Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Blogs  |  Articles  |  Forums  |  Twitter    
 
Category: Endocrinology | Internal Medicine | Nephrology | Pathology | Journal

Back to Journal Articles

Insulin Receptor Substrate 1 Variant Linked to GFR

Last Updated: May 31, 2012.

 

IRS1-linked variation in glomerular filtration rate likely due to impaired insulin receptor signaling

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
A variant of the human insulin receptor substrate 1 gene, which plays an important role in modulating tissue response to insulin, is significantly associated with glomerular filtration rate, according to a study published online May 22 in Diabetes.

THURSDAY, May 31 (HealthDay News) -- A variant of the human insulin receptor substrate 1 (IRS1) gene, which plays an important role in modulating tissue response to insulin, is significantly associated with glomerular filtration rate (GFR), according to a study published online May 22 in Diabetes.

Farook Thameem, M.D., of the University of Texas Health Science Center in San Antonio, and colleagues conducted a study to identify and characterize genetic variants related to GFR linkage on chromosome 2q37 in 670 samples obtained from 39 large Mexican-American families with type 2 diabetes. The 2 kb promoter region and exons of the IRS1 gene were sequenced for 32 individuals.

The researchers identified 11 single nucleotide polymorphisms (SNPs), and eight additional SNPs were selected from HapMap to comprehensively cover the 59-kb-long intron-1. After accounting for trait-specific covariate effects, only the Gly(972)Arg variant of the IRS1 gene was significantly associated with GFR and serum triglyceride levels, with Arg972 carriers exhibiting significantly lower GFR values. The Gly(972)Arg variant contributed to 26 percent of the linkage signal on chromosome 2q37. Insulin-stimulated phosphorylation of IRS1 and Akt kinase were significantly reduced in human mesangial cells expressing the IRS1 mutant Gly(972)Arg.

"Taken together, the data provide the first evidence that genetic variation in IRS1 may influence variation in GFR, probably through impaired insulin receptor signaling," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2012 HealthDay. All rights reserved.


Previous: Infants May Be Exposed to Phthalates From PVC Floors Next: Slow-Growing Melanomas Lose Structure, Vary Color With Time

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.