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Category: Endocrinology | Monthly Briefing

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April 2012 Briefing - Diabetes & Endocrinology

Last Updated: May 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for April 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Electronic Reminders Up Meds Adherence in Short Term

MONDAY, April 30 (HealthDay News) -- The use of electronic reminders (short message service [SMS] reminders, electronic reminder devices, or pagers) is associated with improved adherence to chronic medications in the short term, according to a review published online April 25 in the Journal of the American Medical Informatics Association.

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Imaging Provides Clues to Distribution of Fat in Children

MONDAY, April 30 (HealthDay News) -- The use of imaging studies has contributed to an understanding of differences in fat distribution and their link to metabolic disease in childhood, according to research published online April 22 in Obesity Reviews.

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Stress Reduction Ups Health Status in Type 2 Diabetes

FRIDAY, April 27 (HealthDay News) -- A mindfulness-based stress reduction (MBSR) intervention is effective at improving health status and lowering levels of depression among patients with type 2 diabetes, according to a study published in the May issue of Diabetes Care.

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Early Axonal Dysfunction Precedes Diabetic Neuropathy

FRIDAY, April 27 (HealthDay News) -- Early axonal dysfunction may be detected prior to the development of clinical symptoms of diabetic neuropathy, according to a study published online April 20 in Diabetes.

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Sunscreen Use May Lead to Vitamin D Deficiency

FRIDAY, April 27 (HealthDay News) -- Using the amount and sun protection factor (SPF) of sunscreen recommended by the World Health Organization (WHO) is associated with little or no vitamin D production, suggesting that regular sunscreen use may lead to vitamin D deficiency, according to research published online April 18 in the British Journal of Dermatology.

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Sleep of Short Duration Common in U.S. Workers

THURSDAY, April 26 (HealthDay News) -- A substantial proportion of workers in the United States get less sleep than recommended by the National Sleep Foundation, according to a report published in the April 27 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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Thiazolidinediones Tied to Lower Cancer Risk in Diabetes Patients

THURSDAY, April 26 (HealthDay News) -- Thiazolidinediones are associated with a lower risk of liver and colorectal cancer in patients with type 2 diabetes, according to a study published in the May issue of Hepatology.

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Early Menopause Ups Risk of Osteoporosis, Fractures, Death

THURSDAY, April 26 (HealthDay News) -- The occurrence of menopause before age 47 correlates with increased osteoporosis at age 77, increased incidence of fragility fractures, and increased mortality, according to a study published online April 25 in BJOG: An International Journal of Obstetrics and Gynaecology.

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Warfarin Keeps Stroke Risk Low in Patients With A-Fib

WEDNESDAY, April 25 (HealthDay News) -- Use of warfarin for stroke prevention in patients with nonvalvular atrial fibrillation (AF) is associated with a low risk of stroke or systemic embolism, according to a meta-analysis published in the April 23 issue of the Archives of Internal Medicine.

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Meds, Clinic Noncompliance Linked to Mortality in Diabetes

TUESDAY, April 24 (HealthDay News) -- Insulin-treated patients with type 2 diabetes who are noncompliant with their medication or clinic appointments face increased all-cause mortality, according to a study published online April 17 in Diabetes Care.

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Subclinical Hyperthyroidism Tied to Coronary Heart Disease

TUESDAY, April 24 (HealthDay News) -- Subclinical hyperthyroidism is associated with increased risk of coronary heart disease (CHD) morbidity and mortality; and treatment with levothyroxine for subclinical hypothyroidism is associated with fewer ischemic heart disease (IHD) events in patients aged 40 to 70 years, according to two studies published online April 23 in the Archives of Internal Medicine.

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Metabolites Linked to Insulin Resistance in Normoglycemia

MONDAY, April 23 (HealthDay News) -- Twenty metabolites, including amino acids, intermediates in glucose synthesis, ketone bodies, and fatty acids, are associated with insulin resistance, according to a study published online April 17 in Diabetes.

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Insulin Resistance Cut-Off Established From Clamp Data

MONDAY, April 23 (HealthDay News) -- Cut-offs for predicting insulin resistance based on hyperinsulinemic-euglycemic clamp data and routinely measured clinical and biochemical variables have been determined, according to a study published online April 17 in Diabetes Care.

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High BMI Tied to Non-Specific Foot Pain, Plantar Heel Pain

MONDAY, April 23 (HealthDay News) -- Increased body mass index (BMI) correlates with non-specific foot pain in the general population, and with chronic plantar heel pain in a non-athletic population, according to a meta-analysis published online April 13 in Obesity Reviews.

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Massachusetts Saw Recent Drop in Pediatric Obesity

MONDAY, April 23 (HealthDay News) -- The prevalence of obesity among children younger than 6 years in a Massachusetts cohort was stable from 1999 to 2003, and decreased from 2004 to 2008, according to a study published online April 23 in Pediatrics.

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Patient-Centered Approach Key for T2DM Management

FRIDAY, April 20 (HealthDay News) -- Treatment of type 2 diabetes should be personalized in a patient-centered approach, with diet, exercise, and education forming the basis of any treatment program, supplemented by medications as necessary, according to a joint position statement issued by the American Diabetes Association and the European Association for the Study of Diabetes, published online April 19 in Diabetes Care.

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Impaired Fasting Glucose Affects Male Sexual Health

FRIDAY, April 20 (HealthDay News) -- Nearly 20 percent of men with sexual dysfunction have impaired fasting glucose (IFG) and are more likely than men with normal glucose levels to have severe erectile dysfunction (ED), reduced penile blood flow, and overt hypogonadism as well as increased overall cardiovascular (CV) risk, according to a study published online April 10 in The Journal of Sexual Medicine.

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Metformin + Insulin Comparable to Insulin Alone in T2DM

FRIDAY, April 20 (HealthDay News) -- For patients with type 2 diabetes, treatment with metformin and insulin has no significant effect on all-cause or cardiovascular mortality, compared with insulin alone, although data are limited and suffer from bias, according to a meta-analysis published online April 19 in BMJ.

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Room for Improvement in Knowledge of ABC Levels, Goals

THURSDAY, April 19 (HealthDay News) -- Many individuals with diabetes do not know their last hemoglobin A1C (A1C), blood pressure, and low-density lipoprotein (LDL) cholesterol levels (ABC levels), although the correlation between such knowledge and meeting targets for ABC control is unclear, according to a study published online April 12 in Diabetes Care.

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Review Shows Gum Disease Does Not Cause Heart Disease

THURSDAY, April 19 (HealthDay News) -- Periodontal disease (PD) and atherosclerotic vascular disease (ASVD) share common risk factors, but there is no evidence for a causal relationship between the two, nor evidence that treating PD prevents or alters the outcomes of ASVD, according to a scientific statement from the American Heart Association (AHA) published online April 18 in Circulation.

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Long-Term Air Pollution Linked to Multiple Diseases

THURSDAY, April 19 (HealthDay News) -- Long-term exposure to fine particulate matter in the air increases hospital admissions for respiratory diseases, cardiovascular diseases, stroke, and diabetes in the elderly considerably more than short-term exposure does, according to a study published online April 17 in PLoS One.

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Bariatric Surgery Effective Therapy for Diabetes in Obese

THURSDAY, April 19 (HealthDay News) -- For morbidly obese patients with type 2 diabetes, bariatric surgery is more efficacious than conventional medical treatment, leading to improvement or remission of diabetes and associated comorbidities, according to a study published online April 16 in the Archives of Surgery.

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CV Autonomic Neuropathy Risk for CVD Despite Albumin Status

WEDNESDAY, April 18 (HealthDay News) -- Cardiovascular autonomic neuropathy (CAN) appears to affect the risk of cardiovascular disease even in type 1 diabetes patients with normal albumin excretion rates, according to a study published online April 12 in Diabetes.

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Numerous Genetic Variants Linked to Bone Mineral Density

WEDNESDAY, April 18 (HealthDay News) -- Pooling the results of numerous studies, 56 genetic variants associated with bone mineral density have been identified, of which 14 are associated with fracture risk, according to a study published online April 15 in Nature Genetics.

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Testosterone Ups Exercise Capacity in Heart Failure

TUESDAY, April 17 (HealthDay News) -- Testosterone supplementation is associated with improved exercise capacity in patients with moderate-to-severe heart failure, according to a meta-analysis published online April 17 in Circulation: Heart Failure.

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Evidence Lacking for Value of CKD Screening and Monitoring

TUESDAY, April 17 (HealthDay News) -- There is no evidence that screening and monitoring for chronic kidney disease (CKD) improves clinical outcomes, according to research published in the April 17 issue of the Annals of Internal Medicine.

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Liver Insulin Resistance Correlates With Cardiac Risk

MONDAY, April 16 (HealthDay News) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, according to a study published online April 5 in the Journal of Internal Medicine.

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Social Adversity Contributes to Obesity in Girls

MONDAY, April 16 (HealthDay News) -- Preschool-aged girls who experience higher cumulative social adversity at age 1 or age 3 are about twice as likely to exhibit early-onset obesity by age 5 as those without significant risk factors at either time point, according to research published online April 16 in Pediatrics.

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Metal Binding Important for Metformin Action

FRIDAY, April 13 (HealthDay News) -- The ability of metformin to bind mitochondrial copper may be essential to its mechanism of action, according to a study published online April 9 in Diabetes.

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Pegaptanib Reduces Foveal Thickness in Macular Edema

FRIDAY, April 13 (HealthDay News) -- Intravitreally administered injections of the selective vascular endothelial growth factor (VEGF)-165 inhibitor pegaptanib significantly reduces foveal thickness and improves visual acuity in patients with diabetes and macular edema, according to a study published online April 5 in the British Journal of Clinical Pharmacology.

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Obesity Costs Are Higher Than Previous Estimates

FRIDAY, April 13 (HealthDay News) -- Obesity accounts for nearly 21 percent of U.S. health care costs, much higher than previously estimated, according to a study published in the January issue of the Journal of Health Economics.

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Isomaltulose Doesn't Improve Glycemic Control in Diabetes

FRIDAY, April 13 (HealthDay News) -- For patients with type 2 diabetes, substitution of sucrose with isomaltulose is not associated with improved glycemic control (measured by hemoglobin A1c [HbA1c] levels) at 12 weeks, according to a study published online April 9 in Diabetes Care.

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Blocking Pathway Lowers Glucose in Mice With Diabetes

THURSDAY, April 12 (HealthDay News) -- Blocking a calcium-sensing pathway normally activated by glucagon lowers blood glucose levels without any negative side effects in mice with diabetes, according to a study published online April 12 in Cell Metabolism.

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Prolonged Inadequate Sleep Linked to Obesity and Diabetes

THURSDAY, April 12 (HealthDay News) -- Prolonged inadequate sleep at irregular times lowers the resting metabolic rate and leads to defects in pancreatic insulin secretion, increasing the risk for obesity and diabetes, according to a study published in the April 11 issue of Science Translational Medicine.

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Bevacizumab Offers Lasting Improvement in Macular Edema

THURSDAY, April 12 (HealthDay News) -- At two years of follow-up, diabetes-related clinically significant macular edema (CSME) is more effectively improved by intravitreous bevacizumab than with macular laser therapy (MLT), according to a study published online April 9 in the Archives of Ophthalmology.

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Role of Omega-3 in Secondary Prevention of CVD Questioned

THURSDAY, April 12 (HealthDay News) -- For patients with a history of cardiovascular disease (CVD), evidence is lacking for a secondary preventive effect of omega-3 fatty acid supplements, according to a meta-analysis published online April 9 in the Archives of Internal Medicine.

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U.S. Fertility Measures Largely Unchanged Since 2002

THURSDAY, April 12 (HealthDay News) -- Fertility measures for 15- to 44-year olds for 2006 to 2010 are similar to findings from 2002, according to an April 12 data brief issued by the National Center for Health Statistics (NCHS).

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Study Assesses Glucose Monitoring Trends in Tweens

WEDNESDAY, April 11 (HealthDay News) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April 3 in Diabetes Care.

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For Obese, Deep Organs Receive Lower Doses of Radiation

WEDNESDAY, April 11 (HealthDay News) -- For obese individuals, organs deep within the abdomen may receive lower doses of radiation than the organs of normal-weight individuals, with the same scanner operating parameters, according to a study published online April 5 in Physics in Medicine and Biology.

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Statins Moderate Effect of Metformin on Prostate Cancer

MONDAY, April 9 (HealthDay News) -- For men with type 2 diabetes treated with metformin, prostate cancer (PCa) incidence varies depending on statin use, with a significantly reduced risk for patients taking a combination of metformin and statins, according to a study published online March 28 in Diabetes Care.

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Evidence Lacking for Sleep Length, Energy Metabolism Link

MONDAY, April 9 (HealthDay News) -- Short sleep duration may affect total daily energy expenditure or directly affect energy metabolism, although more study is required, according to a review published online March 22 in Obesity Reviews.

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Maternal Metabolic Disease Tied to Autism

MONDAY, April 9 (HealthDay News) -- Maternal metabolic conditions (MCs) increase the risk that a child will be born with a neurodevelopmental disorder, such as autism or developmental delay, according to a study published online April 9 in Pediatrics.

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Two Novel Genetic Variants Linked to Childhood Obesity

MONDAY, April 9 (HealthDay News) -- Two new genetic variants have been found to be associated with childhood obesity, according to a study published online April 8 in Nature Genetics.

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Variety of Fruits, Vegetables Linked to Lower Diabetes Risk

MONDAY, April 9 (HealthDay News) -- Eating a greater quantity of vegetables and a greater variety of fruits and vegetables (F&V) correlates with a reduced risk of type 2 diabetes (T2D), according to a study published online April 3 in Diabetes Care.

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Low Blood Adiponectin Predicts Future Asthma Risk in Women

FRIDAY, April 6 (HealthDay News) -- Middle-aged women with low blood adiponectin levels are about twice as likely to develop asthma, particularly if they smoke, according to a study published online April 6 in the American Journal of Respiratory and Critical Care Medicine.

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Endodermal Progenitor Cells Generate Into Multiple Cell Types

FRIDAY, April 6 (HealthDay News) -- Endodermal progenitor (EP) cells derived from embryonic stem cells and induced pluripotent stem cells can differentiate into multiple cell types, including functional pancreatic β-cells, and are not tumorigenic, according to a study published in the April 6 issue of Cell Stem Cell.

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Toddlers Getting Little Daily Parent-Supervised Outdoor Play

FRIDAY, April 6 (HealthDay News) -- About half of all preschool-aged children do not have even one parent-supervised outdoor playtime per day, according to research published online April 2 in the Archives of Pediatrics & Adolescent Medicine.

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Low-Energy-Density Diets Effective for Managing Weight

THURSDAY, April 5 (HealthDay News) -- There is an association between energy density and body weight, such that consumption of diets lower in energy density may be an effective strategy for weight management, according to study published online April 5 in the Journal of the Academy of Nutrition and Dietetics.

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Medical Malpractice Claims Incur Substantial Defense Costs

WEDNESDAY, April 4 (HealthDay News) -- Defense costs for medical malpractice claims vary among specialties and are higher for claims that result in indemnity payments, according to a letter published in the April 5 issue of the New England Journal of Medicine.

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Importance of Diabetes Genetic Variants Unclear

WEDNESDAY, April 4 (HealthDay News) -- Genetic variants associated with type 2 diabetes that affect glucagon-like peptide 1 (GLP-1) are not associated with GLP-1 levels or GLP-1-induced insulin secretion in healthy individuals, according to a study published online March 28 in Diabetes.

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Heavy Baby Girls at Future Risk of Cardiometabolic Disease

TUESDAY, April 3 (HealthDay News) -- Heavier baby girls are at increased risk for developing diabetes and cardiovascular disease at age 17 years than are overweight baby boys, according to a study published online March 22 in the Journal of Clinical Endocrinology & Metabolism.

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Waist Measurements Specify Lipid, BP Levels in Obese Teens

TUESDAY, April 3 (HealthDay News) -- Waist measures (waist circumference and waist-to-height ratio [WHtR]) are associated with lipid and blood pressure levels, with increased WHtR linked to worsened lipid profile and hypertension in obese adolescents, according to a study published online April 2 in the Archives of Pediatrics & Adolescent Medicine.

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Obesity Epidemic in U.S. Worse Than Previously Thought

TUESDAY, April 3 (HealthDay News) -- The body mass index (BMI) substantially underdiagnoses obesity when compared to the dual-energy X-ray absorptiometry (DXA) scan, a direct simultaneous measure of body fat, muscle mass, and bone density, according to a study published online April 2 in PLoS One.

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Serious Eye Disease Linked to Bisphosphonate Use

MONDAY, April 2 (HealthDay News) -- First-time users of oral bisphosphonates have an increased risk of both uveitis and scleritis compared with nonusers, according to a study published online April 2 in CMAJ, the journal of the Canadian Medical Association.

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Most Americans Getting Adequate Amounts of Vitamins, Nutrients

MONDAY, April 2 (HealthDay News) -- Most people in the United States are getting adequate nutrition, but some groups experience lower levels of vital nutrients than that which is recommended for good health, according to the Second National Report on Biochemical Indicators of Diet and Nutrition released April 2 by the U.S. Centers for Disease Control and Prevention.

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More Complications After Thyroid Surgery in Elderly

MONDAY, April 2 (HealthDay News) -- Advanced age is a risk factor for complications after thyroidectomy, according to a study published online March 14 in the Journal of Clinical Endocrinology & Metabolism.

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In Taiwan, Diabetes Linked to Increased Parkinson's Risk

MONDAY, April 2 (HealthDay News) -- Individuals with diabetes in Taiwan have a significantly increased risk of Parkinson's disease (PD), which is robust across most age and gender stratifications, according to a study published online March 19 in Diabetes Care.

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