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Category: Internal Medicine | Monthly Briefing

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April 2012 Briefing - Internal Medicine

Last Updated: May 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for April 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Screening Benefits Women in 40s With High Breast CA Risk

MONDAY, April 30 (HealthDay News) -- Women in their 40s, with at least a two-fold increased risk of breast cancer, benefit from biennial screening mammography; and having extremely dense breasts or first-degree relatives with breast cancer is associated with a two-fold increased risk of breast cancer for women in their 40s, according to two studies published in the May 1 issue of the Annals of Internal Medicine.

Abstract - van Ravesteyn
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Abstract - Nelson
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Electronic Reminders Up Meds Adherence in Short Term

MONDAY, April 30 (HealthDay News) -- The use of electronic reminders (short message service [SMS] reminders, electronic reminder devices, or pagers) is associated with improved adherence to chronic medications in the short term, according to a review published online April 25 in the Journal of the American Medical Informatics Association.

Abstract
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Sleep Measures Do Not Predict Clinical Pain in Fibromyalgia

FRIDAY, April 27 (HealthDay News) -- For patients with fibromyalgia, spatial extent of pain, pain aftersensation, and negative mood account for approximately one-third of the variance in clinical pain, but sleep measures do not significantly predict pain, according to a study published in the April issue of The Journal of Pain.

Abstract
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Stress Reduction Ups Health Status in Type 2 Diabetes

FRIDAY, April 27 (HealthDay News) -- A mindfulness-based stress reduction (MBSR) intervention is effective at improving health status and lowering levels of depression among patients with type 2 diabetes, according to a study published in the May issue of Diabetes Care.

Abstract
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Early Axonal Dysfunction Precedes Diabetic Neuropathy

FRIDAY, April 27 (HealthDay News) -- Early axonal dysfunction may be detected prior to the development of clinical symptoms of diabetic neuropathy, according to a study published online April 20 in Diabetes.

Abstract
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Cancer Worry Linked to Continued Symptom Burden

FRIDAY, April 27 (HealthDay News) -- Age, fatigue, symptom burden, and risk perception are significantly associated with greater cancer worry three years after completing adjuvant treatment for breast cancer, according to a study published online March 15 in Psycho-Oncology.

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Sunscreen Use May Lead to Vitamin D Deficiency

FRIDAY, April 27 (HealthDay News) -- Using the amount and sun protection factor (SPF) of sunscreen recommended by the World Health Organization (WHO) is associated with little or no vitamin D production, suggesting that regular sunscreen use may lead to vitamin D deficiency, according to research published online April 18 in the British Journal of Dermatology.

Abstract
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Sleep of Short Duration Common in U.S. Workers

THURSDAY, April 26 (HealthDay News) -- A substantial proportion of workers in the United States get less sleep than recommended by the National Sleep Foundation, according to a report published in the April 27 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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Berries May Slow Cognitive Decline in Older Women

THURSDAY, April 26 (HealthDay News) -- Flavonoid-rich blueberries and strawberries may reduce cognitive decline in elderly women, according to a study published online April 25 in the Annals of Neurology.

Abstract
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Heart Surgery Safe for Compensated Cirrhosis Patients

THURSDAY, April 26 (HealthDay News) -- Patients with compensated cirrhosis, defined by a Child-Pugh (CP) score of <8, have no significant increase in postoperative mortality and morbidity following cardiac surgery with cardiopulmonary bypass, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

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Nutrition, Exercise Guidelines Updated for Cancer Survivors

THURSDAY, April 26 (HealthDay News) -- The American Cancer Society has updated the 2006 guidelines to provide new evidence and clinical practices related to nutrition and physical activity for cancer survivors during the continuum of cancer care, according to a report published online April 26 in CA: A Cancer Journal for Clinicians.

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Hyperalgesia Similar With Drug Therapies for Heroin Addiction

THURSDAY, April 26 (HealthDay News) -- Heroin-addicted patients treated with methadone or buprenorphine have a heightened sensitivity to pain, and the hyperalgesia does not change over the course of treatment, according to a study published in the April issue of The Journal of Pain.

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Age, Life Expectancy Influence Termination of PSA Screening

THURSDAY, April 26 (HealthDay News) -- Most primary care providers consider both a man's age and life expectancy in deciding whether to discontinue prostate-specific antigen (PSA) screenings, but multiple factors are involved in this decision, according to a study published online April 19 in Cancer.

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Subtype Best Predictor of Basal Cell Carcinoma Invasion Depth

THURSDAY, April 26 (HealthDay News) -- Basal cell carcinoma (BCC) subtype identified on biopsy and excision specimens is the best predictor of depth of invasion, according to a study published online April 16 in the Journal of the American Academy of Dermatology.

Abstract
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Adjuvant Therapy Shows Promise in Biliary Tract Cancer

THURSDAY, April 26 (HealthDay News) -- For patients with biliary tract cancers, postresection adjuvant therapy with chemotherapy or chemoradiotherapy appears to be beneficial in treating patients with biliary tract cancers, with significant improvement seen for patients with node or margin positivity, according to research published online April 23 in the Journal of Clinical Oncology.

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Accelerated Aging Evident in Cocaine-Dependent Individuals

THURSDAY, April 26 (HealthDay News) -- The brains of individuals addicted to cocaine show accelerated loss of gray matter over and above the loss due to normal aging, according to a letter published online April 24 in Molecular Psychiatry.

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Early Menopause Ups Risk of Osteoporosis, Fractures, Death

THURSDAY, April 26 (HealthDay News) -- The occurrence of menopause before age 47 correlates with increased osteoporosis at age 77, increased incidence of fragility fractures, and increased mortality, according to a study published online April 25 in BJOG: An International Journal of Obstetrics and Gynaecology.

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Thiazolidinediones Tied to Lower Cancer Risk in Diabetes Patients

THURSDAY, April 26 (HealthDay News) -- Thiazolidinediones are associated with a lower risk of liver and colorectal cancer in patients with type 2 diabetes, according to a study published in the May issue of Hepatology.

Abstract
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Erosive, but Not Nonerosive, GERD Ups Esophageal CA Risk

WEDNESDAY, April 25 (HealthDay News) -- Patients with gastroesophageal reflux disease with a history of esophagitis are at increased risk for esophageal adenocarcinoma, although the absolute risk is low, according to a study published in the May issue of Clinical Gastroenterology and Hepatology.

Abstract
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Low-Dose CT Noninferior for Diagnosing Appendicitis

WEDNESDAY, April 25 (HealthDay News) -- For young adults with suspected appendicitis, low-dose computed tomography (CT) is noninferior to standard-dose CT with respect to negative appendectomy rates, according to a study published in the April 26 issue of the New England Journal of Medicine.

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Warfarin Keeps Stroke Risk Low in Patients With A-Fib

WEDNESDAY, April 25 (HealthDay News) -- Use of warfarin for stroke prevention in patients with nonvalvular atrial fibrillation (AF) is associated with a low risk of stroke or systemic embolism, according to a meta-analysis published in the April 23 issue of the Archives of Internal Medicine.

Abstract
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Ultrasound May Safely Rule Out DVT in Pregnancy

WEDNESDAY, April 25 (HealthDay News) -- For pregnant and postpartum women, a single complete compression ultrasonography may safely exclude a diagnosis of deep vein thrombosis, according to a study published online April 24 in BMJ.

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Resistance Training Aids Memory in Senior Women

WEDNESDAY, April 25 (HealthDay News) -- For senior women with mild cognitive impairment, twice-weekly resistance training (RT) for six months is associated with improved cognition and brain plasticity compared with balance and tone (BAT) exercises, according to a research letter published in the April 23 issue of the Archives of Internal Medicine.

Abstract
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Botox Modestly Improves Chronic Headaches, Migraines

WEDNESDAY, April 25 (HealthDay News) -- Botulinum toxin A provides a modest benefit for patients with chronic migraine headaches and chronic daily headaches, compared with placebo, according to a meta-analysis published in the April 25 issue of the Journal of the American Medical Association.

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Anatomic Existence of the G-Spot Reported

WEDNESDAY, April 25 (HealthDay News) -- The anatomic existence of the G-spot has been documented, and it has been identified as a distinguishable anatomic structure located on the dorsal perineal membrane, according to a study published in the May issue of The Journal of Sexual Medicine.

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Mortality High for Cardiac Device Infective Endocarditis

TUESDAY, April 24 (HealthDay News) -- Patients with infective endocarditis involving implanted cardiac devices experience high in-hospital and one-year mortality rates, particularly if there is valve involvement, according to a study published in the April 25 issue of the Journal of the American Medical Association.

Abstract
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USPSTF Guidelines Haven't Changed PSA Screening Practice

TUESDAY, April 24 (HealthDay News) -- Despite the 2008 changes in U.S. Preventive Services Task Force (USPSTF) recommendations against prostate-specific antigen (PSA)-based screening for prostate cancer in men 75 years or older, screening rates remained unchanged for men of all ages between 2005 and 2010, according to a research letter published in the April 25 issue of the Journal of the American Medical Association.

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Subclinical Hyperthyroidism Tied to Coronary Heart Disease

TUESDAY, April 24 (HealthDay News) -- Subclinical hyperthyroidism is associated with increased risk of coronary heart disease (CHD) morbidity and mortality; and treatment with levothyroxine for subclinical hypothyroidism is associated with fewer ischemic heart disease (IHD) events in patients aged 40 to 70 years, according to two studies published online April 23 in the Archives of Internal Medicine.

Abstract - Collet
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Abstract - Razvi
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Patients With Acute Low Back Pain Have Poor Prognosis

TUESDAY, April 24 (HealthDay News) -- Few patients with acute low back pain (LBP), with or without sciatica, declare sick leave; however, approximately half have one or more recurrences and a considerable proportion experience chronic pain six months or longer after the initial episode, according to a study published in the April 15 issue of Spine.

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2001 to 2010 Saw 74 Percent Drop in Global Measles Mortality

TUESDAY, April 24 (HealthDay News) -- From 2001 to 2010, there was a 74 percent decrease in estimated global measles mortality, with mortality in India and the World Health Organization (WHO) African region accounting for most of the estimated cases in 2010, according to a study published online April 24 in The Lancet.

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Meds, Clinic Noncompliance Linked to Mortality in Diabetes

TUESDAY, April 24 (HealthDay News) -- Insulin-treated patients with type 2 diabetes who are noncompliant with their medication or clinic appointments face increased all-cause mortality, according to a study published online April 17 in Diabetes Care.

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Bladder Cancer Diagnosis Encourages Smokers to Quit

MONDAY, April 23 (HealthDay News) -- Smokers with a new diagnosis of bladder cancer are significantly more likely to quit compared with smokers in the general population, according to a study published online April 23 in the Journal of Clinical Oncology.

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Angiotensin Receptor Blockers Reduce No-Reflow Post-PCI

MONDAY, April 23 (HealthDay News) -- For patients with acute myocardial infarction (AMI), pretreatment with angiotensin receptor blockers (ARBs) is linked with reduced incidence of the no-reflow phenomenon after percutaneous coronary intervention (PCI), according to a study published online April 10 in Cardiovascular Therapeutics.

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Shingles Vaccine Generally Well Tolerated in Older Adults

MONDAY, April 23 (HealthDay News) -- The zoster vaccine is safe and well tolerated in older adults, despite an increased risk of allergic reaction in the days following vaccination, according to a study published in the Journal of Internal Medicine.

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Insulin Resistance Cut-Off Established From Clamp Data

MONDAY, April 23 (HealthDay News) -- Cut-offs for predicting insulin resistance based on hyperinsulinemic-euglycemic clamp data and routinely measured clinical and biochemical variables have been determined, according to a study published online April 17 in Diabetes Care.

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High BMI Tied to Non-Specific Foot Pain, Plantar Heel Pain

MONDAY, April 23 (HealthDay News) -- Increased body mass index (BMI) correlates with non-specific foot pain in the general population, and with chronic plantar heel pain in a non-athletic population, according to a meta-analysis published online April 13 in Obesity Reviews.

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Patient-Centered Approach Key for T2DM Management

FRIDAY, April 20 (HealthDay News) -- Treatment of type 2 diabetes should be personalized in a patient-centered approach, with diet, exercise, and education forming the basis of any treatment program, supplemented by medications as necessary, according to a joint position statement issued by the American Diabetes Association and the European Association for the Study of Diabetes, published online April 19 in Diabetes Care.

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Uric Acid Levels Predict Death in Acute Coronary Syndrome

FRIDAY, April 20 (HealthDay News) -- Elevated uric acid levels are predictive of one-year mortality in patients with acute coronary syndrome, according to a study published in the May 1 issue of The American Journal of Cardiology.

Abstract
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Metformin + Insulin Comparable to Insulin Alone in T2DM

FRIDAY, April 20 (HealthDay News) -- For patients with type 2 diabetes, treatment with metformin and insulin has no significant effect on all-cause or cardiovascular mortality, compared with insulin alone, although data are limited and suffer from bias, according to a meta-analysis published online April 19 in BMJ.

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QRS Width on ECG Linked to Sudden Cardiac Arrest in CAD

FRIDAY, April 20 (HealthDay News) -- For patients with coronary artery disease (CAD), QRS width on electrocardiogram and echocardiographic evidence of heart failure are associated with out-of-hospital sudden cardiac arrest (SCA), regardless of whether they have a history of previous myocardial infarction (MI), according to a study published in the May 1 issue of The American Journal of Cardiology.

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Letting Go of Regret Linked to Healthy Aging

FRIDAY, April 20 (HealthDay News) -- Emotionally healthy aging is associated with an ability to let go of regrets and not dwell on missed opportunities, according to a study published online April 19 in Science.

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Prisoners at Risk for Non-Communicable Diseases

FRIDAY, April 20 (HealthDay News) -- The prevalence of obesity, inadequate exercise, and poor diet among prisoners may put them at risk for non-communicable diseases (NCDS), according to a review published online April 20 in The Lancet.

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Race, Location Affect Probability of Survival to Age 70

FRIDAY, April 20 (HealthDay News) -- The probability of a person surviving from birth to age 70 varies according to geographic location and gender, with a set of 22 socioeconomic and environmental factors accounting for almost all the variation, according to a study published online April 17 in PLoS One.

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CDC: HPV-Associated Cancers Strike More Than 30,000 Yearly

THURSDAY, April 19 (HealthDay News) -- Cancers associated with the human papillomavirus (HPV) are diagnosed in nearly 11 out of 100,000 men and women in the United States annually, and HPV vaccines play an important role in reducing the incidence of those cancers for which screening is not approved, according to a report published in the April 20 issue of the U.S. Centers for Disease Control and Prevention's Morbidity & Mortality Weekly Report.

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Eating Low-Fat Dairy Linked to Reduced Stroke Risk

THURSDAY, April 19 (HealthDay News) -- Eating low-fat dairy products is associated with a reduced risk of total stroke and cerebral infarctions, according to a study published online April 19 in Stroke.

Abstract
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Pulmonary HTN Predicts Heart Failure After Acute MI

THURSDAY, April 19 (HealthDay News) -- Pulmonary hypertension (PH) is a strong independent predictor of heart failure in patients with acute myocardial infarction (AMI), according to a study published in the May 1 issue of The American Journal of Cardiology.

Abstract
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Hospital Readmission Within 30 Days More Likely in Men

THURSDAY, April 19 (HealthDay News) -- Male gender is associated with increased hospital utilization within 30 days after index discharge, with hospital utilization in the preceding six months a risk factor for both males and females, according to a study published online April 3 in BMJ Open.

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Lower Small-Bowel Obstruction Risk With Laparoscopy

THURSDAY, April 19 (HealthDay News) -- Laparoscopic surgical procedures are associated with a lower incidence of small-bowel obstruction (SBO) compared with open surgery, according to a study published in the April issue of the Archives of Surgery.

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Long-Term Air Pollution Linked to Multiple Diseases

THURSDAY, April 19 (HealthDay News) -- Long-term exposure to fine particulate matter in the air increases hospital admissions for respiratory diseases, cardiovascular diseases, stroke, and diabetes in the elderly considerably more than short-term exposure does, according to a study published online April 17 in PLoS One.

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Room for Improvement in Knowledge of ABC Levels, Goals

THURSDAY, April 19 (HealthDay News) -- Many individuals with diabetes do not know their last hemoglobin A1C (A1C), blood pressure, and low-density lipoprotein (LDL) cholesterol levels (ABC levels), although the correlation between such knowledge and meeting targets for ABC control is unclear, according to a study published online April 12 in Diabetes Care.

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Chemoradiotherapy Combo Ups Bladder Cancer Control

WEDNESDAY, April 18 (HealthDay News) -- Locoregional control of muscle-invasive bladder cancer is significantly improved with a treatment regimen consisting of radiotherapy and concurrent chemotherapy with mitomycin C and fluorouracil, according to a phase 3 study published in the April 19 issue of the New England Journal of Medicine.

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Albendazole Cuts Enteric Parasite Prevalence in Refugees

WEDNESDAY, April 18 (HealthDay News) -- The administration of a single 600-mg dose of albendazole to United States-bound refugees prior to departure from Africa and Southeast Asia reduces the prevalence of intestinal nematodes, according to a study published in the April 19 issue of the New England Journal of Medicine.

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Higher Daily Physical Activity Reduces Alzheimer's Risk

WEDNESDAY, April 18 (HealthDay News) -- Higher total daily physical activity is associated with a reduced risk of developing Alzheimer's disease (AD) and with a lower rate of cognitive decline, according to research published online April 18 in Neurology.

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CV Autonomic Neuropathy Risk for CVD Despite Albumin Status

WEDNESDAY, April 18 (HealthDay News) -- Cardiovascular autonomic neuropathy (CAN) appears to affect the risk of cardiovascular disease even in type 1 diabetes patients with normal albumin excretion rates, according to a study published online April 12 in Diabetes.

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Basal Cell Carcinoma on Ear Significantly More Aggressive

WEDNESDAY, April 18 (HealthDay News) -- Basal cell carcinoma (BCC) on the ear is significantly more likely to be aggressive, and occurs more frequently in men, according to a study published in the May issue of the Journal of the American Academy of Dermatology.

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New Treatment Offers Benefit for Hypoxic Laryngeal Tumors

WEDNESDAY, April 18 (HealthDay News) -- For patients with squamous cell laryngeal cancer, regional control rates are improved with accelerated radiotherapy (AR) plus carbogen inhalation and nicotinamide (ARCON) treatment compared with AR-alone, with the improvement seen in patients with hypoxic tumors, according to research published online April 16 in the Journal of Clinical Oncology.

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Study Looks at Patient Perception of Harm During Cancer Care

WEDNESDAY, April 18 (HealthDay News) -- Cancer patients may often experience what they believe to be a preventable, harmful event during the diagnosis or treatment of their cancer, but rarely do they formally report these events, according to research published online April 16 in the Journal of Clinical Oncology.

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Medicare Coverage Gap Leads to Drug Discontinuation

WEDNESDAY, April 18 (HealthDay News) -- Part D Medicare beneficiaries who do not have financial assistance during the coverage gap are at increased risk for cardiovascular drug discontinuation, according to research published online April 17 in Circulation: Cardiovascular Quality and Outcomes.

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Omega-3 Supplements Don't Benefit Patients With MS

WEDNESDAY, April 18 (HealthDay News) -- Omega-3 (ω-3) fatty acid supplements do not improve disease activity in patients with relapsing-remitting multiple sclerosis (MS), according to a study published online April 16 in the Archives of Neurology.

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Fewer Complications With IMRT for Prostate Cancer

TUESDAY, April 17 (HealthDay News) -- For patients with nonmetastatic prostate cancer, treatment with intensity-modulated radiation therapy (IMRT) is associated with fewer complications than proton therapy or conformal radiation therapy, according to a study published in the April 18 issue of the Journal of the American Medical Association, a theme issue on comparative effectiveness research.

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ICD-9 Codes Underestimate Statin-Linked Rhabdomyolysis

TUESDAY, April 17 (HealthDay News) -- Use of diagnostic codes, such as International Classification of Diseases -- Ninth Revision (ICD-9) codes, may result in misclassification of rare, adverse drug reactions (ADRs), including the risk of rhabdomyolysis from high-dose simvastatin, according to a research letter published in the April 18 issue of the Journal of the American Medical Association, a theme issue on comparative effectiveness research.

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Testosterone Ups Exercise Capacity in Heart Failure

TUESDAY, April 17 (HealthDay News) -- Testosterone supplementation is associated with improved exercise capacity in patients with moderate-to-severe heart failure, according to a meta-analysis published online April 17 in Circulation: Heart Failure.

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New Fibrate Use Ups Serum Creatinine Levels in Elderly

TUESDAY, April 17 (HealthDay News) -- For elderly adults, new fibric acid derivative (fibrate) use is associated with an increase in serum creatinine levels, in hospitalizations for these levels, and in nephrologist consultations, according to a study published in the April 17 issue of the Annals of Internal Medicine.

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Nutrition, Mobility Predict Early Death in Elderly Cancer Patients

TUESDAY, April 17 (HealthDay News) -- Low nutritional assessment scores, poor mobility, and advanced disease predict early death after chemotherapy initiation among elderly patients with cancer, according to a study published online April 16 in the Journal of Clinical Oncology.

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Evidence Lacking for Value of CKD Screening and Monitoring

TUESDAY, April 17 (HealthDay News) -- There is no evidence that screening and monitoring for chronic kidney disease (CKD) improves clinical outcomes, according to research published in the April 17 issue of the Annals of Internal Medicine.

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Preexposure Chemoprophylaxis Cuts HIV Infection at a Cost

TUESDAY, April 17 (HealthDay News) -- Models show daily oral preexposure chemoprophylaxis (PrEP) in the general population of men who have sex with men (MSM) could prevent a substantial number of HIV infections, but at a high cost, according to a study published in the April 17 issue of the Annals of Internal Medicine.

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Long-Term Safety Shown for Biodegradable Stent

TUESDAY, April 17 (HealthDay News) -- Long-term follow-up indicates that the fully biodegradable Igaki-Tamai stent is safe for coronary artery use in humans, according to a study published online April 16 in Circulation.

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Epidural Steroid Shot May Offer Modest Benefit in Sciatica

TUESDAY, April 17 (HealthDay News) -- For adults with lumbosacral radiculopathy, epidural steroid injections may be beneficial for short-term pain relief and improvements in functional capacity, according to a study published in the April 17 issue of the Annals of Internal Medicine.

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Low Gastroprotective Drug Adherence Ups Upper GI Events

MONDAY, April 16 (HealthDay News) -- For patients taking cyclooxygenase-2 inhibitors (coxibs), low adherence to gastroprotective agents (GPAs) increases the risk of upper gastrointestinal (UGI) complications, according to a study published online April 16 in Arthritis & Rheumatism.

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Pre-Pregnancy BMI Important Indicator of Offspring Obesity

MONDAY, April 16 (HealthDay News) -- Maternal gestational weight gain (GWG) during the first 20 weeks of pregnancy correlates with body mass index (BMI)-based overweight/obesity and abdominal obesity at age 16, but maternal pre-pregnancy BMI is a stronger indicator of offspring obesity, according to a study published in the May issue of BJOG: An International Journal of Obstetrics and Gynaecology.

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Fast Food Salt Levels Vary Among Six Countries

MONDAY, April 16 (HealthDay News) -- High salt content in pizza, fried chicken, and other products served by multinational food chains varies substantially across six countries, and even incremental reductions of the seasoning could have a big impact on improving the health of the population, according to a study published online April 16 in CMAJ, the journal of the Canadian Medical Association.

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Liver Insulin Resistance Correlates With Cardiac Risk

MONDAY, April 16 (HealthDay News) -- Liver insulin resistance (IR) may be a significant indicator of cardiovascular disease (CVD) risk among men, and correlates more closely with risk factors than whole-body insulin sensitivity, according to a study published online April 5 in the Journal of Internal Medicine.

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IL-32 Expression Upregulated in Chronic Rhinosinusitis

MONDAY, April 16 (HealthDay News) -- Interleukin-32 (IL-32) mRNA expression is significantly higher in biopsies obtained from patients with chronic rhinosinusitis (CRS), compared to levels found in biopsies obtained from individuals without the condition, according to a study published online April 9 in Allergy.

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Alcohol Use With Opioids Common Even Without Abuse Past

MONDAY, April 16 (HealthDay News) -- Alcohol or sedative use during chronic opioid therapy (COT) for non-cancer pain puts patients at risk for adverse events such as respiratory depression or sedation, and the risk of concurrent use of central nervous system (CNS) depressants is not limited to patients with a history of substance abuse, according to a study published in the March issue of The Journal of Pain.

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High SPF Sunscreens Assure Protection From Solar Rays

MONDAY, April 16 (HealthDay News) -- An application of water-resistant sunscreen with a sun protection factor (SPF) of 70 or higher adequately protects people against skin cancer and photodamage even when applied irregularly, according to a study published online April 1 in the Journal of the American Academy of Dermatology.

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Herbal Carcinogen Linked to Urothelial Cancer in Taiwan

FRIDAY, April 13 (HealthDay News) -- A carcinogen produced by Aristolochia plants, which are commonly used in herbal remedies in Taiwan, is associated with signature types of DNA damage linked to aristolochic acid in Taiwanese patients with urothelial carcinoma of the upper urinary tract (UUC), according to a study published online April 9 in the Proceedings of the National Academy of Sciences.

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Crizotinib Treatment Lowers Total Testosterone Levels

FRIDAY, April 13 (HealthDay News) -- Men with non-small-cell lung cancer (NSCLC) treated with crizotinib exhibit rapid suppression of total testosterone (T) levels compared with those who do not receive crizotinib treatment, according to research published online April 4 in Cancer.

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Most Breast Cancer Survivors Experience Lasting Side Effects

FRIDAY, April 13 (HealthDay News) -- The majority of breast cancer survivors experience one or more treatment-related side effects, and the proportion remains stable at six years post-diagnosis, according to a study published in a special supplement to the April 15 issue of Cancer addressing the physical late effects of breast cancer treatment.

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Obesity Costs Are Higher Than Previous Estimates

FRIDAY, April 13 (HealthDay News) -- Obesity accounts for nearly 21 percent of U.S. health care costs, much higher than previously estimated, according to a study published in the January issue of the Journal of Health Economics.

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Isomaltulose Doesn't Improve Glycemic Control in Diabetes

FRIDAY, April 13 (HealthDay News) -- For patients with type 2 diabetes, substitution of sucrose with isomaltulose is not associated with improved glycemic control (measured by hemoglobin A1c [HbA1c] levels) at 12 weeks, according to a study published online April 9 in Diabetes Care.

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Pain Correlates Most Strongly With Disability in Hispanics With RA

FRIDAY, April 13 (HealthDay News) -- For Hispanic patients with rheumatoid arthritis (RA), self-reported pain correlates most strongly with disability, according to a study published online April 5 in Arthritis Care & Research.

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Sequencing Traditional Chinese Medicines Reveals Surprises

FRIDAY, April 13 (HealthDay News) -- DNA sequencing of traditional Chinese medicines (TCMs) using high-throughput sequencing (HTS) reveals that potentially toxic plant ingredients and traces of endangered animals are present, according to a study published online April 12 in PLoS Genetics.

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Copy Number Variants Tied to Increased Prostate Cancer Risk

THURSDAY, April 12 (HealthDay News) -- Copy number variants (CNVs) of two loci are linked to a significantly higher risk of prostate cancer, according to a study published online April 10 in the Proceedings of the National Academy of Sciences.

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Small Number of Genes Involved in X-Linked Ichthyosis

THURSDAY, April 12 (HealthDay News) -- Patients with X-linked recessive ichthyosis (XLRI) have altered expression in a small number of genes, and although moisturizer treatment improves dryness, it doesn't affect other biophysical properties or gene expression, according to a study published online April 5 in the British Journal of Dermatology.

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Risk of Sudden Cardiac Death Up for Black Patients With HTN

THURSDAY, April 12 (HealthDay News) -- Black patients with hypertension face a significantly increased risk of sudden cardiac death (SCD) compared with nonblack patients, even after adjusting for multiple confounding variables, according to a study published in the April issue of Heart Rhythm.

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Bevacizumab Offers Lasting Improvement in Macular Edema

THURSDAY, April 12 (HealthDay News) -- At two years of follow-up, diabetes-related clinically significant macular edema (CSME) is more effectively improved by intravitreous bevacizumab than with macular laser therapy (MLT), according to a study published online April 9 in the Archives of Ophthalmology.

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Mentholated Cigarettes Linked to Increased Stroke Risk

THURSDAY, April 12 (HealthDay News) -- Mentholated cigarettes are associated with a significantly increased risk of stroke, particularly among women and non-African-American smokers, according to a letter published in the April 9 issue of the Archives of Internal Medicine.

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Majority of Obese Adults Do Try to Lose Weight

THURSDAY, April 12 (HealthDay News) -- Nearly two-thirds of obese adults are trying to lose weight, and those that eat less fat, exercise more, and use prescription weight loss medications are more successful at losing weight, according to a study published online April 10 in the American Journal of Preventive Medicine.

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Role of Omega-3 in Secondary Prevention of CVD Questioned

THURSDAY, April 12 (HealthDay News) -- For patients with a history of cardiovascular disease (CVD), evidence is lacking for a secondary preventive effect of omega-3 fatty acid supplements, according to a meta-analysis published online April 9 in the Archives of Internal Medicine.

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Study Assesses Glucose Monitoring Trends in Tweens

WEDNESDAY, April 11 (HealthDay News) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April 3 in Diabetes Care.

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Antidepressants Don't Worsen Parkinson's Symptoms

WEDNESDAY, April 11 (HealthDay News) -- The antidepressants paroxetine and venlafaxine extended release (XR) reduce depression without worsening motor function in patients with Parkinson's disease, according to a study published online April 11 in Neurology.

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Indomethacin Cuts Incidence of Post-ERCP Pancreatitis

WEDNESDAY, April 11 (HealthDay News) -- For patients who undergo endoscopic retrograde cholangiopancreatography (ERCP), a single dose of rectal indomethacin immediately after the procedure is associated with a significantly reduced incidence of pancreatitis, according to a study published in the April 12 issue of the New England Journal of Medicine.

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BMD Loss Occurs Early in Androgen Deprivation Therapy

WEDNESDAY, April 11 (HealthDay News) -- The highest average change in bone mineral density (BMD) occurs during early treatment of nonmetastatic, hormone-sensitive prostate cancer in men receiving intermittent androgen deprivation therapy (ADT), according to research published online April 9 in the Journal of Clinical Oncology.

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Perception of Breast Cancer Care Differs From Actual Care Quality

WEDNESDAY, April 11 (HealthDay News) -- The perception of care for women living in inner cities with newly diagnosed, early-stage breast cancer is dependent, in large part, on factors other than the actual quality of care provided, including the quality of the process of getting care, trust in the physician, and perceptions of racism, according to research published online April 9 in the Journal of Clinical Oncology.

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Smoking Found to Be a Risk Factor for Barrett's Esophagus

WEDNESDAY, April 11 (HealthDay News) -- Cigarette smoking may be a modifiable risk factor for Barrett's esophagus, according to a study published in the April issue of Gastroenterology.

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