Science Translational Medicine.

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Aspirin Enhances Platelet Isoprostanes in Type 2 Diabetes

FRIDAY, March 23 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM) who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published online March 16 in Diabetes.

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State Wealth Linked to Markers of Cardiac Health in Women

THURSDAY, March 22 (HealthDay News) -- State-level macro socioeconomic conditions are associated with biomarkers of inflammation, particularly high-sensitivity C-reactive protein (hsCRP), among healthy women, according to a study published online March 20 in BMC Public Health.

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Health Care Team Members Key for Antimicrobial Stewardship

THURSDAY, March 22 (HealthDay News) -- Antimicrobial stewardship programs (ASPs) that use health care epidemiologists (HEs) and infection preventionists (IPs) have a crucial role to play in the effort to combat health care-associated infections (HAIs), including those caused by multidrug-resistant organisms (MDROs), according to the Association for Professionals in Infection Control and Epidemiology and the Society for Healthcare Epidemiology of America position paper published in the March issue of the American Journal of Infection Control.

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Optimal Prediabetes HbA1c Threshold is 5.7 Percent

THURSDAY, March 22 (HealthDay News) -- Lowering the glycated hemoglobin (HbA1c) cut-off threshold for prediabetes to 5.7 percent is cost-effective even in a high-cost intervention scenario, according to research published online March 13 in the American Journal of Preventive Medicine.

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Diet Soda Linked to Increase in Glucagon-Like Peptide 1 Levels

THURSDAY, March 22 (HealthDay News) -- Drinking a diet soda before a glucose load is associated with increased glucagon-like peptide 1 (GLP-1) secretion in individuals with type 1 diabetes and healthy controls, but not in those with type 2 diabetes, according to research published online March 12 in Diabetes Care.

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REGN727 Monoclonal Antibody Lowers LDL Cholesterol

WEDNESDAY, March 21 (HealthDay News) -- Administration of REGN727, a monoclonal antibody to proprotein convertase subtilisin/kexin 9 (PCSK9), significantly reduces low-density lipoprotein (LDL) cholesterol levels, according to the results of three phase 1 studies published in the March 22 issue of the New England Journal of Medicine.

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Differences in Interarm BP Linked to Increased Mortality

WEDNESDAY, March 21 (HealthDay News) -- For patients with hypertension, an interarm difference in systolic blood pressure of 10 mm Hg or more or 15 mm Hg or more is associated with an increased risk of cardiovascular events and all-cause mortality over 10 years, according to a study published online March 20 in BMJ.

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Survey Describes Docs' Online Professionalism Violations

TUESDAY, March 20 (HealthDay News) -- Most medical licensing authorities receive and act upon reports of physicians' online professionalism violations, according to a research letter published in the March 21 issue of the Journal of the American Medical Association.

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Carbohydrate-Modified Diets As Effective As Portion-Controlled

TUESDAY, March 20 (HealthDay News) -- Low carbohydrate (LC) and reduced glycemic load (RGL) diets are as effective as a standard portion-controlled (PC) diet for weight management in children; however, the low-carbohydrate diet is the hardest for children to follow, according to research published online March 1 in The Journal of Pediatrics.

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Dapagliflozin Aids Glycemic Control in Type 2 Diabetes

TUESDAY, March 20 (HealthDay News) -- For patients with inadequately controlled type 2 diabetes, treatment with dapagliflozin is associated with improved glycemic control, stabilized insulin dosing, and weight reductions, according to research published in the March 20 issue of the Annals of Internal Medicine.

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Antimicrobial Stewardship Saves Millions of Dollars

TUESDAY, March 20 (HealthDay News) -- Antimicrobial stewardship programs save hospitals millions of dollars, according to a study published in the April issue of Infection Control and Hospital Epidemiology.

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H. Pylori Associated With Impaired Glucose Tolerance

TUESDAY, March 20 (HealthDay News) -- Helicobacter pylori (H. pylori) seropositivity is associated with glycosylated hemoglobin (HbA1c) levels, an interaction which may be augmented by a high body mass index (BMI), according to a study published online March 13 in the Journal of Infectious Diseases.

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Cardiovascular Health Metrics Reduce Total, Cardio Mortality

MONDAY, March 19 (HealthDay News) -- Meeting a greater number of the seven cardiovascular health metrics from the American Heart Association is associated with a lower risk of all-cause and cardiovascular disease (CVD) mortality, according to a study published online March 16 in the Journal of the American Medical Association.

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Vets With MS Have Higher Prevalence of Chronic Diseases

FRIDAY, March 16 (HealthDay News) -- Male veterans with multiple sclerosis (MS) have an increased prevalence of chronic diseases compared with the general population and with veterans without MS, according to a study published online Feb. 9 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Eating White Rice Linked to Risk of Type 2 Diabetes

FRIDAY, March 16 (HealthDay News) -- Intake of white rice is associated with an increased risk of type 2 diabetes, particularly for Asians, according to a study published online March 15 in BMJ.

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Poorer Health Literacy Linked to Increased Mortality

FRIDAY, March 16 (HealthDay News) -- A considerable proportion of older adults in England have medium or low health literacy, which is associated with increased mortality, according to a study published online March 15 in BMJ.

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Gene Profile Correlates With Glycemia in Type 1 Diabetes

FRIDAY, March 16 (HealthDay News) -- A gene expression profile in peripheral blood correlates with glycemic control in the first year for patients recently diagnosed with type 1 diabetes, according to a study published online March 8 in Diabetes.

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Statin Use Linked to Modest Reduction in Parkinson's Risk

THURSDAY, March 15 (HealthDay News) -- Regular use of statins may be associated with a small reduction in the risk of developing Parkinson's disease (PD), particularly among younger patients, according to a study published in the March issue of the Archives of Neurology.

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Personal Mobile Computers Improve Resident Efficiency

WEDNESDAY, March 14 (HealthDay News) -- The use of personal mobile computers (Apple iPads) by internal medicine residents improves efficiency, according to a research letter published in the March 12 issue of the Archives of Internal Medicine.

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Daily Exercise Doesn't Further Improve Glycemic Control

WEDNESDAY, March 14 (HealthDay News) -- For individuals with type 2 diabetes, 30 minutes of moderate-intensity endurance exercise once a day or an hour every other day are equally effective for controlling hyperglycemia, according to a study published online March 7 in Diabetes Care.

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Causal Link for IL-6 Receptor, Coronary Heart Disease

WEDNESDAY, March 14 (HealthDay News) -- Genetic data indicate that the interleukin-6 receptor (IL6R) has a causal link with coronary heart disease, according to two studies published online March 14 in The Lancet.

Abstract - Sarwar
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Abstract - Swerdlow
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Higher Spending by Hospitals Improves Outcomes

TUESDAY, March 13 (HealthDay News) -- Hospitals that are part of the universal health care system in Canada that spend more on inpatient care have lower rates of deaths and hospital readmissions, according to a study published in the March 14 issue of the Journal of the American Medical Association.

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Higher Red Meat Consumption Linked to Risk of Death

TUESDAY, March 13 (HealthDay News) -- Eating more red meat appears to be associated with an increased risk of all-cause mortality and death from cardiovascular disease (CVD) and cancer specifically, according to research published online March 12 in the Archives of Internal Medicine.

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U.S. Mortality Rates Dropped 60 Percent From 1935 to 2010

TUESDAY, March 13 (HealthDay News) -- From 1935 to 2010, the death rate in the United States decreased considerably, although the single-year improvements in mortality were often small, according to a March data brief issued by the National Center for Health Statistics (NCHS).

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Behavioral Program Successful in High-Risk Obese Population

MONDAY, March 12 (HealthDay News) -- A two-year behavioral intervention program is associated with modest weight loss and improved blood pressure control in a high-risk, socioeconomically disadvantaged group of obese patients, according to research published online March 12 in the Archives of Internal Medicine.

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Sugary Beverages Linked to Higher Heart Disease Risk

MONDAY, March 12 (HealthDay News) -- For men, increased consumption of sugar-sweetened beverages is associated with an increased risk of developing coronary heart disease, while artificially-sweetened beverages do not increase heart disease risk, according to a study published online March 13 in Circulation.

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Improved Prognosis for Women With Heart Failure

MONDAY, March 12 (HealthDay News) -- Women with heart failure have a better prognosis than men, with the benefit more pronounced in non-ischemic heart failure and reduced by diabetes, according to a meta-analysis published online March 8 in the European Journal of Heart Failure.

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Calcium, Vitamin D Modulate Human Energy Metabolism

MONDAY, March 12 (HealthDay News) -- There is considerable evidence that calcium and vitamin D intake are influential in modulating energy metabolism in humans, according to a study published online March 2 in Obesity Reviews.

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Common Products May Contain Endocrine-Disrupting Chemicals

FRIDAY, March 9 (HealthDay News) -- Many common products, including sunscreen and fragranced products, contain multiple endocrine-disrupting compounds (EDCs) or asthma-related chemicals, which are often not listed on the label, according to a study published online March 8 in Environmental Health Perspectives.

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Flu Vaccine Up Among Medical Staff When They Believe It Works

FRIDAY, March 9 (HealthDay News) -- Hospital health care workers (HCWs) are more likely to receive the seasonal influenza vaccination if they believe it works and are committed to preventing this highly contagious virus, according to research published in the April issue of Occupational & Environmental Medicine.

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Rheumatoid Arthritis Linked to Increased Risk of A-Fib, Stroke

FRIDAY, March 9 (HealthDay News) -- Patients with rheumatoid arthritis have a significantly increased risk of atrial fibrillation and stroke, according to a study published online March 8 in BMJ.

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Surrogates Tend to Misinterpret Poor Prognosis Information

FRIDAY, March 9 (HealthDay News) -- Surrogate decision makers for critically ill patients interpret prognostic statements expressing a low risk of death accurately, but interpret statements conveying poor prognosis optimistically, according to a study published in the March 6 issue of the Annals of Internal Medicine.

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Maternal Glycemic Status Linked to Epigenetic Changes

THURSDAY, March 8 (HealthDay News) -- Maternal glycemic status and adiponectin levels are linked to epigenetic changes in the adiponectin gene (ADIPOQ), according to a study published online March 6 in Diabetes.

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Eating Fruits and Vegetables Improves Skin Color

THURSDAY, March 8 (HealthDay News) -- Increasing fruit and vegetable consumption is associated with a beneficial effect on skin coloration and perceived attractiveness, according to a study published online March 7 in PLoS One.

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ENB-0040 Shows Promise for Hypophosphatasia in Children

THURSDAY, March 8 (HealthDay News) -- For infants and children with hypophosphatasia, treatment with ENB-0040, a bone-targeted, recombinant human tissue-nonspecific isozyme of alkaline phosphatase (TNSALP), is associated with healing of rickets and improved pulmonary and physical function, according to an open-label study published in the March 8 issue of the New England Journal of Medicine.

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Buprenorphine Maintenance Therapy Not Recommended

THURSDAY, March 8 (HealthDay News) -- Opioid substitution therapy with buprenorphine is not recommended for opioid-addicted health care professionals (HCPs), according to research published in the March issue of the Mayo Clinic Proceedings.

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Obesity Not Linked to Mortality in Elderly People Over 85

THURSDAY, March 8 (HealthDay News) -- Obesity does not increase mortality in elderly adults aged 85 years and older, according to an article published in the Journal of Aging Research.

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Pasireotide Reduces Cortisol Levels in Cushing's Disease

WEDNESDAY, March 7 (HealthDay News) -- For patients with Cushing's disease, treatment with pasireotide is associated with reduced cortisol levels, according to a phase 3 study published in the March 8 issue of the New England Journal of Medicine.

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Financial Burden of Medical Care Affects One in Three

WEDNESDAY, March 7 (HealthDay News) -- In the first half of 2011, one in three individuals was in a family that experienced the financial burden of medical care in the United States, according to the results of the National Health Interview Survey published March 7 by the National Center for Health Statistics (NCHS).

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Estrogen-Only HRT Lowers Breast CA in Women With Hysterectomy

WEDNESDAY, March 7 (HealthDay News) -- The use of estrogen-only after hysterectomy lowers the risk of breast cancer, but largely in groups already at low risk of breast cancer, according to a study published online March 7 in The Lancet Oncology.

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Long-Term Cardiac Effects for Childhood Cancer Survivors

WEDNESDAY, March 7 (HealthDay News) -- Regardless of exposure to cardiotoxic cancer therapies, survivors of childhood cancers display cardiovascular abnormalities and have markers of increased systemic inflammation and atherosclerotic disease, according to research published online March 5 in the Journal of Clinical Oncology.

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Economic Stagnation May Have Increased Mortality Rate

WEDNESDAY, March 7 (HealthDay News) -- From the late 1990s through 2005, mortality rates for Japanese men who worked as professionals or managers began to increase, coinciding with the country's period of economic stagnation, according to research published online March 6 in BMJ.

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Interrupting Sitting Lowers Glucose, Insulin Levels in Obese

WEDNESDAY, March 7 (HealthDay News) -- Interrupting long periods of sitting with light- or moderate-intensity activity is associated with significant reductions in postprandial glucose and insulin levels among overweight and obese individuals, according to a study published online Feb. 28 in Diabetes Care.

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Pten Gene Linked to Longevity and Weight in Mice

TUESDAY, March 6 (HealthDay News) -- Mice carrying extra copies of an anti-cancer gene, Pten, live longer, are protected from cancer, and have hyperactive brown fat, according to an experimental study published in the March 7 issue of Cell Metabolism.

Abstract
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Electronic Test Result Access Does Not Reduce Test Ordering

TUESDAY, March 6 (HealthDay News) -- For office-based physicians, electronic access to patient imaging and laboratory test results does not decrease -- and may actually increase -- the number of diagnostic tests ordered, according to research published in the March issue of Health Affairs.

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Diabetic Polyneuropathy Not Up With Impaired Glycemia

FRIDAY, March 2 (HealthDay News) -- Although significantly increased in subjects with new diabetes, the rates of typical diabetic polyneuropathy (DPN), retinopathy, and nephropathy are not significantly different between subjects with and without impaired glycemia (IG), according to research published in the March issue of Diabetes Care.

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Increasing Shift From Islet Antibody Positivity to Diabetes

FRIDAY, March 2 (HealthDay News) -- There is an increase in both the prevalence and levels of islet antigen-2 and zinc transporter 8, as well as in autoantibodies, in newly diagnosed type 1 diabetes patients during a period of rising disease incidence, according to a study published in the March issue of Diabetes.

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Gestational Diabetes, Obesity Impact Pregnancy Outcomes

FRIDAY, March 2 (HealthDay News) -- Women with gestational diabetes mellitus (GDM) who are obese have significantly higher odds of adverse pregnancy outcomes, according to findings from the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study published online Feb. 22 in Diabetes Care.

Abstract
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Trans Fat Intake Tied to Stroke in Postmenopausal Women

THURSDAY, March 1 (HealthDay News) -- Higher trans fat intake increases the risk of ischemic stroke independent of other lifestyle factors, but the adverse effects of trans fat on ischemic stroke may be mitigated by aspirin, according to a study published online March 1 in the Annals of Neurology.

Abstract
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Risk of Stroke Increases With Each Year of Having Diabetes

THURSDAY, March 1 (HealthDay News) -- The risk of stroke increases with the length of time a patient has diabetes, according to a study published online March 1 in Stroke.

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Two Pancreatic-Enzyme Products Approved

THURSDAY, March 1 (HealthDay News) -- Two drugs that supplement the digestion-aiding actions of pancreatic enzymes have been approved by the U.S. Food and Drug Administration, the agency said Thursday in a news release.

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