Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for May 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Pre-Op Chemoradiotherapy Ups Survival in Esophageal Cancer
WEDNESDAY, May 30 (HealthDay News) -- For patients with esophageal or esophagogastric-junction cancer, treatment with neoadjuvant chemoradiotherapy followed by surgical resection is associated with improved survival compared with surgery alone, according to a study published in the May 31 issue of the New England Journal of Medicine.
Pancreatectomy OK Without Downstaging From Therapy
FRIDAY, May 25 (HealthDay News) -- Pancreatectomy improves median survival in pancreatic cancer patients even when presurgical neoadjuvant therapy does not lead to radiographic downstaging of tumors, according to a study published online May 17 in Cancer.
Regorafenib Active in Metastatic GI Stromal Tumors
WEDNESDAY, May 23 (HealthDay News) -- Regorafenib, an inhibitor of multiple cancer-associated kinases, is active in patients with metastatic gastrointestinal stromal tumors (GIST) who have failed to respond to imatinib and sunitinib, according to a study published online May 21 in the Journal of Clinical Oncology.
PEG Tubes Linked to Increased Risk of New Pressure Ulcers
THURSDAY, May 17 (HealthDay News) -- Percutaneous endoscopic gastrostomy (PEG) feeding tubes significantly increase the risk of new pressure ulcers and do not promote the healing of existing pressure ulcers in nursing home residents with advanced cognitive impairment, according to a study published in the May 14 issue of the Archives of Internal Medicine.
Blacks, Hispanics Have Increased Adenoma Prevalence
WEDNESDAY, May 16 (HealthDay News) -- Compared to whites, Hispanic and black patients have an increased prevalence of adenomas and an increased risk of advanced adenomas, according to a study published in the June issue of Alimentary Pharmacology & Therapeutics.
Sex Influences Survival in Esophageal Cancer
WEDNESDAY, May 16 (HealthDay News) -- Sex is an independent prognostic factor for patients with locoregional esophageal cancer (LEC) and metastatic esophageal cancer (MEC), according to a study published online May 14 in the Journal of Clinical Oncology.
CT Colonography Accurate for 10 mm Adenomas
MONDAY, May 14 (HealthDay News) -- For patients at average-to-moderate risk of colon cancer, computed tomographic colonography (CTC) accurately detects adenomas 10 mm or larger, but not smaller lesions, according to a study published in the May 15 issue of the Annals of Internal Medicine.
Beta Blocker Use Is Not Linked to Reduced Colon Cancer Risk
MONDAY, May 14 (HealthDay News) -- The use of beta blockers is not associated with a reduced risk of colorectal cancer (CRC), according to a study published online May 14 in Cancer.
New Technique Removes Inoperable Abdominal Tumors
FRIDAY, May 11 (HealthDay News) -- Multivisceral ex vivo surgery can successfully remove invasive abdominal tumors previously deemed unresectable due to location and vascular involvement, according to a case report published in the May issue of the American Journal of Transplantation.
Review: Physical Activity Cuts Mortality for Cancer Survivors
WEDNESDAY, May 9 (HealthDay News) -- Physical activity correlates with reduced all-cause and breast and colon cancer-specific mortality, according to a study published online May 8 in the Journal of the National Cancer Institute.
FISH + Cytology Beats Cytology Alone for Neoplasia Detection
FRIDAY, May 4 (HealthDay News) -- For patients with diverse pathologies who undergo endoscopic ultrasonography with fine-needle aspiration, adding fluorescence in situ hybridization (FISH) detection methods to conventional cytology improves the sensitivity of cytology alone for detection of neoplastic lesions, according to a study published in the May issue of Gastroenterology.
Many COPD Comorbidities Independently Tied to Mortality
FRIDAY, May 4 (HealthDay News) -- Twelve comorbidities that include cancer and cardiovascular problems are associated with a higher risk of death in patients with chronic obstructive pulmonary disease (COPD), according to a study published online May 3 in the American Journal of Respiratory and Critical Care Medicine.
CMS Policy Helping Hospitals to Prevent Targeted Infections
FRIDAY, May 4 (HealthDay News) -- Hospitals seem to be paying greater attention to preventing targeted health care-associated infections (HAIs) as a result of the Centers for Medicare and Medicaid Services (CMS) nonpayment policy, according to a study published in the May issue of the American Journal of Infection Control.
Endotoxemia Influenced by Diet Type
THURSDAY, May 3 (HealthDay News) -- A Western-style diet is associated with increased levels of endotoxin activity (endotoxemia), and a prudent-style diet (containing moderately greater amounts of omega-3 fatty acids, vitamin C, and vitamin E than the Western-style diet) is linked to reduced endotoxemia, according to a study published in the May issue of Gastroenterology.
No Adverse Effect of Weekend, Nighttime Liver Transplants
WEDNESDAY, May 2 (HealthDay News) -- Performing liver transplantation procedures at night or on weekends does not appear to affect patient or liver graft survival, according to research published in the May issue of Liver Transplantation.
Methodological Heterogeneity Seen in Clinical Trials
TUESDAY, May 1 (HealthDay News) -- Clinical studies registered with ClinicalTrials.gov from 2007 and 2010 are predominately small, single-center trials and contain significant heterogeneity in methodology, according to a study published in the May 2 issue of the Journal of the American Medical Association.
Index Identifies Clot Risk in Outpatient Surgery Patients
TUESDAY, May 1 (HealthDay News) -- Using a weighted risk index, the highest-risk outpatient surgery patients have an almost 20-fold increase in risk of venous thromboembolism (VTE) requiring therapy, according to a study published online April 13 in the Annals of Surgery.
Minimally Invasive Esophagectomy Offers Benefits
TUESDAY, May 1 (HealthDay News) -- Compared with open transthoracic esophagectomy, minimally invasive transthoracic esophagectomy is associated with significantly fewer pulmonary infections and with other short-term benefits in patients with resectable cancer of the esophagus, according to research published online May 1 in The Lancet.
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