Create Account | Sign In: Author or Forum

 
News  |  Journals  |  Conferences  |  Opinion  |  Articles  |  Forums  |  Twitter    
 
Category: Family Medicine | Geriatrics | Internal Medicine | Pathology | Journal

Back to Journal Articles

Elevated Antibody Component Tied to Worse General Survival

Last Updated: June 07, 2012.

 

Two-fold higher risk of death for adults aged 50 or older with high levels of free light chains

Share |

Comments: (0)

Tell-a-Friend

 

  Related
 
Middle-aged and elderly individuals with elevated levels of immunoglobulin free light chains, without plasma cell disorders, have a two-fold higher risk of death, according to a study published in the June issue of the Mayo Clinic Proceedings.

THURSDAY, June 7 (HealthDay News) -- Middle-aged and elderly individuals with elevated levels of immunoglobulin free light chains (FLCs), without plasma cell disorders, have a two-fold higher risk of death, according to a study published in the June issue of the Mayo Clinic Proceedings.

Angela Dispenzieri, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues measured the levels of Σ FLC (sum of κ and λ FLC) in 15,859 individuals, aged 50 years or older, without plasma cell disorders. Baseline data were collected from March 1995 to November 2003, and participants were followed up through June 2009. The association between Σ FLC and overall survival was assessed.

During 158,003 person-years of follow-up, the researchers recorded 4,348 deaths. Worse overall survival was significantly predicted by a high Σ FLC. Those in the highest 10 percent of Σ FLC (≥4.72 mg/dL) were at much higher risk of death compared with the remaining subjects (risk ratio, 4.4). After adjustment for age, sex, and renal insufficiency, the risk ratio was 2.1. The excess deaths were not restricted to any particular cause.

"We do not recommend this test as a screening test, because it will only cause alarm," coauthor Vincent Rajkumar, M.D., also of the Mayo Clinic, said in a statement. "We do not know why this marker is associated with higher rates of death. We do not have a way of turning things around. Therefore, I would urge caution in using this test until we figure out what to do about it and what these results mean."

The FLC reagent used in the study was provided by Binding Site; several authors disclosed financial ties to Binding Site.

Abstract
Full Text
Editorial

Copyright © 2012 HealthDay. All rights reserved.


Previous: NAFLD Independently Linked to Cardiovascular Disease Next: Early Rapid Growth Partly Mediates Genetic Obesity Risk

Reader comments on this article are listed below. Review our comments policy.


Submit your opinion:

Name:

Email:

Location:

URL:

Remember my personal information

Notify me of follow-up comments?

advertisement.gif (61x7 -- 0 bytes)
 

Are you a Doctor, Pharmacist, PA or a Nurse?

Join the Doctors Lounge online medical community

  • Editorial activities: Publish, peer review, edit online articles.

Doctors Lounge Membership Application

 
     

 advertisement.gif (61x7 -- 0 bytes)

 

 

Useful Sites
MediLexicon
  Tools & Services: Follow DoctorsLounge on Twitter Follow us on Twitter | RSS News | Newsletter | Contact us
Copyright © 2001-2014
Doctors Lounge.
All rights reserved.

Medical Reference:
Diseases | Symptoms
Drugs | Labs | Procedures
Software | Tutorials

Advertising
Links | Humor
Forum Archive
CME | Conferences

Privacy Statement
Terms & Conditions
Editorial Board
About us | Email

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.