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Two Groups of Cells ID’ed in Healing Potential of Omentum

Last Updated: June 08, 2012.

 

Immunomodulatory myeloid-derived suppressor cells, omnipotent stem cells support tissue repair

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Immunomodulatory myeloid-derived suppressor cells and omnipotent stem cells are two of the groups of cells in the omentum which are involved in tissue repair, according to an experimental study published online June 6 in PLoS One.

FRIDAY, June 8 (HealthDay News) -- Immunomodulatory myeloid-derived suppressor cells and omnipotent stem cells are two of the groups of cells in the omentum which are involved in tissue repair, according to an experimental study published online June 6 in PLoS One.

To investigate the mechanism of tissue repair support by the omentum, Shivanee Shah, from Loyola University Chicago, and colleagues analyzed the cell subsets derived from the mouse omentum on T-cell immune and inflammatory responses.

The researchers found that the omentum contains at least two groups of cells which support tissue repair, including omnipotent stem cells, which are indistinguishable from mesenchymal stem cells, and immunomodulatory myeloid derived suppressor cells.

"These data demonstrate that the omentum is equipped to help tissue healing, as observed clinically in various settings, and that the function results from multiple subsets of cells that specialize in immune modulation and tissue regeneration," the authors write. "In the future, cells from the omentum may be applicable for use in support for tissue healing and regeneration in a variety of inflammatory disorders."

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