May 2012 Briefing - RheumatologyLast Updated: June 01, 2012.
Here are what the editors at HealthDay consider to be the most important developments in Rheumatology for May 2012. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.
Oral, Injected Methotrexate Have Similar Efficacy in JIA
WEDNESDAY, May 30 (HealthDay News) -- Oral and injected methotrexate are equally effective for treating children with juvenile idiopathic arthritis, according to a study published online May 30 in Arthritis Care & Research.
Risk Models Only Slightly Up Prediction of Complex Diseases
WEDNESDAY, May 30 (HealthDay News) -- Risk models that take gene-gene and gene-environment interactions into account only slightly improve the prediction of risk for three complex diseases, according to a study published online May 24 in the American Journal of Human Genetics.
Gender, High DAS28-P Index Predictive of Pain in Early RA
FRIDAY, May 18 (HealthDay News) -- For patients with rheumatoid arthritis (RA), female gender and having a high proportion of disease activity score (DAS28) attributable to patient-reported components (joint tenderness and visual analog score) (DAS28-P) at baseline are predictive of less improvement in pain at one year, according to a study published online May 3 in Arthritis Care & Research.
African-Americans Have More Severe Sclerosis Complications
FRIDAY, May 11 (HealthDay News) -- African-American patients with systemic sclerosis have more severe complications than Caucasian patients, and these complications are related to the type of autoantibody and severity of lung disease, according to a study published online May 10 in Arthritis & Rheumatism.
High Infection Rates Seen in Juvenile Idiopathic Arthritis
WEDNESDAY, May 9 (HealthDay News) -- Children with juvenile idiopathic arthritis (JIA) have higher rates of hospitalized bacterial infection than children without the condition, and high-dose steroids significantly increase the rate of infection, according to a study published online May 8 in Arthritis & Rheumatism.
CMS Policy Helping Hospitals to Prevent Targeted Infections
FRIDAY, May 4 (HealthDay News) -- Hospitals seem to be paying greater attention to preventing targeted health care-associated infections (HAIs) as a result of the Centers for Medicare and Medicaid Services (CMS) nonpayment policy, according to a study published in the May issue of the American Journal of Infection Control.
Lupus Nephritis Screening and Management Guidelines Issued
FRIDAY, May 4 (HealthDay News) -- The American College of Rheumatology has produced new guidelines for the screening, treatment, and management of lupus nephritis; the guidelines have been published in the June issue of Arthritis Care & Research.
Lower All-Cause, Cardio Mortality in Obese With RA
WEDNESDAY, May 2 (HealthDay News) -- Overweight and obese patients with rheumatoid arthritis (RA) have lower all-cause and cardiovascular mortality, but have substantially increased risks of comorbidities, medical costs, and reduced quality of life compared with normal-weight RA patients, according to a study published online April 18 in Arthritis Care & Research.
Mechanism ID'd for Benefit of Stem Cells in Autoimmunity
WEDNESDAY, May 2 (HealthDay News) -- Bone marrow mesenchymal stem cells (BMMSCs) activate a mechanism involving coupling of FAS/FAS ligand to induce T cell apoptosis and immune tolerance, according to an experimental study published online April 26 in Cell Stem Cell.
Methodological Heterogeneity Seen in Clinical Trials
TUESDAY, May 1 (HealthDay News) -- Clinical studies registered with ClinicalTrials.gov from 2007 and 2010 are predominately small, single-center trials and contain significant heterogeneity in methodology, according to a study published in the May 2 issue of the Journal of the American Medical Association.
A Third of Adults With Arthritis Have Anxiety, Depression
TUESDAY, May 1 (HealthDay News) -- One-third of U.S. adults with physician-diagnosed arthritis report having anxiety or depression, with anxiety more prevalent than depression, according to a study published online May 1 in Arthritis Care & Research.
Indirect Link ID'd Between Pain Catastrophizing, Severity
TUESDAY, May 1 (HealthDay News) -- Pain catastrophizing, in particular ruminating about pain, has an indirect effect on clinical pain severity and pain-related interference, through sleep disturbance, according to a study published online March 14 in Pain.
Obesity, Increased Incidence of Rheumatoid Arthritis Linked
TUESDAY, May 1 (HealthDay News) -- Obesity is linked with the risk of developing rheumatoid arthritis (RA), and seems to have contributed to the recent increase in incidence of the condition, according to a study published online April 18 in Arthritis Care & Research.