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Category: Endocrinology | Monthly Briefing

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May 2012 Briefing - Diabetes & Endocrinology

Last Updated: June 01, 2012.

 

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for May 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Phlebotomy Benefits Patients With Metabolic Syndrome

THURSDAY, May 31 (HealthDay News) -- For patients with metabolic syndrome, phlebotomy correlates with lower systolic blood pressure and improvements in cardiovascular risk markers and glycemic control, with the changes associated with a reduction in ferritin, according to research published online May 30 in BMC Medicine.

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Insulin Receptor Substrate 1 Variant Linked to GFR

THURSDAY, May 31 (HealthDay News) -- A variant of the human insulin receptor substrate 1 (IRS1) gene, which plays an important role in modulating tissue response to insulin, is significantly associated with glomerular filtration rate (GFR), according to a study published online May 22 in Diabetes.

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Intensive Glucose Control Helps Surrogate Renal End Points

THURSDAY, May 31 (HealthDay News) -- Intensive glucose therapy significantly reduces microalbuminuria and macroalbuminuria in adults with type 2 diabetes, but does not improve clinical renal outcomes, according to a study published in the May 28 issue of the Archives of Internal Medicine.

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BMI Thresholds for Gestational Diabetes Differ by Race

THURSDAY, May 31 (HealthDay News) -- There is considerable racial/ethnic variation in the prevalence of gestational diabetes mellitus (GDM) by body mass index (BMI), according to a study published online May 22 in Diabetes Care.

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Link Between Obesity and Lower-Extremity Lymphedema Explored

WEDNESDAY, May 30 (HealthDay News) -- Lower-extremity lymphedema may be due to extreme obesity, as there appears to be a body mass index (BMI) threshold above which lymphatic flow becomes impaired, according to a letter to the editor published in the May 31 issue of the New England Journal of Medicine.

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Risk Models Only Slightly Up Prediction of Complex Diseases

WEDNESDAY, May 30 (HealthDay News) -- Risk models that take gene-gene and gene-environment interactions into account only slightly improve the prediction of risk for three complex diseases, according to a study published online May 24 in the American Journal of Human Genetics.

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Mobile Technology Helps Improve Lifestyle Coaching

WEDNESDAY, May 30 (HealthDay News) -- Coaching supported by mobile technology can help adults improve their lifestyle, most significantly through increasing their intake of fruits and vegetables and decreasing sedentary leisure time, according to a study published in the May 28 issue of the Archives of Internal Medicine.

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Glucose Levels at Admission Predict Death in Pneumonia

WEDNESDAY, May 30 (HealthDay News) -- For patients with community-acquired pneumonia without preexisting diabetes, serum glucose levels at admission are predictive of death at 28 and 90 days, according to a study published online May 29 in BMJ.

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Diabetes Linked to Lung Cancer in Postmenopausal Women

WEDNESDAY, May 30 (HealthDay News) -- Postmenopausal women with diabetes are at a significantly higher risk of developing lung cancer, particularly if they require insulin therapy, according to research published online May 22 in Diabetes Care.

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Lower Limb Muscle Limitations Hamper Walking in Diabetes

TUESDAY, May 29 (HealthDay News) -- In older adults, diabetes correlates with slower walking speed, and diabetes-linked reductions in muscle strength and worse muscle quality contribute to these walking limitations, according to a study published online May 17 in Diabetes Care.

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Low-Glucose Suspend Function in Insulin Pumps Deemed Safe

THURSDAY, May 24 (HealthDay News) -- Sensor-augmented pump therapy with a low-glucose suspend (LGS) function appears to be safe for patients with type 1 diabetes, according to a study published online May 14 in Diabetes Care.

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Low Vitamin D Intake Tied to Risk of Thromboembolic Stroke

THURSDAY, May 24 (HealthDay News) -- In Japanese-American men, low dietary vitamin D intake is associated with an increased risk of all stroke and thromboembolic stroke during a 34-year follow-up period, according to a study published online May 24 in Stroke.

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Extending Care Helps Maintain Long-Term Weight Loss

THURSDAY, May 24 (HealthDay News) -- Extended patient care has a moderate effect on long-term maintenance of weight loss, according to a systematic review and meta-analysis published in the June issue of Obesity Reviews.

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Diabetes-Linked Cardio, All-Cause Mortality Decreasing

WEDNESDAY, May 23 (HealthDay News) -- From 1997 to 2006, there was a significant decrease in the cardiovascular disease (CVD) and all-cause mortality rates for U.S. men and women with diabetes, according to research published in the June issue of Diabetes Care.

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Maternal Weight Ups Infant Size More Than Glucose Intolerance

WEDNESDAY, May 23 (HealthDay News) -- For women without gestational diabetes, excess maternal weight gain during pregnancy and body mass index (BMI) before pregnancy are greater predictors of large-for-gestational-age infants than mild glucose intolerance and lipid levels, according to a study published online May 22 in CMAJ, the journal of the Canadian Medical Association.

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Genetic Testing Doesn't Up Post-Test Health Care Use

WEDNESDAY, May 23 (HealthDay News) -- Receiving genetic susceptibility testing is associated with an increase in physician visits before testing, but does not impact subsequent health care utilization, according to a study published online May 17 in Genetics in Medicine.

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For Older Women, Saturated Fats Linked to Worse Cognition

TUESDAY, May 22 (HealthDay News) -- For older women, higher saturated fatty acid (SFA) intake correlates with worse global cognition and verbal memory trajectories, while higher intake of monounsaturated fatty acids (MUFA) correlates with improved trajectories, according to a study published online May 17 in the Annals of Neurology.

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Weight Loss Reduces Potential Breast Cancer Biomarkers

TUESDAY, May 22 (HealthDay News) -- Postmenopausal weight loss through diet and the combination of diet and exercise is associated with a significant reduction in serum estrogens and free testosterone, according to a study published online May 21 in the Journal of Clinical Oncology.

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Cardiac Disease Risk Factors Prevalent Among U.S. Teens

MONDAY, May 21 (HealthDay News) -- From 1999 to 2008 the prevalence of several cardiovascular disease risk factors remained stable among U.S. adolescents, but the burden of risk factors is still considerable, according to a study published online May 21 in Pediatrics.

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Altered Amino Acid Metabolism Precedes Hyperglycemia

MONDAY, May 21 (HealthDay News) -- In a population of middle-aged men and women, branched-chain and aromatic amino acid metabolism alterations precede the development of hyperglycemia, and alanine, lactate, tyrosine, and pyruvate predict postchallenge glucose, according to a study published online May 4 in Diabetes Care.

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Increase in Physical Activity in Men Optimizes Peak Bone Mass

FRIDAY, May 18 (HealthDay News) -- For young men, increasing physical activity over a five-year period is associated with improvements in bone mineral content (BMC) and bone mineral density (BMD), according to a study published in the May issue of the Journal of Bone and Mineral Research.

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Generic Versions of Plavix Approved

THURSDAY, May 17 (HealthDay News) -- The first generic versions of Plavix (clopidogrel bisulfate) have been approved by the U.S. Food and Drug Administration.

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Retinal Vessel Diameter Linked to Heart Disease, Hypertension

THURSDAY, May 17 (HealthDay News) -- Baseline retinal vessel diameter is an independent predictor of incident hypertension, lower extremity arterial disease (LEAD), and any cardiovascular disease (CVD) at six years in African-American patients with type 1 diabetes mellitus, according to a study published in the May issue of the Archives of Ophthalmology.

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Causality Link Between HDL Cholesterol, MI Challenged

THURSDAY, May 17 (HealthDay News) -- Genetic mechanisms that are associated with high plasma levels of high-density lipoprotein (HDL) cholesterol do not reduce the risk of myocardial infarction (MI), adding question to causality of link, according to a study published online May 17 in The Lancet.

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Statins Benefit Those at Low Risk for Vascular Events

THURSDAY, May 17 (HealthDay News) -- Reduction of low-density lipoprotein (LDL) cholesterol with statins is associated with a decrease in major vascular events, even for individuals with a five-year risk of less than 10 percent, according to research published online May 17 in The Lancet.

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Screening for Retinopathy Every Two Years Deemed Safe

TUESDAY, May 15 (HealthDay News) -- For patients with type 2 diabetes without evidence of retinopathy, increasing the screening interval to every two years yields no increased risk of retinopathy-mediated vision loss and reduces screening costs, according to a study published online May 7 in Diabetes Care.

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Team-Centered Multicondition Care Deemed Cost-Effective

THURSDAY, May 10 (HealthDay News) -- For adults with depression and poorly controlled diabetes and/or coronary heart disease (CHD), a collaborative care intervention is cost-effective, according to a study published in the May issue of the Archives of General Psychiatry.

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Substantial Survival for Older Adults With Diabetes

THURSDAY, May 10 (HealthDay News) -- Middle-aged and older adults with diabetes have substantial five-year survival, with survival exceeding 50 percent for almost all age and clinical groups, according to a study published online April 6 in The Journals of Gerontology: Series A.

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Glycemic Variability Affects Mood and Quality of Life

THURSDAY, May 10 (HealthDay News) -- Glycemic variability appears to be associated with lower quality of life and negative moods in women with type 2 diabetes, according to a study published in the March 30 issue of Diabetes Technology & Therapeutics.

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Amino Acid Levels Linked to Type 2 Diabetes Risk

WEDNESDAY, May 9 (HealthDay News) -- Levels of some amino acids are associated with glycemia and insulin resistance and predict the development of type 2 diabetes in men, according to a study published online May 2 in Diabetes.

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Long Auto Commutes Found to Be Hazardous to Health

WEDNESDAY, May 9 (HealthDay News) -- Commuting distance is negatively associated with physical activity and cardiorespiratory fitness (CRF), and positively associated with obesity and metabolic risk indicators, according to a study published online May 8 in the American Journal of Preventive Medicine.

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Chromosomal Screening Improves IVF Pregnancy Rates

WEDNESDAY, May 9 (HealthDay News) -- Screening embryos produced by in vitro fertilization using array comparative genomic hybridization (aCGH) plus morphology improves pregnancy rates over screening by morphology alone in single embryo transfers, according to a study published online May 2 in Molecular Cytogenetics.

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Oxygen Treatment Beneficial in Diabetes-Prone Mice

TUESDAY, May 8 (HealthDay News) -- Hyperbaric oxygen treatment of a preclinical diabetes mouse model reduces the incidence of diabetes and preserves insulin-producing β-cells, according to a study published online May 7 in Diabetes.

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Pleasure Eating Stimulates Chemical Reward System

FRIDAY, May 4 (HealthDay News) -- Pleasure eating is associated with increased peripheral levels of two endogenous rewarding mediators, according to a pilot study published online March 22 in the Journal of Clinical Endocrinology & Metabolism.

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Gene Variants Linked to Hot Flashes in Women Who Smoke

FRIDAY, May 3 (HealthDay News) -- Variants in genes that metabolize sex steroids are associated with a greater frequency or severity of hot flashes in older women who smoke, according to a study published online March 30 in the Journal of Clinical Endocrinology & Metabolism.

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CMS Policy Helping Hospitals to Prevent Targeted Infections

FRIDAY, May 4 (HealthDay News) -- Hospitals seem to be paying greater attention to preventing targeted health care-associated infections (HAIs) as a result of the Centers for Medicare and Medicaid Services (CMS) nonpayment policy, according to a study published in the May issue of the American Journal of Infection Control.

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Many COPD Comorbidities Independently Tied to Mortality

FRIDAY, May 4 (HealthDay News) -- Twelve comorbidities that include cancer and cardiovascular problems are associated with a higher risk of death in patients with chronic obstructive pulmonary disease (COPD), according to a study published online May 3 in the American Journal of Respiratory and Critical Care Medicine.

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Low Vitamin D Linked to Poorer Outcomes in Lung Recipients

THURSDAY, May 3 (HealthDay News) -- For lung transplant recipients, 25-hydroxyvitamin D (25[OH]D) deficiency is associated with increased incidence of acute rejection and infection, and deficiency at one year after transplant is linked with increased mortality, according to a study published online March 5 in The Journal of Heart and Lung Transplantation.

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Endotoxemia Influenced by Diet Type

THURSDAY, May 3 (HealthDay News) -- A Western-style diet is associated with increased levels of endotoxin activity (endotoxemia), and a prudent-style diet (containing moderately greater amounts of omega-3 fatty acids, vitamin C, and vitamin E than the Western-style diet) is linked to reduced endotoxemia, according to a study published in the May issue of Gastroenterology.

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For Thyroid Cancer, Thyrotropin + Low-Dose Radioiodine Effective

THURSDAY, May 3 (HealthDay News) -- For patients with thyroid cancer who undergo complete surgical resection, low-dose radioiodine plus thyrotropin is as effective as high-dose radioiodine, according to two studies published in the May 3 issue of the New England Journal of Medicine.

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Mitotane + Chemo Combo May Benefit Adrenocortical Cancer

WEDNESDAY, May 2 (HealthDay News) -- For patients with advanced adrenocortical cancer, mitotane plus a combination of etoposide, doxorubicin, and cisplatin (EDP) is superior to streptozocin-mitotane for rates of response and progression-free survival, but does not improve overall survival, according to a study published online May 2 in the New England Journal of Medicine.

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Body Fat Linked to Reduced Fracture Risk for Women

WEDNESDAY, May 2 (HealthDay News) -- Higher body fat mass is associated with a reduced risk of fracture among women, but not men, according to a study published in the May issue of the Journal of Internal Medicine.

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Nonsupportive Family Members Sabotage Diabetes Self-Care

WEDNESDAY, May 2 (HealthDay News) -- Diabetes patients with nonsupportive family members are less adherent to their diabetes medication regimen and have worse glycemic control, according to a study published online April 26 in Diabetes Care.

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Causal Link ID'd Between BMI, Ischemic Heart Disease

WEDNESDAY, May 2 (HealthDay News) -- The positive association between body mass index (BMI) and ischemic heart disease (IHD) is likely to be causal, according to a study published online May 1 in PLoS Medicine.

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Lower All-Cause, Cardio Mortality in Obese With RA

WEDNESDAY, May 2 (HealthDay News) -- Overweight and obese patients with rheumatoid arthritis (RA) have lower all-cause and cardiovascular mortality, but have substantially increased risks of comorbidities, medical costs, and reduced quality of life compared with normal-weight RA patients, according to a study published online April 18 in Arthritis Care & Research.

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Elelyso Approved for Type 1 Gaucher Disease

TUESDAY, May 1 (HealthDay News) -- Elelyso (taliglucerase alfa) has been approved by the U.S. Food and Drug Administration as a long-term enzyme replacement therapy for people with Type 1 Gaucher disease.

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Methodological Heterogeneity Seen in Clinical Trials

TUESDAY, May 1 (HealthDay News) -- Clinical studies registered with ClinicalTrials.gov from 2007 and 2010 are predominately small, single-center trials and contain significant heterogeneity in methodology, according to a study published in the May 2 issue of the Journal of the American Medical Association.

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Obesity, Increased Incidence of Rheumatoid Arthritis Linked

TUESDAY, May 1 (HealthDay News) -- Obesity is linked with the risk of developing rheumatoid arthritis (RA), and seems to have contributed to the recent increase in incidence of the condition, according to a study published online April 18 in Arthritis Care & Research.

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Caloric Restriction Linked to Reduced Inflammation Markers

TUESDAY, May 1 (HealthDay News) -- Implementation of a caloric restriction weight-loss diet, with or without exercise, is associated with measurable reductions in markers of inflammation for obese or overweight postmenopausal women, according to a study published in the May 1 issue of Cancer Research.

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Index Identifies Clot Risk in Outpatient Surgery Patients

TUESDAY, May 1 (HealthDay News) -- Using a weighted risk index, the highest-risk outpatient surgery patients have an almost 20-fold increase in risk of venous thromboembolism (VTE) requiring therapy, according to a study published online April 13 in the Annals of Surgery.

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